SEH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEH1_HUMAN
• UniProt AC: Q96EE3
• Protein Name: Nucleoporin SEH1 {ECO:0000305}
• Gene Name: SEH1L
• Organism: Homo sapiens (Human).
• Sequence Length: 360
• Subcellular Localization: Chromosome, centromere, kinetochore . Nucleus, nuclear pore complex . Lysosome membrane .
• Protein Description: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. [PubMed: 23723238 It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1]
• Protein Sequence: MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGRKHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MFVARSIAADHKD --CCCCCCCCCCCCH	13.57	21406692
12	Acetylation	RSIAADHKDLIHDVS CCCCCCCCHHCCEEC	55.57	26051181
12 (in isoform 1)	Ubiquitination	-	55.57	-
12	Sumoylation	RSIAADHKDLIHDVS CCCCCCCCHHCCEEC	55.57	28112733
12	Ubiquitination	RSIAADHKDLIHDVS CCCCCCCCHHCCEEC	55.57	23000965
19	Phosphorylation	KDLIHDVSFDFHGRR CHHCCEECEEECCCE	25.75	20873877
29	Phosphorylation	FHGRRMATCSSDQSV ECCCEEEECCCCCCE	11.99	20068231
31	Phosphorylation	GRRMATCSSDQSVKV CCEEEECCCCCCEEE	32.37	26270265
32	Phosphorylation	RRMATCSSDQSVKVW CEEEECCCCCCEEEE	41.64	20068231
35	Phosphorylation	ATCSSDQSVKVWDKS EECCCCCCEEEEECC	28.97	26270265
37	Acetylation	CSSDQSVKVWDKSES CCCCCCEEEEECCCC	42.74	26051181
37	Ubiquitination	CSSDQSVKVWDKSES CCCCCCEEEEECCCC	42.74	29967540
37 (in isoform 1)	Ubiquitination	-	42.74	-
41	Ubiquitination	QSVKVWDKSESGDWH CCEEEEECCCCCCEE	40.17	29967540
41 (in isoform 1)	Ubiquitination	-	40.17	-
44	Phosphorylation	KVWDKSESGDWHCTA EEEECCCCCCEEEEE	49.49	-
52	Phosphorylation	GDWHCTASWKTHSGS CCEEEEEEEEECCCE	15.79	24719451
54	Acetylation	WHCTASWKTHSGSVW EEEEEEEEECCCEEE	33.59	26051181
57	Phosphorylation	TASWKTHSGSVWRVT EEEEEECCCEEEEEE	37.69	24719451
71	Ubiquitination	TWAHPEFGQVLASCS EEECCCHHHHHHHCC	18.28	22817900
75	Ubiquitination	PEFGQVLASCSFDRT CCHHHHHHHCCCCCH	15.05	22817900
82	Phosphorylation	ASCSFDRTAAVWEEI HHCCCCCHHHHHHHH	22.32	20068231
83	Ubiquitination	SCSFDRTAAVWEEIV HCCCCCHHHHHHHHH	10.83	22817900
86	Ubiquitination	FDRTAAVWEEIVGES CCCHHHHHHHHHCCC	7.87	22817900
96 (in isoform 2)	Ubiquitination	-	44.31	21890473
96	Ubiquitination	IVGESNDKLRGQSHW HHCCCCCHHCCCCEE	44.31	22053931
96 (in isoform 1)	Ubiquitination	-	44.31	21890473
96	Acetylation	IVGESNDKLRGQSHW HHCCCCCHHCCCCEE	44.31	26051181
103	Ubiquitination	KLRGQSHWVKRTTLV HHCCCCEEEEEEEEC	11.54	22817900
106	Ubiquitination	GQSHWVKRTTLVDSR CCCEEEEEEEECCCC	24.27	22817900
107	Phosphorylation	QSHWVKRTTLVDSRT CCEEEEEEEECCCCC	20.82	20068231
108	Phosphorylation	SHWVKRTTLVDSRTS CEEEEEEEECCCCCC	28.90	20068231
112	Phosphorylation	KRTTLVDSRTSVTDV EEEEECCCCCCCCCC	29.94	20068231
114	Phosphorylation	TTLVDSRTSVTDVKF EEECCCCCCCCCCCC	31.34	20068231
115	Phosphorylation	TLVDSRTSVTDVKFA EECCCCCCCCCCCCC	23.16	20068231
117	Phosphorylation	VDSRTSVTDVKFAPK CCCCCCCCCCCCCCC	34.54	20068231
120 (in isoform 1)	Ubiquitination	-	38.32	21890473
120 (in isoform 2)	Ubiquitination	-	38.32	21890473
120	Ubiquitination	RTSVTDVKFAPKHMG CCCCCCCCCCCCCCC	38.32	22817900
124 (in isoform 1)	Ubiquitination	-	42.67	-
124	Ubiquitination	TDVKFAPKHMGLMLA CCCCCCCCCCCEEEE	42.67	22817900
159	Ubiquitination	QWSLQHEISCKLSCS HHHHCEEEEEEEEEE	5.70	22817900
162	Ubiquitination	LQHEISCKLSCSCIS HCEEEEEEEEEEEEE	36.32	22817900
179	Phosphorylation	PSSSRAHSPMIAVGS CCCCCCCCCEEEECC	18.38	29255136
179	Ubiquitination	PSSSRAHSPMIAVGS CCCCCCCCCEEEECC	18.38	22817900
181	Ubiquitination	SSRAHSPMIAVGSDD CCCCCCCEEEECCCC	3.26	21890473
182	Ubiquitination	SRAHSPMIAVGSDDS CCCCCCEEEECCCCC	2.97	22817900
186	Phosphorylation	SPMIAVGSDDSSPNA CCEEEECCCCCCCCC	31.48	30108239
189	Phosphorylation	IAVGSDDSSPNAMAK EEECCCCCCCCCEEE	53.32	30108239
189	Ubiquitination	IAVGSDDSSPNAMAK EEECCCCCCCCCEEE	53.32	23000965
190	Phosphorylation	AVGSDDSSPNAMAKV EECCCCCCCCCEEEE	29.21	28112733
195	Ubiquitination	DSSPNAMAKVQIFEY CCCCCCEEEEEEEEE	13.37	23000965
196 (in isoform 1)	Ubiquitination	-	22.91	-
201	Ubiquitination	MAKVQIFEYNENTRK EEEEEEEEECHHHHH	49.42	21890473
208	Ubiquitination	EYNENTRKYAKAETL EECHHHHHHEEEEEE	47.74	22817900
209	Phosphorylation	YNENTRKYAKAETLM ECHHHHHHEEEEEEE	15.28	-
209	Ubiquitination	YNENTRKYAKAETLM ECHHHHHHEEEEEEE	15.28	23000965
211 (in isoform 1)	Ubiquitination	-	43.60	21890473
211	Ubiquitination	ENTRKYAKAETLMTV HHHHHHEEEEEEEEE	43.60	22817900
211 (in isoform 2)	Ubiquitination	-	43.60	21890473
214	Phosphorylation	RKYAKAETLMTVTDP HHHEEEEEEEEECCC	27.04	-
215	Ubiquitination	KYAKAETLMTVTDPV HHEEEEEEEEECCCH	1.72	23000965
217	Phosphorylation	AKAETLMTVTDPVHD EEEEEEEEECCCHHH	24.30	-
228	Ubiquitination	PVHDIAFAPNLGRSF CHHHHEECCCCCCCE	5.31	22817900
231	Ubiquitination	DIAFAPNLGRSFHIL HHEECCCCCCCEEEE	6.16	22817900
251	Acetylation	DVRIFTLKPVRKELT CEEEEEECEECHHHH	38.11	25953088
251 (in isoform 1)	Ubiquitination	-	38.11	-
251	Ubiquitination	DVRIFTLKPVRKELT CEEEEEECEECHHHH	38.11	-
255	Ubiquitination	FTLKPVRKELTSSGG EEECEECHHHHCCCC	58.26	29967540
257	Ubiquitination	LKPVRKELTSSGGPT ECEECHHHHCCCCCC	6.71	21890473
258	Phosphorylation	KPVRKELTSSGGPTK CEECHHHHCCCCCCE	23.18	25850435
259	Phosphorylation	PVRKELTSSGGPTKF EECHHHHCCCCCCEE	39.34	26657352
260	Phosphorylation	VRKELTSSGGPTKFE ECHHHHCCCCCCEEE	42.40	25849741
264	Phosphorylation	LTSSGGPTKFEIHIV HHCCCCCCEEEEEEE	52.20	25850435
265	Ubiquitination	TSSGGPTKFEIHIVA HCCCCCCEEEEEEEE	44.10	23000965
271	Ubiquitination	TKFEIHIVAQFDNHN CEEEEEEEEEECCCC	1.80	23000965
277	Ubiquitination	IVAQFDNHNSQVWRV EEEEECCCCCEEEEE	36.84	21890473
285	Ubiquitination	NSQVWRVSWNITGTV CCEEEEEEEEEECEE	13.06	23000965
291	Ubiquitination	VSWNITGTVLASSGD EEEEEECEEEEECCC	12.05	23000965
306	Methylation	DGCVRLWKANYMDNW CCEEEEEEEECCCCC	31.20	44858439
306 (in isoform 2)	Ubiquitination	-	31.20	21890473
306 (in isoform 1)	Ubiquitination	-	31.20	21890473
306	Ubiquitination	DGCVRLWKANYMDNW CCEEEEEEEECCCCC	31.20	21890473
314 (in isoform 1)	Ubiquitination	-	28.33	-
314	Acetylation	ANYMDNWKCTGILKG EECCCCCEEEEEEEC	28.33	26051181
314	Ubiquitination	ANYMDNWKCTGILKG EECCCCCEEEEEEEC	28.33	23000965
320	Ubiquitination	WKCTGILKGNGSPVN CEEEEEEECCCCCCC	48.70	23000965
324	Phosphorylation	GILKGNGSPVNGSSQ EEEECCCCCCCCCCC	29.67	28985074
326	Ubiquitination	LKGNGSPVNGSSQQG EECCCCCCCCCCCCC	15.78	21890473
334	Ubiquitination	NGSSQQGTSNPSLGS CCCCCCCCCCCCHHH	22.46	23000965
340	Ubiquitination	GTSNPSLGSTIPSLQ CCCCCCHHHCHHHHH	27.38	23000965
361 (in isoform 1)	Phosphorylation	-		22673903
365	Phosphorylation	KHS------------ CCC------------		24719451
365 (in isoform 1)	Phosphorylation	-		21815630
367	Methylation	S-------------- C--------------		-
407 (in isoform 1)	Phosphorylation	-		23186163
409	Phosphorylation	-------------------------------------------------------- --------------------------------------------------------		24719451
409 (in isoform 1)	Phosphorylation	-		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NU107_HUMAN	NUP107	physical	15146057
NUP85_HUMAN	NUP85	physical	15146057
NU133_HUMAN	NUP133	physical	15146057
NU160_HUMAN	NUP160	physical	22863883
NUP37_HUMAN	NUP37	physical	22863883
NUP43_HUMAN	NUP43	physical	22863883
NUP98_HUMAN	NUP98	physical	26344197
BUB1_HUMAN	BUB1	physical	26496610
GLE1_HUMAN	GLE1	physical	26496610
NUP88_HUMAN	NUP88	physical	26496610
NUP98_HUMAN	NUP98	physical	26496610
RBP2_HUMAN	RANBP2	physical	26496610
RAGP1_HUMAN	RANGAP1	physical	26496610
SEC13_HUMAN	SEC13	physical	26496610
TCPG_HUMAN	CCT3	physical	26496610
SUMO1_HUMAN	SUMO1	physical	26496610
NU214_HUMAN	NUP214	physical	26496610
AAAS_HUMAN	AAAS	physical	26496610
NU155_HUMAN	NUP155	physical	26496610
NUP93_HUMAN	NUP93	physical	26496610
NU153_HUMAN	NUP153	physical	26496610
NXF1_HUMAN	NXF1	physical	26496610
TCPH_HUMAN	CCT7	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
NU205_HUMAN	NUP205	physical	26496610
PO210_HUMAN	NUP210	physical	26496610
NU160_HUMAN	NUP160	physical	26496610
NU188_HUMAN	NUP188	physical	26496610
MIO_HUMAN	MIOS	physical	26496610
TM214_HUMAN	TMEM214	physical	26496610
NDC1_HUMAN	NDC1	physical	26496610
NU133_HUMAN	NUP133	physical	26496610
NU107_HUMAN	NUP107	physical	26496610
NUP37_HUMAN	NUP37	physical	26496610
WDR59_HUMAN	WDR59	physical	26496610
NUP85_HUMAN	NUP85	physical	26496610
WDR24_HUMAN	WDR24	physical	26496610
TM209_HUMAN	TMEM209	physical	26496610
NUP53_HUMAN	NUP35	physical	26496610
PPR37_HUMAN	PPP1R37	physical	26496610
NUP43_HUMAN	NUP43	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.