PPR37_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPR37_HUMAN
• UniProt AC: O75864
• Protein Name: Protein phosphatase 1 regulatory subunit 37
• Gene Name: PPP1R37
• Organism: Homo sapiens (Human).
• Sequence Length: 691
• Protein Description: Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes..
• Protein Sequence: MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVEPKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETPCPALVPPTDSLGPGDRSPPGSPSTPTEQRISVSSPGRGHKVFVVTRVESPPERAEPPASPTPPSPPPPPSPPASPSLPPAGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHELSCSKNEKELEELLLEASQESGQETL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	EAPAEAGSPSPASPP CCCCCCCCCCCCCCC	29.29	28348404
29	Phosphorylation	PAEAGSPSPASPPAD CCCCCCCCCCCCCCC	34.49	28348404
32	Phosphorylation	AGSPSPASPPADGRL CCCCCCCCCCCCCCH	34.50	29507054
47	Phosphorylation	KAAAKRVTFPSDEDI HHHHHHCCCCCCHHH	33.58	28192239
50	Phosphorylation	AKRVTFPSDEDIVSG HHHCCCCCCHHHCCC	49.82	25159151
56	Phosphorylation	PSDEDIVSGAVEPKD CCCHHHCCCCCCCCC	22.74	27050516
103	Phosphorylation	LRQLQEFTDLGHRLD HHHHHHHHHHHHHCC	29.57	29083192
177	Phosphorylation	SFNKHIGTRGWQAAA EECCCCCHHHHHHHH	25.96	-
219	Phosphorylation	ARALRIRSSLAVLHL HHHHHHHHHHHHHHH	27.60	28188228
220	Phosphorylation	RALRIRSSLAVLHLE HHHHHHHHHHHHHHC	15.53	28188228
230	Phosphorylation	VLHLENASLSGRPLM HHHHCCCCCCCHHHH	34.35	28188228
232	Phosphorylation	HLENASLSGRPLMLL HHCCCCCCCHHHHHH	30.20	26503514
418	Phosphorylation	LALKVNHSLLRLDLD HHHHHCHHHHCCCCC	24.72	19664994
526	Phosphorylation	EEGERDETPCPALVP HCCCCCCCCCCCCCC	34.18	23312004
535	Phosphorylation	CPALVPPTDSLGPGD CCCCCCCCCCCCCCC	31.95	27794612
537	Phosphorylation	ALVPPTDSLGPGDRS CCCCCCCCCCCCCCC	37.39	27794612
544	Phosphorylation	SLGPGDRSPPGSPST CCCCCCCCCCCCCCC	39.94	19664994
548	Phosphorylation	GDRSPPGSPSTPTEQ CCCCCCCCCCCCCCE	22.81	29255136
550	Phosphorylation	RSPPGSPSTPTEQRI CCCCCCCCCCCCEEE	49.03	29255136
551	Phosphorylation	SPPGSPSTPTEQRIS CCCCCCCCCCCEEEE	37.30	27251275
553	Phosphorylation	PGSPSTPTEQRISVS CCCCCCCCCEEEEEC	44.85	23312004
558	Phosphorylation	TPTEQRISVSSPGRG CCCCEEEEECCCCCC	20.38	30266825
560	Phosphorylation	TEQRISVSSPGRGHK CCEEEEECCCCCCCE	24.83	30266825
561	Phosphorylation	EQRISVSSPGRGHKV CEEEEECCCCCCCEE	29.26	29255136
576	Phosphorylation	FVVTRVESPPERAEP EEEEEECCCCHHCCC	42.78	29255136
586	Phosphorylation	ERAEPPASPTPPSPP HHCCCCCCCCCCCCC	34.77	30278072
588	Phosphorylation	AEPPASPTPPSPPPP CCCCCCCCCCCCCCC	45.39	28188228
591	Phosphorylation	PASPTPPSPPPPPSP CCCCCCCCCCCCCCC	51.77	25849741
597	Phosphorylation	PSPPPPPSPPASPSL CCCCCCCCCCCCCCC	49.65	26657352
601	Phosphorylation	PPPSPPASPSLPPAG CCCCCCCCCCCCCCC	22.31	29255136
603	Phosphorylation	PSPPASPSLPPAGAI CCCCCCCCCCCCCCC	51.52	29255136
612	Phosphorylation	PPAGAIDTRDTGSSE CCCCCCCCCCCCCCC	25.08	30177828
667	Phosphorylation	CGLEHELSCSKNEKE CCCCEECCCCCCHHH	17.23	26657352
669	Phosphorylation	LEHELSCSKNEKELE CCEECCCCCCHHHHH	34.83	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPR37_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPR37_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPR37_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PPR37_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-561, AND MASSSPECTROMETRY.
PubMed: 18669648