TM214_HUMAN - dbPTM
TM214_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TM214_HUMAN
UniProt AC Q6NUQ4
Protein Name Transmembrane protein 214
Gene Name TMEM214
Organism Homo sapiens (Human).
Sequence Length 689
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress..
Protein Sequence MATKTAGVGRWEVVKKGRRPGVGAGAGGRGGGRNRRALGEANGVWKYDLTPAIQTTSTLYERGFENIMKRQNKEQVPPPAVEPKKPGNKKQPKKVATPPNQNQKQGRFRSLEEALKALDVADLQKELDKSQSVFSGNPSIWLKDLASYLNYKLQAPLSEPTLSQHTHDYPYSLVSRELRGIIRGLLAKAAGSLELFFDHCLFTMLQELDKTPGESLHGYRICIQAILQDKPKIATANLGKFLELLRSHQSRPAKCLTIMWALGQAGFANLTEGLKVWLGIMLPVLGIKSLSPFAITYLDRLLLMHPNLTKGFGMIGPKDFFPLLDFAYMPNNSLTPSLQEQLCQLYPRLKVLAFGAKPDSTLHTYFPSFLSRATPSCPPEMKKELLSSLTECLTVDPLSASVWRQLYPKHLSQSSLLLEHLLSSWEQIPKKVQKSLQETIQSLKLTNQELLRKGSSNNQDVVTCDMACKGLLQQVQGPRLPWTRLLLLLLVFAVGFLCHDLRSHSSFQASLTGRLLRSSGFLPASQQACAKLYSYSLQGYSWLGETLPLWGSHLLTVVRPSLQLAWAHTNATVSFLSAHCASHLAWFGDSLTSLSQRLQIQLPDSVNQLLRYLRELPLLFHQNVLLPLWHLLLEALAWAQEHCHEACRGEVTWDCMKTQLSEAVHWTWLCLQDITVAFLDWALALISQQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MATKTAGVG
------CCCCCCCCC		20.1522814378
4Ubiquitination----MATKTAGVGRW
----CCCCCCCCCCE		27.1733845483
5Phosphorylation---MATKTAGVGRWE
---CCCCCCCCCCEE		25.0422210691
29DimethylationVGAGAGGRGGGRNRR
CCCCCCCCCCCCCCH		39.40-
29MethylationVGAGAGGRGGGRNRR
CCCCCCCCCCCCCCH		39.4024394781
33MethylationAGGRGGGRNRRALGE
CCCCCCCCCCHHHHC		36.44115918625
47PhosphorylationEANGVWKYDLTPAIQ
CCCCEEEEECCCHHH		10.6520068231
50PhosphorylationGVWKYDLTPAIQTTS
CEEEEECCCHHHHHH		14.0520068231
55PhosphorylationDLTPAIQTTSTLYER
ECCCHHHHHHHHHHH		19.3220068231
56PhosphorylationLTPAIQTTSTLYERG
CCCHHHHHHHHHHHH		11.8820068231
57PhosphorylationTPAIQTTSTLYERGF
CCHHHHHHHHHHHHH		21.5828796482
58PhosphorylationPAIQTTSTLYERGFE
CHHHHHHHHHHHHHH		31.1328796482
60PhosphorylationIQTTSTLYERGFENI
HHHHHHHHHHHHHHH		12.0328796482
69MethylationRGFENIMKRQNKEQV
HHHHHHHHHCCCCCC		47.22115979879
69UbiquitinationRGFENIMKRQNKEQV
HHHHHHHHHCCCCCC		47.2229967540
97PhosphorylationKQPKKVATPPNQNQK
CCCCCCCCCCCCCCC		42.1222167270
104UbiquitinationTPPNQNQKQGRFRSL
CCCCCCCCCCCCCCH		63.3729967540
107UbiquitinationNQNQKQGRFRSLEEA
CCCCCCCCCCCHHHH		22.7023000965
110PhosphorylationQKQGRFRSLEEALKA
CCCCCCCCHHHHHHH		37.1023312004
116UbiquitinationRSLEEALKALDVADL
CCHHHHHHHCCHHHH		54.6832015554
125UbiquitinationLDVADLQKELDKSQS
CCHHHHHHHHHHHHH		68.4929967540
129AcetylationDLQKELDKSQSVFSG
HHHHHHHHHHHCCCC		64.1226051181
129UbiquitinationDLQKELDKSQSVFSG
HHHHHHHHHHHCCCC		64.1229967540
187UbiquitinationGIIRGLLAKAAGSLE
HHHHHHHHHHHCCHH		12.4132142685
195UbiquitinationKAAGSLELFFDHCLF
HHHCCHHHHHHHHHH		6.6821890473
195UbiquitinationKAAGSLELFFDHCLF
HHHCCHHHHHHHHHH		6.6821890473
195UbiquitinationKAAGSLELFFDHCLF
HHHCCHHHHHHHHHH		6.6821890473
230MalonylationIQAILQDKPKIATAN
HHHHHCCCCCEEECC		34.9426320211
232UbiquitinationAILQDKPKIATANLG
HHHCCCCCEEECCHH		51.1932142685
240UbiquitinationIATANLGKFLELLRS
EEECCHHHHHHHHHH		50.3621906983
269N-linked_GlycosylationLGQAGFANLTEGLKV
HHHCCCCCHHHHHHH		45.28UniProtKB CARBOHYD
289PhosphorylationLPVLGIKSLSPFAIT
HHHHCCCCCCHHHHH		31.96-
291PhosphorylationVLGIKSLSPFAITYL
HHCCCCCCHHHHHHH		25.68-
305UbiquitinationLDRLLLMHPNLTKGF
HHHHHHHCCCCCCCC		14.2027667366
307N-linked_GlycosylationRLLLMHPNLTKGFGM
HHHHHCCCCCCCCCC		45.74UniProtKB CARBOHYD
312UbiquitinationHPNLTKGFGMIGPKD
CCCCCCCCCCCCCHH		6.8229967540
337UbiquitinationPNNSLTPSLQEQLCQ
CCCCCCHHHHHHHHH		37.1333845483
350UbiquitinationCQLYPRLKVLAFGAK
HHHHHHHHHHHCCCC		36.1627667366
357UbiquitinationKVLAFGAKPDSTLHT
HHHHCCCCCCCCHHH		50.1429967540
371PhosphorylationTYFPSFLSRATPSCP
HHCHHHHHHCCCCCC		20.1924719451
3822-HydroxyisobutyrylationPSCPPEMKKELLSSL
CCCCHHHHHHHHHHH		41.24-
382UbiquitinationPSCPPEMKKELLSSL
CCCCHHHHHHHHHHH		41.2433845483
383UbiquitinationSCPPEMKKELLSSLT
CCCHHHHHHHHHHHH		52.89-
389UbiquitinationKKELLSSLTECLTVD
HHHHHHHHHHHCCCC		4.1433845483
399UbiquitinationCLTVDPLSASVWRQL
HCCCCCCCHHHHHHH		24.7221890473
399UbiquitinationCLTVDPLSASVWRQL
HCCCCCCCHHHHHHH		24.7223000965
399UbiquitinationCLTVDPLSASVWRQL
HCCCCCCCHHHHHHH		24.7221890473
408UbiquitinationSVWRQLYPKHLSQSS
HHHHHHCCCCCCHHH		26.6129967540
409UbiquitinationVWRQLYPKHLSQSSL
HHHHHCCCCCCHHHH		43.55-
410PhosphorylationWRQLYPKHLSQSSLL
HHHHCCCCCCHHHHH		26.6433259812
434UbiquitinationQIPKKVQKSLQETIQ
HHCHHHHHHHHHHHH		57.0033845483
444UbiquitinationQETIQSLKLTNQELL
HHHHHHHHCCCHHHH		59.5223000965
453UbiquitinationTNQELLRKGSSNNQD
CCHHHHHCCCCCCCC		64.2129967540
455PhosphorylationQELLRKGSSNNQDVV
HHHHHCCCCCCCCCH		32.6925159151
456PhosphorylationELLRKGSSNNQDVVT
HHHHCCCCCCCCCHH		48.7625849741
463PhosphorylationSNNQDVVTCDMACKG
CCCCCCHHHHHHHHH		11.5727251275
470UbiquitinationTCDMACKGLLQQVQG
HHHHHHHHHHHHCCC		31.3521890473
508UbiquitinationLRSHSSFQASLTGRL
HHCCCHHHHHHHHHH		31.8023000965
529S-nitrosylationLPASQQACAKLYSYS
CCHHHHHHHHHHCCC		2.742212679
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TM214_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TM214_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TM214_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TM214_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TM214_HUMAN

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Related Literatures of Post-Translational Modification

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