| UniProt ID | GUC2D_HUMAN | |
|---|---|---|
| UniProt AC | Q02846 | |
| Protein Name | Retinal guanylyl cyclase 1 | |
| Gene Name | GUCY2D | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1103 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
| Protein Description | Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.. | |
| Protein Sequence | MTACARRAGGLPDPGLCGPAWWAPSLPRLPRALPRLPLLLLLLLLQPPALSAVFTVGVLGPWACDPIFSRARPDLAARLAAARLNRDPGLAGGPRFEVALLPEPCRTPGSLGAVSSALARVSGLVGPVNPAACRPAELLAEEAGIALVPWGCPWTQAEGTTAPAVTPAADALYALLRAFGWARVALVTAPQDLWVEAGRSLSTALRARGLPVASVTSMEPLDLSGAREALRKVRDGPRVTAVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSLVFLPFDTIHYALSPGPEALAALANSSQLRRAHDAVLTLTRHCPSEGSVLDSLRRAQERRELPSDLNLQQVSPLFGTIYDAVFLLARGVAEARAAAGGRWVSGAAVARHIRDAQVPGFCGDLGGDEEPPFVLLDTDAAGDRLFATYMLDPARGSFLSAGTRMHFPRGGSAPGPDPSCWFDPNNICGGGLEPGLVFLGFLLVVGMGLAGAFLAHYVRHRLLHMQMVSGPNKIILTVDDITFLHPHGGTSRKVAQGSRSSLGARSMSDIRSGPSQHLDSPNIGVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAMLELTPEEVVQRVRSPPPLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDLQPGSSNHGISLQEIPPERRRKLEKARPGQFS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 107 | Phosphorylation | LLPEPCRTPGSLGAV ECCCCCCCCCHHHHH | 38.42 | 27251275 | |
| 110 | Phosphorylation | EPCRTPGSLGAVSSA CCCCCCCHHHHHHHH | 25.49 | 27251275 | |
| 115 | Phosphorylation | PGSLGAVSSALARVS CCHHHHHHHHHHHHH | 14.90 | 27251275 | |
| 116 | Phosphorylation | GSLGAVSSALARVSG CHHHHHHHHHHHHHC | 22.24 | 27251275 | |
| 200 | Phosphorylation | LWVEAGRSLSTALRA HHHHCCCCHHHHHHH | 26.25 | - | |
| 202 | Phosphorylation | VEAGRSLSTALRARG HHCCCCHHHHHHHCC | 16.93 | 23403867 | |
| 203 | Phosphorylation | EAGRSLSTALRARGL HCCCCHHHHHHHCCC | 34.70 | 23403867 | |
| 214 | Phosphorylation | ARGLPVASVTSMEPL HCCCCCEEECCCCCC | 26.60 | - | |
| 283 | Phosphorylation | LPFDTIHYALSPGPE EECCCEEHHCCCCHH | 12.85 | - | |
| 297 | N-linked_Glycosylation | EALAALANSSQLRRA HHHHHHHCHHHHHHH | 42.94 | UniProtKB CARBOHYD | |
| 298 | Phosphorylation | ALAALANSSQLRRAH HHHHHHCHHHHHHHH | 17.54 | - | |
| 426 | Phosphorylation | MLDPARGSFLSAGTR EECCCCCCCCCCCCC | 19.91 | 23612710 | |
| 429 | Phosphorylation | PARGSFLSAGTRMHF CCCCCCCCCCCCCCC | 23.73 | 23612710 | |
| 432 | Phosphorylation | GSFLSAGTRMHFPRG CCCCCCCCCCCCCCC | 25.24 | 23612710 | |
| 520 | Phosphorylation | LHPHGGTSRKVAQGS EECCCCCCCHHHCCC | 33.12 | 24719451 | |
| 645 | Phosphorylation | LDWMFKSSLLLDLIK HHHHHHHHHHHHHHH | 24.51 | 19413330 | |
| 819 | Phosphorylation | RKTNIIDSMLRMLEQ CCCHHHHHHHHHHHH | 14.87 | 29083192 | |
| 867 | Phosphorylation | SVAEALKTGTPVEPE HHHHHHHHCCCCCHH | 47.33 | 22468782 | |
| 869 | Phosphorylation | AEALKTGTPVEPEYF HHHHHHCCCCCHHHH | 29.41 | 22468782 | |
| 962 | Phosphorylation | DILSAVGTFRMRHMP HHHHHHCCCHHHCCC | 11.06 | 24719451 | |
| 1024 | Phosphorylation | RIHVNLSTVGILRAL EEEEEHHHHHHHHHH | 26.39 | 30257219 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GUC2D_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GUC2D_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GUC2D_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GUC2D_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00481 | Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); R | |||||
| H00837 | Leber congenital amaurosis (LCR) | |||||
| OMIM Disease | ||||||
| 204000 | Leber congenital amaurosis 1 (LCA1) | |||||
| 601777 | Cone-rod dystrophy 6 (CORD6) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
