CSMD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSMD3_HUMAN
• UniProt AC: Q7Z407
• Protein Name: CUB and sushi domain-containing protein 3
• Gene Name: CSMD3
• Organism: Homo sapiens (Human).
• Sequence Length: 3707
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Involved in dendrite development..
• Protein Sequence: MKGIRKGESRAKESKPWEPGKRRCAKCGRLDFILMKKMGIKSGFTFWNLVFLLTVSCVKGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSEEQRVQVTSLRNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKKAIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPICEAGSKILVKDPRPALGTPSPKLSVPDDVFAQNYIWKGSYNFKGRKQPMTLTVTSFNASTGRVNATLSNSNMELLLSGVYKSQEARLMLRIYLIKVPAHASVKKMKEENWAMDGFVSAEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNAKSVEGKAVRFDPNLNTVCTMV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73	N-linked_Glycosylation	GGTLKGLNGTIESPG CCCCCCCCCEECCCC	54.98	UniProtKB CARBOHYD
90	N-linked_Glycosylation	YGYPNGANCTWVIIA CCCCCCCCEEEEEEE	25.75	UniProtKB CARBOHYD
361	N-linked_Glycosylation	TGELEEHNRTTTGAI CCCEEECCCCCCCEE	46.39	UniProtKB CARBOHYD
391	Phosphorylation	AVTIHRLSEEQRVQV EEEEEECCHHHCEEE	38.76	-
409	N-linked_Glycosylation	RNSGLDPNTSKDGLS CCCCCCCCCCCCCCC	57.56	UniProtKB CARBOHYD
724	N-linked_Glycosylation	CIFPCLSNFTAPMGT EEEECCCCCCCCCCC	25.91	UniProtKB CARBOHYD
823	N-linked_Glycosylation	SMSGRGFNITYNTFG CCCCCCEEEEEECCC	28.63	UniProtKB CARBOHYD
966	N-linked_Glycosylation	SPLLGSYNGTQVPQF HHHHCCCCCCCCCEE	49.05	UniProtKB CARBOHYD
1022	Phosphorylation	IPVHGRRYGHDFSIG CCCCCEEECCCCCCC	19.90	24043423
1027	Phosphorylation	RRYGHDFSIGSTVSF EEECCCCCCCCEEEE	31.90	24043423
1030	Phosphorylation	GHDFSIGSTVSFSCD CCCCCCCCEEEEECC	24.78	24043423
1031	Phosphorylation	HDFSIGSTVSFSCDS CCCCCCCEEEEECCC	18.24	24043423
1033	Phosphorylation	FSIGSTVSFSCDSGY CCCCCEEEEECCCCC	16.13	24043423
1035	Phosphorylation	IGSTVSFSCDSGYRL CCCEEEEECCCCCCC	14.98	24043423
1038	Phosphorylation	TVSFSCDSGYRLSHE EEEEECCCCCCCCCC	41.89	24043423
1040	Phosphorylation	SFSCDSGYRLSHEEP EEECCCCCCCCCCCC	16.60	24043423
1092	N-linked_Glycosylation	EFYPNSLNCTWTVDV CCCCCCCCEEEEEEC	22.46	UniProtKB CARBOHYD
1126	N-linked_Glycosylation	DYLLITENGSFTQPL CEEEEECCCCCCCCC	42.64	UniProtKB CARBOHYD
1171	N-linked_Glycosylation	SISYEGFNITFSEYN EEEEECEEEEEEECC	43.16	UniProtKB CARBOHYD
1231	Phosphorylation	GGGRRVWSAPLPRCV CCCCEEECCCCCCHH	19.70	22985185
1280	N-linked_Glycosylation	VQAGKGINISARTFH EECCCCCEEEEEEEE	30.72	UniProtKB CARBOHYD
1297	Phosphorylation	QGDVLKIYDGKDKTT CCCEEEEECCCCCHH	19.63	29083192
1303	Phosphorylation	IYDGKDKTTHLLGAF EECCCCCHHHHEHHH	29.58	29083192
1304	Phosphorylation	YDGKDKTTHLLGAFT ECCCCCHHHHEHHHC	19.10	29083192
1311	Phosphorylation	THLLGAFTGASMRGL HHHEHHHCCCCCCCC	31.16	29083192
1314	Phosphorylation	LGAFTGASMRGLTLS EHHHCCCCCCCCEEE	15.45	29083192
1391	Phosphorylation	GYTLHGSSLLKCMTG CCEECCHHHHHCCCC	42.17	24719451
1536	N-linked_Glycosylation	RDPGVPMNGTRNGDG CCCCCCCCCCCCCCC	42.48	UniProtKB CARBOHYD
1591	N-linked_Glycosylation	CIAPCGGNLTGSSGF EEEECCCCCCCCCCE	21.51	UniProtKB CARBOHYD
1670	Phosphorylation	LPERIESSSNTMHLA CCHHHHCCCCEEEEE	18.15	29978859
1671	Phosphorylation	PERIESSSNTMHLAF CHHHHCCCCEEEEEE	45.67	29978859
1673	Phosphorylation	RIESSSNTMHLAFRS HHHCCCCEEEEEEEC	14.12	29978859
1709	N-linked_Glycosylation	FDPGNIMNGTRLGMD CCCCCCCCCEEECCC	44.91	UniProtKB CARBOHYD
1717	Phosphorylation	GTRLGMDYKLGSTVT CEEECCCCCCCCEEE	10.14	-
1731	Phosphorylation	TYYCDAGYVLQGYST EEEECCCCEECCEEE	10.33	-
1781	N-linked_Glycosylation	LSPNYPKNYSVGHNC CCCCCCCCCEECCCE	29.79	UniProtKB CARBOHYD
1929	N-linked_Glycosylation	PNSLAQWNDSLPTCI CCCHHHCCCCCCCEE	19.53	UniProtKB CARBOHYD
2019	N-linked_Glycosylation	TTIPHLLNSTSNNLY CCHHHHHCCCCCCEE	49.99	UniProtKB CARBOHYD
2155	N-linked_Glycosylation	GVHLQFVNFSTETIH EEEEEEEECCCCCCH	26.83	UniProtKB CARBOHYD
2286	N-linked_Glycosylation	CEALCGGNITAMNGT CHHHHCCCEEEECCE	17.45	UniProtKB CARBOHYD
2291	N-linked_Glycosylation	GGNITAMNGTIYSPG CCCEEEECCEEECCC	41.83	UniProtKB CARBOHYD
2324	N-linked_Glycosylation	PGNGIYINFTVLQTE CCCCEEEEEEEEECC	15.01	UniProtKB CARBOHYD
2489	Phosphorylation	QMCAWSISVEKGYNI EEEEEEEEECCCCCE	20.78	-
2495	N-linked_Glycosylation	ISVEKGYNITMFVEF EEECCCCCEEEEEEE	31.74	UniProtKB CARBOHYD
2537	N-linked_Glycosylation	GDYSSAFNITSNGHE CCCCCCEEECCCCEE	36.02	UniProtKB CARBOHYD
2711	N-linked_Glycosylation	HGRWRIVNGSHYEYK CCCEEEECCCCCEEE	43.83	UniProtKB CARBOHYD
2713	Phosphorylation	RWRIVNGSHYEYKTK CEEEECCCCCEEEEE	20.07	-
2715	Phosphorylation	RIVNGSHYEYKTKVV EEECCCCCEEEEEEE	23.74	-
2717	Phosphorylation	VNGSHYEYKTKVVFS ECCCCCEEEEEEEEE	19.45	-
2719	Phosphorylation	GSHYEYKTKVVFSCD CCCCEEEEEEEEEEC	28.33	-
2742	N-linked_Glycosylation	ASIECLPNGTWSWRN CEEEECCCCCCCCCC	47.80	UniProtKB CARBOHYD
2862	N-linked_Glycosylation	RICQQDHNWSGQLPS EEECCCCCCCCCCCC	42.79	UniProtKB CARBOHYD
2922	Phosphorylation	CQANRQWSHPPPMCK HHHHCCCCCCCCCEE	20.13	28258704
2932	N-linked_Glycosylation	PPMCKVVNCSDPGIP CCCEEEEECCCCCCC	23.67	UniProtKB CARBOHYD
2952	N-linked_Glycosylation	ESKIEHGNFTYGTVV CHHCCCCCCCCEEEE	28.17	UniProtKB CARBOHYD
3099	N-linked_Glycosylation	EERTCLANGSWTGRQ CCEEEECCCCCCCCC	31.89	UniProtKB CARBOHYD
3158	N-linked_Glycosylation	SVRQCTANGTWSGTL CCEEECCCCCEECCC	30.21	UniProtKB CARBOHYD
3167	N-linked_Glycosylation	TWSGTLPNCTIISCG CEECCCCCCEEEECC	38.38	UniProtKB CARBOHYD
3194	N-linked_Glycosylation	DDYVVGQNVSYMCQP CCEEECCCEEEEECC	20.83	UniProtKB CARBOHYD
3208	N-linked_Glycosylation	PGYTMELNGSRIRTC CCEEEEECCCEEEEE	32.84	UniProtKB CARBOHYD
3214	Phosphorylation	LNGSRIRTCTINGTW ECCCEEEEEEECCEE	16.19	-
3218	N-linked_Glycosylation	RIRTCTINGTWSGVM EEEEEEECCEECCCC	24.56	UniProtKB CARBOHYD
3227	Phosphorylation	TWSGVMPTCRAVTCP EECCCCCCEEEEECC	9.13	-
3235	Phosphorylation	CRAVTCPTPPQISNG EEEEECCCCCCCCCC	50.15	-
3240	Phosphorylation	CPTPPQISNGRLEGT CCCCCCCCCCCCCCC	28.16	-
3276	N-linked_Glycosylation	AVLTCVGNGTWSGEV EEEEECCCCCCCCCC	25.07	UniProtKB CARBOHYD
3364	N-linked_Glycosylation	VPRHGSQNNTFGFQV CCCCCCCCCCCCEEC	51.73	UniProtKB CARBOHYD
3483	Phosphorylation	DPRPALGTPSPKLSV CCCCCCCCCCCCCCC	22.80	24719451
3485	Phosphorylation	RPALGTPSPKLSVPD CCCCCCCCCCCCCCC	34.21	21406692
3515	Phosphorylation	KGRKQPMTLTVTSFN CCCCCCEEEEEEEEE	26.43	22210691
3517	Phosphorylation	RKQPMTLTVTSFNAS CCCCEEEEEEEEECC	16.75	24043423
3519	Phosphorylation	QPMTLTVTSFNASTG CCEEEEEEEEECCCC	23.51	24043423
3520	Phosphorylation	PMTLTVTSFNASTGR CEEEEEEEEECCCCC	16.50	24043423
3522	N-linked_Glycosylation	TLTVTSFNASTGRVN EEEEEEEECCCCCEE	32.52	UniProtKB CARBOHYD
3524	Phosphorylation	TVTSFNASTGRVNAT EEEEEECCCCCEEEE	32.28	24043423
3525	Phosphorylation	VTSFNASTGRVNATL EEEEECCCCCEEEEE	26.96	24043423
3529	N-linked_Glycosylation	NASTGRVNATLSNSN ECCCCCEEEEECCCC	26.33	UniProtKB CARBOHYD
3533	Phosphorylation	GRVNATLSNSNMELL CCEEEEECCCCHHHH	33.58	22210691
3545	Phosphorylation	ELLLSGVYKSQEARL HHHHHCCCCCHHHHH	14.40	22210691
3612	N-linked_Glycosylation	GLQRLGLNMSEGSNS CHHHCCCCCCCCCCC	30.09	UniProtKB CARBOHYD
3618	N-linked_Glycosylation	LNMSEGSNSSNQPHG CCCCCCCCCCCCCCC	61.38	UniProtKB CARBOHYD
3627	N-linked_Glycosylation	SNQPHGTNSSSVAIA CCCCCCCCHHHHHHH	44.48	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSMD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSMD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSMD3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CSMD3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.