dbPTM

P121A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	P121A_HUMAN
UniProt AC	Q96HA1
Protein Name	Nuclear envelope pore membrane protein POM 121
Gene Name	POM121
Organism	Homo sapiens (Human).
Sequence Length	1249
Subcellular Localization	Nucleus, nuclear pore complex . Nucleus membrane Single-pass membrane protein . Endoplasmic reticulum membrane Single-pass membrane protein. Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase..
Protein Description	Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL)..
Protein Sequence	MSPAAAAAGAGERRRPIASVRDGRGRGCGGPARAVLLGLSLVGLLLYLVPAAAALAWLTVGATAAWWGLSREPRGSRPLSSFVRKARHRRPLSSFVRKARHRRTLFASPLAKSTANGNLLEPRTLLEGPDPAELLLMGSYLGKPGPPQPAAAPEGQDLRDRPGRRPPARPAPRSPPPRSPPPRSPPPSPPTHRAHHVYPSLPTPLLRPSRRPSPRDCGTLPNRFVITPRRRYPIHQAQYSCLGVLPTVCWNGYHKKAVLSPRNSRMVCSPVTVRIAPPDRRFSRSAIPEQIISSTLSSPSSNAPDPCAKETVLSALKEKEKKRTVEEEDQIFLDGQENKRRRHDSSGSGHSAFEPLVANGVPASFVPKPGSLKRGLNSQSSDDHLNKRSRSSSMSSLTGAYASGIPSSSRNAITSSYSSTRGISQLWKRNGPSSSPFSSPASSRSQTPERPAKKIREEELCHHSSSSTPLAADRESQGEKAADTTPRKKQNSNSQSTPGSSGQRKRKVQLLPSRRGEQLTLPPPPQLGYSITAEDLDLEKKASLQWFNQALEDKSDAASNSVTETPPITQPSFTFTLPAAAPASPPTSLLAPSTNPLLESLKKMQTPPSLPPCPESAGAATTEALSPPKTPSLLPPLGLSQSGPPGLLPSPSFDSKPPTTLLGLIPAPSMVPATDTKAPPTLQAETATKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPAASSAPPMFKPIFTAPPKSEKEGPTPPGPSVTATAPSSSSLPTTTSTTAPTFQPVFSSMGPPASVPLPAPFFKQTTTPATAPTTTAPLFTGLASATSAVAPITSASPSTDSASKPAFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPALPTTTTVTTFSQSLHTAVPTATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTPTFNIPFGSSAKSPLPSYPGANPQPAFGAAEGQPPGAAKPALAPSFGSSFTFGNSAAPAAAPTPAPPSMIKVVPAYVPTPIHPIFGGATHSAFGLKATASAFGAPASSQPAFGGSTAVFFGAATSSGFGATTQTASSGSSSSVFGSTTPSPFTFGGSAAPAGSGSFGINVATPGSSTTTGAFSFGAGQSGSTATSTPFAGGLGQNALGTTGQSTPFAFNVSSTTESKPVFGGTATPTFGLNTPAPGVGTSGSSLSFGASSAPAQGFVGVAPFGSAALSFSIGAGSKTPGARQRLQARRQHTRKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSPAAAAAG ------CCHHHHHCC	34.25	30266825
4	Phosphorylation	----MSPAAAAAGAG ----CCHHHHHCCCC	21.01	19691289
4 (in isoform 2)	Phosphorylation	-	21.01	19691289
4 (in isoform 3)	Phosphorylation	-	21.01	19691289
19	Phosphorylation	ERRRPIASVRDGRGR CCCCCCCCCCCCCCC	20.57	28555341
33	Phosphorylation	RGCGGPARAVLLGLS CCCCHHHHHHHHHHH	28.50	18669648
33 (in isoform 3)	Phosphorylation	-	28.50	27251275
35	Phosphorylation	CGGPARAVLLGLSLV CCHHHHHHHHHHHHH	3.65	18669648
36	Phosphorylation	GGPARAVLLGLSLVG CHHHHHHHHHHHHHH	2.83	18669648
44	Ubiquitination	LGLSLVGLLLYLVPA HHHHHHHHHHHHHHH	2.02	33845483
46	Phosphorylation	LSLVGLLLYLVPAAA HHHHHHHHHHHHHHH	3.60	19413330
49	Phosphorylation	VGLLLYLVPAAAALA HHHHHHHHHHHHHHH	1.59	20068231
49 (in isoform 3)	Phosphorylation	-	1.59	27251275
52	Ubiquitination	LLYLVPAAAALAWLT HHHHHHHHHHHHHHH	6.28	33845483
74	Ubiquitination	WGLSREPRGSRPLSS HCCCCCCCCCCCHHH	51.47	21963094
74 (in isoform 2)	Ubiquitination	-	51.47	21890473
74 (in isoform 3)	Ubiquitination	-	51.47	21890473
76	Phosphorylation	LSREPRGSRPLSSFV CCCCCCCCCCHHHHH	31.82	23186163
80	Phosphorylation	PRGSRPLSSFVRKAR CCCCCCHHHHHHHHH	25.14	30266825
80 (in isoform 2)	Phosphorylation	-	25.14	24719451
80 (in isoform 3)	Phosphorylation	-	25.14	27251275
81	Phosphorylation	RGSRPLSSFVRKARH CCCCCHHHHHHHHHH	35.13	30266825
81 (in isoform 2)	Phosphorylation	-	35.13	24719451
81 (in isoform 3)	Phosphorylation	-	35.13	27251275
83	Phosphorylation	SRPLSSFVRKARHRR CCCHHHHHHHHHHCC	7.10	17081983
86	Phosphorylation	LSSFVRKARHRRPLS HHHHHHHHHHCCCHH	11.27	17081983
93	Phosphorylation	ARHRRPLSSFVRKAR HHHCCCHHHHHHHHH	25.14	30266825
94	Phosphorylation	RHRRPLSSFVRKARH HHCCCHHHHHHHHHH	35.13	30266825
104	Phosphorylation	RKARHRRTLFASPLA HHHHHHCHHHCCCCC	26.61	29396449
108	Phosphorylation	HRRTLFASPLAKSTA HHCHHHCCCCCCCCC	17.08	22617229
112	Ubiquitination	LFASPLAKSTANGNL HHCCCCCCCCCCCCC	56.90	23000965
113 (in isoform 3)	Phosphorylation	-	27.43	27251275
115	Phosphorylation	SPLAKSTANGNLLEP CCCCCCCCCCCCCCC	29.08	17081983
115 (in isoform 3)	Phosphorylation	-	29.08	27251275
116	Phosphorylation	PLAKSTANGNLLEPR CCCCCCCCCCCCCCH	39.72	19651622
116 (in isoform 3)	Phosphorylation	-	39.72	27251275
122	Ubiquitination	ANGNLLEPRTLLEGP CCCCCCCCHHHHCCC	34.23	33845483
124	Phosphorylation	GNLLEPRTLLEGPDP CCCCCCHHHHCCCCH	46.54	17081983
126 (in isoform 3)	Phosphorylation	-	7.65	27251275
127	Phosphorylation	LEPRTLLEGPDPAEL CCCHHHHCCCCHHHH	72.32	18669648
128	Phosphorylation	EPRTLLEGPDPAELL CCHHHHCCCCHHHHH	31.70	32142685
128 (in isoform 2)	Phosphorylation	-	31.70	24719451
130	Phosphorylation	RTLLEGPDPAELLLM HHHHCCCCHHHHHHC	66.93	18669648
130 (in isoform 2)	Phosphorylation	-	66.93	24719451
131	Phosphorylation	TLLEGPDPAELLLMG HHHCCCCHHHHHHCH	30.66	18669648
131 (in isoform 2)	Phosphorylation	-	30.66	24719451
131 (in isoform 3)	Phosphorylation	-	30.66	27251275
136	Phosphorylation	PDPAELLLMGSYLGK CCHHHHHHCHHHCCC	5.97	17081983
138	Phosphorylation	PAELLLMGSYLGKPG HHHHHHCHHHCCCCC	17.07	20068231
139	Phosphorylation	AELLLMGSYLGKPGP HHHHHCHHHCCCCCC	11.83	29507054
142	Phosphorylation	LLMGSYLGKPGPPQP HHCHHHCCCCCCCCC	26.36	17081983
143	Phosphorylation	LMGSYLGKPGPPQPA HCHHHCCCCCCCCCC	44.18	17081983
143	Ubiquitination	LMGSYLGKPGPPQPA HCHHHCCCCCCCCCC	44.18	-
144	Phosphorylation	MGSYLGKPGPPQPAA CHHHCCCCCCCCCCC	59.74	17081983
149	Phosphorylation	GKPGPPQPAAAPEGQ CCCCCCCCCCCCCCC	29.64	18669648
154	Phosphorylation	PQPAAAPEGQDLRDR CCCCCCCCCCCCCCC	65.83	18669648
159 (in isoform 3)	Phosphorylation	-	46.30	27251275
163	Ubiquitination	QDLRDRPGRRPPARP CCCCCCCCCCCCCCC	38.84	21890473
163	Ubiquitination	QDLRDRPGRRPPARP CCCCCCCCCCCCCCC	38.84	21890473
163 (in isoform 2)	Ubiquitination	-	38.84	21890473
163 (in isoform 3)	Ubiquitination	-	38.84	21890473
168	Phosphorylation	RPGRRPPARPAPRSP CCCCCCCCCCCCCCC	32.54	20068231
170	Phosphorylation	GRRPPARPAPRSPPP CCCCCCCCCCCCCCC	49.04	19691289
170 (in isoform 3)	Phosphorylation	-	49.04	27251275
173	Phosphorylation	PPARPAPRSPPPRSP CCCCCCCCCCCCCCC	64.99	20068231
174	Phosphorylation	PARPAPRSPPPRSPP CCCCCCCCCCCCCCC	40.47	30266825
178	Phosphorylation	APRSPPPRSPPPRSP CCCCCCCCCCCCCCC	68.52	20068231
178 (in isoform 3)	Phosphorylation	-	68.52	27251275
179	Phosphorylation	PRSPPPRSPPPRSPP CCCCCCCCCCCCCCC	47.75	30266825
182 (in isoform 3)	Phosphorylation	-	53.41	27251275
183	Methylation	PPRSPPPRSPPPSPP CCCCCCCCCCCCCCC	68.52	115488251
184	Phosphorylation	PRSPPPRSPPPSPPT CCCCCCCCCCCCCCC	47.75	23401153
188	Phosphorylation	PPRSPPPSPPTHRAH CCCCCCCCCCCCCCC	49.65	23401153
189	Ubiquitination	PRSPPPSPPTHRAHH CCCCCCCCCCCCCCC	43.51	29967540
191	Phosphorylation	SPPPSPPTHRAHHVY CCCCCCCCCCCCCCC	27.64	30266825
200	Phosphorylation	RAHHVYPSLPTPLLR CCCCCCCCCCCCCCC	29.33	27174698
203	Phosphorylation	HVYPSLPTPLLRPSR CCCCCCCCCCCCCCC	31.68	27174698
209	Phosphorylation	PTPLLRPSRRPSPRD CCCCCCCCCCCCCCC	34.19	30576142
213	Phosphorylation	LRPSRRPSPRDCGTL CCCCCCCCCCCCCCC	30.65	20068231
215	Methylation	PSRRPSPRDCGTLPN CCCCCCCCCCCCCCC	57.07	115488243
223	Dimethylation	DCGTLPNRFVITPRR CCCCCCCCEEECCCC	25.85	-
223	Methylation	DCGTLPNRFVITPRR CCCCCCCCEEECCCC	25.85	58854881
227	Phosphorylation	LPNRFVITPRRRYPI CCCCEEECCCCCCCC	12.87	21815630
227 (in isoform 3)	Phosphorylation	-	12.87	27251275
229	Dimethylation	NRFVITPRRRYPIHQ CCEEECCCCCCCCHH	27.36	-
229	Methylation	NRFVITPRRRYPIHQ CCEEECCCCCCCCHH	27.36	58855379
229	Phosphorylation	NRFVITPRRRYPIHQ CCEEECCCCCCCCHH	27.36	18077418
231	Phosphorylation	FVITPRRRYPIHQAQ EEECCCCCCCCHHHH	42.74	18077418
232	Phosphorylation	VITPRRRYPIHQAQY EECCCCCCCCHHHHH	12.53	22115753
235	Phosphorylation	PRRRYPIHQAQYSCL CCCCCCCHHHHHHHH	16.66	18077418
239	Phosphorylation	YPIHQAQYSCLGVLP CCCHHHHHHHHCCCC	12.36	22115753
240	Phosphorylation	PIHQAQYSCLGVLPT CCHHHHHHHHCCCCC	7.26	22115753
247	Phosphorylation	SCLGVLPTVCWNGYH HHHCCCCCCCCCCHH	24.92	22115753
253	Phosphorylation	PTVCWNGYHKKAVLS CCCCCCCHHHCCEEC	13.78	22115753
260	Phosphorylation	YHKKAVLSPRNSRMV HHHCCEECCCCCCEE	18.40	21815630
265	Dimethylation	VLSPRNSRMVCSPVT EECCCCCCEEEECEE	25.71	-
269	Phosphorylation	RNSRMVCSPVTVRIA CCCCEEEECEEEEEC	15.82	29255136
272	Phosphorylation	RMVCSPVTVRIAPPD CEEEECEEEEECCCC	13.88	29255136
275	Ubiquitination	CSPVTVRIAPPDRRF EECEEEEECCCCCCC	6.16	29967540
276	Ubiquitination	SPVTVRIAPPDRRFS ECEEEEECCCCCCCC	10.06	29967540
283	Phosphorylation	APPDRRFSRSAIPEQ CCCCCCCCCCCCCHH	24.42	26074081
285	Phosphorylation	PDRRFSRSAIPEQII CCCCCCCCCCCHHHH	29.38	30108239
293	Phosphorylation	AIPEQIISSTLSSPS CCCHHHHHHHCCCCC	20.92	30576142
294	Phosphorylation	IPEQIISSTLSSPSS CCHHHHHHHCCCCCC	23.98	30108239
295	Phosphorylation	PEQIISSTLSSPSSN CHHHHHHHCCCCCCC	24.70	25159151
297	Phosphorylation	QIISSTLSSPSSNAP HHHHHHCCCCCCCCC	40.05	25159151
298	Phosphorylation	IISSTLSSPSSNAPD HHHHHCCCCCCCCCC	31.73	30278072
300	Phosphorylation	SSTLSSPSSNAPDPC HHHCCCCCCCCCCHH	37.87	30278072
301	Phosphorylation	STLSSPSSNAPDPCA HHCCCCCCCCCCHHH	40.16	30108239
309	Ubiquitination	NAPDPCAKETVLSAL CCCCHHHHHHHHHHH	61.71	-
311	Phosphorylation	PDPCAKETVLSALKE CCHHHHHHHHHHHHH	26.49	23403867
314	Phosphorylation	CAKETVLSALKEKEK HHHHHHHHHHHHHHH	27.50	30266825
317	Acetylation	ETVLSALKEKEKKRT HHHHHHHHHHHHCCC	67.47	10733337
317	Ubiquitination	ETVLSALKEKEKKRT HHHHHHHHHHHHCCC	67.47	-
319	Acetylation	VLSALKEKEKKRTVE HHHHHHHHHHCCCCC	73.56	10733339
319	Ubiquitination	VLSALKEKEKKRTVE HHHHHHHHHHCCCCC	73.56	-
322	Phosphorylation	ALKEKEKKRTVEEED HHHHHHHCCCCCHHH	55.16	17081983
323	Phosphorylation	LKEKEKKRTVEEEDQ HHHHHHCCCCCHHHH	55.88	17081983
324	Phosphorylation	KEKEKKRTVEEEDQI HHHHHCCCCCHHHHC	40.94	24961811
325	Phosphorylation	EKEKKRTVEEEDQIF HHHHCCCCCHHHHCE	11.49	17081983
328	Phosphorylation	KKRTVEEEDQIFLDG HCCCCCHHHHCEECC	41.53	17081983
339	Acetylation	FLDGQENKRRRHDSS EECCCCCCCCCCCCC	46.67	26051181
339	Ubiquitination	FLDGQENKRRRHDSS EECCCCCCCCCCCCC	46.67	21963094
339 (in isoform 1)	Ubiquitination	-	46.67	21890473
345	Phosphorylation	NKRRRHDSSGSGHSA CCCCCCCCCCCCCCC	30.39	27273156
346	Phosphorylation	KRRRHDSSGSGHSAF CCCCCCCCCCCCCCC	42.93	27273156
348	Phosphorylation	RRHDSSGSGHSAFEP CCCCCCCCCCCCCHH	34.97	27273156
351	Phosphorylation	DSSGSGHSAFEPLVA CCCCCCCCCCHHHHC	37.87	27273156
364	Phosphorylation	VANGVPASFVPKPGS HCCCCCHHHCCCCCC	22.25	20068231
366	Phosphorylation	NGVPASFVPKPGSLK CCCCHHHCCCCCCCC	5.73	17081983
368	Phosphorylation	VPASFVPKPGSLKRG CCHHHCCCCCCCCCC	57.62	17081983
371	Phosphorylation	SFVPKPGSLKRGLNS HHCCCCCCCCCCCCC	38.96	26055452
372	Phosphorylation	FVPKPGSLKRGLNSQ HCCCCCCCCCCCCCC	5.63	17081983
373	Phosphorylation	VPKPGSLKRGLNSQS CCCCCCCCCCCCCCC	46.23	17081983
375	Phosphorylation	KPGSLKRGLNSQSSD CCCCCCCCCCCCCCH	27.85	17081983
378	Phosphorylation	SLKRGLNSQSSDDHL CCCCCCCCCCCHHHH	36.16	22167270
380	Phosphorylation	KRGLNSQSSDDHLNK CCCCCCCCCHHHHHH	35.24	22167270
381	Phosphorylation	RGLNSQSSDDHLNKR CCCCCCCCHHHHHHH	39.15	23401153
387	Ubiquitination	SSDDHLNKRSRSSSM CCHHHHHHHHHHHHH	59.10	-
389	Phosphorylation	DDHLNKRSRSSSMSS HHHHHHHHHHHHHHH	37.82	28450419
391	Phosphorylation	HLNKRSRSSSMSSLT HHHHHHHHHHHHHHH	28.19	23401153
392	Phosphorylation	LNKRSRSSSMSSLTG HHHHHHHHHHHHHHH	29.02	23927012
393	Phosphorylation	NKRSRSSSMSSLTGA HHHHHHHHHHHHHHH	24.75	23927012
395	Phosphorylation	RSRSSSMSSLTGAYA HHHHHHHHHHHHHHH	24.92	26434552
396	Phosphorylation	SRSSSMSSLTGAYAS HHHHHHHHHHHHHHC	22.70	23927012
398	Phosphorylation	SSSMSSLTGAYASGI HHHHHHHHHHHHCCC	23.01	23927012
401	Phosphorylation	MSSLTGAYASGIPSS HHHHHHHHHCCCCCC	11.57	23927012
403	Phosphorylation	SLTGAYASGIPSSSR HHHHHHHCCCCCCCC	25.28	23927012
407	Phosphorylation	AYASGIPSSSRNAIT HHHCCCCCCCCCCCC	38.74	23403867
408	Phosphorylation	YASGIPSSSRNAITS HHCCCCCCCCCCCCC	28.14	23403867
409	Phosphorylation	ASGIPSSSRNAITSS HCCCCCCCCCCCCCC	33.61	23927012
414	Phosphorylation	SSSRNAITSSYSSTR CCCCCCCCCCCCCHH	14.81	18669648
415	Phosphorylation	SSRNAITSSYSSTRG CCCCCCCCCCCCHHH	22.59	25159151
416	Phosphorylation	SRNAITSSYSSTRGI CCCCCCCCCCCHHHH	22.00	25159151
417	Phosphorylation	RNAITSSYSSTRGIS CCCCCCCCCCHHHHH	13.35	29396449
418	Phosphorylation	NAITSSYSSTRGISQ CCCCCCCCCHHHHHH	27.47	23401153
419	Phosphorylation	AITSSYSSTRGISQL CCCCCCCCHHHHHHH	17.56	18669648
420	Phosphorylation	ITSSYSSTRGISQLW CCCCCCCHHHHHHHH	27.29	21406692
424	Phosphorylation	YSSTRGISQLWKRNG CCCHHHHHHHHHHHC	23.26	29396449
428	Methylation	RGISQLWKRNGPSSS HHHHHHHHHHCCCCC	44.57	-
428	O-linked_Glycosylation	RGISQLWKRNGPSSS HHHHHHHHHHCCCCC	44.57	20068230
428	Ubiquitination	RGISQLWKRNGPSSS HHHHHHHHHHCCCCC	44.57	21890473
428 (in isoform 1)	Ubiquitination	-	44.57	21890473
429	O-linked_Glycosylation	GISQLWKRNGPSSSP HHHHHHHHHCCCCCC	41.58	20068230
432	Phosphorylation	QLWKRNGPSSSPFSS HHHHHHCCCCCCCCC	34.29	19413330
432 (in isoform 3)	Phosphorylation	-	34.29	27251275
433	Phosphorylation	LWKRNGPSSSPFSSP HHHHHCCCCCCCCCC	44.86	30266825
434	Phosphorylation	WKRNGPSSSPFSSPA HHHHCCCCCCCCCCC	45.20	30266825
435	Phosphorylation	KRNGPSSSPFSSPAS HHHCCCCCCCCCCCC	34.01	29255136
438	Phosphorylation	GPSSSPFSSPASSRS CCCCCCCCCCCCCCC	38.50	30266825
439	Phosphorylation	PSSSPFSSPASSRSQ CCCCCCCCCCCCCCC	25.51	29255136
442	Phosphorylation	SPFSSPASSRSQTPE CCCCCCCCCCCCCCC	29.66	23927012
443	Phosphorylation	PFSSPASSRSQTPER CCCCCCCCCCCCCCC	37.75	23927012
445	Phosphorylation	SSPASSRSQTPERPA CCCCCCCCCCCCCCH	40.11	30266825
447	Phosphorylation	PASSRSQTPERPAKK CCCCCCCCCCCCHHH	28.50	30266825
449 (in isoform 3)	Phosphorylation	-	74.76	27251275
450	Phosphorylation	SRSQTPERPAKKIRE CCCCCCCCCHHHHCH	37.37	19413330
464	Phosphorylation	EEELCHHSSSSTPLA HHHHCCCCCCCCCCC	14.30	23663014
465	Phosphorylation	EELCHHSSSSTPLAA HHHCCCCCCCCCCCC	24.77	23663014
466	Phosphorylation	ELCHHSSSSTPLAAD HHCCCCCCCCCCCCC	41.04	23663014
467	Phosphorylation	LCHHSSSSTPLAADR HCCCCCCCCCCCCCH	35.67	23663014
468	Phosphorylation	CHHSSSSTPLAADRE CCCCCCCCCCCCCHH	25.03	23663014
472	Acetylation	SSSTPLAADRESQGE CCCCCCCCCHHHHCC	24.87	19608861
473	O-linked_Glycosylation	SSTPLAADRESQGEK CCCCCCCCHHHHCCC	49.63	20068230
476	Phosphorylation	PLAADRESQGEKAAD CCCCCHHHHCCCCCC	44.36	23917254
484	Phosphorylation	QGEKAADTTPRKKQN HCCCCCCCCCCCCCC	33.69	28176443
485	Phosphorylation	GEKAADTTPRKKQNS CCCCCCCCCCCCCCC	22.95	30576142
492	Phosphorylation	TPRKKQNSNSQSTPG CCCCCCCCCCCCCCC	35.05	23403867
494	Phosphorylation	RKKQNSNSQSTPGSS CCCCCCCCCCCCCCC	25.90	23403867
496	Phosphorylation	KQNSNSQSTPGSSGQ CCCCCCCCCCCCCHH	36.07	23403867
497	Phosphorylation	QNSNSQSTPGSSGQR CCCCCCCCCCCCHHH	24.83	25849741
500	Phosphorylation	NSQSTPGSSGQRKRK CCCCCCCCCHHHHHE	32.28	23663014
501	Phosphorylation	SQSTPGSSGQRKRKV CCCCCCCCHHHHHEE	44.88	23663014
513	Phosphorylation	RKVQLLPSRRGEQLT HEEEECCCCCCCCCC	34.28	25278378
541	Ubiquitination	EDLDLEKKASLQWFN HHCCHHHHHHHHHHH	33.56	-
543	Phosphorylation	LDLEKKASLQWFNQA CCHHHHHHHHHHHHH	29.94	25159151
606	Phosphorylation	ESLKKMQTPPSLPPC HHHHHCCCCCCCCCC	33.40	25627689
609	Phosphorylation	KKMQTPPSLPPCPES HHCCCCCCCCCCCCC	55.50	25627689
626	Phosphorylation	AATTEALSPPKTPSL CCCCCCCCCCCCCCC	46.32	25159151
639	Phosphorylation	SLLPPLGLSQSGPPG CCCCCCCCCCCCCCC	5.77	32142685
650	Phosphorylation	GPPGLLPSPSFDSKP CCCCCCCCCCCCCCC	32.90	26074081
652	Phosphorylation	PGLLPSPSFDSKPPT CCCCCCCCCCCCCCC	46.12	26074081
655	Phosphorylation	LPSPSFDSKPPTTLL CCCCCCCCCCCCEEE	45.08	28348404
659	Phosphorylation	SFDSKPPTTLLGLIP CCCCCCCCEEEECEE	38.31	28348404
660	Phosphorylation	FDSKPPTTLLGLIPA CCCCCCCEEEECEEC	26.26	29496963
681	Phosphorylation	TDTKAPPTLQAETAT CCCCCCCCCCCCCCC	30.37	29978859
686	Phosphorylation	PPTLQAETATKPQAT CCCCCCCCCCCCCCC	42.51	30266825
688	Phosphorylation	TLQAETATKPQATSA CCCCCCCCCCCCCCC	51.15	30266825
689	Acetylation	LQAETATKPQATSAP CCCCCCCCCCCCCCC	32.44	26051181
689	Ubiquitination	LQAETATKPQATSAP CCCCCCCCCCCCCCC	32.44	-
693	O-linked_Glycosylation	TATKPQATSAPSPAP CCCCCCCCCCCCCCC	21.85	30620550
693	Phosphorylation	TATKPQATSAPSPAP CCCCCCCCCCCCCCC	21.85	30266825
693 (in isoform 3)	Phosphorylation	-	21.85	27251275
694	O-linked_Glycosylation	ATKPQATSAPSPAPK CCCCCCCCCCCCCCC	40.99	30620550
694	Phosphorylation	ATKPQATSAPSPAPK CCCCCCCCCCCCCCC	40.99	30266825
697	Phosphorylation	PQATSAPSPAPKQSF CCCCCCCCCCCCCEE	33.15	29255136
698	Phosphorylation	QATSAPSPAPKQSFL CCCCCCCCCCCCEEE	52.07	32142685
703	Phosphorylation	PSPAPKQSFLFGTQN CCCCCCCEEEECCCC	30.00	26074081
708	Phosphorylation	KQSFLFGTQNTSPSS CCEEEECCCCCCCCC	16.00	22199227
711	Phosphorylation	FLFGTQNTSPSSPAA EEECCCCCCCCCCCC	32.00	22199227
712	Phosphorylation	LFGTQNTSPSSPAAP EECCCCCCCCCCCCC	30.27	22199227
714	Phosphorylation	GTQNTSPSSPAAPAA CCCCCCCCCCCCCCC	49.04	22199227
715	Phosphorylation	TQNTSPSSPAAPAAS CCCCCCCCCCCCCCC	23.18	22199227
722	Phosphorylation	SPAAPAASSAPPMFK CCCCCCCCCCCCCCC	29.19	26074081
723	Phosphorylation	PAAPAASSAPPMFKP CCCCCCCCCCCCCCC	39.82	26074081
733	Phosphorylation	PMFKPIFTAPPKSEK CCCCCCCCCCCCCCC	38.69	26074081
737	Acetylation	PIFTAPPKSEKEGPT CCCCCCCCCCCCCCC	70.91	19608861
738	O-linked_Glycosylation	IFTAPPKSEKEGPTP CCCCCCCCCCCCCCC	60.72	-
794	Phosphorylation	PAPFFKQTTTPATAP CCCCCCCCCCCCCCC	32.97	21406692
795	Phosphorylation	APFFKQTTTPATAPT CCCCCCCCCCCCCCC	28.43	21406692
796	Phosphorylation	PFFKQTTTPATAPTT CCCCCCCCCCCCCCC	17.83	21406692
799	Phosphorylation	KQTTTPATAPTTTAP CCCCCCCCCCCCCCC	34.08	21406692
802	Phosphorylation	TTPATAPTTTAPLFT CCCCCCCCCCCCHHH	34.02	21406692
803	Phosphorylation	TPATAPTTTAPLFTG CCCCCCCCCCCHHHC	21.65	21406692
804	Phosphorylation	PATAPTTTAPLFTGL CCCCCCCCCCHHHCH	28.84	21406692
809	Phosphorylation	TTTAPLFTGLASATS CCCCCHHHCHHCCCC	38.68	21406692
813	Phosphorylation	PLFTGLASATSAVAP CHHHCHHCCCCCEEC	36.80	21406692
815	Phosphorylation	FTGLASATSAVAPIT HHCHHCCCCCEECCC	18.09	21406692
816	Phosphorylation	TGLASATSAVAPITS HCHHCCCCCEECCCC	22.06	21406692
822	Phosphorylation	TSAVAPITSASPSTD CCCEECCCCCCCCCC	19.72	21406692
823	Phosphorylation	SAVAPITSASPSTDS CCEECCCCCCCCCCC	27.71	21406692
825	Phosphorylation	VAPITSASPSTDSAS EECCCCCCCCCCCCC	21.10	21406692
827	Phosphorylation	PITSASPSTDSASKP CCCCCCCCCCCCCCC	42.21	21406692
828	Phosphorylation	ITSASPSTDSASKPA CCCCCCCCCCCCCCC	37.04	21406692
830	Phosphorylation	SASPSTDSASKPAFG CCCCCCCCCCCCCCC	34.23	21406692
832	Phosphorylation	SPSTDSASKPAFGFG CCCCCCCCCCCCCEE	43.02	21406692
945	Phosphorylation	LTFSNTSTPTFNIPF EEECCCCCCEEECCC	25.06	-
958	Phosphorylation	PFGSSAKSPLPSYPG CCCCCCCCCCCCCCC	31.24	28355574
962	Phosphorylation	SAKSPLPSYPGANPQ CCCCCCCCCCCCCCC	52.20	22199227
963	Phosphorylation	AKSPLPSYPGANPQP CCCCCCCCCCCCCCC	12.07	25850435
992 (in isoform 3)	Phosphorylation	-	27.07	20860994
1024	Phosphorylation	VVPAYVPTPIHPIFG EEEECCCCCCCCCCC	25.49	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of P121A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of P121A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of P121A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
C43BP_HUMAN	COL4A3BP	physical	16189514
AGR2_HUMAN	AGR2	physical	16189514
CEP55_HUMAN	CEP55	physical	16189514
TEX11_HUMAN	TEX11	physical	16189514
RBPMS_HUMAN	RBPMS	physical	16189514
AGR2_HUMAN	AGR2	physical	25416956
RBPMS_HUMAN	RBPMS	physical	25416956
PAXI1_HUMAN	PAXIP1	physical	25416956
TEX11_HUMAN	TEX11	physical	25416956
CEP76_HUMAN	CEP76	physical	25416956
BRCA1_HUMAN	BRCA1	physical	25184681

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of P121A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-311; SER-697 ANDSER-715, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-227; SER-269; SER-314;SER-345; SER-346; SER-351 AND SER-697, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-401, AND MASSSPECTROMETRY.	19690332 [Abstract]