dbPTM

C43BP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	C43BP_HUMAN
UniProt AC	Q9Y5P4
Protein Name	Collagen type IV alpha-3-binding protein
Gene Name	COL4A3BP
Organism	Homo sapiens (Human).
Sequence Length	624
Subcellular Localization	Cytoplasm . Golgi apparatus . Endoplasmic reticulum . Preferentially localized to the Golgi apparatus.
Protein Description	Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner..
Protein Sequence	MSDNQSWNSSGSEEDPETESGPPVERCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISVNDSVWYLRAQDPDHRQQWIDAIEQHKTESGYGSESSLRRHGSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFRDILCRQVDTLQKYFDACADAVSKDELQRDKVVEDDEDDFPTTRSDGDFLHSTNGNKEKLFPHVTPKGINGIDFKGEAITFKATTAGILATLSHCIELMVKREDSWQKRLDKETEKKRRTEEAYKNAMTELKKKSHFGGPDYEEGPNSLINEEEFFDAVEAALDRQDKIEEQSQSEKVRLHWPTSLPSGDAFSSVGTHRFVQKPYSRSSSMSSIDLVSASDDVHRFSSQVEEMVQNHMTYSLQDVGGDANWQLVVEEGEMKVYRREVEENGIVLDPLKATHAVKGVTGHEVCNYFWNVDVRNDWETTIENFHVVETLADNAIIIYQTHKRVWPASQRDVLYLSVIRKIPALTENDPETWIVCNFSVDHDSAPLNNRCVRAKINVAMICQTLVSPPEGNQEISRDNILCKITYVANVNPGGWAPASVLRAVAKREYPKFLKRFTSYVQEKTAGKPILF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59 (in isoform 3)	Phosphorylation	-	75.18	20873877
73	Malonylation	RGSICLSKAVITPHD CCEEEEECEEECCCC	33.45	26320211
73	Acetylation	RGSICLSKAVITPHD CCEEEEECEEECCCC	33.45	25953088
119 (in isoform 2)	Phosphorylation	-	42.41	-
126 (in isoform 2)	Phosphorylation	-	23.11	-
132 (in isoform 2)	Phosphorylation	-	15.19	-
150 (in isoform 2)	Phosphorylation	-	40.97	-
160	Acetylation	KGHSLREKLAEMETF CCCCHHHHHHCHHHH	46.71	25953088
191	Acetylation	ACADAVSKDELQRDK HHHHHCCHHHHHHCC	48.93	26822725
251 (in isoform 3)	Phosphorylation	-	20.12	27251275
254 (in isoform 3)	Phosphorylation	-	17.22	27251275
260 (in isoform 3)	Phosphorylation	-	16.38	27251275
263 (in isoform 3)	Phosphorylation	-	3.69	27251275
269 (in isoform 3)	Phosphorylation	-	41.36	27251275
272 (in isoform 3)	Phosphorylation	-	27.01	27251275
275 (in isoform 3)	Phosphorylation	-	48.98	27251275
315 (in isoform 2)	Phosphorylation	-	33.49	-
344 (in isoform 2)	Ubiquitination	-	37.59	21906983
344 (in isoform 1)	Ubiquitination	-	37.59	21906983
360 (in isoform 3)	Phosphorylation	-	26.32	27251275
437 (in isoform 3)	Phosphorylation	-	31.80	27642862
501 (in isoform 3)	Phosphorylation	-	11.55	27251275
503 (in isoform 3)	Phosphorylation	-	47.93	27251275
504 (in isoform 3)	Phosphorylation	-	33.25	27251275
505 (in isoform 3)	Phosphorylation	-	27.43	27251275
507 (in isoform 3)	Phosphorylation	-	4.11	27251275
738 (in isoform 3)	Phosphorylation	-		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
132	S	Phosphorylation	Kinase	CSNK1G2	P78368	GPS
132	S	Phosphorylation	Kinase	PRKD1	Q15139	PSP
132	S	Phosphorylation	Kinase	PKD	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of C43BP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of C43BP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
C43BP_HUMAN	COL4A3BP	physical	16189514
RTN3_HUMAN	RTN3	physical	16189514
CENPR_HUMAN	ITGB3BP	physical	16189514
RTN4_HUMAN	RTN4	physical	16189514
CBS_HUMAN	CBS	physical	19447967
TGM2_HUMAN	TGM2	physical	21988832
PACN2_HUMAN	PACSIN2	physical	22863883
2A5G_HUMAN	PPP2R5C	physical	22863883
C43BP_HUMAN	COL4A3BP	physical	25416956
AR6P1_HUMAN	ARL6IP1	physical	25416956
CENPR_HUMAN	ITGB3BP	physical	25416956
ACTL8_HUMAN	ACTL8	physical	25416956
RBP2_HUMAN	RANBP2	physical	26344197
MARK1_HUMAN	MARK1	physical	28514442
MARK2_HUMAN	MARK2	physical	28514442
MARK3_HUMAN	MARK3	physical	28514442
TRAF7_HUMAN	TRAF7	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616351	Mental retardation, autosomal dominant 34 (MRD34)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of C43BP_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-380, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Regulation of secretory transport by protein kinase D-mediatedphosphorylation of the ceramide transfer protein."; Fugmann T., Hausser A., Schoeffler P., Schmid S., Pfizenmaier K.,Olayioye M.A.; J. Cell Biol. 178:15-22(2007). Cited for: PHOSPHORYLATION AT SER-132, FUNCTION, AND MUTAGENESIS OF SER-132.	17591919 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, AND MASSSPECTROMETRY.	17081983 [Abstract]