AR6P1_HUMAN - dbPTM
AR6P1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AR6P1_HUMAN
UniProt AC Q15041
Protein Name ADP-ribosylation factor-like protein 6-interacting protein 1
Gene Name ARL6IP1
Organism Homo sapiens (Human).
Sequence Length 203
Subcellular Localization Endomembrane system
Multi-pass membrane protein . Endoplasmic reticulum membrane
Multi-pass membrane protein . Endoplasmic reticulum . Predominantly localized to intracytoplasmic membranes. Preferentially localizes at the ER tubules and the edge
Protein Description Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules. [PubMed: 24262037 Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9 Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself]
Protein Sequence MAEGDNRSTNLLAAETASLEEQLQGWGEVMLMADKVLRWERAWFPPAIMGVVSLVFLIIYYLDPSVLSGVSCFVMFLCLADYLVPILAPRIFGSNKWTTEQQQRFHEICSNLVKTRRRAVGWWKRLFTLKEEKPKMYFMTMIVSLAAVAWVGQQVHNLLLTYLIVTSLLLLPGLNQHGIILKYIGMAKREINKLLKQKEKKNE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
67UbiquitinationYYLDPSVLSGVSCFV
HHHCHHHHHHHHHHH		4.29-
85UbiquitinationCLADYLVPILAPRIF
HHHHHHHHHHHHHHC		17.18-
95UbiquitinationAPRIFGSNKWTTEQQ
HHHHCCCCCCCHHHH		44.24-
96UbiquitinationPRIFGSNKWTTEQQQ
HHHCCCCCCCHHHHH		47.8421906983
96AcetylationPRIFGSNKWTTEQQQ
HHHCCCCCCCHHHHH		47.8425825284
96UbiquitinationPRIFGSNKWTTEQQQ
HHHCCCCCCCHHHHH		47.8421890473
962-HydroxyisobutyrylationPRIFGSNKWTTEQQQ
HHHCCCCCCCHHHHH		47.84-
96UbiquitinationPRIFGSNKWTTEQQQ
HHHCCCCCCCHHHHH		47.8421890473
114UbiquitinationEICSNLVKTRRRAVG
HHHHHHHHHHHHHHH		39.2121906983
114AcetylationEICSNLVKTRRRAVG
HHHHHHHHHHHHHHH		39.2125953088
114UbiquitinationEICSNLVKTRRRAVG
HHHHHHHHHHHHHHH		39.2121890473
124UbiquitinationRRAVGWWKRLFTLKE
HHHHHHHHHHHHCCC		32.4921906983
124UbiquitinationRRAVGWWKRLFTLKE
HHHHHHHHHHHHCCC		32.4921890473
1242-HydroxyisobutyrylationRRAVGWWKRLFTLKE
HHHHHHHHHHHHCCC		32.49-
1302-HydroxyisobutyrylationWKRLFTLKEEKPKMY
HHHHHHCCCCCCCHH		61.85-
159UbiquitinationGQQVHNLLLTYLIVT
HHHHHHHHHHHHHHH		4.00-
164UbiquitinationNLLLTYLIVTSLLLL
HHHHHHHHHHHHHHC		1.93-
1882-HydroxyisobutyrylationLKYIGMAKREINKLL
HHHHHHHHHHHHHHH		41.49-
188UbiquitinationLKYIGMAKREINKLL
HHHHHHHHHHHHHHH		41.49-
193UbiquitinationMAKREINKLLKQKEK
HHHHHHHHHHHHHHH		61.94-
193AcetylationMAKREINKLLKQKEK
HHHHHHHHHHHHHHH		61.9427452117
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AR6P1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AR6P1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AR6P1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
INP5K_HUMANINPP5Kphysical
16189514
FBXW7_HUMANFBXW7physical
16169070
FDFT_HUMANFDFT1physical
16169070
AR6P1_HUMANARL6IP1physical
25416956
GORS2_HUMANGORASP2physical
25416956
WIPI2_HUMANWIPI2physical
25416956
SNX10_HUMANSNX10physical
25416956
SNX15_HUMANSNX15physical
25416956
SNX11_HUMANSNX11physical
25416956
SNX12_HUMANSNX12physical
25416956
MTEF3_HUMANMTERF3physical
25416956
TIM16_HUMANPAM16physical
25416956
SPG21_HUMANSPG21physical
25416956
DBLOH_HUMANDIABLOphysical
25416956
RTN4_HUMANRTN4physical
25416956
SENP2_HUMANSENP2physical
25416956
SNAB_HUMANNAPBphysical
25416956
GOLP3_HUMANGOLPH3physical
25416956
NDRG4_HUMANNDRG4physical
25416956
ZFY21_HUMANZFYVE21physical
25416956
ACSF2_HUMANACSF2physical
25416956
RETR3_HUMANFAM134Cphysical
25416956
ZN391_HUMANZNF391physical
25416956
GLP3L_HUMANGOLPH3Lphysical
21516116
SNX1_HUMANSNX1physical
21516116
ACSF2_HUMANACSF2physical
21516116
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615685Spastic paraplegia 61, autosomal recessive (SPG61)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AR6P1_HUMAN

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Related Literatures of Post-Translational Modification

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