GLP3L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLP3L_HUMAN
• UniProt AC: Q9H4A5
• Protein Name: Golgi phosphoprotein 3-like
• Gene Name: GOLPH3L
• Organism: Homo sapiens (Human).
• Sequence Length: 285
• Subcellular Localization: Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein ; Cytoplasmic side . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein ; Cytoplasmic side . Phosphatidylinositol 4-phosphate (PtdIns4P)-binding mediates rec
• Protein Description: Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane..
• Protein Sequence: MTTLTHRARRTEISKNSEKKMESEEDSNWEKSPDNEDSGDSKDIRLTLMEEVLLLGLKDKEGYTSFWNDCISSGLRGGILIELAMRGRIYLEPPTMRKKRLLDRKVLLKSDSPTGDVLLDETLKHIKATEPTETVQTWIELLTGETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQDSVLERWVNDPQRMDKRTLALLVLAHSSDVLENVFSSLTDDKYDVAMNRAKDLVELDPEVEGTKPSATEMIWAVLAAFNKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	RARRTEISKNSEKKM HHHHHHCCCCHHHHC	21.39	28258704
17	Phosphorylation	RTEISKNSEKKMESE HHHCCCCHHHHCCCC	55.30	28258704
19	Acetylation	EISKNSEKKMESEED HCCCCHHHHCCCCCC	58.19	12438023
20	Sumoylation	ISKNSEKKMESEEDS CCCCHHHHCCCCCCC	43.80	-
20	Sumoylation	ISKNSEKKMESEEDS CCCCHHHHCCCCCCC	43.80	-
23	Phosphorylation	NSEKKMESEEDSNWE CHHHHCCCCCCCCCC	42.67	25159151
27	Phosphorylation	KMESEEDSNWEKSPD HCCCCCCCCCCCCCC	47.31	28102081
31	Ubiquitination	EEDSNWEKSPDNEDS CCCCCCCCCCCCCCC	59.93	-
32	Phosphorylation	EDSNWEKSPDNEDSG CCCCCCCCCCCCCCC	26.43	28985074
38	Phosphorylation	KSPDNEDSGDSKDIR CCCCCCCCCCCHHHH	38.02	25849741
41	Phosphorylation	DNEDSGDSKDIRLTL CCCCCCCCHHHHHHH	35.43	26852163
42	Ubiquitination	NEDSGDSKDIRLTLM CCCCCCCHHHHHHHH	63.01	-
60	Ubiquitination	LLLGLKDKEGYTSFW HHHCCCCCCCCCHHH	51.99	-
90	Phosphorylation	LAMRGRIYLEPPTMR HHHCCCEEECCCCHH	12.03	26846344
95	Phosphorylation	RIYLEPPTMRKKRLL CEEECCCCHHHHHHC	40.08	26846344
109	Sumoylation	LDRKVLLKSDSPTGD CCCEEEECCCCCCCC	48.32	-
109	Ubiquitination	LDRKVLLKSDSPTGD CCCEEEECCCCCCCC	48.32	32015554
110	Phosphorylation	DRKVLLKSDSPTGDV CCEEEECCCCCCCCC	43.20	27732954
112	Phosphorylation	KVLLKSDSPTGDVLL EEEECCCCCCCCCCH	31.30	25159151
114	Phosphorylation	LLKSDSPTGDVLLDE EECCCCCCCCCCHHH	50.38	23186163
122	Phosphorylation	GDVLLDETLKHIKAT CCCCHHHHHHHHHCC	40.55	-
124	Ubiquitination	VLLDETLKHIKATEP CCHHHHHHHHHCCCC	51.18	32015554
126	Ubiquitination	LDETLKHIKATEPTE HHHHHHHHHCCCCCH	2.87	21906983
170	Ubiquitination	IAKNLVEKGILTTEK HHHHHHHCCCCCCCC	43.71	21906983
177	Ubiquitination	KGILTTEKQNFLLFD CCCCCCCCCCEEEEE	48.74	29967540
196	Ubiquitination	PVTNTTEKQRLVKKL CCCCCHHHHHHHHHH	38.33	29967540
201	Ubiquitination	TEKQRLVKKLQDSVL HHHHHHHHHHHHHHH	52.97	24816145
202	Ubiquitination	EKQRLVKKLQDSVLE HHHHHHHHHHHHHHH	43.85	29967540
215	Ubiquitination	LERWVNDPQRMDKRT HHHHCCCHHHCCHHH	20.62	24816145
267	Phosphorylation	LDPEVEGTKPSATEM CCCCCCCCCCCHHHH	26.69	19690332

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLP3L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLP3L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLP3L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LNX1_HUMAN	LNX1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.