TIM16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TIM16_HUMAN
• UniProt AC: Q9Y3D7
• Protein Name: Mitochondrial import inner membrane translocase subunit TIM16
• Gene Name: PAM16
• Organism: Homo sapiens (Human).
• Sequence Length: 125
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .
• Protein Description: Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity..
• Protein Sequence: MAKYLAQIIVMGVQVVGRAFARALRQEFAASRAAADARGRAGHRSAAASNLSGLSLQEAQQILNVSKLSPEEVQKNYEHLFKVNDKSVGGSFYLQSKVVRAKERLDEELKIQAQEDREKGQMPHT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAKYLAQIIVM ----CHHHHHHHHHH	9.57	-
45	Phosphorylation	RGRAGHRSAAASNLS HCCHHHHHHHHHCCC	19.31	26434776
49	Phosphorylation	GHRSAAASNLSGLSL HHHHHHHHCCCCCCH	33.31	30177828
52	Phosphorylation	SAAASNLSGLSLQEA HHHHHCCCCCCHHHH	41.77	30177828
55	Phosphorylation	ASNLSGLSLQEAQQI HHCCCCCCHHHHHHH	31.37	30177828
66	Phosphorylation	AQQILNVSKLSPEEV HHHHHCHHCCCHHHH	27.14	23663014
69	Phosphorylation	ILNVSKLSPEEVQKN HHCHHCCCHHHHHHH	33.72	25849741
75	Acetylation	LSPEEVQKNYEHLFK CCHHHHHHHHHHHHC	67.67	27452117
77	Phosphorylation	PEEVQKNYEHLFKVN HHHHHHHHHHHHCCC	16.26	-
82	Ubiquitination	KNYEHLFKVNDKSVG HHHHHHHCCCCCCCC	46.63	22817900
86	Ubiquitination	HLFKVNDKSVGGSFY HHHCCCCCCCCCCHH	41.66	33845483
87	Phosphorylation	LFKVNDKSVGGSFYL HHCCCCCCCCCCHHH	28.94	24247654
91	Phosphorylation	NDKSVGGSFYLQSKV CCCCCCCCHHHHHHH	12.56	-
119	Ubiquitination	QAQEDREKGQMPHT- HHHHHHHCCCCCCC-	56.17	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TIM16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TIM16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TIM16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FEZ1_HUMAN	FEZ1	physical	16169070
TIM14_HUMAN	DNAJC19	physical	20053669
TIM14_YEAST	PAM18	physical	20053669
FEZ1_HUMAN	FEZ1	physical	21900206
MOFA1_HUMAN	MRFAP1	physical	21900206
GPM6A_HUMAN	GPM6A	physical	21900206
CEP70_HUMAN	CEP70	physical	21900206
BL1S2_HUMAN	BLOC1S2	physical	21900206
DNM3B_HUMAN	DNMT3B	physical	21900206
PGRC1_HUMAN	PGRMC1	physical	21900206
DJC15_HUMAN	DNAJC15	physical	23263864
TIM16_HUMAN	PAM16	physical	23263864
TI17A_HUMAN	TIMM17A	physical	23263864
TI17B_HUMAN	TIMM17B	physical	23263864
TIM44_HUMAN	TIMM44	physical	22031295
MARC1_HUMAN	MARC1	physical	27173435
TFB2M_HUMAN	TFB2M	physical	27173435
MCATL_HUMAN	SLC25A29	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613320: Spondylometaphyseal dysplasia, Megarbane-Dagher-Melike type (SMDMDM)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.