dbPTM

GPM6A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GPM6A_HUMAN
UniProt AC	P51674
Protein Name	Neuronal membrane glycoprotein M6-a
Gene Name	GPM6A
Organism	Homo sapiens (Human).
Sequence Length	278
Subcellular Localization	Cell membrane Multi-pass membrane protein. Cell projection, axon. Cell projection, dendritic spine. Cell projection, filopodium. Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of
Protein Description	Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor..
Protein Sequence	MEENMEEGQTQKGCFECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQTYFEMARTAGDTLDVFTMIDIFKYVIYGIAAAFFVYGILLMVEGFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNLWTICRNTTLVEGANLCLDLRQFGIVTIGEEKKICTVSENFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNAYT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEENMEEG -------CCCCCCCC	15.27	22223895
10	Phosphorylation	ENMEEGQTQKGCFEC CCCCCCCCCCCHHHH	43.00	12359212
164	N-linked_Glycosylation	NLWTICRNTTLVEGA HHHHHHCCCCCCCCC	32.76	UniProtKB CARBOHYD
208	N-linked_Glycosylation	MCESTELNMTFHLFI HHHCCCCHHHHHHHH	22.63	UniProtKB CARBOHYD
220	Ubiquitination	LFIVALAGAGAAVIA HHHHHHHHCHHHHHH	25.95	32142685
222	Ubiquitination	IVALAGAGAAVIAMV HHHHHHCHHHHHHHH	17.10	32142685
244	Ubiquitination	ANWAYVKDACRMQKY CCCHHHHHHHHCCCH	40.64	32142685
246	Ubiquitination	WAYVKDACRMQKYED CHHHHHHHHCCCHHH	5.51	32142685
248	Ubiquitination	YVKDACRMQKYEDIK HHHHHHHCCCHHHHC	3.97	32142685
250	Ubiquitination	KDACRMQKYEDIKSK HHHHHCCCHHHHCCH	41.06	32142685
251	Phosphorylation	DACRMQKYEDIKSKE HHHHCCCHHHHCCHH	11.27	25332170
255	Ubiquitination	MQKYEDIKSKEEQEL CCCHHHHCCHHHHHH	68.73	32142685
256	Phosphorylation	QKYEDIKSKEEQELH CCHHHHCCHHHHHHH	45.71	18510355
257	Ubiquitination	KYEDIKSKEEQELHD CHHHHCCHHHHHHHH	61.34	32142685
267	Phosphorylation	QELHDIHSTRSKERL HHHHHHHHCCCHHHH	26.33	15822905
268	Phosphorylation	ELHDIHSTRSKERLN HHHHHHHCCCHHHHH	25.46	28270605
270	Phosphorylation	HDIHSTRSKERLNAY HHHHHCCCHHHHHCC	38.67	28270605
277	Phosphorylation	SKERLNAYT------ CHHHHHCCC------	16.35	24927040
278	Phosphorylation	KERLNAYT------- HHHHHCCC-------	29.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
10	T	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GPM6A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GPM6A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZDH17_HUMAN	ZDHHC17	physical	24705354
CC126_HUMAN	CCDC126	physical	26186194
MGT5A_HUMAN	MGAT5	physical	26186194
RMD3_HUMAN	RMDN3	physical	26186194
S35B2_HUMAN	SLC35B2	physical	26186194
PLCC_HUMAN	AGPAT3	physical	26186194
FITM2_HUMAN	FITM2	physical	26186194
ERMP1_HUMAN	ERMP1	physical	26186194
HAX1_HUMAN	HAX1	physical	26186194
IKIP_HUMAN	IKBIP	physical	26186194
RFT1_HUMAN	RFT1	physical	26186194
QCR9_HUMAN	UQCR10	physical	26186194
YIPF3_HUMAN	YIPF3	physical	26186194
F189B_HUMAN	FAM189B	physical	26186194
SCAM2_HUMAN	SCAMP2	physical	26186194
PXMP2_HUMAN	PXMP2	physical	26186194
GP1BB_HUMAN	GP1BB	physical	26186194
VKORL_HUMAN	VKORC1L1	physical	26186194
ZDH18_HUMAN	ZDHHC18	physical	26186194
CC126_HUMAN	CCDC126	physical	28514442
MGT5A_HUMAN	MGAT5	physical	28514442
HAX1_HUMAN	HAX1	physical	28514442
IKIP_HUMAN	IKBIP	physical	28514442
FITM2_HUMAN	FITM2	physical	28514442
TSN3_HUMAN	TSPAN3	physical	28514442
YIPF3_HUMAN	YIPF3	physical	28514442
ZDH18_HUMAN	ZDHHC18	physical	28514442
ERMP1_HUMAN	ERMP1	physical	28514442
GP1BB_HUMAN	GP1BB	physical	28514442
FKRP_HUMAN	FKRP	physical	28514442

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GPM6A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteomic analysis of synaptosomes from human cerebralcortex."; DeGiorgis J.A., Jaffe H., Moreira J.E., Carlotti C.G. Jr., Leite J.P.,Pant H.C., Dosemeci A.; J. Proteome Res. 4:306-315(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, AND MASSSPECTROMETRY.	15822905 [Abstract]