ZDH18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZDH18_HUMAN
• UniProt AC: Q9NUE0
• Protein Name: Palmitoyltransferase ZDHHC18
• Gene Name: ZDHHC18
• Organism: Homo sapiens (Human).
• Sequence Length: 388
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Has palmitoyltransferase activity towards HRAS and LCK..
• Protein Sequence: MKDCEYQQISPGAAPLPASPGARRPGPAASPTPGPGPAPPAAPAPPRWSSSGSGSGSGSGSLGRRPRRKWEVFPGRNRFYCGGRLMLAGHGGVFALTLLLILTTTGLFFVFDCPYLARKLTLAIPIIAAILFFFVMSCLLQTSFTDPGILPRATVCEAAALEKQIDNTGSSTYRPPPRTREVLINGQMVKLKYCFTCKMFRPPRTSHCSVCDNCVERFDHHCPWVGNCVGRRNYRFFYAFILSLSFLTAFIFACVVTHLTLRAQGSNFLSTLKETPASVLELVICFFSIWSILGLSGFHTYLVASNLTTNEDIKGSWSSKRGGEASVNPYSHKSIITNCCAVLCGPLPPSLIDRRGFVQSDTVLPSPIRSDEPACRAKPDASMVGGHP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MKDCEYQQISPGA --CCCCCCCCCCCCC	16.43	18180459
10	Phosphorylation	DCEYQQISPGAAPLP CCCCCCCCCCCCCCC	16.97	21712546
19	Phosphorylation	GAAPLPASPGARRPG CCCCCCCCCCCCCCC	23.17	19664994
30	Phosphorylation	RRPGPAASPTPGPGP CCCCCCCCCCCCCCC	31.26	29255136
32	Phosphorylation	PGPAASPTPGPGPAP CCCCCCCCCCCCCCC	38.08	25849741
49	Phosphorylation	APAPPRWSSSGSGSG CCCCCCCCCCCCCCC	18.86	23898821
50	Phosphorylation	PAPPRWSSSGSGSGS CCCCCCCCCCCCCCC	31.58	25850435
51	Phosphorylation	APPRWSSSGSGSGSG CCCCCCCCCCCCCCC	31.31	27080861
53	Phosphorylation	PRWSSSGSGSGSGSG CCCCCCCCCCCCCCC	31.56	25850435
55	Phosphorylation	WSSSGSGSGSGSGSL CCCCCCCCCCCCCCC	31.33	30108239
57	Phosphorylation	SSGSGSGSGSGSLGR CCCCCCCCCCCCCCC	31.33	30108239
59	Phosphorylation	GSGSGSGSGSLGRRP CCCCCCCCCCCCCCC	27.23	30108239
61	Phosphorylation	GSGSGSGSLGRRPRR CCCCCCCCCCCCCCC	29.37	30108239
168	Phosphorylation	LEKQIDNTGSSTYRP HHHHHCCCCCCCCCC	34.39	21945579
170	Phosphorylation	KQIDNTGSSTYRPPP HHHCCCCCCCCCCCC	19.91	21945579
171	Phosphorylation	QIDNTGSSTYRPPPR HHCCCCCCCCCCCCC	30.70	21945579
172	Phosphorylation	IDNTGSSTYRPPPRT HCCCCCCCCCCCCCC	25.83	21945579
173	Phosphorylation	DNTGSSTYRPPPRTR CCCCCCCCCCCCCCE	24.07	21945579
190	Acetylation	LINGQMVKLKYCFTC EECCEEEEEEEEEEC	33.64	24469689
198	Acetylation	LKYCFTCKMFRPPRT EEEEEECCCCCCCCC	37.71	24469697
334	Phosphorylation	VNPYSHKSIITNCCA CCCCCHHHHHHCCCH	17.50	19413330
360	Phosphorylation	DRRGFVQSDTVLPSP CCCCCCCCCCCCCCC	29.91	25850435
362	Phosphorylation	RGFVQSDTVLPSPIR CCCCCCCCCCCCCCC	29.23	25850435
366	Phosphorylation	QSDTVLPSPIRSDEP CCCCCCCCCCCCCCC	28.88	29255136
378	Ubiquitination	DEPACRAKPDASMVG CCCHHHCCCCHHHCC	24.87	-
382	Phosphorylation	CRAKPDASMVGGHP- HHCCCCHHHCCCCC-	22.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZDH18_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZDH18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZDH18_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZDH18_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.