dbPTM

VKORL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VKORL_HUMAN
UniProt AC	Q8N0U8
Protein Name	Vitamin K epoxide reductase complex subunit 1-like protein 1
Gene Name	VKORC1L1
Organism	Homo sapiens (Human).
Sequence Length	176
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins..
Protein Sequence	MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRWGRGFGLLGSIFGKDGVLNQPNSVFGLIFYILQLLLGMTASAVAALILMTSSIMSVVGSLYLAYILYFVLKEFCIICIVTYVLNFLLLIINYKRLVYLNEAWKRQLQPKQD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Ubiquitination	CDLGPWVKCSAALAS HHCHHHHHHHHHHHH	20.71	-
57	Ubiquitination	CDLGPWVKCSAALAS HHCHHHHHHHHHHHH	20.71	-
58	S-palmitoylation	DLGPWVKCSAALASR HCHHHHHHHHHHHHH	2.12	29575903
64	Phosphorylation	KCSAALASRWGRGFG HHHHHHHHHHCCCCH	29.44	22964224
168	Ubiquitination	VYLNEAWKRQLQPKQ HHHHHHHHHHCCCCC	37.00	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VKORL_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VKORL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VKORL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of VKORL_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VKORL_HUMAN

Related Literatures of Post-Translational Modification