YIPF3_HUMAN - dbPTM
YIPF3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YIPF3_HUMAN
UniProt AC Q9GZM5
Protein Name Protein YIPF3
Gene Name YIPF3
Organism Homo sapiens (Human).
Sequence Length 350
Subcellular Localization Cell membrane
Multi-pass membrane protein. Cytoplasm. Golgi apparatus, cis-Golgi network membrane
Multi-pass membrane protein. Localization to the cytoplasm or to the cell membrane is developmentally and ontogenetically regulated.
Protein Description Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis..
Protein Sequence MATTAAPAGGARNGAGPEWGGFEENIQGGGSAVIDMENMDDTSGSSFEDMGELHQRLREEEVDADAADAAAAEEEDGEFLGMKGFKGQLSRQVADQMWQAGKRQASRAFSLYANIDILRPYFDVEPAQVRSRLLESMIPIKMVNFPQKIAGELYGPLMLVFTLVAILLHGMKTSDTIIREGTLMGTAIGTCFGYWLGVSSFIYFLAYLCNAQITMLQMLALLGYGLFGHCIVLFITYNIHLHALFYLFWLLVGGLSTLRMVAVLVSRTVGPTQRLLLCGTLAALHMLFLLYLHFAYHKVVEGILDTLEGPNIPPIQRVPRDIPAMLPAARLPTTVLNATAKAVAVTLQSH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MATTAAPAG
------CCCCCCCCC		17.4122814378
48UbiquitinationDTSGSSFEDMGELHQ
CCCCCCHHHHHHHHH		49.3821963094
51UbiquitinationGSSFEDMGELHQRLR
CCCHHHHHHHHHHHH		46.7827667366
67UbiquitinationEEVDADAADAAAAEE
HHCCHHHHHHHHHHH		13.9227667366
83UbiquitinationDGEFLGMKGFKGQLS
CCCCCCCCCCCHHHH		60.4421906983
86UbiquitinationFLGMKGFKGQLSRQV
CCCCCCCCHHHHHHH		55.1827667366
102UbiquitinationDQMWQAGKRQASRAF
HHHHHHHHHHHHHHH		44.3327667366
106UbiquitinationQAGKRQASRAFSLYA
HHHHHHHHHHHHHHH		18.7922817900
136PhosphorylationVRSRLLESMIPIKMV
HHHHHHHHCCCEEEC		23.21-
137SulfoxidationRSRLLESMIPIKMVN
HHHHHHHCCCEEECC		2.8521406390
141UbiquitinationLESMIPIKMVNFPQK
HHHCCCEEECCCCHH		31.2921906983
148UbiquitinationKMVNFPQKIAGELYG
EECCCCHHHHHHHHH		34.46-
272PhosphorylationVSRTVGPTQRLLLCG
HHCCCCHHHHHHHHH		22.01-
333O-linked_GlycosylationLPAARLPTTVLNATA
CCHHCCCHHHHHHHH		33.8421757827
334O-linked_GlycosylationPAARLPTTVLNATAK
CHHCCCHHHHHHHHH		22.5121757827
337N-linked_GlycosylationRLPTTVLNATAKAVA
CCCHHHHHHHHHHHH		30.8021757827
339O-linked_GlycosylationPTTVLNATAKAVAVT
CHHHHHHHHHHHHHH		27.8455823995
346O-linked_GlycosylationTAKAVAVTLQSH---
HHHHHHHHCCCC---		14.8922171320
349O-linked_GlycosylationAVAVTLQSH------
HHHHHCCCC------		33.9955834431
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YIPF3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YIPF3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YIPF3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YIPF4_HUMANYIPF4physical
16189514
YIPF4_HUMANYIPF4physical
21757827
GOGA2_HUMANGOLGA2physical
21757827
GORS1_HUMANGORASP1physical
21757827
LMAN1_HUMANLMAN1physical
21757827
CALX_HUMANCANXphysical
21757827
KRA32_HUMANKRTAP3-2physical
25416956
YIPF4_HUMANYIPF4physical
25416956
KRA94_HUMANKRTAP9-4physical
25416956
KR108_HUMANKRTAP10-8physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
S22A5_HUMANSLC22A5physical
28514442
LAT3_HUMANSLC43A1physical
28514442
MGT4B_HUMANMGAT4Bphysical
28514442
RETR2_HUMANFAM134Aphysical
28514442
CAV1_HUMANCAV1physical
28514442
ERGI2_HUMANERGIC2physical
28514442
ENDD1_HUMANENDOD1physical
28514442
PIGN_HUMANPIGNphysical
28514442
REEP4_HUMANREEP4physical
28514442
NIPA2_HUMANNIPA2physical
28514442
AT8B2_HUMANATP8B2physical
28514442
CDS1_HUMANCDS1physical
28514442
SC6A8_HUMANSLC6A8physical
28514442
NDUB5_HUMANNDUFB5physical
28514442
NDUB6_HUMANNDUFB6physical
28514442
NDUB8_HUMANNDUFB8physical
28514442
UN93B_HUMANUNC93B1physical
28514442
T120B_HUMANTMEM120Bphysical
28514442
NDUS4_HUMANNDUFS4physical
28514442
NU4M_HUMANND4physical
28514442
AT133_HUMANATP13A3physical
28514442
ERGI3_HUMANERGIC3physical
28514442
NDUB3_HUMANNDUFB3physical
28514442
PIGW_HUMANPIGWphysical
28514442
NDUAC_HUMANNDUFA12physical
28514442
MFSD5_HUMANMFSD5physical
28514442
ADCY6_HUMANADCY6physical
28514442
F213A_HUMANFAM213Aphysical
28514442
TM245_HUMANTMEM245physical
28514442
NU5M_HUMANND5physical
28514442
SYVN1_HUMANSYVN1physical
28514442
KTN1_HUMANKTN1physical
28514442
T120A_HUMANTMEM120Aphysical
28514442
S19A2_HUMANSLC19A2physical
28514442
ATP9A_HUMANATP9Aphysical
28514442
PIEZ1_HUMANPIEZO1physical
28514442
BRI3B_HUMANBRI3BPphysical
28514442
APOB_HUMANAPOBphysical
28514442
T161B_HUMANTMEM161Bphysical
28514442
MBRL_HUMANTMEM259physical
28514442
SPPL3_HUMANSPPL3physical
28514442
AG10A_HUMANALG10physical
28514442
SIDT2_HUMANSIDT2physical
28514442
SEC63_HUMANSEC63physical
28514442
GOGA5_HUMANGOLGA5physical
28514442
LAT4_HUMANSLC43A2physical
28514442
S35F5_HUMANSLC35F5physical
28514442
PCX3_HUMANPCNXL3physical
28514442
YIPF4_HUMANYIPF4physical
28514442
TMM43_HUMANTMEM43physical
28514442
SURF4_HUMANSURF4physical
28514442
S35B2_HUMANSLC35B2physical
28514442
CTR2_HUMANSLC7A2physical
28514442
PHB_HUMANPHBphysical
28514442
TM223_HUMANTMEM223physical
28514442
NDUV3_HUMANNDUFV3physical
28514442
SC5D_HUMANSC5Dphysical
28514442
SNG1_HUMANSYNGR1physical
28514442
PLCC_HUMANAGPAT3physical
28514442
ALG8_HUMANALG8physical
28514442
NDUC2_HUMANNDUFC2physical
28514442
SOAT1_HUMANSOAT1physical
28514442
GPAA1_HUMANGPAA1physical
28514442
TMM56_HUMANTMEM56physical
28514442
CSCL2_HUMANTMEM63Bphysical
28514442
P5I11_HUMANTP53I11physical
28514442
WFS1_HUMANWFS1physical
28514442
FA8A1_HUMANFAM8A1physical
28514442
PIGU_HUMANPIGUphysical
28514442
PTH2_HUMANPTRH2physical
28514442
MFSD8_HUMANMFSD8physical
28514442
SGPP1_HUMANSGPP1physical
28514442
LMBR1_HUMANLMBR1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YIPF3_HUMAN

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Related Literatures of Post-Translational Modification
O-linked Glycosylation
ReferencePubMed
"Human urinary glycoproteomics; attachment site specific analysis ofN-and O-linked glycosylations by CID and ECD.";
Halim A., Nilsson J., Ruetschi U., Hesse C., Larson G.;
Mol. Cell. Proteomics 0:0-0(2011).
Cited for: GLYCOSYLATION AT THR-346, STRUCTURE OF CARBOHYDRATES, AND MASSSPECTROMETRY.
"Characterization of YIPF3 and YIPF4, cis-Golgi localizing Yip domainfamily proteins.";
Tanimoto K., Suzuki K., Jokitalo E., Sakai N., Sakaguchi T.,Tamura D., Fujii G., Aoki K., Takada S., Ishida R., Tanabe M.,Itoh H., Yoneda Y., Sohda M., Misumi Y., Nakamura N.;
Cell Struct. Funct. 36:171-185(2011).
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH YIPF4, ANDGLYCOSYLATION AT THR-333; THR-334; ASN-337 AND THR-346.

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