dbPTM

SC5D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SC5D_HUMAN
UniProt AC	O75845
Protein Name	Lathosterol oxidase
Gene Name	SC5D
Organism	Homo sapiens (Human).
Sequence Length	299
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol..
Protein Sequence	MDLVLRVADYYFFTPYVYPATWPEDDIFRQAISLLIVTNVGAYILYFFCATLSYYFVFDHALMKHPQFLKNQVRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQILQPFINGSAHHTDHHMFFDYNYGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Ubiquitination	MKHPQFLKNQVRREI HHCHHHHHHHHHHHH	46.77	21890473
253	Phosphorylation	LWDRIGGSFKNPSSF EHHHCCCCCCCCHHC	28.03	28450419
255	Ubiquitination	DRIGGSFKNPSSFEG HHCCCCCCCCHHCCC	70.42	21890473
255	Ubiquitination	DRIGGSFKNPSSFEG HHCCCCCCCCHHCCC	70.42	21890473
263	Ubiquitination	NPSSFEGKGPLSYVK CCHHCCCCCCHHHHH	50.59	21890473
263	Ubiquitination	NPSSFEGKGPLSYVK CCHHCCCCCCHHHHH	50.59	21890473
270	Ubiquitination	KGPLSYVKEMTEGKR CCCHHHHHHHHCCCC	33.27	-
286	Acetylation	SHSGNGCKNEKLFNG CCCCCCCCCCEECCC	70.33	7711205
289	Ubiquitination	GNGCKNEKLFNGEFT CCCCCCCEECCCCCE	68.70	-
297	Ubiquitination	LFNGEFTKTE----- ECCCCCEECC-----	56.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SC5D_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SC5D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SC5D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SC5D_HUMAN !!

Drug and Disease Associations

Kegg Disease
H01281	Lathosterolosis
OMIM Disease
607330	Lathosterolosis (LATHST)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SC5D_HUMAN

Related Literatures of Post-Translational Modification