ENDD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENDD1_HUMAN
• UniProt AC: O94919
• Protein Name: Endonuclease domain-containing 1 protein
• Gene Name: ENDOD1
• Organism: Homo sapiens (Human).
• Sequence Length: 500
• Subcellular Localization: Secreted .
• Protein Description: May act as a DNase and a RNase..
• Protein Sequence: MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPPAGLAADSHVKICQRAEGAERFATLYSTRDRIPVYSAFRAPRPAPGGAEQRWLVEPQIDDPNSNLEEAINEAEAITSVNSLGSKQALNTDYLDSDYQRGQLYPFSLSSDVQVATFTLTNSAPMTQSFQERWYVNLHSLMDRALTPQCGSGEDLYILTGTVPSDYRVKDKVAVPEFVWLAACCAVPGGGWAMGFVKHTRDSDIIEDVMVKDLQKLLPFNPQLFQNNCGETEQDTEKMKKILEVVNQIQDEERMVQSQKSSSPLSSTRSKRSTLLPPEASEGSSSFLGKLMGFIATPFIKLFQLIYYLVVAILKNIVYFLWCVTKQVINGIESCLYRLGSATISYFMAIGEELVSIPWKVLKVVAKVIRALLRILCCLLKAICRVLSIPVRVLVDVATFPVYTMGAIPIVCKDIALGLGGTVSLLFDTAFGTLGGLFQVVFSVCKRIGYKVTFDNSGEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
137	Phosphorylation	LNTDYLDSDYQRGQL CCCCCCCCCCCCCCC	35.31	-
207	Phosphorylation	TGTVPSDYRVKDKVA ECCCCCCCCCCCCCC	22.95	-
250	Sulfoxidation	SDIIEDVMVKDLQKL CCCCHHHHHHHHHHH	4.85	21406390
300	Ubiquitination	ERMVQSQKSSSPLSS HHHHHCCCCCCCCCC	58.51	21906983
301	Phosphorylation	RMVQSQKSSSPLSST HHHHCCCCCCCCCCC	28.54	26437602
301	O-linked_Glycosylation	RMVQSQKSSSPLSST HHHHCCCCCCCCCCC	28.54	OGP
302	Phosphorylation	MVQSQKSSSPLSSTR HHHCCCCCCCCCCCC	42.90	28857561
303	Phosphorylation	VQSQKSSSPLSSTRS HHCCCCCCCCCCCCC	36.63	28857561
306	Phosphorylation	QKSSSPLSSTRSKRS CCCCCCCCCCCCCCC	32.80	22817900
307	Phosphorylation	KSSSPLSSTRSKRST CCCCCCCCCCCCCCC	35.21	22817900
308	Phosphorylation	SSSPLSSTRSKRSTL CCCCCCCCCCCCCCC	35.27	26437602
310	Phosphorylation	SPLSSTRSKRSTLLP CCCCCCCCCCCCCCC	32.29	22817900
313	Phosphorylation	SSTRSKRSTLLPPEA CCCCCCCCCCCCCCC	27.43	-
314	Phosphorylation	STRSKRSTLLPPEAS CCCCCCCCCCCCCCC	36.03	-
407	Acetylation	KVLKVVAKVIRALLR HHHHHHHHHHHHHHH	26.95	19608861
490	Phosphorylation	SVCKRIGYKVTFDNS HHHHHHCCEEEECCC	10.42	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENDD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENDD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENDD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-407, AND MASS SPECTROMETRY.
PubMed: 19608861