WFS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WFS1_HUMAN
• UniProt AC: O76024
• Protein Name: Wolframin
• Gene Name: WFS1
• Organism: Homo sapiens (Human).
• Sequence Length: 890
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store..
• Protein Sequence: MDSNTAPLGPSCPQPPPAPQPQARSRLNATASLEQERSERPRAPGPQAGPGPGVRDAAAPAEPQAQHTRSRERADGTGPTKGDMEIPFEEVLERAKAGDPKAQTEVGKHYLQLAGDTDEELNSCTAVDWLVLAAKQGRREAVKLLRRCLADRRGITSENEREVRQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVAELLENVGQVNEHDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVEITKKYAKGVIPSSLFLQDDEDDDELAGKSPEDLPLRLKVVKYPLHAIMEIKEYLIDMASRAGMHWLSTIIPTHHINALIFFFIVSNLTIDFFAFFIPLVIFYLSFISMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQAEVNFGWNHLEPYAHFLLSVFFVIFSFPIASKDCIPCSELAVITGFFTVTSYLSLSTHAEPYTRRALATEVTAGLLSLLPSMPLNWPYLKVLGQTFITVPVGHLVVLNVSVPCLLYVYLLYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILLESTGLGLLRASIGYFLFLFALPILVAGLALVGVLQFARWFTSLELTKIAVTVAVCSVPLLLRWWTKASFSVVGMVKSLTRSSMVKLILVWLTAIVLFCWFYVYRSEGMKVYNSTLTWQQYGALCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTDIDNSAESAINMLPFFIGDWMRCLYGEAYPACSPGNTSTAEEELCRLKLLAKHPCHIKKFDRYKFEITVGMPFSSGADGSRSREEDDVTKDIVLRASSEFKSVLLSLRQGSLIEFSTILEGRLGSKWPVFELKAISCLNCMAQLSPTRRHVKIEHDWRSTVHGAVKFAFDFFFFPFLSAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDSNTAPL -------CCCCCCCC	13.23	22814378
25	Phosphorylation	APQPQARSRLNATAS CCCCCHHHHHCCCCC	44.10	23403867
28	N-linked_Glycosylation	PQARSRLNATASLEQ CCHHHHHCCCCCHHH	33.85	-
28	N-linked_Glycosylation	PQARSRLNATASLEQ CCHHHHHCCCCCHHH	33.85	11181517
30	Phosphorylation	ARSRLNATASLEQER HHHHHCCCCCHHHHH	18.73	29255136
32	Phosphorylation	SRLNATASLEQERSE HHHCCCCCHHHHHHC	28.25	29255136
38	Phosphorylation	ASLEQERSERPRAPG CCHHHHHHCCCCCCC	36.89	23403867
68	Phosphorylation	AEPQAQHTRSRERAD CCCCCHHCCCCCCCC	20.47	23532336
70	Phosphorylation	PQAQHTRSRERADGT CCCHHCCCCCCCCCC	39.38	24173317
143	Malonylation	QGRREAVKLLRRCLA CCHHHHHHHHHHHHH	49.18	26320211
157	Phosphorylation	ADRRGITSENEREVR HHHCCCCCHHHHHHH	36.18	-
167	Phosphorylation	EREVRQLSSETDLER HHHHHHHCCHHHHHH	20.14	30622161
168	Phosphorylation	REVRQLSSETDLERA HHHHHHCCHHHHHHH	53.78	30622161
170	Phosphorylation	VRQLSSETDLERAVR HHHHCCHHHHHHHHH	48.08	30622161
184	Phosphorylation	RKAALVMYWKLNPKK HHHHHHHHHCCCHHH	7.60	27642862
221	Ubiquitination	AQPGPVPKSLQKQRR CCCCCCCHHHHHHHH	65.12	-
235	Phosphorylation	RMLERLVSSESKNYI HHHHHHHCCCCCCEE	32.74	30266825
236	Phosphorylation	MLERLVSSESKNYIA HHHHHHCCCCCCEEE	38.11	27273156
238	Phosphorylation	ERLVSSESKNYIALD HHHHCCCCCCEEEHH	28.31	30266825
241	Phosphorylation	VSSESKNYIALDDFV HCCCCCCEEEHHHHH	7.42	28152594
252	Ubiquitination	DDFVEITKKYAKGVI HHHHHHHHHHHCCCC	49.82	21906983
256	Ubiquitination	EITKKYAKGVIPSSL HHHHHHHCCCCCHHH	51.09	21906983
262	Phosphorylation	AKGVIPSSLFLQDDE HCCCCCHHHCCCCCC	20.13	24173317
277	Ubiquitination	DDDELAGKSPEDLPL CCCHHCCCCHHHCCH	58.17	21906983
278	Phosphorylation	DDELAGKSPEDLPLR CCHHCCCCHHHCCHH	32.38	-
335	N-linked_Glycosylation	IFFFIVSNLTIDFFA HHHHHHCCCCHHHHH	30.24	-
335	N-linked_Glycosylation	IFFFIVSNLTIDFFA HHHHHHCCCCHHHHH	30.24	11181517
369	Ubiquitination	LKVFQDSKAWENFRT HHHHCCCHHHHHHHH	66.85	-
500	N-linked_Glycosylation	VGHLVVLNVSVPCLL CCCEEECCCHHHHHH	16.65	-
500	N-linked_Glycosylation	VGHLVVLNVSVPCLL CCCEEECCCHHHHHH	16.65	11181517
630	Phosphorylation	MVKSLTRSSMVKLIL HHHHCCHHHHHHHHH	19.97	20068230
631	Phosphorylation	VKSLTRSSMVKLILV HHHCCHHHHHHHHHH	25.05	20068230
661	N-linked_Glycosylation	SEGMKVYNSTLTWQQ HCCCEEECCEEEHHH	31.35	11181517
661	N-linked_Glycosylation	SEGMKVYNSTLTWQQ HCCCEEECCEEEHHH	31.35	UniProtKB CARBOHYD
679	Ubiquitination	LCGPRAWKETNMART HHCHHHHHHHCHHHH	54.39	21906983
686	Phosphorylation	KETNMARTQILCSHL HHHCHHHHHHHHHHH	15.49	29209046
691	Phosphorylation	ARTQILCSHLEGHRV HHHHHHHHHHCCCEE	27.88	29209046
699	Phosphorylation	HLEGHRVTWTGRFKY HHCCCEEEEEEECEE	19.77	29209046
701	Phosphorylation	EGHRVTWTGRFKYVR CCCEEEEEEECEEEE	14.76	29209046
746	N-linked_Glycosylation	YPACSPGNTSTAEEE CCCCCCCCCCHHHHH	33.95	UniProtKB CARBOHYD
746	N-linked_Glycosylation	YPACSPGNTSTAEEE CCCCCCCCCCHHHHH	33.95	11181517
762	Ubiquitination	CRLKLLAKHPCHIKK HHHHHHHHCCCCCCC	48.31	-
792	Phosphorylation	SGADGSRSREEDDVT CCCCCCCCCCCCCCC	45.82	-
799	Phosphorylation	SREEDDVTKDIVLRA CCCCCCCCHHHHHHH	29.96	-
800	Ubiquitination	REEDDVTKDIVLRAS CCCCCCCHHHHHHHC	45.35	21906983
811	Ubiquitination	LRASSEFKSVLLSLR HHHCHHHHHHHHHHH	35.29	21906983
821	Phosphorylation	LLSLRQGSLIEFSTI HHHHHCCCEEEEEHH	20.17	21406692
826	Phosphorylation	QGSLIEFSTILEGRL CCCEEEEEHHHCCCC	11.18	21406692
827	Phosphorylation	GSLIEFSTILEGRLG CCEEEEEHHHCCCCC	34.60	21406692
836	Ubiquitination	LEGRLGSKWPVFELK HCCCCCCCCCCHHHH	54.43	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
30	T	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
32	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WFS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WFS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMUF1_HUMAN	SMURF1	physical	21454619
ATF6A_HUMAN	ATF6	physical	20160352
PSA5_HUMAN	PSMA5	physical	20160352
SYVN1_HUMAN	SYVN1	physical	20160352

Drug and Disease Associations

• Kegg Disease
• H00409: Type II diabetes mellitus
• H00604: Deafness, autosomal dominant
• H00854: Wolfram syndrome (WFS); DIDMOAD syndrome
• OMIM Disease
• 222300: Wolfram syndrome 1 (WFS1)
• 600965: Deafness, autosomal dominant, 6 (DFNA6)
• 614296: Wolfram-like syndrome autosomal dominant (WFSL)
• 116400: Cataract 41 (CTRCT41)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.