UniProt ID | AT133_HUMAN | |
---|---|---|
UniProt AC | Q9H7F0 | |
Protein Name | Probable cation-transporting ATPase 13A3 | |
Gene Name | ATP13A3 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 1226 | |
Subcellular Localization |
Membrane Multi-pass membrane protein. |
|
Protein Description | ||
Protein Sequence | MDREERKTINQGQEDEMEIYGYNLSRWKLAIVSLGVICSGGFLLLLLYWMPEWRVKATCVRAAIKDCEVVLLRTTDEFKMWFCAKIRVLSLETYPVSSPKSMSNKLSNGHAVCLIENPTEENRHRISKYSQTESQQIRYFTHHSVKYFWNDTIHNFDFLKGLDEGVSCTSIYEKHSAGLTKGMHAYRKLLYGVNEIAVKVPSVFKLLIKEVLNPFYIFQLFSVILWSTDEYYYYALAIVVMSIVSIVSSLYSIRKQYVMLHDMVATHSTVRVSVCRVNEEIEEIFSTDLVPGDVMVIPLNGTIMPCDAVLINGTCIVNESMLTGESVPVTKTNLPNPSVDVKGIGDELYNPETHKRHTLFCGTTVIQTRFYTGELVKAIVVRTGFSTSKGQLVRSILYPKPTDFKLYRDAYLFLLCLVAVAGIGFIYTIINSILNEVQVGVIIIESLDIITITVPPALPAAMTAGIVYAQRRLKKIGIFCISPQRINICGQLNLVCFDKTGTLTEDGLDLWGIQRVENARFLSPEENVCNEMLVKSQFVACMATCHSLTKIEGVLSGDPLDLKMFEAIGWILEEATEEETALHNRIMPTVVRPPKQLLPESTPAGNQEMELFELPATYEIGIVRQFPFSSALQRMSVVARVLGDRKMDAYMKGAPEAIAGLCKPETVPVDFQNVLEDFTKQGFRVIALAHRKLESKLTWHKVQNISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGDSMLTAVSVARDCGMILPQDKVIIAEALPPKDGKVAKINWHYADSLTQCSHPSAIDPEAIPVKLVHDSLEDLQMTRYHFAMNGKSFSVILEHFQDLVPKLMLHGTVFARMAPDQKTQLIEALQNVDYFVGMCGDGANDCGALKRAHGGISLSELEASVASPFTSKTPSISCVPNLIREGRAALITSFCVFKFMALYSIIQYFSVTLLYSILSNLGDFQFLFIDLAIILVVVFTMSLNPAWKELVAQRPPSGLISGALLFSVLSQIIICIGFQSLGFFWVKQQPWYEVWHPKSDACNTTGSGFWNSSHVDNETELDEHNIQNYENTTVFFISSFQYLIVAIAFSKGKPFRQPCYKNYFFVFSVIFLYIFILFIMLYPVASVDQVLQIVCVPYQWRVTMLIIVLVNAFVSITVEESVDRWGKCCLPWALGCRKKTPKAKYMYLAQELLVDPEWPPKPQTTTEAKALVKENGSCQIITIT | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
8 | Phosphorylation | MDREERKTINQGQED CCHHHHHCCCCCCCC | 31.23 | 18452278 | |
33 | Phosphorylation | RWKLAIVSLGVICSG HHHEEHHHHHCCCCH | 17.19 | 28111955 | |
39 | Phosphorylation | VSLGVICSGGFLLLL HHHHCCCCHHHHHHH | 30.72 | 28111955 | |
65 | Ubiquitination | TCVRAAIKDCEVVLL HHHHHHHCCCEEEEE | 52.15 | - | |
65 (in isoform 2) | Ubiquitination | - | 52.15 | 21906983 | |
74 | Phosphorylation | CEVVLLRTTDEFKMW CEEEEEEECHHHHHH | 38.27 | 22210691 | |
75 | Phosphorylation | EVVLLRTTDEFKMWF EEEEEEECHHHHHHH | 27.39 | 22210691 | |
78 (in isoform 2) | Ubiquitination | - | 7.96 | 21906983 | |
85 | Acetylation | FKMWFCAKIRVLSLE HHHHHEEEEEEEEEE | 32.02 | 20167786 | |
90 | Phosphorylation | CAKIRVLSLETYPVS EEEEEEEEEEECCCC | 22.69 | - | |
93 | Phosphorylation | IRVLSLETYPVSSPK EEEEEEEECCCCCCC | 38.12 | 28450419 | |
94 | Phosphorylation | RVLSLETYPVSSPKS EEEEEEECCCCCCCH | 7.71 | 30108239 | |
97 | Phosphorylation | SLETYPVSSPKSMSN EEEECCCCCCCHHHC | 36.10 | 30266825 | |
98 | Phosphorylation | LETYPVSSPKSMSNK EEECCCCCCCHHHCC | 36.26 | 30266825 | |
100 (in isoform 1) | Ubiquitination | - | 61.82 | 21906983 | |
100 | Ubiquitination | TYPVSSPKSMSNKLS ECCCCCCCHHHCCCC | 61.82 | 21906983 | |
100 (in isoform 2) | Ubiquitination | - | 61.82 | 21906983 | |
103 | Phosphorylation | VSSPKSMSNKLSNGH CCCCCHHHCCCCCCE | 37.59 | 30108239 | |
107 | Phosphorylation | KSMSNKLSNGHAVCL CHHHCCCCCCEEEEE | 42.23 | 30108239 | |
112 (in isoform 2) | Ubiquitination | - | 1.96 | 21906983 | |
127 | Phosphorylation | EENRHRISKYSQTES HHHCHHHHCCCCCHH | 26.04 | 28450419 | |
128 (in isoform 1) | Ubiquitination | - | 46.69 | 21906983 | |
128 | Ubiquitination | ENRHRISKYSQTESQ HHCHHHHCCCCCHHH | 46.69 | 21906983 | |
129 | Phosphorylation | NRHRISKYSQTESQQ HCHHHHCCCCCHHHH | 10.14 | 30108239 | |
130 | Phosphorylation | RHRISKYSQTESQQI CHHHHCCCCCHHHHH | 34.07 | 28450419 | |
132 | Phosphorylation | RISKYSQTESQQIRY HHHCCCCCHHHHHHH | 31.50 | 28450419 | |
134 | Phosphorylation | SKYSQTESQQIRYFT HCCCCCHHHHHHHHH | 30.67 | 30108239 | |
139 | Phosphorylation | TESQQIRYFTHHSVK CHHHHHHHHHHHCHH | 17.92 | 27642862 | |
144 | Phosphorylation | IRYFTHHSVKYFWND HHHHHHHCHHHHCCC | 16.82 | 27642862 | |
160 | Ubiquitination | IHNFDFLKGLDEGVS CCCCHHHCCCCCCCC | 58.37 | - | |
174 | Ubiquitination | SCTSIYEKHSAGLTK CCCHHHHHHCCCCCC | 26.36 | - | |
181 | Ubiquitination | KHSAGLTKGMHAYRK HHCCCCCCHHHHHHH | 60.32 | - | |
188 | Ubiquitination | KGMHAYRKLLYGVNE CHHHHHHHHHHCCCH | 30.12 | 21906983 | |
188 (in isoform 1) | Ubiquitination | - | 30.12 | 21906983 | |
191 | Phosphorylation | HAYRKLLYGVNEIAV HHHHHHHHCCCHHHC | 29.48 | - | |
252 | Phosphorylation | SIVSSLYSIRKQYVM HHHHHHHHHHHHHHH | 22.62 | 24719451 | |
342 | Ubiquitination | PNPSVDVKGIGDELY CCCCCCCCCCCCCCC | 40.11 | 21906983 | |
342 (in isoform 1) | Ubiquitination | - | 40.11 | 21906983 | |
349 | Phosphorylation | KGIGDELYNPETHKR CCCCCCCCCCCCCCC | 26.99 | - | |
355 (in isoform 1) | Ubiquitination | - | 53.98 | 21906983 | |
355 | Ubiquitination | LYNPETHKRHTLFCG CCCCCCCCCCEEEEC | 53.98 | 21906983 | |
371 | Phosphorylation | TVIQTRFYTGELVKA EEEEEEECCCCEEEE | 15.56 | 28102081 | |
372 | Phosphorylation | VIQTRFYTGELVKAI EEEEEECCCCEEEEE | 22.82 | 28102081 | |
377 (in isoform 1) | Ubiquitination | - | 45.05 | 21906983 | |
377 | Ubiquitination | FYTGELVKAIVVRTG ECCCCEEEEEEEECC | 45.05 | 21906983 | |
389 (in isoform 1) | Ubiquitination | - | 51.25 | 21906983 | |
389 | Ubiquitination | RTGFSTSKGQLVRSI ECCCCCCCCCEEEEE | 51.25 | 21906983 | |
450 (in isoform 2) | Ubiquitination | - | 1.97 | 21906983 | |
523 | Phosphorylation | VENARFLSPEENVCN CCCCCCCCCCCCCHH | 27.79 | 22817900 | |
556 | Phosphorylation | TKIEGVLSGDPLDLK HEEECHHCCCCCCHH | 38.45 | 23898821 | |
615 (in isoform 2) | Ubiquitination | - | 18.50 | 21906983 | |
696 | Ubiquitination | AHRKLESKLTWHKVQ CCHHHHHCCCHHHCC | 40.33 | - | |
727 | Ubiquitination | IIMQNKLKQETPAVL HHHHHHHCCCCHHHH | 47.93 | 21906983 | |
727 (in isoform 1) | Ubiquitination | - | 47.93 | 21906983 | |
739 | Ubiquitination | AVLEDLHKANIRTVM HHHHHHHHCCCCEEE | 50.88 | - | |
744 | Phosphorylation | LHKANIRTVMVTGDS HHHCCCCEEEECCCH | 14.79 | 28270605 | |
748 | Phosphorylation | NIRTVMVTGDSMLTA CCCEEEECCCHHHHH | 19.71 | 28270605 | |
751 | Phosphorylation | TVMVTGDSMLTAVSV EEEECCCHHHHHHHH | 19.62 | 28270605 | |
754 | Phosphorylation | VTGDSMLTAVSVARD ECCCHHHHHHHHHHH | 19.17 | 28270605 | |
757 | Phosphorylation | DSMLTAVSVARDCGM CHHHHHHHHHHHCCC | 13.95 | 28270605 | |
780 | Ubiquitination | IAEALPPKDGKVAKI EEEECCCCCCCEEEE | 76.73 | - | |
817 | Phosphorylation | PVKLVHDSLEDLQMT CEEEECCCHHHHHHH | 20.84 | 29255136 | |
824 | Phosphorylation | SLEDLQMTRYHFAMN CHHHHHHHEEEEHHC | 18.34 | 23927012 | |
892 | Ubiquitination | ANDCGALKRAHGGIS HHHHHHHHHHCCCCC | 47.18 | 2190698 | |
892 (in isoform 1) | Ubiquitination | - | 47.18 | 21906983 | |
909 | Phosphorylation | ELEASVASPFTSKTP HHHHHHCCCCCCCCC | 20.56 | - | |
914 | Ubiquitination | VASPFTSKTPSISCV HCCCCCCCCCCCCHH | 62.49 | - | |
1169 | Ubiquitination | ESVDRWGKCCLPWAL CCCHHHHHCHHHHHC | 18.15 | - | |
1187 | Phosphorylation | KKTPKAKYMYLAQEL CCCCHHHHHHHHHHH | 8.89 | 28270605 | |
1189 | Phosphorylation | TPKAKYMYLAQELLV CCHHHHHHHHHHHHC | 8.87 | 28270605 | |
1206 | Phosphorylation | EWPPKPQTTTEAKAL CCCCCCCCCHHHHHH | 44.18 | 26657352 | |
1207 | Phosphorylation | WPPKPQTTTEAKALV CCCCCCCCHHHHHHH | 19.86 | 28270605 | |
1208 | Phosphorylation | PPKPQTTTEAKALVK CCCCCCCHHHHHHHH | 37.02 | 28270605 | |
1215 | Ubiquitination | TEAKALVKENGSCQI HHHHHHHHHCCCEEE | 46.44 | - | |
1219 | Phosphorylation | ALVKENGSCQIITIT HHHHHCCCEEEEEEC | 17.90 | 30576142 | |
1224 | Phosphorylation | NGSCQIITIT----- CCCEEEEEEC----- | 21.86 | 28102081 | |
1226 | Phosphorylation | SCQIITIT------- CEEEEEEC------- | 24.73 | 28102081 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AT133_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AT133_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AT133_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of AT133_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-817, AND MASSSPECTROMETRY. | |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-817, AND MASSSPECTROMETRY. | |
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-817, AND MASSSPECTROMETRY. | |
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-817, AND MASSSPECTROMETRY. |