NDUS4_HUMAN - dbPTM
NDUS4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NDUS4_HUMAN
UniProt AC O43181
Protein Name NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Gene Name NDUFS4
Organism Homo sapiens (Human).
Sequence Length 175
Subcellular Localization Mitochondrion inner membrane
Peripheral membrane protein
Matrix side .
Protein Description Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
Protein Sequence MAAVSMSVVLRQTLWRRRAVAVAALSVSRVPTRSLRTSTWRLAQDQTQDTQLITVDEKLDITTLTGVPEEHIKTRKVRIFVPARNNMQSGVNNTKKWKMEFDTRERWENPLMGWASTADPLSNMVLTFSTKEDAVSFAEKNGWSYDIEERKVPKPKSKSYGANFSWNKRTRVSTK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MAAVSMSVVLRQTL
-CCCCCHHHHHHHHH
11.1025690035
26PhosphorylationAVAVAALSVSRVPTR
HHHHHHHCCCCCCCC
17.2024719451
32PhosphorylationLSVSRVPTRSLRTST
HCCCCCCCCCCCCCC
29.9916094384
34PhosphorylationVSRVPTRSLRTSTWR
CCCCCCCCCCCCCEE
25.3616094384
952-HydroxyisobutyrylationQSGVNNTKKWKMEFD
CCCCCCCCCEEEEEC
59.78-
129PhosphorylationSNMVLTFSTKEDAVS
HCCEEEEECHHHHHH
33.0823532336
136PhosphorylationSTKEDAVSFAEKNGW
ECHHHHHHHHHHHCC
22.0624719451
157PhosphorylationRKVPKPKSKSYGANF
CCCCCCCCCCCCCCC
35.0520068231
159PhosphorylationVPKPKSKSYGANFSW
CCCCCCCCCCCCCCC
35.5720068231
160PhosphorylationPKPKSKSYGANFSWN
CCCCCCCCCCCCCCC
24.8029496907
165PhosphorylationKSYGANFSWNKRTRV
CCCCCCCCCCCCCCC
29.5520068231
168AcetylationGANFSWNKRTRVSTK
CCCCCCCCCCCCCCC
49.222401417
173PhosphorylationWNKRTRVSTK-----
CCCCCCCCCC-----
27.4718291624

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
173SPhosphorylationKinasePRKACAP17612
GPS
173SPhosphorylationKinasePKA-Uniprot

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NDUS4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NDUS4_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
NDUS6_HUMANNDUFS6physical
22939629
NDUS7_HUMANNDUFS7physical
22939629
QCR7_HUMANUQCRBphysical
22939629
RM15_HUMANMRPL15physical
22939629
ODP2_HUMANDLATphysical
22939629
RS2_HUMANRPS2physical
22939629
NU188_HUMANNUP188physical
22939629
PERI_HUMANPRPHphysical
22939629
TOM20_HUMANTOMM20physical
22939629
UB2G2_HUMANUBE2G2physical
21988832
ATPG_HUMANATP5C1physical
26344197
NDUV1_HUMANNDUFV1physical
26344197
RL14_HUMANRPL14physical
26344197
VDAC1_HUMANVDAC1physical
26344197
VDAC2_HUMANVDAC2physical
26344197
NDUS1_HUMANNDUFS1physical
24344204
NDUA9_HUMANNDUFA9physical
24344204
NDUAD_HUMANNDUFA13physical
24344204
NDUV3_HUMANNDUFV3physical
24344204
NDUV2_HUMANNDUFV2physical
24344204
COX7R_HUMANCOX7A2Lphysical
24344204
NDUA2_HUMANNDUFA2physical
24344204
NDUB8_HUMANNDUFB8physical
24344204
NDUS2_HUMANNDUFS2physical
24344204
NU5M_HUMANND5physical
24344204
NDUAB_HUMANNDUFA11physical
24344204
NDUBA_HUMANNDUFB10physical
24344204
NDUV1_HUMANNDUFV1physical
24344204
NU4M_HUMANND4physical
24344204
NDUB4_HUMANNDUFB4physical
24344204
NDUS3_HUMANNDUFS3physical
24344204
NDUA7_HUMANNDUFA7physical
24344204
NDUS8_HUMANNDUFS8physical
24344204
NDUAC_HUMANNDUFA12physical
24344204
NU1M_HUMANND1physical
24344204

Drug and Disease Associations
Kegg Disease
H00473 Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
OMIM Disease
252010Mitochondrial complex I deficiency (MT-C1D)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NDUS4_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry.";
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.;
Nat. Methods 2:591-598(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-32 AND SER-34, AND MASSSPECTROMETRY.

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