UniProt ID | NDUS4_HUMAN | |
---|---|---|
UniProt AC | O43181 | |
Protein Name | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | |
Gene Name | NDUFS4 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 175 | |
Subcellular Localization |
Mitochondrion inner membrane Peripheral membrane protein Matrix side . |
|
Protein Description | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.. | |
Protein Sequence | MAAVSMSVVLRQTLWRRRAVAVAALSVSRVPTRSLRTSTWRLAQDQTQDTQLITVDEKLDITTLTGVPEEHIKTRKVRIFVPARNNMQSGVNNTKKWKMEFDTRERWENPLMGWASTADPLSNMVLTFSTKEDAVSFAEKNGWSYDIEERKVPKPKSKSYGANFSWNKRTRVSTK | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
7 | Phosphorylation | -MAAVSMSVVLRQTL -CCCCCHHHHHHHHH | 11.10 | 25690035 | |
26 | Phosphorylation | AVAVAALSVSRVPTR HHHHHHHCCCCCCCC | 17.20 | 24719451 | |
32 | Phosphorylation | LSVSRVPTRSLRTST HCCCCCCCCCCCCCC | 29.99 | 16094384 | |
34 | Phosphorylation | VSRVPTRSLRTSTWR CCCCCCCCCCCCCEE | 25.36 | 16094384 | |
95 | 2-Hydroxyisobutyrylation | QSGVNNTKKWKMEFD CCCCCCCCCEEEEEC | 59.78 | - | |
129 | Phosphorylation | SNMVLTFSTKEDAVS HCCEEEEECHHHHHH | 33.08 | 23532336 | |
136 | Phosphorylation | STKEDAVSFAEKNGW ECHHHHHHHHHHHCC | 22.06 | 24719451 | |
157 | Phosphorylation | RKVPKPKSKSYGANF CCCCCCCCCCCCCCC | 35.05 | 20068231 | |
159 | Phosphorylation | VPKPKSKSYGANFSW CCCCCCCCCCCCCCC | 35.57 | 20068231 | |
160 | Phosphorylation | PKPKSKSYGANFSWN CCCCCCCCCCCCCCC | 24.80 | 29496907 | |
165 | Phosphorylation | KSYGANFSWNKRTRV CCCCCCCCCCCCCCC | 29.55 | 20068231 | |
168 | Acetylation | GANFSWNKRTRVSTK CCCCCCCCCCCCCCC | 49.22 | 2401417 | |
173 | Phosphorylation | WNKRTRVSTK----- CCCCCCCCCC----- | 27.47 | 18291624 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
173 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
173 | S | Phosphorylation | Kinase | PKA | - | Uniprot |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NDUS4_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NDUS4_HUMAN !! |
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Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry."; Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.; Nat. Methods 2:591-598(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-32 AND SER-34, AND MASSSPECTROMETRY. |