UB2G2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UB2G2_HUMAN
• UniProt AC: P60604
• Protein Name: Ubiquitin-conjugating enzyme E2 G2
• Gene Name: UBE2G2
• Organism: Homo sapiens (Human).
• Sequence Length: 165
• Protein Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD)..
• Protein Sequence: MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPAILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGTALKRL ------CCHHHHHHH	24.84	25944712
4	Phosphorylation	----MAGTALKRLMA ----CCHHHHHHHHH	21.19	23401153
7	Ubiquitination	-MAGTALKRLMAEYK -CCHHHHHHHHHHHH	40.81	24816145
7	2-Hydroxyisobutyrylation	-MAGTALKRLMAEYK -CCHHHHHHHHHHHH	40.81	-
7	Malonylation	-MAGTALKRLMAEYK -CCHHHHHHHHHHHH	40.81	26320211
13	Phosphorylation	LKRLMAEYKQLTLNP HHHHHHHHHCCCCCC	8.42	23401153
67	Phosphorylation	FPLDYPLSPPKMRFT CCCCCCCCCCCCEEE	34.35	24719451
72	Ubiquitination	PLSPPKMRFTCEMFH CCCCCCCEEEEEECC	29.83	21963094
83	Ubiquitination	EMFHPNIYPDGRVCI EECCCCCCCCCCEEE	11.25	23000965
86	Ubiquitination	HPNIYPDGRVCISIL CCCCCCCCCEEEEEE	21.29	23000965
91	Ubiquitination	PDGRVCISILHAPGD CCCCEEEEEEECCCC	17.61	33845483
103	Phosphorylation	PGDDPMGYESSAERW CCCCCCCCCCCCCCC	13.34	28796482
105	Phosphorylation	DDPMGYESSAERWSP CCCCCCCCCCCCCCC	26.77	28796482
106	Phosphorylation	DPMGYESSAERWSPV CCCCCCCCCCCCCCC	23.39	28796482
111	Phosphorylation	ESSAERWSPVQSVEK CCCCCCCCCCHHHHH	22.78	21406692
114	Ubiquitination	AERWSPVQSVEKILL CCCCCCCHHHHHHHH	45.18	21963094
115	Phosphorylation	ERWSPVQSVEKILLS CCCCCCHHHHHHHHH	32.26	21406692
125	Ubiquitination	KILLSVVSMLAEPND HHHHHHHHHHCCCCC	13.11	21890473
125	Ubiquitination	KILLSVVSMLAEPND HHHHHHHHHHCCCCC	13.11	23000965
128	Ubiquitination	LSVVSMLAEPNDESG HHHHHHHCCCCCCCC	22.89	21890473
128	Ubiquitination	LSVVSMLAEPNDESG HHHHHHHCCCCCCCC	22.89	23000965
133	Ubiquitination	MLAEPNDESGANVDA HHCCCCCCCCCCCCH	58.68	33845483
142	Ubiquitination	GANVDASKMWRDDRE CCCCCHHHHCHHHHH	44.17	21906983
153	Ubiquitination	DDREQFYKIAKQIVQ HHHHHHHHHHHHHHH	37.16	23000965
156	Ubiquitination	EQFYKIAKQIVQKSL HHHHHHHHHHHHHHH	43.99	23000965
161	Ubiquitination	IAKQIVQKSLGL--- HHHHHHHHHHCC---	36.43	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UB2G2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UB2G2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UB2G2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AMFR_HUMAN	AMFR	physical	17353931
UBP15_HUMAN	USP15	physical	17353931
AUP1_HUMAN	AUP1	physical	17353931
MALT1_HUMAN	MALT1	physical	17353931
COR1A_HUMAN	CORO1A	physical	17353931
BIRC8_HUMAN	BIRC8	physical	19690564
MDM2_HUMAN	MDM2	physical	19690564
MGRN1_HUMAN	MGRN1	physical	19690564
RFFL_HUMAN	RFFL	physical	19690564
RN111_HUMAN	RNF111	physical	19690564
RN146_HUMAN	RNF146	physical	19690564
RN157_HUMAN	RNF157	physical	19690564
RN168_HUMAN	RNF168	physical	19690564
RNF26_HUMAN	RNF26	physical	19690564
TRIM3_HUMAN	TRIM3	physical	19690564
TRI43_HUMAN	TRIM43	physical	19690564
ZNRF4_HUMAN	ZNRF4	physical	19690564
AMFR_HUMAN	AMFR	physical	16407162
AUP1_HUMAN	AUP1	physical	21127063
AMFR_HUMAN	AMFR	physical	19223579
UBC_HUMAN	UBC	physical	21098018
UBC_HUMAN	UBC	physical	16214370
ECM29_HUMAN	KIAA0368	physical	20682791
AUP1_HUMAN	AUP1	physical	23223569
VAMP8_HUMAN	VAMP8	physical	21988832
UB2G2_HUMAN	UBE2G2	physical	24366945
UB2G2_HUMAN	UBE2G2	physical	20061386
UB2G2_HUMAN	UBE2G2	physical	25409783
UB2G2_HUMAN	UBE2G2	physical	19223579
ROAA_HUMAN	HNRNPAB	physical	26344197
HNRPD_HUMAN	HNRNPD	physical	26344197
HNRDL_HUMAN	HNRNPDL	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.