BIRC8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BIRC8_HUMAN
• UniProt AC: Q96P09
• Protein Name: Baculoviral IAP repeat-containing protein 8
• Gene Name: BIRC8
• Organism: Homo sapiens (Human).
• Sequence Length: 236
• Subcellular Localization: Cytoplasm .
• Protein Description: Protects against apoptosis mediated by BAX..
• Protein Sequence: MTGYEARLITFGTWMYSVNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHAKWYPGCKYLLEEKGHEYINNIHLTRSLEGALVQTTKKTPSLTKRISDTIFPNPMLQEAIRMGFDFKDVKKIMEERIQTSGSNYKTLEVLVADLVSAQKDTTENELNQTSLQREISPEEPLRRLQEEKLCKICMDRHIAVVFIPCGHLVTCKQCAEAVDRCPMCSAVIDFKQRVFMS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	GYEARLITFGTWMYS CCEEEEEEECCCEEE	22.17	28509920
13	Phosphorylation	ARLITFGTWMYSVNK EEEEEECCCEEECCH	11.67	28509920
16	Phosphorylation	ITFGTWMYSVNKEQL EEECCCEEECCHHHH	10.88	28509920
143	Phosphorylation	IQTSGSNYKTLEVLV HHCCCCCCHHHHHHH	13.67	18083107
155	Phosphorylation	VLVADLVSAQKDTTE HHHHHHHHCCCCCCH	32.07	23911959
187	Ubiquitination	LRRLQEEKLCKICMD HHHHHHHHHHHHHCC	59.43	-
189	S-nitrosocysteine	RLQEEKLCKICMDRH HHHHHHHHHHHCCCC	4.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BIRC8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BIRC8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BIRC8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DBLOH_HUMAN	DIABLO	physical	15485395
DHE3_HUMAN	GLUD1	physical	26186194
DBLOH_HUMAN	DIABLO	physical	26186194
XIAP_HUMAN	XIAP	physical	26186194
HTRA2_HUMAN	HTRA2	physical	26186194
XIAP_HUMAN	XIAP	physical	28514442
HTRA2_HUMAN	HTRA2	physical	28514442
DBLOH_HUMAN	DIABLO	physical	28514442
DHE3_HUMAN	GLUD1	physical	28514442
CASP9_HUMAN	CASP9	physical	28514442
CDK19_HUMAN	CDK19	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.