CDK19_HUMAN - dbPTM
CDK19_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDK19_HUMAN
UniProt AC Q9BWU1
Protein Name Cyclin-dependent kinase 19
Gene Name CDK19
Organism Homo sapiens (Human).
Sequence Length 502
Subcellular Localization
Protein Description
Protein Sequence MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDYDFKAK
-------CCHHHHHH		10.9922814378
26UbiquitinationLFEYEGCKVGRGTYG
HHHCCCCEECCCCCC		59.59-
31PhosphorylationGCKVGRGTYGHVYKA
CCEECCCCCCEEEEC		25.60-
52UbiquitinationDEKEYALKQIEGTGI
CHHHHHHHHCCCCCC		40.85-
62PhosphorylationEGTGISMSACREIAL
CCCCCCHHHHHHHHH		19.8924043423
141PhosphorylationQILDGIHYLHANWVL
HHHHHHHHHCCCEEE		9.77-
276PhosphorylationDIRKMPEYPTLQKDF
HHHCCCCCCCHHHHH		8.81-
286PhosphorylationLQKDFRRTTYANSSL
HHHHHHHHHHCCHHH		21.6518452278
287PhosphorylationQKDFRRTTYANSSLI
HHHHHHHHHCCHHHH		20.8722964224
288PhosphorylationKDFRRTTYANSSLIK
HHHHHHHHCCHHHHH		11.8122964224
291PhosphorylationRRTTYANSSLIKYME
HHHHHCCHHHHHHHH		20.5325072903
292PhosphorylationRTTYANSSLIKYMEK
HHHHCCHHHHHHHHH		33.6422964224
296PhosphorylationANSSLIKYMEKHKVK
CCHHHHHHHHHCCCC		11.9625072903
322UbiquitinationLLTMDPTKRITSEQA
HHCCCCCCCCCCHHH		47.38-
445PhosphorylationKKPRLGPSGANSGGP
CCCCCCCCCCCCCCC		49.0623401153
449PhosphorylationLGPSGANSGGPVMPS
CCCCCCCCCCCCCCC		44.5919369195
456PhosphorylationSGGPVMPSDYQHSSS
CCCCCCCCCCCCCCC		30.7427080861
458PhosphorylationGPVMPSDYQHSSSRL
CCCCCCCCCCCCCCC		16.6827732954
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDK19_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDK19_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDK19_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MYBPP_HUMANMYCBPAPphysical
17353931
RBCC1_HUMANRB1CC1physical
17353931
SRSF7_HUMANSRSF7physical
12501247
SMCA4_HUMANSMARCA4physical
22668559
BCL6_HUMANBCL6physical
22668559
SUZ12_HUMANSUZ12physical
22668559
MED9_HUMANMED9physical
22939629
MED18_HUMANMED18physical
22939629
MED1_HUMANMED1physical
22939629
MED16_HUMANMED16physical
22939629
FKB15_HUMANFKBP15physical
22939629
GNAQ_HUMANGNAQphysical
22939629
MYEF2_HUMANMYEF2physical
22939629
COMD4_HUMANCOMMD4physical
22939629
MK67I_HUMANNIFKphysical
22939629
CTCF_HUMANCTCFphysical
22939629
GPN1_HUMANGPN1physical
22939629
CUTA_HUMANCUTAphysical
22939629
RBM40_HUMANRNPC3physical
22939629
APOD_HUMANAPODphysical
23602568
RB6I2_HUMANERC1physical
23602568
MED12_HUMANMED12physical
23602568
MED1_HUMANMED1physical
23602568
MED13_HUMANMED13physical
23602568
MED14_HUMANMED14physical
23602568
MED16_HUMANMED16physical
23602568
MED17_HUMANMED17physical
23602568
MD13L_HUMANMED13Lphysical
23602568
MED4_HUMANMED4physical
23602568
MED15_HUMANMED15physical
23602568
CLUS_HUMANCLUphysical
23602568
MED6_HUMANMED6physical
23602568
MED24_HUMANMED24physical
23602568
MED8_HUMANMED8physical
23602568
CCNC_HUMANCCNCphysical
23602568
MED23_HUMANMED23physical
23602568
MED27_HUMANMED27physical
23602568
MED20_HUMANMED20physical
23602568
ZA2G_HUMANAZGP1physical
23602568
MED29_HUMANMED29physical
23602568
MED31_HUMANMED31physical
23602568
MED28_HUMANMED28physical
23602568
MED22_HUMANMED22physical
23602568
PIP_HUMANPIPphysical
23602568
MED18_HUMANMED18physical
23602568
MED9_HUMANMED9physical
23602568
MED11_HUMANMED11physical
23602568
MED30_HUMANMED30physical
23602568
MED7_HUMANMED7physical
23602568
MASP1_HUMANMASP1physical
23602568
MED13_HUMANMED13physical
26186194
MED27_HUMANMED27physical
26186194
MED31_HUMANMED31physical
26186194
MED16_HUMANMED16physical
26186194
MED14_HUMANMED14physical
26186194
MED12_HUMANMED12physical
26186194
MD12L_HUMANMED12Lphysical
26186194
MD13L_HUMANMED13Lphysical
26186194
MED1_HUMANMED1physical
26186194
MED6_HUMANMED6physical
26186194
MED4_HUMANMED4physical
26186194
MED17_HUMANMED17physical
26186194
MED23_HUMANMED23physical
26186194
MED29_HUMANMED29physical
26186194
MED22_HUMANMED22physical
26186194
MED24_HUMANMED24physical
26186194
MED28_HUMANMED28physical
26186194
MED15_HUMANMED15physical
26186194
MED9_HUMANMED9physical
26186194
MED10_HUMANMED10physical
26186194
MED8_HUMANMED8physical
26186194
MED20_HUMANMED20physical
26186194
MED30_HUMANMED30physical
26186194
MED24_HUMANMED24physical
26344197
MED6_HUMANMED6physical
26344197
MED8_HUMANMED8physical
26344197
ANM5_HUMANPRMT5physical
23749998
STK38_HUMANSTK38physical
23749998
MEP50_HUMANWDR77physical
23749998
MED17_HUMANMED17physical
23749998
MED12_HUMANMED12physical
23749998
MED15_HUMANMED15physical
23749998
MED13_HUMANMED13physical
28514442
MED12_HUMANMED12physical
28514442
MED29_HUMANMED29physical
28514442
MED14_HUMANMED14physical
28514442
MED17_HUMANMED17physical
28514442
MED28_HUMANMED28physical
28514442
MED6_HUMANMED6physical
28514442
MED22_HUMANMED22physical
28514442
MED8_HUMANMED8physical
28514442
MED30_HUMANMED30physical
28514442
MED24_HUMANMED24physical
28514442
MED10_HUMANMED10physical
28514442
MD13L_HUMANMED13Lphysical
28514442
MED9_HUMANMED9physical
28514442
MED16_HUMANMED16physical
28514442
MED27_HUMANMED27physical
28514442
MED31_HUMANMED31physical
28514442
MD12L_HUMANMED12Lphysical
28514442
MED20_HUMANMED20physical
28514442
MED4_HUMANMED4physical
28514442
MED23_HUMANMED23physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDK19_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-445 AND SER-449, ANDMASS SPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-449, AND MASSSPECTROMETRY.

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