MYBPP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYBPP_HUMAN
• UniProt AC: Q8TBZ2
• Protein Name: MYCBP-associated protein
• Gene Name: MYCBPAP {ECO:0000312|EMBL:AAH28393.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 947
• Subcellular Localization: Cytoplasm . Membrane . Colocalizes with MYCBP in the cytoplasm.
• Protein Description: May play a role in spermatogenesis. May be involved in synaptic processes (By similarity)..
• Protein Sequence: MVPGGTMKSLKKDSRLRITPTRLLEASENVKEKKRAKGPEQPTPTIQEEPEPVSNVLQGDDILALAIKKEDLKEQHIPRLTEKEDKRVITQKFIIRKLKPMDPRRKVCHLVARPANPDEATKPLDYSGPGDSFDGSDQILPHHILGSLQDFKRIALARGNTQLAERIPTSPCLMTLISAEGESKQKAPKEEKRPPWAPPPQHNFLKNWQRNTALRKKQQEALSEHLKKPVSELLMHTGETYRRIQEERELIDCTLPTRRDRKSWENSGFWSRLEYLGDEMTGLVMTKTKTQRGLMEPITHIRKPHSIRVETGLPAQRDASYRYTWDRSLFLIYRRKELQRIMEELDFSQQDIDGLEVVGKGWPFSAVTVEDYTVFERSQGSSSEDTAYLGTLASSSDVSMPILGPSLLFCGKPACWIRGSNPQDKRQVGIAAHLTFETLEGEKTSSELTVVNNGTVAIWYDWRRQHQPDTFQDLKKNRMQRFYFDNREGVILPGEIKTFTFFFKSLTAGVFREFWEFRTHPTLLGGAILQVNLHAVSLTQDVFEDERKVLESKLTAHEAVTVVREVLQELLMGVLTPERTPSPVDAYLTEEDLFRHRNPPLHYEHQVVQSLHQLWRQYMTLPAKAEEARPGDKEHVSPIATEKASVNAELLPRFRSPISETQVPRPENEALRESGSQKARVGTKSPQRKSIMEEILVEESPDVDSTKSPWEPDGLPLLEWNLCLEDFRKAVMVLPDENHREDALMRLNKAALELCQKPRPLQSNLLHQMCLQLWRDVIDSLVGHSMWLRSVLGLPEKETIYLNVPEEQDQKSPPIMEVKVPVGKAGKEERKGAAQEKKQLGIKDKEDKKGAKLLGKEDRPNSKKHKAKDDKKVIKSASQDRFSLEDPTPDIILSSQEPIDPLVMGKYTQSLHSEVRGLLDTLVTDLMVLADELSPIKNVEEALRLCR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MVPGGTMKSLKKD --CCCCCCHHCCCCC	27.60	23403867
19	Phosphorylation	KDSRLRITPTRLLEA CCCCCCCCHHHHHHH	16.51	24719451
27	Phosphorylation	PTRLLEASENVKEKK HHHHHHHCHHHHHHH	21.96	27461979
169	Phosphorylation	QLAERIPTSPCLMTL HHHHHCCCCCHHHHH	42.82	28634298
170	Phosphorylation	LAERIPTSPCLMTLI HHHHCCCCCHHHHHH	14.30	28634298
175	Phosphorylation	PTSPCLMTLISAEGE CCCCHHHHHHHCCCC	14.16	28634298
183	Phosphorylation	LISAEGESKQKAPKE HHHCCCCCCCCCCCC	51.77	28634298
223	Phosphorylation	KKQQEALSEHLKKPV HHHHHHHHHHCHHHH	29.98	24505115
231	Phosphorylation	EHLKKPVSELLMHTG HHCHHHHHHHHHHHH	30.93	-
241	Phosphorylation	LMHTGETYRRIQEER HHHHHHHHHHHHHHH	8.13	-
286	Phosphorylation	EMTGLVMTKTKTQRG HCCCEEEECCCCCCC	28.25	24114839
435	Phosphorylation	VGIAAHLTFETLEGE CEEEEEEEEEECCCC	15.01	-
438	Phosphorylation	AAHLTFETLEGEKTS EEEEEEEECCCCCCC	26.39	-
555	Phosphorylation	KVLESKLTAHEAVTV HHHHHHCCHHHHHHH	29.70	-
576	Phosphorylation	ELLMGVLTPERTPSP HHHCCCCCCCCCCCC	22.24	30622161
582	Phosphorylation	LTPERTPSPVDAYLT CCCCCCCCCCCEECC	36.62	-
589	Phosphorylation	SPVDAYLTEEDLFRH CCCCEECCHHHHHHC	25.34	26074081
603	Phosphorylation	HRNPPLHYEHQVVQS CCCCCCHHHHHHHHH	23.84	26074081
610	Phosphorylation	YEHQVVQSLHQLWRQ HHHHHHHHHHHHHHH	19.06	26074081
656	Phosphorylation	ELLPRFRSPISETQV HHHHHCCCCCCCCCC	24.71	29255136
661	Phosphorylation	FRSPISETQVPRPEN CCCCCCCCCCCCCCH	28.24	18077418
693	Phosphorylation	PQRKSIMEEILVEES HHHHHHHHHHHCCCC	39.97	18077418
698	Phosphorylation	IMEEILVEESPDVDS HHHHHHCCCCCCCCC	49.68	18077418
707	Acetylation	SPDVDSTKSPWEPDG CCCCCCCCCCCCCCC	59.48	30590551
876	Phosphorylation	DDKKVIKSASQDRFS CCHHHHHHHCCCCCC	23.25	25693802
878	Phosphorylation	KKVIKSASQDRFSLE HHHHHHHCCCCCCCC	39.44	25693802
883	Phosphorylation	SASQDRFSLEDPTPD HHCCCCCCCCCCCCC	31.57	25693802
888	Phosphorylation	RFSLEDPTPDIILSS CCCCCCCCCCEEECC	46.01	25693802
894	Phosphorylation	PTPDIILSSQEPIDP CCCCEEECCCCCCCH	21.40	25693802
895	Phosphorylation	TPDIILSSQEPIDPL CCCEEECCCCCCCHH	34.81	25693802
921	Phosphorylation	EVRGLLDTLVTDLMV HHHHHHHHHHHHHHH	24.09	29083192
924	Phosphorylation	GLLDTLVTDLMVLAD HHHHHHHHHHHHHHH	26.91	29083192
934	Phosphorylation	MVLADELSPIKNVEE HHHHHHCCCCCCHHH	23.64	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	CBL	P22681	PMID:17255943

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYBPP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYBPP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYCBP_HUMAN	MYCBP	physical	12151104

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.