MYCBP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYCBP_HUMAN
• UniProt AC: Q99417
• Protein Name: c-Myc-binding protein
• Gene Name: MYCBP
• Organism: Homo sapiens (Human).
• Sequence Length: 103
• Subcellular Localization: Cytoplasm. Nucleus. Mitochondrion. Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.
• Protein Description: May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC..
• Protein Sequence: MAHYKAADSKREQFRRYLEKSGVLDTLTKVLVALYEEPEKPNSALDFLKHHLGAATPENPEIELLRLELAEMKEKYEAIVEENKKLKAKLAQYEPPQEEKRAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MAHYKAADSKRE ---CCCCCCCHHHHH	27.51	25953088
5	Ubiquitination	---MAHYKAADSKRE ---CCCCCCCHHHHH	27.51	33845483
10	Ubiquitination	HYKAADSKREQFRRY CCCCCHHHHHHHHHH	61.58	24816145
20	Acetylation	QFRRYLEKSGVLDTL HHHHHHHHHCHHHHH	50.33	23954790
20	Ubiquitination	QFRRYLEKSGVLDTL HHHHHHHHHCHHHHH	50.33	21890473
20	Ubiquitination	QFRRYLEKSGVLDTL HHHHHHHHHCHHHHH	50.33	23000965
29	Ubiquitination	GVLDTLTKVLVALYE CHHHHHHHHHHHHHC	36.36	-
35	Phosphorylation	TKVLVALYEEPEKPN HHHHHHHHCCCCCCC	14.44	27642862
40	Ubiquitination	ALYEEPEKPNSALDF HHHCCCCCCCCHHHH	61.28	33845483
56	Phosphorylation	KHHLGAATPENPEIE HHHHCCCCCCCHHHH	30.51	28450419
75	Acetylation	ELAEMKEKYEAIVEE HHHHHHHHHHHHHHH	42.76	25953088
76	Phosphorylation	LAEMKEKYEAIVEEN HHHHHHHHHHHHHHH	16.22	26657352
84	Acetylation	EAIVEENKKLKAKLA HHHHHHHHHHHHHHH	63.86	25953088
84	Ubiquitination	EAIVEENKKLKAKLA HHHHHHHHHHHHHHH	63.86	33845483
89	Acetylation	ENKKLKAKLAQYEPP HHHHHHHHHHHCCCC	42.65	25953088
89	Ubiquitination	ENKKLKAKLAQYEPP HHHHHHHHHHHCCCC	42.65	29967540
100	Ubiquitination	YEPPQEEKRAE---- CCCCHHHHHCC----	57.04	32015554

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYCBP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYCBP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYCBP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYBPP_HUMAN	MYCBPAP	physical	12151104
COF1_HUMAN	CFL1	physical	16169070
ARH40_HUMAN	ARHGEF40	physical	16169070
DISP3_HUMAN	PTCHD2	physical	16169070
SSRP1_HUMAN	SSRP1	physical	16169070
CSN6_HUMAN	COPS6	physical	16169070
GDF9_HUMAN	GDF9	physical	16169070
PTN_HUMAN	PTN	physical	16169070
CFA91_HUMAN	MAATS1	physical	12223483
MYC_HUMAN	MYC	physical	9797456
AKAP1_HUMAN	AKAP1	physical	11483602
REPI1_HUMAN	REPIN1	physical	22863883
IF5AL_HUMAN	EIF5AL1	physical	26344197
TCTP_HUMAN	TPT1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.