ARH40_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARH40_HUMAN
• UniProt AC: Q8TER5
• Protein Name: Rho guanine nucleotide exchange factor 40
• Gene Name: ARHGEF40
• Organism: Homo sapiens (Human).
• Sequence Length: 1519
• Subcellular Localization: Cytoplasm . Concentrated in the perinuclear region.
• Protein Description: May act as a guanine nucleotide exchange factor (GEF)..
• Protein Sequence: MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLAKVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLALKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAELICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTGGVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGILGLSRQSHARALSDPTTPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Ubiquitination	LDFLVPAKHLLAKVQ HHHHHHHHHHHHHHH	28.81	21890473
56 (in isoform 1)	Ubiquitination	-	28.81	21890473
56 (in isoform 3)	Ubiquitination	-	28.81	21890473
56 (in isoform 4)	Ubiquitination	-	28.81	21890473
61	Ubiquitination	PAKHLLAKVQQEACA HHHHHHHHHHHHHHH	40.31	22817900
101	Ubiquitination	ALPWQLLRPGDFYLQ HCCHHHCCCCCEEEE	41.57	23000965
138	Ubiquitination	VQEVPVPNEACAYLF CEEECCCCCCHHHHH	50.13	21987572
163	Phosphorylation	DRPTGRLSTCLLSAP CCCCCCCCHHHHCCC	18.73	23403867
164	Phosphorylation	RPTGRLSTCLLSAPS CCCCCCCHHHHCCCC	16.27	23403867
168	Phosphorylation	RLSTCLLSAPSGIQR CCCHHHHCCCCCCCC	25.78	23403867
189	Ubiquitination	ICPRFVHKEGLMVGH HCCCCCCCCCCCCCC	48.45	23000965
189 (in isoform 1)	Ubiquitination	-	48.45	21890473
189 (in isoform 3)	Ubiquitination	-	48.45	21890473
189 (in isoform 4)	Ubiquitination	-	48.45	21890473
214	Phosphorylation	SGPPGLPSPPLPEEA CCCCCCCCCCCCHHH	44.16	28348404
226	Phosphorylation	EEALGTRSPGDGHNA HHHCCCCCCCCCCCC	32.83	26657352
242	Phosphorylation	VEGPEGEYVELLEVT CCCCCCCEEEEEEEE	15.30	27259358
247	Phosphorylation	GEYVELLEVTLPVRG CCEEEEEEEEEECCC	46.19	32645325
255	Phosphorylation	VTLPVRGSPTDAEGS EEEECCCCCCCCCCC	17.67	30266825
257	Phosphorylation	LPVRGSPTDAEGSPG EECCCCCCCCCCCCC	49.92	26657352
262	Phosphorylation	SPTDAEGSPGLSRVR CCCCCCCCCCCCCEE	13.80	19664994
266	Phosphorylation	AEGSPGLSRVRTVPT CCCCCCCCCEEECCC	34.34	30266825
270	Phosphorylation	PGLSRVRTVPTRKGA CCCCCEEECCCCCCC	28.16	24719451
272	Phosphorylation	LSRVRTVPTRKGAGG CCCEEECCCCCCCCC	26.35	32142685
293	Ubiquitination	HRAWMHQKGLGPRGQ HHHHHHHCCCCCCCC	41.23	23000965
318	Phosphorylation	STGASPESPPGAEAV CCCCCCCCCCCCCCC	39.52	28348404
360	Phosphorylation	GELRGGGGGGQGAEG CCCCCCCCCCCCCCC	40.09	32142685
371	Phosphorylation	GAEGPPGTPRRTGKG CCCCCCCCCCCCCCC	21.28	30266825
388	Methylation	RKKRAAGRGALSRGG HHHCCCCCCCCCCCC	23.61	115917493
392	Phosphorylation	AAGRGALSRGGDSAP CCCCCCCCCCCCCCC	28.48	25247763
397	Phosphorylation	ALSRGGDSAPLSPGD CCCCCCCCCCCCCCC	34.75	25850435
401	Phosphorylation	GGDSAPLSPGDKEDA CCCCCCCCCCCHHHC	26.27	29255136
409	Phosphorylation	PGDKEDASHQEALGN CCCHHHCCHHHHHCC	37.72	26657352
419	Phosphorylation	EALGNLPSPSEHKLP HHHCCCCCCCHHCCC	44.20	29255136
421	Phosphorylation	LGNLPSPSEHKLPEC HCCCCCCCHHCCCCC	57.58	29255136
477 (in isoform 2)	Ubiquitination	-	22.38	21906983
495	Phosphorylation	PEGPLSDTPTPPLET CCCCCCCCCCCCCHH	26.20	-
497	Phosphorylation	GPLSDTPTPPLETVQ CCCCCCCCCCCHHHC	39.36	-
525	Ubiquitination	VSVSDHPDVAWDLMA EECCCCCHHHHHHHH	39.07	21963094
529	Ubiquitination	DHPDVAWDLMASGFL CCCHHHHHHHHCCEE	19.48	22817900
564	Phosphorylation	PPEEPPPSRDTLNTT CCCCCCCCCHHHHHH	48.87	23828894
577	Phosphorylation	TTLHYLHSLLRPDLQ HHHHHHHHHHCCCHH	26.89	24719451
660	Ubiquitination	AKPEELQWELGGHRD CCHHHHHHHCCCCCC	18.53	21987572
680	Ubiquitination	WVEIHQEVVRLCRLC HHHHHHHHHHHHHHH	2.15	29967540
693	Phosphorylation	LCQGVLGSVRQAIEE HHHHHHHHHHHHHHH	15.23	24719451
717	Ubiquitination	EEAVGMPKPLQKVLA HHHCCCCCCHHHHHC	49.85	21963094
721	Ubiquitination	GMPKPLQKVLADPRL CCCCCHHHHHCCHHH	47.07	22817900
730	Phosphorylation	LADPRLTALQRDGGA HCCHHHHEEEECCCE	13.29	32142685
744	Phosphorylation	AILMRLRSTPSSKLE EEEEEEECCCCHHCC	49.62	24173317
748	Phosphorylation	RLRSTPSSKLEGQGP EEECCCCHHCCCCCC	42.32	25332170
759	Phosphorylation	GQGPATLYQEVDEAI CCCCCHHHHHHHHHH	9.77	27642862
778	Phosphorylation	RLSNLHVQQQEQRQC HHCCCCCCHHHHHHH	28.61	32142685
806	Phosphorylation	PGEEQLASFAMPGDT CCHHHHHHCCCCCCH	23.33	-
828	Phosphorylation	ELRFRAFSAEVQERL HHHHHHHCHHHHHHH	23.64	-
852	Ubiquitination	EENATSQKVLDIFEQ HCCCCHHHHHHHHHH	44.53	21987572
866	Phosphorylation	QRLEQVESGLHRALR HHHHHHHHHHHHHHH	48.04	25159151
931	Phosphorylation	ALALDLGSPAALREW HHHHHCCCHHHHHHH	20.75	19664994
961	Phosphorylation	QHVGEEASPRGYRRR HHHCCCCCCCCCCCC	20.57	30266825
963	Methylation	VGEEASPRGYRRRRA HCCCCCCCCCCCCCC	52.89	115917497
966	Methylation	EASPRGYRRRRADGA CCCCCCCCCCCCCCC	28.58	115917501
974	Phosphorylation	RRRADGASSGGAQWG CCCCCCCCCCCCCCC	34.74	30576142
975	Phosphorylation	RRADGASSGGAQWGP CCCCCCCCCCCCCCC	40.49	30576142
983	Methylation	GGAQWGPRSPSPSLS CCCCCCCCCCCCCHH	58.21	115917505
984	Phosphorylation	GAQWGPRSPSPSLSS CCCCCCCCCCCCHHH	32.63	26657352
986	Phosphorylation	QWGPRSPSPSLSSLL CCCCCCCCCCHHHHC	28.50	16964243
988	Phosphorylation	GPRSPSPSLSSLLLP CCCCCCCCHHHHCCC	45.26	26657352
990	Phosphorylation	RSPSPSLSSLLLPSS CCCCCCHHHHCCCCC	24.23	20873877
991	Phosphorylation	SPSPSLSSLLLPSSP CCCCCHHHHCCCCCC	28.47	26657352
996	Phosphorylation	LSSLLLPSSPGPRPA HHHHCCCCCCCCCCC	49.48	25850435
997	Phosphorylation	SSLLLPSSPGPRPAP HHHCCCCCCCCCCCC	31.75	27732954
1016	Phosphorylation	LAPCGEDYEEEGPEL CCCCCCCCHHHCCCC	22.42	27642862
1043	Phosphorylation	LIRGLEVTSTEVVDR EEECEEEECEEEECC	22.13	28348404
1044	Phosphorylation	IRGLEVTSTEVVDRT EECEEEECEEEECCC	27.96	28348404
1051	Phosphorylation	STEVVDRTCSPREHV CEEEECCCCCCCCCE	16.93	29214152
1053	Phosphorylation	EVVDRTCSPREHVLL EEECCCCCCCCCEEE	26.78	24719451
1062	Methylation	REHVLLGRARGPDGP CCCEEECCCCCCCCC	22.53	115917485
1064	Methylation	HVLLGRARGPDGPWG CEEECCCCCCCCCCC	56.68	115917489
1074	Phosphorylation	DGPWGVGTPRMERKR CCCCCCCCHHHHHHC	12.81	22617229
1082	Phosphorylation	PRMERKRSISAQQRL HHHHHHCCCCHHHHH	24.75	20363803
1084	Phosphorylation	MERKRSISAQQRLVS HHHHCCCCHHHHHHH	22.67	21406692
1116	Phosphorylation	PPPGPELTPELRGTW CCCCCCCCHHHCHHH	17.04	24719451
1187	Phosphorylation	ENGLAALSPLSKGSM HHCHHHCCCCCCCCC	21.04	30576142
1190	Phosphorylation	LAALSPLSKGSMEAG HHHCCCCCCCCCCCC	38.05	29523821
1191	Ubiquitination	AALSPLSKGSMEAGP HHCCCCCCCCCCCCC	63.79	2190698
1191 (in isoform 1)	Ubiquitination	-	63.79	21890473
1191 (in isoform 3)	Ubiquitination	-	63.79	21890473
1191 (in isoform 4)	Ubiquitination	-	63.79	21890473
1193	Phosphorylation	LSPLSKGSMEAGPYL CCCCCCCCCCCCCCH	19.72	30576142
1199	Phosphorylation	GSMEAGPYLPRALQQ CCCCCCCCHHHHHHH	28.55	29083192
1301	Phosphorylation	FEHLLLFSKLKGPEG HHHHHHHHHHCCCCC	36.73	24719451
1321	Phosphorylation	VYKQAFKTADMGLTE EEEHHHCCCCCCCCC	22.80	-
1388	Phosphorylation	LRVQQMVSMGIGNKP HHHHHHHHCCCCCCC	13.12	25159151
1394	Ubiquitination	VSMGIGNKPFLDIKA HHCCCCCCCCCCHHH	31.75	29967540
1406	Phosphorylation	IKALGERTLSALLTG HHHHCHHHHHHHHHC	22.29	-
1408	Phosphorylation	ALGERTLSALLTGRA HHCHHHHHHHHHCHH	19.09	30087585
1412	Phosphorylation	RTLSALLTGRAARTR HHHHHHHHCHHHHHC	26.02	-
1418	Phosphorylation	LTGRAARTRASVAVS HHCHHHHHCCEEEEE	26.34	28348404
1421	Phosphorylation	RAARTRASVAVSSFE HHHHHCCEEEEECCC	13.81	27732954
1425	Phosphorylation	TRASVAVSSFEHAGP HCCEEEEECCCCCCC	21.41	27732954
1426	Phosphorylation	RASVAVSSFEHAGPS CCEEEEECCCCCCCC	28.23	29255136
1433	Phosphorylation	SFEHAGPSLPGLSPG CCCCCCCCCCCCCCC	46.40	29255136
1438	Phosphorylation	GPSLPGLSPGACSLP CCCCCCCCCCCCCCC	27.48	26657352
1443	Phosphorylation	GLSPGACSLPARVEE CCCCCCCCCCCHHHH	36.53	29255136
1461	Phosphorylation	DLDVKQISLAPETLD CCCHHEEECCCCCCC	18.91	26699800
1466	Phosphorylation	QISLAPETLDSSGDV EEECCCCCCCCCCCC	34.50	26699800
1469	Phosphorylation	LAPETLDSSGDVSPG CCCCCCCCCCCCCCC	39.06	22617229
1470	Phosphorylation	APETLDSSGDVSPGP CCCCCCCCCCCCCCC	38.38	30266825
1474	Phosphorylation	LDSSGDVSPGPRNSP CCCCCCCCCCCCCCC	28.95	30266825
1480	Phosphorylation	VSPGPRNSPSLQPPH CCCCCCCCCCCCCCC	19.69	25850435
1482	Phosphorylation	PGPRNSPSLQPPHPG CCCCCCCCCCCCCCC	39.18	25850435
1490	Phosphorylation	LQPPHPGSSTPTLAS CCCCCCCCCCCCHHH	35.17	22167270
1491	Phosphorylation	QPPHPGSSTPTLASR CCCCCCCCCCCHHHC	44.30	22167270
1492	Phosphorylation	PPHPGSSTPTLASRG CCCCCCCCCCHHHCC	23.22	22167270
1494	Phosphorylation	HPGSSTPTLASRGIL CCCCCCCCHHHCCCC	34.74	22167270
1497	Phosphorylation	SSTPTLASRGILGLS CCCCCHHHCCCCCCC	33.87	22167270
1504	Phosphorylation	SRGILGLSRQSHARA HCCCCCCCHHHHHHH	26.86	29449344
1513	Phosphorylation	QSHARALSDPTTPL- HHHHHHHCCCCCCC-	40.33	30266825
1516	Phosphorylation	ARALSDPTTPL---- HHHHCCCCCCC----	46.14	30266825
1517	Phosphorylation	RALSDPTTPL----- HHHCCCCCCC-----	28.16	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARH40_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARH40_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARH40_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STC2_HUMAN	STC2	physical	16169070
A4_HUMAN	APP	physical	21832049
SPERT_HUMAN	SPERT	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-262 AND SER-961, ANDMASS SPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-262 AND THR-371, ANDMASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-931, AND MASSSPECTROMETRY.
PubMed: 18669648