DISP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DISP3_HUMAN
• UniProt AC: Q9P2K9
• Protein Name: Protein dispatched homolog 3 {ECO:0000303|PubMed:15645143}
• Gene Name: DISP3 {ECO:0000303|PubMed:15645143, ECO:0000312|HGNC:HGNC:29251}
• Organism: Homo sapiens (Human).
• Sequence Length: 1392
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Nucleus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . Predominantly localized to cholester
• Protein Description: Plays a role in neuronal proliferation and differentiation. [PubMed: 25281927 Plays a role in the accumulation of cellular cholesterol (By similarity Involved in intracellular lipid droplet formation]
• Protein Sequence: MDTEDDPLLQDVWLEEEQEEEEATGETFLGAQKPGPQPGAGGQCCWRHWPLASRPPASGFWSTLGWAFTNPCCAGLVLFLGCSIPMALSAFMFLYYPPLDIDISYNAFEIRNHEASQRFDALTLALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLHLGNRSRQASRAPRVIPAASLGGPGPYRDTSAAQKPTANRSGRLRRETPPLEDLAANQSEDPRNQRLSKNGRYQPSIPPHAAVAANQSRARRGASRWDYSRAYVSANTQTHAHWRIELIFLARGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCSPPSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSADNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSLYLAPLESSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEEPVSLELGDVSLVSVSPEGLQPASNTGSRGHLIVQLQELLHHWVLWSAVKSRWVIVGLFVSILILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQNNIRTSLEKKRRGSGVPWASRPEATLQDFPGTVYISKVKSQGHPAVYRLSLNASLPAPWQAVSPGDGEVPSFQVYRAPFGNFTKKLTACMSTVGLLQAASPSRKWMLTTLACDAKRGWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRVCMAPPGCLLSSSPDGPTKGFFFVPSEKVPKARLSATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGVNRTRQVDNHVIGDPGSVVYDSSFDLFKEIGHLCHLCKAIAANSELVKPGGAQCLPSGYSISSFLQMLHPECKELPEPNLLPGQLSHGAVGVREGRVQWISMAFESTTYKGKSSFQTYSDYLRWESFLQQQLQALPEGSVLRRGFQTCEHWKQIFMEIVGVQSALCGLVLSLLICVAAVAVFTTHILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGKIVALNTGVSILYTLTVSTALLGIMAPSSFTRTRTSFLKALGAVLLAGALGLGACLVLLQSGYKIPLPAGASL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
116	Phosphorylation	EIRNHEASQRFDALT EECCCHHHHHHHHHH		-
163	N-linked_Glycosylation	LQQLHLGNRSRQASR HHHHHCCCHHHHHHC		UniProtKB CARBOHYD
207	Phosphorylation	SGRLRRETPPLEDLA CCCCCCCCCCHHHHH		21964256
393	Phosphorylation	SADNLKSSLLRSEIL CCCHHHHHHHHHHHH		24719451
428	Phosphorylation	KFQSFVVTYVAMLAK HHHHHHHHHHHHHHH		29396449
754	Phosphorylation	ASRLRPASRAPLLFR HHCCCCCCCCCEEEC		22210691
782	Phosphorylation	NLSAEGISCITCSGL CCCCCCEEEEECCCC		22210691
785	Phosphorylation	AEGISCITCSGLFQE CCCEEEEECCCCCCC		22210691
787	Phosphorylation	GISCITCSGLFQEKP CEEEEECCCCCCCCC		22210691
966	Phosphorylation	SSSPDGPTKGFFFVP ECCCCCCCCCEEEEC		-
1021	N-linked_Glycosylation	VFGIIGVNRTRQVDN EEEEECCCCCEEECC		UniProtKB CARBOHYD
1036	Phosphorylation	HVIGDPGSVVYDSSF CCCCCCCCEEEECCH		22468782
1041	Phosphorylation	PGSVVYDSSFDLFKE CCCEEEECCHHHHHH		22468782
1105	Phosphorylation	NLLPGQLSHGAVGVR CCCCCCCCCCCCCCE		-
1355	Phosphorylation	SFTRTRTSFLKALGA CCCCHHHHHHHHHHH		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DISP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DISP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DISP3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DISP3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.