dbPTM

AKAP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AKAP1_HUMAN
UniProt AC	Q92667
Protein Name	A-kinase anchor protein 1, mitochondrial
Gene Name	AKAP1
Organism	Homo sapiens (Human).
Sequence Length	903
Subcellular Localization	Mitochondrion outer membrane .
Protein Description	Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane..
Protein Sequence	MAIQFRSLFPLALPGMLALLGWWWFFSRKKGHVSSHDEQQVEAGAVQLRADPAIKEPLPVEDVCPKVVSTPPSVTEPPEKELSTVSKLPAEPPALLQTHPPCRRSESSGILPNTTDMRLRPGTRRDDSTKLELALTGGEAKSIPLECPLSSPKGVLFSSKSAEVCKQDSPFSRVPRKVQPGYPVVPAEKRSSGERARETGGAEGTGDAVLGEKVLEEALLSREHVLELENSKGPSLASLEGEEDKGKSSSSQVVGPVQEEEYVAEKLPSRFIESAHTELAKDDAAPAPPVADAKAQDRGVEGELGNEESLDRNEEGLDRNEEGLDRNEESLDRNEEGLDRNEEIKRAAFQIISQVISEATEQVLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDAGLPLPGLPAEGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASCLALTTPSEELPDRAGILVEDATCVTCMSDSSQSVPLVASPGHCSDSFSTSGLEDSCTETSSSPRDKAITPPLPESTVPFSNGVLKGELSDLGAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLKKTESFQNAQAGSNPKKVDLIIWEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQSVQICHIEGSQHHVDKALNLIGKKFKELNLTNIYAPPLPSLALPSLPMTSWLMLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAAPGADGAWWRAQVVASYEETNEVEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMPLSDDDQFSPEADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVGDEVVLINRSLVERGLAQWVDSYYTSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	SRKKGHVSSHDEQQV HCCCCCCCCCCHHHH	19.11	26471730
35	Phosphorylation	RKKGHVSSHDEQQVE CCCCCCCCCCHHHHH	33.59	26471730
55	Ubiquitination	LRADPAIKEPLPVED EECCCHHCCCCCHHH	56.22	-
55	Acetylation	LRADPAIKEPLPVED EECCCHHCCCCCHHH	56.22	26051181
64	Glutathionylation	PLPVEDVCPKVVSTP CCCHHHCCCCCCCCC	4.11	22555962
64	S-palmitoylation	PLPVEDVCPKVVSTP CCCHHHCCCCCCCCC	4.11	21044946
66	Acetylation	PVEDVCPKVVSTPPS CHHHCCCCCCCCCCC	50.58	26051181
69	Phosphorylation	DVCPKVVSTPPSVTE HCCCCCCCCCCCCCC	37.88	23401153
70	Phosphorylation	VCPKVVSTPPSVTEP CCCCCCCCCCCCCCC	27.84	30266825
70 (in isoform 2)	Phosphorylation	-	27.84	-
73	Phosphorylation	KVVSTPPSVTEPPEK CCCCCCCCCCCCCHH	42.76	30266825
75	Phosphorylation	VSTPPSVTEPPEKEL CCCCCCCCCCCHHHC	47.30	30266825
83	Phosphorylation	EPPEKELSTVSKLPA CCCHHHCCCCCCCCC	28.05	23186163
84	Phosphorylation	PPEKELSTVSKLPAE CCHHHCCCCCCCCCC	41.23	23186163
98	Phosphorylation	EPPALLQTHPPCRRS CCCHHHCCCCCCCCC	36.00	24043423
105	Phosphorylation	THPPCRRSESSGILP CCCCCCCCCCCCCCC	23.60	23401153
105 (in isoform 2)	Phosphorylation	-	23.60	-
107	Phosphorylation	PPCRRSESSGILPNT CCCCCCCCCCCCCCC	34.80	29255136
107 (in isoform 2)	Phosphorylation	-	34.80	-
108	Phosphorylation	PCRRSESSGILPNTT CCCCCCCCCCCCCCC	26.29	30266825
108 (in isoform 2)	Phosphorylation	-	26.29	-
114	Phosphorylation	SSGILPNTTDMRLRP CCCCCCCCCCCCCCC	23.41	29396449
115	Phosphorylation	SGILPNTTDMRLRPG CCCCCCCCCCCCCCC	34.14	29396449
117	Sulfoxidation	ILPNTTDMRLRPGTR CCCCCCCCCCCCCCC	4.00	21406390
128	Phosphorylation	PGTRRDDSTKLELAL CCCCCCCCCEEEEEE	31.56	24400703
129	Phosphorylation	GTRRDDSTKLELALT CCCCCCCCEEEEEEE	46.79	28857561
136	Phosphorylation	TKLELALTGGEAKSI CEEEEEEECCCCCCC	37.22	28674419
142	Phosphorylation	LTGGEAKSIPLECPL EECCCCCCCEEECCC	36.16	25159151
150	Phosphorylation	IPLECPLSSPKGVLF CEEECCCCCCCEEEE	29.72	25159151
151	Phosphorylation	PLECPLSSPKGVLFS EEECCCCCCCEEEEE	38.01	25159151
151 (in isoform 2)	Phosphorylation	-	38.01	-
158	Phosphorylation	SPKGVLFSSKSAEVC CCCEEEEECCCHHHH	32.47	20806193
159	Phosphorylation	PKGVLFSSKSAEVCK CCEEEEECCCHHHHC	24.24	29116813
161	Phosphorylation	GVLFSSKSAEVCKQD EEEEECCCHHHHCCC	31.45	24732914
169	Phosphorylation	AEVCKQDSPFSRVPR HHHHCCCCCCCCCCC	25.92	25159151
169 (in isoform 2)	Phosphorylation	-	25.92	-
172	Phosphorylation	CKQDSPFSRVPRKVQ HCCCCCCCCCCCCCC	35.43	24732914
189	2-Hydroxyisobutyrylation	YPVVPAEKRSSGERA CCCCCHHHCCCCHHH	60.74	-
213	Ubiquitination	GDAVLGEKVLEEALL CCHHHCHHHHHHHHH	50.77	-
231	Phosphorylation	HVLELENSKGPSLAS HHHHHHCCCCCCCHH	29.61	25849741
235	Phosphorylation	LENSKGPSLASLEGE HHCCCCCCCHHCCCC	45.28	29214152
238	Phosphorylation	SKGPSLASLEGEEDK CCCCCCHHCCCCCCC	32.04	26657352
248	Phosphorylation	GEEDKGKSSSSQVVG CCCCCCCCCCCCEEC	44.09	28348404
249	Phosphorylation	EEDKGKSSSSQVVGP CCCCCCCCCCCEECC	37.18	28348404
250	Phosphorylation	EDKGKSSSSQVVGPV CCCCCCCCCCEECCC	31.70	28348404
251	Phosphorylation	DKGKSSSSQVVGPVQ CCCCCCCCCEECCCC	29.01	28348404
262	Phosphorylation	GPVQEEEYVAEKLPS CCCCHHHHHHHHCCH	14.29	28796482
266	Ubiquitination	EEEYVAEKLPSRFIE HHHHHHHHCCHHHHH	56.83	-
266	Acetylation	EEEYVAEKLPSRFIE HHHHHHHHCCHHHHH	56.83	26051181
269	Phosphorylation	YVAEKLPSRFIESAH HHHHHCCHHHHHHHH	50.70	29978859
274	Phosphorylation	LPSRFIESAHTELAK CCHHHHHHHHHHHHH	22.12	23312004
309	Phosphorylation	GELGNEESLDRNEEG CCCCCHHHCCCCHHC	29.41	25849741
330	Phosphorylation	GLDRNEESLDRNEEG HCCCCHHHHHHCHHC	29.41	72272759
353	Phosphorylation	RAAFQIISQVISEAT HHHHHHHHHHHHHHH	21.74	22817900
353 (in isoform 2)	Phosphorylation	-	21.74	-
357	Phosphorylation	QIISQVISEATEQVL HHHHHHHHHHHHHHH	23.48	22817900
357 (in isoform 2)	Phosphorylation	-	23.48	-
360	Phosphorylation	SQVISEATEQVLATT HHHHHHHHHHHHHHC	23.93	2499759
360 (in isoform 2)	Phosphorylation	-	23.93	-
366	Phosphorylation	ATEQVLATTVGKVAG HHHHHHHHCHHHHHH	20.18	11113651
366 (in isoform 2)	Phosphorylation	-	20.18	-
385	Acetylation	ASQLQGQKEESCVPV HHHHCCCCCCCCCCC	70.98	26051181
396	Phosphorylation	CVPVHQKTVLGPDTA CCCCCCCEECCCCCC	17.88	26552605
402	Phosphorylation	KTVLGPDTAEPATAE CEECCCCCCCCCCCH	35.73	26552605
407	Phosphorylation	PDTAEPATAEAAVAP CCCCCCCCCHHHCCC	35.43	26552605
429	Phosphorylation	PGLPAEGSPPPKTYV CCCCCCCCCCCHHHH	26.24	29255136
434	Phosphorylation	EGSPPPKTYVSCLKS CCCCCCHHHHHHHHH	34.62	26552605
435	Phosphorylation	GSPPPKTYVSCLKSL CCCCCHHHHHHHHHH	9.11	22210691
437	Phosphorylation	PPPKTYVSCLKSLLS CCCHHHHHHHHHHHC	11.88	26552605
440	Methylation	KTYVSCLKSLLSSPT HHHHHHHHHHHCCCC	43.30	-
441	Phosphorylation	TYVSCLKSLLSSPTK HHHHHHHHHHCCCCC	22.92	30266825
441 (in isoform 2)	Phosphorylation	-	22.92	-
444	Phosphorylation	SCLKSLLSSPTKDSK HHHHHHHCCCCCCCC	39.29	30266825
445	Phosphorylation	CLKSLLSSPTKDSKP HHHHHHCCCCCCCCC	36.24	29255136
445 (in isoform 2)	Phosphorylation	-	36.24	-
447	Phosphorylation	KSLLSSPTKDSKPNI HHHHCCCCCCCCCCC	49.81	30266825
447 (in isoform 2)	Phosphorylation	-	49.81	-
455	Phosphorylation	KDSKPNISAHHISLA CCCCCCCCHHHHHHH	28.34	28464451
468	Phosphorylation	LASCLALTTPSEELP HHHHHHHCCCCHHCC	30.93	27251275
469	Phosphorylation	ASCLALTTPSEELPD HHHHHHCCCCHHCCC	26.18	27251275
503	Phosphorylation	QSVPLVASPGHCSDS CCCCEEECCCCCCCC	24.76	26074081
508	Phosphorylation	VASPGHCSDSFSTSG EECCCCCCCCCCCCC	30.52	26074081
523	Phosphorylation	LEDSCTETSSSPRDK CCCCCCCCCCCCCCC	18.76	26074081
524	Phosphorylation	EDSCTETSSSPRDKA CCCCCCCCCCCCCCC	23.68	26074081
525	Phosphorylation	DSCTETSSSPRDKAI CCCCCCCCCCCCCCC	52.35	26074081
526	Phosphorylation	SCTETSSSPRDKAIT CCCCCCCCCCCCCCC	24.58	26074081
533	Phosphorylation	SPRDKAITPPLPEST CCCCCCCCCCCCCCC	24.58	29255136
533 (in isoform 2)	Phosphorylation	-	24.58	-
539	Phosphorylation	ITPPLPESTVPFSNG CCCCCCCCCCCCCCC	32.53	23927012
540	Phosphorylation	TPPLPESTVPFSNGV CCCCCCCCCCCCCCE	30.45	23927012
544	Phosphorylation	PESTVPFSNGVLKGE CCCCCCCCCCEEEEE	26.97	26074081
553	Phosphorylation	GVLKGELSDLGAEDG CEEEEEHHHCCCCCC	26.87	26074081
562	Phosphorylation	LGAEDGWTMDAEADH CCCCCCCEECCCCCC	15.65	28985074
570	Phosphorylation	MDAEADHSGGSDRNS ECCCCCCCCCCCCCC	45.45	24275569
573	Phosphorylation	EADHSGGSDRNSMDS CCCCCCCCCCCCCCH	36.60	28985074
577	Phosphorylation	SGGSDRNSMDSVDSC CCCCCCCCCCHHHHH	25.51	46161171
580	Phosphorylation	SDRNSMDSVDSCCSL CCCCCCCHHHHHHCC	21.12	21815630
583	Phosphorylation	NSMDSVDSCCSLKKT CCCCHHHHHHCCCCC	18.18	25159151
586	Phosphorylation	DSVDSCCSLKKTESF CHHHHHHCCCCCHHH	47.77	46161189
588	Acetylation	VDSCCSLKKTESFQN HHHHHCCCCCHHHHC	41.16	26051181
589	Ubiquitination	DSCCSLKKTESFQNA HHHHCCCCCHHHHCC	63.92	-
590	Phosphorylation	SCCSLKKTESFQNAQ HHHCCCCCHHHHCCC	34.96	30266825
592	Phosphorylation	CSLKKTESFQNAQAG HCCCCCHHHHCCCCC	37.05	23401153
600	Phosphorylation	FQNAQAGSNPKKVDL HHCCCCCCCCCCCCE	53.64	25159151
603	Ubiquitination	AQAGSNPKKVDLIIW CCCCCCCCCCCEEEE	70.45	-
603	2-Hydroxyisobutyrylation	AQAGSNPKKVDLIIW CCCCCCCCCCCEEEE	70.45	-
631	Phosphorylation	GKQGRYVSFLKQTSG CCCCCEEEEEEECCC	18.87	24719451
634	Ubiquitination	GRYVSFLKQTSGAKI CCEEEEEEECCCCEE	49.90	21890473
634 (in isoform 1)	Ubiquitination	-	49.90	21890473
666	Ubiquitination	GSQHHVDKALNLIGK CCHHHHHHHHHHHHH	54.40	-
673	Ubiquitination	KALNLIGKKFKELNL HHHHHHHHHHHHCCC	48.30	-
676	Ubiquitination	NLIGKKFKELNLTNI HHHHHHHHHCCCCCE	70.89	-
783	Phosphorylation	RAQVVASYEETNEVE EEEEEEEECCCCCEE	14.19	30576142
799	Phosphorylation	RYVDYGGYKRVKVDV EEEECCCCEEEEEEH	7.40	30576142
800	Ubiquitination	YVDYGGYKRVKVDVL EEECCCCEEEEEEHH	54.73	2189047
800 (in isoform 1)	Ubiquitination	-	54.73	21890473
803	Ubiquitination	YGGYKRVKVDVLRQI CCCCEEEEEEHHHHH	36.43	-
900	Phosphorylation	AQWVDSYYTSL---- HHHHHHHHHCC----	8.19	30455815
901	Phosphorylation	QWVDSYYTSL----- HHHHHHHHCC-----	18.47	28348404
902	Phosphorylation	WVDSYYTSL------ HHHHHHHCC------	18.89	28192239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH2	O43255	PMID:18323779

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AKAP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AKAP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAP1_HUMAN	PRKAR1B	physical	12634056
AMY1_HUMAN	AMY1A	physical	12414807
KAP0_HUMAN	PRKAR1A	physical	10764601
KAP2_HUMAN	PRKAR2A	physical	10764601
KAP2_HUMAN	PRKAR2A	physical	10413680
CFA91_HUMAN	MAATS1	physical	12223483
MYCBP_HUMAN	MYCBP	physical	12223483
MYCBP_HUMAN	MYCBP	physical	11483602
A4_HUMAN	APP	physical	21832049
PHB_HUMAN	PHB	physical	26496610
KAP2_HUMAN	PRKAR2A	physical	26496610
RL12_HUMAN	RPL12	physical	26496610
TNNI3_HUMAN	TNNI3	physical	26496610
CKAP5_HUMAN	CKAP5	physical	26496610
FARP1_HUMAN	FARP1	physical	26496610
PHB2_HUMAN	PHB2	physical	26496610
PYM1_HUMAN	WIBG	physical	26496610
LARP4_HUMAN	LARP4	physical	26496610
KAPCA_HUMAN	PRKACA	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AKAP1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-429 AND THR-533, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-70; SER-151 AND THR-533,AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-70, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-533, AND MASSSPECTROMETRY.	15302935 [Abstract]