LARP4_HUMAN - dbPTM
LARP4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LARP4_HUMAN
UniProt AC Q71RC2
Protein Name La-related protein 4
Gene Name LARP4
Organism Homo sapiens (Human).
Sequence Length 724
Subcellular Localization Cytoplasm, Stress granule . Cytoplasm, cytosol . Localized throughout the cytosol. Partially localized in stress granules in response to arsenite treatment.
Protein Description RNA binding protein that binds to the poly-A tract of mRNA molecules. [PubMed: 21098120 Associates with the 40S ribosomal subunit and with polysomes]
Protein Sequence MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTDGMILGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFIPIWTVANMEEIKKLTTDPDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPIEEVKGLFKSENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINTFFAKNGYRLMDSSIYSHPIQTQAQYASPVFMQPVYNPHQQYSVYSIVPQSWSPNPTPYFETPLAPFPNGSFVNGFNSPGSYKTNAAAMNMGRPFQKNRVKPQFRSSGGSEHSTEGSVSLGDGQLNRYSSRNFPAERHNPTVTGHQEQTYLQKETSTLQVEQNGDYGRGRRTLFRGRRRREDDRISRPHPSTAESKAPTPKFDLLASNFPPLPGSSSRMPGELVLENRMSDVVKGVYKEKDNEELTISCPVPADEQTECTSAQQLNMSTSSPCAAELTALSTTQQEKDLIEDSSVQKDGLNQTTIPVSPPSTTKPSRASTASPCNNNINAATAVALQEPRKLSYAEVCQKPPKEPSSVLVQPLRELRSNVVSPTKNEDNGAPENSVEKPHEKPEARASKDYSGFRGNIIPRGAAGKIREQRRQFSHRAIPQGVTRRNGKEQYVPPRSPK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MLLFVEQV
-------CCEEEEEH		7.0919413330
11UbiquitinationFVEQVASKGTGLNPN
EEEEHHHCCCCCCCC		51.24-
20UbiquitinationTGLNPNAKVWQEIAP
CCCCCCCCCHHHCCC		51.12-
42PhosphorylationVTHGTESSWHEIAAT
CCCCCCCCCCHHHHC		26.6424275569
68PhosphorylationSEDICKEYEVMYSSS
CHHHHHHCEEEEECC		10.1821945579
72PhosphorylationCKEYEVMYSSSCETT
HHHCEEEEECCCCCC		15.5821945579
73PhosphorylationKEYEVMYSSSCETTR
HHCEEEEECCCCCCC		9.5521945579
74PhosphorylationEYEVMYSSSCETTRN
HCEEEEECCCCCCCC		22.8621945579
74 (in isoform 4)Phosphorylation-22.8627642862
75PhosphorylationYEVMYSSSCETTRNT
CEEEEECCCCCCCCC		15.2721945579
78 (in isoform 4)Phosphorylation-35.0727642862
79PhosphorylationYSSSCETTRNTTGIE
EECCCCCCCCCCCCE		10.3030576142
141PhosphorylationENLSKDLYLISQMDS
CCCCCCEEEEEECCC		16.4824719451
144PhosphorylationSKDLYLISQMDSDQF
CCCEEEEEECCCCCC		19.5024719451
148PhosphorylationYLISQMDSDQFIPIW
EEEEECCCCCCCEEE		28.1524719451
165UbiquitinationANMEEIKKLTTDPDL
ECHHHHHHHCCCHHH		57.64-
171 (in isoform 4)Ubiquitination-49.50-
179PhosphorylationLILEVLRSSPMVQVD
HHHHHHHCCCCEEEC		34.3325627689
180PhosphorylationILEVLRSSPMVQVDE
HHHHHHCCCCEEECC		15.5825627689
181 (in isoform 2)Ubiquitination-28.3621890473
182SulfoxidationEVLRSSPMVQVDEKG
HHHHCCCCEEECCCC		3.3921406390
188AcetylationPMVQVDEKGEKVRPS
CCEEECCCCCCCCCC		68.8326051181
188UbiquitinationPMVQVDEKGEKVRPS
CCEEECCCCCCCCCC		68.83-
191UbiquitinationQVDEKGEKVRPSHKR
EECCCCCCCCCCCCE		52.81-
194 (in isoform 4)Ubiquitination-43.71-
195PhosphorylationKGEKVRPSHKRCIVI
CCCCCCCCCCEEEEE		30.95-
216AcetylationTTPIEEVKGLFKSEN
CCCHHHHHHHHHCCC		53.8526051181
216UbiquitinationTTPIEEVKGLFKSEN
CCCHHHHHHHHHCCC		53.85-
220AcetylationEEVKGLFKSENCPKV
HHHHHHHHCCCCCCE		63.0025953088
220UbiquitinationEEVKGLFKSENCPKV
HHHHHHHHCCCCCCE		63.00-
222 (in isoform 4)Ubiquitination-64.54-
226 (in isoform 4)Ubiquitination-55.17-
260UbiquitinationKYLREEVKTFQGKPI
HHHHHHHHHHCCCCH		47.07-
265AcetylationEVKTFQGKPIMARIK
HHHHHCCCCHHHHHH		22.1626051181
265UbiquitinationEVKTFQGKPIMARIK
HHHHHCCCCHHHHHH		22.16-
271 (in isoform 4)Ubiquitination-2.28-
272UbiquitinationKPIMARIKAINTFFA
CCHHHHHHHHHHHHH		37.35-
276PhosphorylationARIKAINTFFAKNGY
HHHHHHHHHHHHCCE		17.6421406692
278 (in isoform 4)Ubiquitination-9.96-
280AcetylationAINTFFAKNGYRLMD
HHHHHHHHCCEEECC		45.8326051181
280UbiquitinationAINTFFAKNGYRLMD
HHHHHHHHCCEEECC		45.832189047
280 (in isoform 1)Ubiquitination-45.8321890473
280 (in isoform 3)Ubiquitination-45.8321890473
282 (in isoform 5)Phosphorylation-14.29-
286 (in isoform 4)Ubiquitination-3.3021890473
291PhosphorylationRLMDSSIYSHPIQTQ
EECCCCCCCCCCCCC		11.68-
292PhosphorylationLMDSSIYSHPIQTQA
ECCCCCCCCCCCCCH		22.55-
314 (in isoform 5)Phosphorylation-24.60-
321PhosphorylationHQQYSVYSIVPQSWS
CCCEEEEEEECCCCC		18.2318669648
321 (in isoform 5)Phosphorylation-18.23-
353PhosphorylationSFVNGFNSPGSYKTN
CCCCCCCCCCCHHHH		28.5123312004
359PhosphorylationNSPGSYKTNAAAMNM
CCCCCHHHHHHHHHC		23.1220860994
368MethylationAAAMNMGRPFQKNRV
HHHHHCCCCCCCCCC		20.3524129315
372UbiquitinationNMGRPFQKNRVKPQF
HCCCCCCCCCCCCCC		47.29-
378 (in isoform 4)Ubiquitination-40.44-
381PhosphorylationRVKPQFRSSGGSEHS
CCCCCCCCCCCCCCC		34.3225159151
382PhosphorylationVKPQFRSSGGSEHST
CCCCCCCCCCCCCCC		42.8125159151
385PhosphorylationQFRSSGGSEHSTEGS
CCCCCCCCCCCCCCC		35.3423401153
388PhosphorylationSSGGSEHSTEGSVSL
CCCCCCCCCCCCEEC		24.8921712546
389PhosphorylationSGGSEHSTEGSVSLG
CCCCCCCCCCCEECC		46.3923663014
391 (in isoform 4)Phosphorylation-33.17-
392PhosphorylationSEHSTEGSVSLGDGQ
CCCCCCCCEECCCCC		11.4221712546
394PhosphorylationHSTEGSVSLGDGQLN
CCCCCCEECCCCCCC		28.4723663014
398 (in isoform 4)Phosphorylation-31.88-
404PhosphorylationDGQLNRYSSRNFPAE
CCCCCCCCCCCCCHH		21.4223186163
405PhosphorylationGQLNRYSSRNFPAER
CCCCCCCCCCCCHHH		23.4723186163
416PhosphorylationPAERHNPTVTGHQEQ
CHHHCCCCCCCCHHH		35.7021945579
418PhosphorylationERHNPTVTGHQEQTY
HHCCCCCCCCHHHEE		31.2721945579
419 (in isoform 5)Phosphorylation-19.02-
424PhosphorylationVTGHQEQTYLQKETS
CCCCHHHEEEEECCC		26.0021945579
425PhosphorylationTGHQEQTYLQKETST
CCCHHHEEEEECCCE		13.5621945579
430PhosphorylationQTYLQKETSTLQVEQ
HEEEEECCCEEEEEE		33.7628555341
434 (in isoform 5)Phosphorylation-36.47-
441PhosphorylationQVEQNGDYGRGRRTL
EEEECCCCCCCCCCC		15.32-
443MethylationEQNGDYGRGRRTLFR
EECCCCCCCCCCCCC		29.2612019497
445MethylationNGDYGRGRRTLFRGR
CCCCCCCCCCCCCCC		27.3516187583
450MethylationRGRRTLFRGRRRRED
CCCCCCCCCCCCCCC		40.6054557077
461PhosphorylationRREDDRISRPHPSTA
CCCCCCCCCCCCCCC		40.4221406692
466PhosphorylationRISRPHPSTAESKAP
CCCCCCCCCCCCCCC		36.9028555341
467PhosphorylationISRPHPSTAESKAPT
CCCCCCCCCCCCCCC		38.6128555341
470PhosphorylationPHPSTAESKAPTPKF
CCCCCCCCCCCCCCC		31.49-
474PhosphorylationTAESKAPTPKFDLLA
CCCCCCCCCCCCCHH		43.9322199227
479 (in isoform 2)Phosphorylation-4.9119276368
484 (in isoform 2)Phosphorylation-6.4622210691
487 (in isoform 2)Phosphorylation-8.3719276368
488 (in isoform 2)Phosphorylation-46.5222210691
489 (in isoform 2)Phosphorylation-48.0919276368
490PhosphorylationNFPPLPGSSSRMPGE
CCCCCCCCCCCCCCE		24.1718669648
491PhosphorylationFPPLPGSSSRMPGEL
CCCCCCCCCCCCCEE		28.0721712546
494SulfoxidationLPGSSSRMPGELVLE
CCCCCCCCCCEEEEC		5.5921406390
496 (in isoform 4)Phosphorylation-31.37-
503MethylationGELVLENRMSDVVKG
CEEEECCCHHHHHCC		19.33115481807
505PhosphorylationLVLENRMSDVVKGVY
EEECCCHHHHHCCEE		24.8222199227
509AcetylationNRMSDVVKGVYKEKD
CCHHHHHCCEEECCC		42.3727452117
511 (in isoform 4)Phosphorylation-5.24-
512 (in isoform 5)Phosphorylation-23.30-
515 (in isoform 5)Phosphorylation-62.80-
516 (in isoform 5)Phosphorylation-69.71-
517 (in isoform 5)Phosphorylation-56.56-
523PhosphorylationDNEELTISCPVPADE
CCCEEEEECCCCCCC		13.7219664995
523 (in isoform 5)Phosphorylation-13.72-
524 (in isoform 5)Phosphorylation-3.30-
526 (in isoform 5)Phosphorylation-7.77-
532PhosphorylationPVPADEQTECTSAQQ
CCCCCCCCCCCCCHH		30.8628348404
535PhosphorylationADEQTECTSAQQLNM
CCCCCCCCCCHHHCC		22.3628348404
536PhosphorylationDEQTECTSAQQLNMS
CCCCCCCCCHHHCCC		35.4228348404
536 (in isoform 5)Phosphorylation-35.42-
543PhosphorylationSAQQLNMSTSSPCAA
CCHHHCCCCCCCCHH		24.8628348404
544PhosphorylationAQQLNMSTSSPCAAE
CHHHCCCCCCCCHHH		23.5826074081
545PhosphorylationQQLNMSTSSPCAAEL
HHHCCCCCCCCHHHH		25.6121815630
546PhosphorylationQLNMSTSSPCAAELT
HHCCCCCCCCHHHHH		24.8821815630
553PhosphorylationSPCAAELTALSTTQQ
CCCHHHHHHCCCCHH		19.6330576142
569PhosphorylationKDLIEDSSVQKDGLN
HHHHCCCCCCCCCCC		40.6721815630
572 (in isoform 5)Phosphorylation-52.16-
576 (in isoform 5)Phosphorylation-42.56-
578PhosphorylationQKDGLNQTTIPVSPP
CCCCCCCCCCCCCCC		26.1429255136
578 (in isoform 5)Phosphorylation-26.14-
579PhosphorylationKDGLNQTTIPVSPPS
CCCCCCCCCCCCCCC		17.3330266825
583PhosphorylationNQTTIPVSPPSTTKP
CCCCCCCCCCCCCCC		26.2429255136
586PhosphorylationTIPVSPPSTTKPSRA
CCCCCCCCCCCCCCC		52.6829255136
587PhosphorylationIPVSPPSTTKPSRAS
CCCCCCCCCCCCCCC		44.6122167270
588PhosphorylationPVSPPSTTKPSRAST
CCCCCCCCCCCCCCC		45.3422167270
589 (in isoform 4)Phosphorylation-40.87-
591PhosphorylationPPSTTKPSRASTASP
CCCCCCCCCCCCCCC		41.8722167270
592 (in isoform 4)Phosphorylation-40.87-
593 (in isoform 4)Phosphorylation-18.64-
594PhosphorylationTTKPSRASTASPCNN
CCCCCCCCCCCCCCC		24.3229255136
594 (in isoform 4)Phosphorylation-24.32-
595PhosphorylationTKPSRASTASPCNNN
CCCCCCCCCCCCCCC		30.1229255136
597PhosphorylationPSRASTASPCNNNIN
CCCCCCCCCCCCCCC		30.0329255136
600 (in isoform 4)Phosphorylation-48.22-
601 (in isoform 4)Phosphorylation-58.43-
603 (in isoform 4)Phosphorylation-3.95-
607PhosphorylationNNNINAATAVALQEP
CCCCCHHHHHHHCCC		21.1823927012
613 (in isoform 4)Phosphorylation-48.17-
618PhosphorylationLQEPRKLSYAEVCQK
HCCCCCCCHHHHHCC		25.9020873877
619PhosphorylationQEPRKLSYAEVCQKP
CCCCCCCHHHHHCCC		19.7423312004
625AcetylationSYAEVCQKPPKEPSS
CHHHHHCCCCCCCCC		59.1526051181
628AcetylationEVCQKPPKEPSSVLV
HHHCCCCCCCCCCEE		85.6026051181
632PhosphorylationKPPKEPSSVLVQPLR
CCCCCCCCCEEHHHH		30.1328555341
643PhosphorylationQPLRELRSNVVSPTK
HHHHHHHHCCCCCCC		46.7525159151
647PhosphorylationELRSNVVSPTKNEDN
HHHHCCCCCCCCCCC		23.6723927012
649PhosphorylationRSNVVSPTKNEDNGA
HHCCCCCCCCCCCCC		38.7123927012
649 (in isoform 4)Phosphorylation-38.71-
651 (in isoform 5)Phosphorylation-65.42-
653 (in isoform 4)Phosphorylation-69.15-
655 (in isoform 4)Phosphorylation-55.63-
660PhosphorylationDNGAPENSVEKPHEK
CCCCCCCCCCCCCCC		29.9523927012
667AcetylationSVEKPHEKPEARASK
CCCCCCCCCCHHHCC		45.167976085
673PhosphorylationEKPEARASKDYSGFR
CCCCHHHCCCCCCCC		22.1026657352
674MethylationKPEARASKDYSGFRG
CCCHHHCCCCCCCCC		60.75115972345
676PhosphorylationEARASKDYSGFRGNI
CHHHCCCCCCCCCCC		17.9028796482
677PhosphorylationARASKDYSGFRGNII
HHHCCCCCCCCCCCC		41.4028796482
680MethylationSKDYSGFRGNIIPRG
CCCCCCCCCCCCCCC		40.5554557061
682 (in isoform 4)Phosphorylation-25.4327642862
686MethylationFRGNIIPRGAAGKIR
CCCCCCCCCHHHHHH		36.6524129315
691AcetylationIPRGAAGKIREQRRQ
CCCCHHHHHHHHHHH		33.5925953088
691MethylationIPRGAAGKIREQRRQ
CCCCHHHHHHHHHHH		33.59115481799
700PhosphorylationREQRRQFSHRAIPQG
HHHHHHHCCCCCCCC		12.06-
717PhosphorylationRRNGKEQYVPPRSPK
CCCCCCCCCCCCCCC		18.9328176443
721PhosphorylationKEQYVPPRSPK----
CCCCCCCCCCC----		60.5715144186
722PhosphorylationEQYVPPRSPK-----
CCCCCCCCCC-----		42.7023927012
728 (in isoform 4)Phosphorylation--
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LARP4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LARP4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LARP4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
RACK1_HUMANGNB2L1physical
28514442
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LARP4_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-583; THR-595; SER-597; SER-643; SER-647 ANDTHR-649, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-583; THR-595; SER-597; SER-643; SER-647 ANDTHR-649, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392; SER-583; SER-586AND SER-722, AND MASS SPECTROMETRY.

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