MED22_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED22_HUMAN
• UniProt AC: Q15528
• Protein Name: Mediator of RNA polymerase II transcription subunit 22
• Gene Name: MED22
• Organism: Homo sapiens (Human).
• Sequence Length: 200
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors..
• Protein Sequence: MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRTLQEECDRKLITLRDEISIDLYELEEEYYSSSSSLCEANDLPLCEAYGRLDLDTDSADGLSAPLLASPEPSAGPLQVAAPAHSHAGGPGPTEHA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	QRALPQSKETLLQSY CCCCCCCHHHHHHHH	49.85	21890473
11 (in isoform 2)	Ubiquitination	-	49.85	21890473
11 (in isoform 1)	Ubiquitination	-	49.85	21890473
20	Ubiquitination	TLLQSYNKRLKDDIK HHHHHHHHHHHHHHH	51.37	-
28	O-linked_Glycosylation	RLKDDIKSIMDNFTE HHHHHHHHHHHHHHH	24.39	30379171
34	Phosphorylation	KSIMDNFTEIIKTAK HHHHHHHHHHHHHCC	32.31	-
38	Ubiquitination	DNFTEIIKTAKIEDE HHHHHHHHHCCCCCC	48.36	-
39	O-linked_Glycosylation	NFTEIIKTAKIEDET HHHHHHHHCCCCCCC	23.83	30379171
59	Phosphorylation	TQGEQDNYEMHVRAA HCCCCCCCHHHHHHH	23.95	28796482
74	Phosphorylation	NIVRAGESLMKLVSD HHHHHHHHHHHHHHH	32.61	-
83	Ubiquitination	MKLVSDLKQFLILND HHHHHHHHHHHHHCC	43.95	-
107	Phosphorylation	QRNQQLRTLQEECDR HHHHHHHHHHHHHHH	41.19	19664994
160	Phosphorylation	YGRLDLDTDSADGLS HCCCCCCCCCCCCCC	38.87	28122231
162	Phosphorylation	RLDLDTDSADGLSAP CCCCCCCCCCCCCCC	30.28	28122231
167	Phosphorylation	TDSADGLSAPLLASP CCCCCCCCCCEECCC	33.11	26074081
173	Phosphorylation	LSAPLLASPEPSAGP CCCCEECCCCCCCCC	29.75	26074081
177	Phosphorylation	LLASPEPSAGPLQVA EECCCCCCCCCCEEE	44.17	26074081
189	Phosphorylation	QVAAPAHSHAGGPGP EEECCCCCCCCCCCC	19.69	26074081
197	Phosphorylation	HAGGPGPTEHA---- CCCCCCCCCCC----	46.44	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MED22_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED22_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED22_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED27_HUMAN	MED27	physical	12584197
MED7_HUMAN	MED7	physical	12584197
MED30_HUMAN	MED30	physical	12584197
THOC7_HUMAN	THOC7	physical	12584197
MED11_HUMAN	MED11	physical	12584197
MED24_HUMAN	MED24	physical	22939629
MED4_HUMAN	MED4	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.