MED27_HUMAN - dbPTM
MED27_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MED27_HUMAN
UniProt AC Q6P2C8
Protein Name Mediator of RNA polymerase II transcription subunit 27
Gene Name MED27
Organism Homo sapiens (Human).
Sequence Length 311
Subcellular Localization Nucleus .
Protein Description Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors..
Protein Sequence MADVINVSVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26PhosphorylationSAIQALRSSVSRVFD
HHHHHHHHHHHHHHH		35.6221406692
27PhosphorylationAIQALRSSVSRVFDC
HHHHHHHHHHHHHHH		20.0621406692
29PhosphorylationQALRSSVSRVFDCLK
HHHHHHHHHHHHHHH		25.3619664994
36UbiquitinationSRVFDCLKDGMRNKE
HHHHHHHHHHHCCHH		59.58-
36AcetylationSRVFDCLKDGMRNKE
HHHHHHHHHHHCCHH		59.5826051181
42UbiquitinationLKDGMRNKETLEGRE
HHHHHCCHHHHCHHH		41.53-
50 (in isoform 2)Ubiquitination-47.4321890473
50 (in isoform 1)Ubiquitination-47.4321890473
50UbiquitinationETLEGREKAFIAHFQ
HHHCHHHHHHHHHHH		47.4321890473
79 (in isoform 2)Ubiquitination-37.5821890473
79 (in isoform 1)Ubiquitination-37.5821890473
79UbiquitinationRLSNLVGKPSENHPL
HHHHHCCCCCCCCCC		37.5821906983
100UbiquitinationSLDPVQDKTPLYSQL
CCCCCCCCCCHHHHH		34.64-
104PhosphorylationVQDKTPLYSQLLQAY
CCCCCCHHHHHHHHH		8.7927642862
112 (in isoform 2)Ubiquitination-47.3521890473
112 (in isoform 1)Ubiquitination-47.3521890473
112UbiquitinationSQLLQAYKWSNKLQY
HHHHHHHHHCCHHHH		47.3521890473
116UbiquitinationQAYKWSNKLQYHAGL
HHHHHCCHHHHHHHH		31.3021890473
116 (in isoform 2)Ubiquitination-31.3021890473
116 (in isoform 1)Ubiquitination-31.3021890473
119PhosphorylationKWSNKLQYHAGLASG
HHCCHHHHHHHHHHH		12.2224117733
125PhosphorylationQYHAGLASGLLNQQS
HHHHHHHHHHCCHHH		34.7124117733
132PhosphorylationSGLLNQQSLKRSANQ
HHHCCHHHHHHHHHH		26.5422199227
134MethylationLLNQQSLKRSANQMG
HCCHHHHHHHHHHHC		49.9424129315
134UbiquitinationLLNQQSLKRSANQMG
HCCHHHHHHHHHHHC		49.9421906983
134 (in isoform 2)Ubiquitination-49.9421890473
134 (in isoform 1)Ubiquitination-49.9421890473
145 (in isoform 2)Ubiquitination-41.2421890473
145AcetylationNQMGVSAKRRPKAQP
HHHCCCCCCCCCCCC		41.2425953088
145 (in isoform 1)Ubiquitination-41.2421890473
145UbiquitinationNQMGVSAKRRPKAQP
HHHCCCCCCCCCCCC		41.2421906983
177PhosphorylationDRMFPEMSIHLSRPN
HHHCCCCEEEECCCC		12.75-
181PhosphorylationPEMSIHLSRPNGTSA
CCCEEEECCCCCCCH		31.37-
215UbiquitinationFIDRTIVKGYNENVY
CCCCHHHCCCCCCCC		52.4021906983
215 (in isoform 1)Ubiquitination-52.4021890473
222PhosphorylationKGYNENVYTEDGKLD
CCCCCCCCCCCCCEE		18.92-
227UbiquitinationNVYTEDGKLDIWSKS
CCCCCCCCEEEEECC		56.1421906983
227 (in isoform 1)Ubiquitination-56.1421890473
232PhosphorylationDGKLDIWSKSNYQVF
CCCEEEEECCCHHHH		26.92-
233 (in isoform 1)Ubiquitination-27.9421890473
233UbiquitinationGKLDIWSKSNYQVFQ
CCEEEEECCCHHHHH		27.9421890473
234PhosphorylationKLDIWSKSNYQVFQK
CEEEEECCCHHHHHH		34.94-
236PhosphorylationDIWSKSNYQVFQKVT
EEEECCCHHHHHHHC		17.10-
239 (in isoform 2)Ubiquitination-3.2521890473
243PhosphorylationYQVFQKVTDHATTAL
HHHHHHHCHHHHHHH		29.15-
275 (in isoform 1)Ubiquitination-34.7121890473
275UbiquitinationTWLRSYIKLFQAPCQ
HHHHHHHHHHHHHHH		34.7121890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MED27_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MED27_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MED27_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MED4_HUMANMED4physical
22939629
SUH_HUMANRBPJphysical
21988832
SOX5_HUMANSOX5physical
21988832
MED12_HUMANMED12physical
26344197
MED16_HUMANMED16physical
26344197
MED17_HUMANMED17physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MED27_HUMAN

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Related Literatures of Post-Translational Modification

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