SOX5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOX5_HUMAN
• UniProt AC: P35711
• Protein Name: Transcription factor SOX-5
• Gene Name: SOX5
• Organism: Homo sapiens (Human).
• Sequence Length: 763
• Subcellular Localization: Nucleus .
• Protein Description: Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro..
• Protein Sequence: MLTDPDLPQEFERMSSKRPASPYGEADGEVAMVTSRQKVEEEESDGLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGHRTPTSQHNTMEVDGNKVMSSFAPHNSSTSPQKAEEGGRQSGESLSSTALGTPERRKGSLADVVDTLKQRKMEELIKNEPEETPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQLYAAQLAAMQVSPGGKLPGIPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPTSPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQVLDGKVAVVNSLGLNNCRTEKEKTTLESLTQQLAVKQNEEGKFSHAMMDFNLSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPGAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGVKGEEPHIKEEIQAEDINGEIYDEYDEEEDDPDVDYGSDSENHIAGQAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8 (in isoform 4)	Phosphorylation	-	38.75	29507054
8 (in isoform 2)	Phosphorylation	-	38.75	29507054
15	Phosphorylation	PQEFERMSSKRPASP CHHHHHHHCCCCCCC	38.64	24043423
16	Phosphorylation	QEFERMSSKRPASPY HHHHHHHCCCCCCCC	24.28	24043423
21	Phosphorylation	MSSKRPASPYGEADG HHCCCCCCCCCCCCC	22.72	29255136
23	Phosphorylation	SKRPASPYGEADGEV CCCCCCCCCCCCCCE	25.71	24043423
34	Phosphorylation	DGEVAMVTSRQKVEE CCCEEEEECCHHHHH	12.71	24043423
35	Phosphorylation	GEVAMVTSRQKVEEE CCEEEEECCHHHHHH	22.70	24043423
82	Phosphorylation	QETCGHRTPTSQHNT CCCCCCCCCCCCCCC	25.83	29255136
84	Phosphorylation	TCGHRTPTSQHNTME CCCCCCCCCCCCCEE	40.17	25002506
85	Phosphorylation	CGHRTPTSQHNTMEV CCCCCCCCCCCCEEE	30.55	25002506
89	Phosphorylation	TPTSQHNTMEVDGNK CCCCCCCCEEECCCE	16.75	29255136
99	Phosphorylation	VDGNKVMSSFAPHNS ECCCEEEHHCCCCCC	25.87	27251275
100	Phosphorylation	DGNKVMSSFAPHNSS CCCEEEHHCCCCCCC	13.82	26714015
106	Phosphorylation	SSFAPHNSSTSPQKA HHCCCCCCCCCHHHH	31.77	29255136
107	Phosphorylation	SFAPHNSSTSPQKAE HCCCCCCCCCHHHHH	37.92	29255136
108	Phosphorylation	FAPHNSSTSPQKAEE CCCCCCCCCHHHHHH	44.22	29255136
109	Phosphorylation	APHNSSTSPQKAEEG CCCCCCCCHHHHHHC	27.55	29255136
120	Phosphorylation	AEEGGRQSGESLSST HHHCCCCCCCCCCCC	43.07	29255136
123	Phosphorylation	GGRQSGESLSSTALG CCCCCCCCCCCCCCC	36.76	29255136
125	Phosphorylation	RQSGESLSSTALGTP CCCCCCCCCCCCCCC	34.62	29255136
126	Phosphorylation	QSGESLSSTALGTPE CCCCCCCCCCCCCCH	24.00	23403867
127	Phosphorylation	SGESLSSTALGTPER CCCCCCCCCCCCCHH	23.64	27732954
131	Phosphorylation	LSSTALGTPERRKGS CCCCCCCCCHHHCCC	23.87	29255136
138	Phosphorylation	TPERRKGSLADVVDT CCHHHCCCHHHHHHH	24.34	29255136
145	Phosphorylation	SLADVVDTLKQRKME CHHHHHHHHHHHHHH	25.01	23312004
162	Phosphorylation	IKNEPEETPSIEKLL HHCCCCCCCCHHHHH	22.22	26270265
164	Phosphorylation	NEPEETPSIEKLLSK CCCCCCCCHHHHHCC	51.29	26270265
164	O-linked_Glycosylation	NEPEETPSIEKLLSK CCCCCCCCHHHHHCC	51.29	30379171
170	Phosphorylation	PSIEKLLSKDWKDKL CCHHHHHCCCHHHHH	38.72	26270265
171	Ubiquitination	SIEKLLSKDWKDKLL CHHHHHCCCHHHHHH	68.52	-
182	Phosphorylation	DKLLAMGSGNFGEIK HHHHHCCCCCCCCCC	19.92	-
191	Phosphorylation	NFGEIKGTPESLAEK CCCCCCCCHHHHHHH	20.91	25850435
194	Phosphorylation	EIKGTPESLAEKERQ CCCCCHHHHHHHHHH	33.80	25850435
210	Phosphorylation	MGMINQLTSLREQLL HHHHHHHHHHHHHHH	18.89	24043423
211	Phosphorylation	GMINQLTSLREQLLA HHHHHHHHHHHHHHH	33.74	25690035
370	Phosphorylation	GNLGAAVSPTSIHTD CCCCCCCCCCCCCCC	20.10	29255136
372	Phosphorylation	LGAAVSPTSIHTDKS CCCCCCCCCCCCCCC	32.57	29255136
373	Phosphorylation	GAAVSPTSIHTDKST CCCCCCCCCCCCCCC	18.76	29255136
376	Phosphorylation	VSPTSIHTDKSTNSP CCCCCCCCCCCCCCC	43.37	30108239
379	Phosphorylation	TSIHTDKSTNSPPPK CCCCCCCCCCCCCCC	35.31	25002506
380	Phosphorylation	SIHTDKSTNSPPPKS CCCCCCCCCCCCCCC	45.52	25002506
382	Phosphorylation	HTDKSTNSPPPKSKD CCCCCCCCCCCCCHH	38.58	25002506
403	Phosphorylation	NLSAKPKTSDGKSPT CCCCCCCCCCCCCCC	40.35	30108239
404	Phosphorylation	LSAKPKTSDGKSPTS CCCCCCCCCCCCCCC	50.95	30576142
408	Phosphorylation	PKTSDGKSPTSPTSP CCCCCCCCCCCCCCC	38.65	30576142
410	Phosphorylation	TSDGKSPTSPTSPHM CCCCCCCCCCCCCCC	55.20	28348404
411	Phosphorylation	SDGKSPTSPTSPHMP CCCCCCCCCCCCCCC	29.57	28348404
413	Phosphorylation	GKSPTSPTSPHMPAL CCCCCCCCCCCCCCE	55.44	28348404
414	Phosphorylation	KSPTSPTSPHMPALR CCCCCCCCCCCCCEE	19.05	30177828
424	Phosphorylation	MPALRINSGAGPLKA CCCEEECCCCCCCCC	27.87	26714015
432	Phosphorylation	GAGPLKASVPAALAS CCCCCCCCCCHHHCC	27.35	23312004
439	Phosphorylation	SVPAALASPSARVST CCCHHHCCCCCCEEE	21.90	29255136
441	Phosphorylation	PAALASPSARVSTIG CHHHCCCCCCEEECC	26.64	29255136
445	Phosphorylation	ASPSARVSTIGYLND CCCCCCEEECCCCCC	14.57	-
446	Phosphorylation	SPSARVSTIGYLNDH CCCCCEEECCCCCCH	18.63	-
467	Sumoylation	IQEARQMKEQLRREQ HHHHHHHHHHHHHHH	33.69	-
486	Phosphorylation	GKVAVVNSLGLNNCR CCEEEEECCCCCCCC	16.53	26714015
503	Phosphorylation	KEKTTLESLTQQLAV HHHHHHHHHHHHHHH	39.57	-
505	Phosphorylation	KTTLESLTQQLAVKQ HHHHHHHHHHHHHHC	24.45	-
519	Phosphorylation	QNEEGKFSHAMMDFN CCCCCCCCEEEEEEE	17.52	18669648
528	Phosphorylation	AMMDFNLSGDSDGSA EEEEEECCCCCCCCC	41.48	20363803
531	Phosphorylation	DFNLSGDSDGSAGVS EEECCCCCCCCCCCC	47.61	20363803
534	Phosphorylation	LSGDSDGSAGVSESR CCCCCCCCCCCCHHH	27.17	20363803
538	Phosphorylation	SDGSAGVSESRIYRE CCCCCCCCHHHHHHH	29.01	18669648
540	Phosphorylation	GSAGVSESRIYRESR CCCCCCHHHHHHHCC	19.24	18669648
549	Methylation	IYRESRGRGSNEPHI HHHHCCCCCCCCCCC	44.23	115917553
595	Acetylation	KILGSRWKAMTNLEK HHHHHHHHHHHCCCC	27.46	19822063
619	Ubiquitination	LSKQHLEKYPDYKYK HHHHHHHHCCCCCCC	69.33	-
620	Phosphorylation	SKQHLEKYPDYKYKP HHHHHHHCCCCCCCC	7.61	26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOX5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOX5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOX5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
TTC1_HUMAN	TTC1	physical	21988832
UCRI_HUMAN	UQCRFS1	physical	21988832
TAF6_HUMAN	TAF6	physical	23884650
SOX5_HUMAN	SOX5	physical	25416956
CDC23_HUMAN	CDC23	physical	25416956
KAT5_HUMAN	KAT5	physical	25416956
ARI5A_HUMAN	ARID5A	physical	25416956
ZN581_HUMAN	ZNF581	physical	25416956
CBX8_HUMAN	CBX8	physical	25416956
FA46B_HUMAN	FAM46B	physical	25416956
PR20E_HUMAN	PRR20A	physical	25416956
PR20C_HUMAN	PRR20A	physical	25416956
PR20D_HUMAN	PRR20A	physical	25416956
PR20B_HUMAN	PRR20A	physical	25416956
PR20A_HUMAN	PRR20A	physical	25416956
MORN3_HUMAN	MORN3	physical	25416956
SOX6_HUMAN	SOX6	physical	28514442
SOX13_HUMAN	SOX13	physical	28514442
SOX1_HUMAN	SOX1	physical	28514442
ANR40_HUMAN	ANKRD40	physical	28514442
SOX11_HUMAN	SOX11	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.