SOX13_HUMAN - dbPTM
SOX13_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SOX13_HUMAN
UniProt AC Q9UN79
Protein Name Transcription factor SOX-13
Gene Name SOX13
Organism Homo sapiens (Human).
Sequence Length 622
Subcellular Localization Nucleus .
Protein Description Binds to the sequence 5'-AACAAT-3'..
Protein Sequence MSMRSPISAQLALDGVGTMVNCTIKSEEKKEPCHEAPQGSATAAEPQPGDPARASQDSADPQAPAQGNFRGSWDCSSPEGNGSPEPKRPGVSEAASGSQEKLDFNRNLKEVVPAIEKLLSSDWKERFLGRNSMEAKDVKGTQESLAEKELQLLVMIHQLSTLRDQLLTAHSEQKNMAAMLFEKQQQQMELARQQQEQIAKQQQQLIQQQHKINLLQQQIQQVNMPYVMIPAFPPSHQPLPVTPDSQLALPIQPIPCKPVEYPLQLLHSPPAPVVKRPGAMATHHPLQEPSQPLNLTAKPKAPELPNTSSSPSLKMSSCVPRPPSHGGPTRDLQSSPPSLPLGFLGEGDAVTKAIQDARQLLHSHSGALDGSPNTPFRKDLISLDSSPAKERLEDGCVHPLEEAMLSCDMDGSRHFPESRNSSHIKRPMNAFMVWAKDERRKILQAFPDMHNSSISKILGSRWKSMTNQEKQPYYEEQARLSRQHLEKYPDYKYKPRPKRTCIVEGKRLRVGEYKALMRTRRQDARQSYVIPPQAGQVQMSSSDVLYPRAAGMPLAQPLVEHYVPRSLDPNMPVIVNTCSLREEGEGTDDRHSVADGEMYRYSEDEDSEGEEKSDGELVVLTD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSMRSPISA
------CCCCCCHHH		23.9324719451
5Phosphorylation---MSMRSPISAQLA
---CCCCCCHHHHHH		20.2425850435
8PhosphorylationMSMRSPISAQLALDG
CCCCCCHHHHHHHCC		17.2225850435
72PhosphorylationAQGNFRGSWDCSSPE
CCCCCCCCCCCCCCC		18.5823090842
76PhosphorylationFRGSWDCSSPEGNGS
CCCCCCCCCCCCCCC		46.5928450419
77PhosphorylationRGSWDCSSPEGNGSP
CCCCCCCCCCCCCCC		33.0529507054
83PhosphorylationSSPEGNGSPEPKRPG
CCCCCCCCCCCCCCC		30.0428192239
96PhosphorylationPGVSEAASGSQEKLD
CCCCHHHCCCHHHCC		46.1328450419
98PhosphorylationVSEAASGSQEKLDFN
CCHHHCCCHHHCCCC		32.4425849741
101UbiquitinationAASGSQEKLDFNRNL
HHCCCHHHCCCCCCH		45.8029967540
117UbiquitinationEVVPAIEKLLSSDWK
HHHHHHHHHHCCHHH		48.9229967540
120PhosphorylationPAIEKLLSSDWKERF
HHHHHHHCCHHHHHH		36.3723403867
121PhosphorylationAIEKLLSSDWKERFL
HHHHHHCCHHHHHHH		47.6723403867
124UbiquitinationKLLSSDWKERFLGRN
HHHCCHHHHHHHCCC		43.9629967540
132PhosphorylationERFLGRNSMEAKDVK
HHHHCCCCCCHHHCC		19.3525159151
139SumoylationSMEAKDVKGTQESLA
CCCHHHCCCCHHHHH		67.39-
139SumoylationSMEAKDVKGTQESLA
CCCHHHCCCCHHHHH		67.39-
141PhosphorylationEAKDVKGTQESLAEK
CHHHCCCCHHHHHHH		24.36-
144PhosphorylationDVKGTQESLAEKELQ
HCCCCHHHHHHHHHH		24.06-
183UbiquitinationMAAMLFEKQQQQMEL
HHHHHHHHHHHHHHH		46.1829967540
200UbiquitinationQQQEQIAKQQQQLIQ
HHHHHHHHHHHHHHH		50.7129967540
268PhosphorylationYPLQLLHSPPAPVVK
CCCHHHCCCCCCCCC		32.3325849741
290PhosphorylationHHPLQEPSQPLNLTA
CCCCCCCCCCCCCCC		43.6120068231
298PhosphorylationQPLNLTAKPKAPELP
CCCCCCCCCCCCCCC		41.6418669648
298AcetylationQPLNLTAKPKAPELP
CCCCCCCCCCCCCCC		41.6419829995
299PhosphorylationPLNLTAKPKAPELPN
CCCCCCCCCCCCCCC		35.2618669648
307PhosphorylationKAPELPNTSSSPSLK
CCCCCCCCCCCCCCC		28.2230278072
308PhosphorylationAPELPNTSSSPSLKM
CCCCCCCCCCCCCCH		35.1430278072
309PhosphorylationPELPNTSSSPSLKMS
CCCCCCCCCCCCCHH		44.2030278072
310PhosphorylationELPNTSSSPSLKMSS
CCCCCCCCCCCCHHH		20.4825159151
312PhosphorylationPNTSSSPSLKMSSCV
CCCCCCCCCCHHHCC		42.4422617229
316PhosphorylationSSPSLKMSSCVPRPP
CCCCCCHHHCCCCCC		20.9918669648
317PhosphorylationSPSLKMSSCVPRPPS
CCCCCHHHCCCCCCC		18.6818669648
324PhosphorylationSCVPRPPSHGGPTRD
HCCCCCCCCCCCCCC		37.1325849741
329PhosphorylationPPSHGGPTRDLQSSP
CCCCCCCCCCCCCCC		39.8423927012
334PhosphorylationGPTRDLQSSPPSLPL
CCCCCCCCCCCCCCC		52.7030278072
335PhosphorylationPTRDLQSSPPSLPLG
CCCCCCCCCCCCCCE		28.0630278072
338PhosphorylationDLQSSPPSLPLGFLG
CCCCCCCCCCCEECC		46.1030278072
351PhosphorylationLGEGDAVTKAIQDAR
CCCCHHHHHHHHHHH		19.24-
365PhosphorylationRQLLHSHSGALDGSP
HHHHHHCCCCCCCCC		28.8620068231
371PhosphorylationHSGALDGSPNTPFRK
CCCCCCCCCCCCCHH		18.0425159151
374PhosphorylationALDGSPNTPFRKDLI
CCCCCCCCCCHHHHC		27.4726055452
378UbiquitinationSPNTPFRKDLISLDS
CCCCCCHHHHCCCCC		58.2129967540
382PhosphorylationPFRKDLISLDSSPAK
CCHHHHCCCCCCHHH		33.1625159151
385PhosphorylationKDLISLDSSPAKERL
HHHCCCCCCHHHHHH		43.4429255136
386PhosphorylationDLISLDSSPAKERLE
HHCCCCCCHHHHHHC		28.6619664994
389UbiquitinationSLDSSPAKERLEDGC
CCCCCHHHHHHCCCC		46.9129967540
452PhosphorylationAFPDMHNSSISKILG
HCCCCCHHHHHHHHH		17.8625627689
453PhosphorylationFPDMHNSSISKILGS
CCCCCHHHHHHHHHH		35.8825627689
474PhosphorylationNQEKQPYYEEQARLS
CCCCCCHHHHHHHHH		21.48-
487UbiquitinationLSRQHLEKYPDYKYK
HHHHHHHHCCCCCCC		69.3329967540
488PhosphorylationSRQHLEKYPDYKYKP
HHHHHHHCCCCCCCC		7.6126657352
514SumoylationRLRVGEYKALMRTRR
EEEHHHHHHHHHHHC		30.64-
514SumoylationRLRVGEYKALMRTRR
EEEHHHHHHHHHHHC		30.64-
592PhosphorylationEGTDDRHSVADGEMY
CCCCCCCCCCCCCEE		21.6421406692
599PhosphorylationSVADGEMYRYSEDED
CCCCCCEEEECCCCC		11.3320068231
601PhosphorylationADGEMYRYSEDEDSE
CCCCEEEECCCCCCC		10.0221406692
602PhosphorylationDGEMYRYSEDEDSEG
CCCEEEECCCCCCCC		29.5820363803
607PhosphorylationRYSEDEDSEGEEKSD
EECCCCCCCCCCCCC		45.5120363803
613PhosphorylationDSEGEEKSDGELVVL
CCCCCCCCCCCEEEE		54.8725159151
621PhosphorylationDGELVVLTD------
CCCEEEECC------		28.2225159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SOX13_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SOX13_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SOX13_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SOX13_HUMANSOX13physical
10871192
YTDC1_HUMANYTHDC1physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SOX13_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335; SER-382 ANDSER-386, AND MASS SPECTROMETRY.

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