SOX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOX1_HUMAN
• UniProt AC: O00570
• Protein Name: Transcription factor SOX-1
• Gene Name: SOX1
• Organism: Homo sapiens (Human).
• Sequence Length: 391
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity)..
• Protein Sequence: MYSMMMETDLHSPGGAQAPTNLSGPAGAGGGGGGGGGGGGGGGAKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKDKYSLAGGLLAAGAGGGGAAVAMGVGVGVGAAAVGQRLESPGGAAGGGYAHVNGWANGAYPGSVAAAAAAAAMMQEAQLAYGQHPGAGGAHPHAHPAHPHPHHPHAHPHNPQPMHRYDMGALQYSPISNSQGYMSASPSGYGGLPYGAAAAAAAAAGGAHQNSAVAAAAAAAAASSGALGALGSLVKSEPSGSPPAPAHSRAPCPGDLREMISMYLPAGEGGDPAAAAAAAAQSRLHSLPQHYQGAGAGVNGTVPLTHI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MYSMMMETD ------CCCCCCCCC	12.79	23403867
3	Phosphorylation	-----MYSMMMETDL -----CCCCCCCCCC	10.02	28857561
8	Phosphorylation	MYSMMMETDLHSPGG CCCCCCCCCCCCCCC	26.43	28857561
12	Phosphorylation	MMETDLHSPGGAQAP CCCCCCCCCCCCCCC	32.32	28857561
20	Phosphorylation	PGGAQAPTNLSGPAG CCCCCCCCCCCCCCC	52.38	28857561
23	Phosphorylation	AQAPTNLSGPAGAGG CCCCCCCCCCCCCCC	44.81	28857561
62	Phosphorylation	MNAFMVWSRGQRRKM CCCHHHCCHHHHHHH	18.34	30631047
79	Phosphorylation	ENPKMHNSEISKRLG HCCCCCHHHHHHHHC	22.94	-
82	Phosphorylation	KMHNSEISKRLGAEW CCCHHHHHHHHCCHH	13.99	-
83	Acetylation	MHNSEISKRLGAEWK CCHHHHHHHHCCHHH	58.25	18585041
93	Phosphorylation	GAEWKVMSEAEKRPF CCHHHCCCHHHHCCC	36.32	24719451
132	Acetylation	KTKTLLKKDKYSLAG CCHHHHHCCCCCHHH	60.46	15607489
320	Phosphorylation	ALGSLVKSEPSGSPP HHHHHHHCCCCCCCC	47.46	28555341
323	Phosphorylation	SLVKSEPSGSPPAPA HHHHCCCCCCCCCCC	48.10	28555341
325	Phosphorylation	VKSEPSGSPPAPAHS HHCCCCCCCCCCCCC	31.86	26670566

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNB1_HUMAN	CTNNB1	physical	22767186

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.