UCRI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UCRI_HUMAN
• UniProt AC: P47985
• Protein Name: Cytochrome b-c1 complex subunit Rieske, mitochondrial
• Gene Name: UQCRFS1 {ECO:0000312|HGNC:HGNC:12587}
• Organism: Homo sapiens (Human).
• Sequence Length: 274
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein .
• Protein Description: Cytochrome b-c1 complex subunit Rieske, mitochondrial: Component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. [PubMed: 28673544 Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity; Cytochrome b-c1 complex subunit 9: Possible component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis]
• Protein Sequence: MLSVASRSGPFAPVLSATSRGVAGALRPLVQATVPATPEQPVLDLKRPFLSRESLSGQAVRRPLVASVGLNVPASVCYSHTDIKVPDFSEYRRLEVLDSTKSSRESSEARKGFSYLVTGVTTVGVAYAAKNAVTQFVSSMSASADVLALAKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTQKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRLGPAPLNLEVPTYEFTSDDMVIVG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MLSVASRSGP -----CCCCCCCCCC	17.84	27251275
6	Phosphorylation	--MLSVASRSGPFAP --CCCCCCCCCCCHH	25.48	27251275
8	Phosphorylation	MLSVASRSGPFAPVL CCCCCCCCCCCHHHC	48.61	27251275
16	Phosphorylation	GPFAPVLSATSRGVA CCCHHHCCCCCCCHH	29.72	27251275
18	Phosphorylation	FAPVLSATSRGVAGA CHHHCCCCCCCHHHH	18.64	27251275
19	Phosphorylation	APVLSATSRGVAGAL HHHCCCCCCCHHHHH	27.10	27251275
37	Phosphorylation	VQATVPATPEQPVLD EECCCCCCCCCCCCC	22.68	26657352
46	Acetylation	EQPVLDLKRPFLSRE CCCCCCCCCCCCCCC	58.66	24469447
46	Ubiquitination	EQPVLDLKRPFLSRE CCCCCCCCCCCCCCC	58.66	23503661
54	Phosphorylation	RPFLSRESLSGQAVR CCCCCCCCCCCCCCC	27.07	28787133
91	Phosphorylation	KVPDFSEYRRLEVLD CCCCHHHHHHHHHHH	10.39	23917254
99	Phosphorylation	RRLEVLDSTKSSRES HHHHHHHCCCCCHHC	33.31	30266825
99	O-linked_Glycosylation	RRLEVLDSTKSSRES HHHHHHHCCCCCHHC	33.31	30379171
100	Phosphorylation	RLEVLDSTKSSRESS HHHHHHCCCCCHHCH	34.31	30266825
101	Ubiquitination	LEVLDSTKSSRESSE HHHHHCCCCCHHCHH	50.84	24816145
102	Phosphorylation	EVLDSTKSSRESSEA HHHHCCCCCHHCHHH	34.41	24641631
103	Phosphorylation	VLDSTKSSRESSEAR HHHCCCCCHHCHHHH	41.44	24641631
115	Phosphorylation	EARKGFSYLVTGVTT HHHHCCCEEHHCCCH	11.70	18083107
122	Phosphorylation	YLVTGVTTVGVAYAA EEHHCCCHHHHHHHH	16.92	-
151	Ubiquitination	ADVLALAKIEIKLSD HHHHHHEEEEEEHHH	41.54	23503661
155	Ubiquitination	ALAKIEIKLSDIPEG HHEEEEEEHHHCCCC	29.19	23503661
157	Phosphorylation	AKIEIKLSDIPEGKN EEEEEEHHHCCCCCC	28.61	20833797
163	Ubiquitination	LSDIPEGKNMAFKWR HHHCCCCCCCCEEEC	41.72	21906983
163	Acetylation	LSDIPEGKNMAFKWR HHHCCCCCCCCEEEC	41.72	2380351
168	Ubiquitination	EGKNMAFKWRGKPLF CCCCCCEEECCEEEE	26.83	22817900
172	Ubiquitination	MAFKWRGKPLFVRHR CCEEECCEEEEEECC	29.94	22817900
182	Ubiquitination	FVRHRTQKEIEQEAA EEECCCHHHHHHHHH	61.11	21906983
193	Phosphorylation	QEAAVELSQLRDPQH HHHHHHHHHHCCCCC	17.42	30266825
196	Methylation	AVELSQLRDPQHDLD HHHHHHHCCCCCCHH	46.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UCRI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UCRI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UCRI_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VAPB_HUMAN	VAPB	physical	22939629
ZN454_HUMAN	ZNF454	physical	22939629
AL1B1_HUMAN	ALDH1B1	physical	26344197
CX6B1_HUMAN	COX6B1	physical	26344197
CY1_HUMAN	CYC1	physical	26344197
CYC_HUMAN	CYCS	physical	26344197
LYAG_HUMAN	GAA	physical	26344197
LEG1_HUMAN	LGALS1	physical	26344197
MDHC_HUMAN	MDH1	physical	26344197
CYB_HUMAN	CYTB	physical	26344197
NDUA9_HUMAN	NDUFA9	physical	26344197
PGM1_HUMAN	PGM1	physical	26344197
TPIS_HUMAN	TPI1	physical	26344197
TXD17_HUMAN	TXNDC17	physical	26344197
QCR8_HUMAN	UQCRQ	physical	26344197
XPP1_HUMAN	XPNPEP1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.