ZN454_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN454_HUMAN
• UniProt AC: Q8N9F8
• Protein Name: Zinc finger protein 454
• Gene Name: ZNF454
• Organism: Homo sapiens (Human).
• Sequence Length: 522
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MAVSHLPTMVQESVTFKDVAILFTQEEWGQLSPAQRALYRDVMLENYSNLVSLGLLGPKPDTFSQLEKREVWMPEDTPGGFCLDWMTMPASKKSTVKAEIPEEELDQWTIKERFSSSSHWKCASLLEWQCGGQEISLQRVVLTHPNTPSQECDESGSTMSSSLHSDQSQGFQPSKNAFECSECGKVFSKSSTLNKHQKIHNEKNANQKIHIKEKRYECRECGKAFHQSTHLIHHQRIHTGEKPYECKECGKAFSVSSSLTYHQKIHTGEKPFECNLCGKAFIRNIHLAHHHRIHTGEKPFKCNICEKAFVCRAHLTKHQNIHSGEKPYKCNECGKAFNQSTSFLQHQRIHTGEKPFECNECGKAFRVNSSLTEHQRIHTGEKPYKCNECGKAFRDNSSFARHRKIHTGEKPYRCGLCEKAFRDQSALAQHQRIHTGEKPYTCNICEKAFSDHSALTQHKRIHTREKPYKCKICEKAFIRSTHLTQHQRIHTGEKPYKCNKCGKAFNQTANLIQHQRHHIGEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
94	Phosphorylation	TMPASKKSTVKAEIP ECCCCCCCCEEEECC	42.01	29449344
95	Phosphorylation	MPASKKSTVKAEIPE CCCCCCCCEEEECCH	34.60	29449344
109	Phosphorylation	EEELDQWTIKERFSS HHHHHHHCHHHHHCC	19.28	29449344
115	Phosphorylation	WTIKERFSSSSHWKC HCHHHHHCCCCCCCH	35.22	29449344
116	Phosphorylation	TIKERFSSSSHWKCA CHHHHHCCCCCCCHH	32.90	29449344
117	Phosphorylation	IKERFSSSSHWKCAS HHHHHCCCCCCCHHH	25.64	29449344
118	Phosphorylation	KERFSSSSHWKCASL HHHHCCCCCCCHHHH	35.00	29449344
136	Phosphorylation	QCGGQEISLQRVVLT CCCCEEEEEEEEEEE	20.07	24719451
239	Phosphorylation	IHHQRIHTGEKPYEC HCCCCCCCCCCCEEC	44.67	29496963
247	Sumoylation	GEKPYECKECGKAFS CCCCEECCCCCCEEE	44.06	-
247	Sumoylation	GEKPYECKECGKAFS CCCCEECCCCCCEEE	44.06	-
254	Phosphorylation	KECGKAFSVSSSLTY CCCCCEEEEECCEEE	26.42	30576142
256	Phosphorylation	CGKAFSVSSSLTYHQ CCCEEEEECCEEEEE	17.01	30576142
260	Phosphorylation	FSVSSSLTYHQKIHT EEEECCEEEEECCCC	22.39	30576142
261	Phosphorylation	SVSSSLTYHQKIHTG EEECCEEEEECCCCC	13.93	30576142
295	Phosphorylation	AHHHRIHTGEKPFKC HHCCCCCCCCCCCCC	44.67	18669648
323	Phosphorylation	TKHQNIHSGEKPYKC CCCCCCCCCCCCEEC	44.87	29496963
329	Sumoylation	HSGEKPYKCNECGKA CCCCCCEECCCHHHH	38.83	-
329	Sumoylation	HSGEKPYKCNECGKA CCCCCCEECCCHHHH	38.83	-
351	Phosphorylation	LQHQRIHTGEKPFEC HHHCCCCCCCCCEEC	44.67	21712546
354	Ubiquitination	QRIHTGEKPFECNEC CCCCCCCCCEECCCC	57.25	-
379	Phosphorylation	TEHQRIHTGEKPYKC CCCCCCCCCCCCCCC	44.67	29496963
384	Phosphorylation	IHTGEKPYKCNECGK CCCCCCCCCCCCCHH	38.96	18767875
385	Sumoylation	HTGEKPYKCNECGKA CCCCCCCCCCCCHHH	38.83	-
385	Sumoylation	HTGEKPYKCNECGKA CCCCCCCCCCCCHHH	38.83	-
407	Phosphorylation	ARHRKIHTGEKPYRC HHCCCCCCCCCCCCC	50.97	29496963
410	Sumoylation	RKIHTGEKPYRCGLC CCCCCCCCCCCCCCC	49.01	-
410	Sumoylation	RKIHTGEKPYRCGLC CCCCCCCCCCCCCCC	49.01	-
410	Ubiquitination	RKIHTGEKPYRCGLC CCCCCCCCCCCCCCC	49.01	-
435	Phosphorylation	AQHQRIHTGEKPYTC HHHHCHHCCCCCCCC	44.67	26055452
456	Phosphorylation	FSDHSALTQHKRIHT CCCCCHHHHCCCCCC	28.48	-
463	Phosphorylation	TQHKRIHTREKPYKC HHCCCCCCCCCCCCC	37.85	-
491	Phosphorylation	TQHQRIHTGEKPYKC CCCCCCCCCCCCCCC	44.67	29496963
508	Phosphorylation	CGKAFNQTANLIQHQ CHHHHHHHHHHHHHH	20.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN454_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN454_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN454_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN454_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.