QCR8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: QCR8_HUMAN
• UniProt AC: O14949
• Protein Name: Cytochrome b-c1 complex subunit 8
• Gene Name: UQCRQ
• Organism: Homo sapiens (Human).
• Sequence Length: 82
• Subcellular Localization: Mitochondrion inner membrane.
• Protein Description: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone..
• Protein Sequence: MGREFGNLTRMRHVISYSLSPFEQRAYPHVFTKGIPNVLRRIRESFFRVVPQFVVFYLIYTWGTEEFERSKRKNPAAYENDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Methylation	REFGNLTRMRHVISY CCCCHHHHHCHHHEE	24.25	115919565
12	Methylation	FGNLTRMRHVISYSL CCHHHHHCHHHEEEC	20.03	115919569
16	Phosphorylation	TRMRHVISYSLSPFE HHHCHHHEEECCHHH	13.95	28152594
17	Phosphorylation	RMRHVISYSLSPFEQ HHCHHHEEECCHHHH	11.51	28152594
18	Phosphorylation	MRHVISYSLSPFEQR HCHHHEEECCHHHHH	18.64	28152594
20	Phosphorylation	HVISYSLSPFEQRAY HHHEEECCHHHHHCC	22.92	28152594
25	Methylation	SLSPFEQRAYPHVFT ECCHHHHHCCCCHHC	28.96	115919573
32	Phosphorylation	RAYPHVFTKGIPNVL HCCCCHHCCCHHHHH	27.54	-
33	Ubiquitination	AYPHVFTKGIPNVLR CCCCHHCCCHHHHHH	43.29	23000965
33	Succinylation	AYPHVFTKGIPNVLR CCCCHHCCCHHHHHH	43.29	-
33	Malonylation	AYPHVFTKGIPNVLR CCCCHHCCCHHHHHH	43.29	26320211
33	Succinylation	AYPHVFTKGIPNVLR CCCCHHCCCHHHHHH	43.29	-
33	Acetylation	AYPHVFTKGIPNVLR CCCCHHCCCHHHHHH	43.29	25953088
45	Phosphorylation	VLRRIRESFFRVVPQ HHHHHHHHHHHHHHH	21.60	24719451
73	Ubiquitination	EFERSKRKNPAAYEN HHHHHHCCCHHHHCC	71.65	27667366
73	Acetylation	EFERSKRKNPAAYEN HHHHHHCCCHHHHCC	71.65	26051181
78	Phosphorylation	KRKNPAAYENDK--- HCCCHHHHCCCC---	19.85	29496907
82	Acetylation	PAAYENDK------- HHHHCCCC-------	74.04	2380467

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of QCR8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of QCR8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of QCR8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SSBP_HUMAN	SSBP1	physical	22939629
THIL_HUMAN	ACAT1	physical	26344197
AL1B1_HUMAN	ALDH1B1	physical	26344197
AL3A2_HUMAN	ALDH3A2	physical	26344197
AT2A2_HUMAN	ATP2A2	physical	26344197
ATPG_HUMAN	ATP5C1	physical	26344197
CPT2_HUMAN	CPT2	physical	26344197
OST48_HUMAN	DDOST	physical	26344197
GPDM_HUMAN	GPD2	physical	26344197
ILVBL_HUMAN	ILVBL	physical	26344197
MIC60_HUMAN	IMMT	physical	26344197
NDUS3_HUMAN	NDUFS3	physical	26344197
PDC6I_HUMAN	PDCD6IP	physical	26344197
ODPB_HUMAN	PDHB	physical	26344197
PHB_HUMAN	PHB	physical	26344197
RAB1B_HUMAN	RAB1B	physical	26344197
SFXN1_HUMAN	SFXN1	physical	26344197
SFXN3_HUMAN	SFXN3	physical	26344197
SGPL1_HUMAN	SGPL1	physical	26344197
QCR2_HUMAN	UQCRC2	physical	26344197
QCR7_HUMAN	UQCRB	physical	28514442
COX7R_HUMAN	COX7A2L	physical	28514442
CYB_HUMAN	CYTB	physical	28514442
BPIA2_HUMAN	BPIFA2	physical	28514442
CYTN_HUMAN	CST1	physical	28514442
CX6B1_HUMAN	COX6B1	physical	28514442
QCR1_HUMAN	UQCRC1	physical	28514442
QCR2_HUMAN	UQCRC2	physical	28514442
CYTS_HUMAN	CST4	physical	28514442
PGES2_HUMAN	PTGES2	physical	28514442
COX1_HUMAN	COX1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00473: Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
• OMIM Disease
• 615159: Mitochondrial complex III deficiency, nuclear 4 (MC3DN4)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.