AL3A2_HUMAN - dbPTM
AL3A2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AL3A2_HUMAN
UniProt AC P51648
Protein Name Fatty aldehyde dehydrogenase
Gene Name ALDH3A2
Organism Homo sapiens (Human).
Sequence Length 485
Subcellular Localization Microsome membrane
Single-pass membrane protein . Endoplasmic reticulum membrane
Single-pass membrane protein
Cytoplasmic side .
Protein Description Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. [PubMed: 9133646]
Protein Sequence MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKAEYY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationRVRQAFLSGRSRPLR
HHHHHHHCCCCCCHH		26.2146162025
18UbiquitinationAFLSGRSRPLRFRLQ
HHHCCCCCCHHHHHH		32.6732015554
25UbiquitinationRPLRFRLQQLEALRR
CCHHHHHHHHHHHHH		41.3729901268
31MethylationLQQLEALRRMVQERE
HHHHHHHHHHHHHHH		31.53-
39UbiquitinationRMVQEREKDILTAIA
HHHHHHHHHHHHHHH		57.1829967540
73UbiquitinationGEIDFMLENLPEWVT
HHHHHHHHCCCHHHC		44.9533845483
81UbiquitinationNLPEWVTAKPVKKNV
CCCHHHCCCCCCCCH		12.4433845483
106UbiquitinationPQPLGVVLIIGAWNY
CCCCEEEEEECCCCC		1.8833845483
131UbiquitinationGAIAAGNAVIIKPSE
HHHHCCCEEEECHHH		7.9333845483
133UbiquitinationIAAGNAVIIKPSELS
HHCCCEEEECHHHCC		2.8833845483
145UbiquitinationELSENTAKILAKLLP
HCCHHHHHHHHHHHH		35.8933845483
150UbiquitinationTAKILAKLLPQYLDQ
HHHHHHHHHHHHCCC		7.5933845483
176UbiquitinationETTELLKQRFDHIFY
HHHHHHHHHCCEEEE		51.7733845483
199UbiquitinationIVMEAAAKHLTPVTL
HHHHHHHCCCCCEEE		34.1329967540
202PhosphorylationEAAAKHLTPVTLELG
HHHHCCCCCEEEEEC		18.55110746271
2112-HydroxyisobutyrylationVTLELGGKSPCYIDK
EEEEECCCCCEECCC		49.80-
211UbiquitinationVTLELGGKSPCYIDK
EEEEECCCCCEECCC		49.8032015554
218UbiquitinationKSPCYIDKDCDLDIV
CCCEECCCCCCCEEE		51.1829901268
218AcetylationKSPCYIDKDCDLDIV
CCCEECCCCCCCEEE		51.1825825284
259UbiquitinationSLQNQIVWKIKETVK
HHCCCHHHHHHHHHH		9.7833845483
262UbiquitinationNQIVWKIKETVKEFY
CCHHHHHHHHHHHHH		43.5422817900
266 (in isoform 2)Ubiquitination-49.9121890473
266UbiquitinationWKIKETVKEFYGENI
HHHHHHHHHHHCCCC		49.9121890473
266UbiquitinationWKIKETVKEFYGENI
HHHHHHHHHHHCCCC		49.9122817900
2662-HydroxyisobutyrylationWKIKETVKEFYGENI
HHHHHHHHHHHCCCC		49.91-
266 (in isoform 1)Ubiquitination-49.9121890473
274 (in isoform 2)Ubiquitination-64.8221890473
274UbiquitinationEFYGENIKESPDYER
HHHCCCCCCCCCHHH		64.8221906983
274 (in isoform 1)Ubiquitination-64.8221890473
293PhosphorylationRHFKRILSLLEGQKI
HHHHHHHHHHCCCCE		28.6525159151
299 (in isoform 1)Ubiquitination-47.0221890473
299 (in isoform 2)Ubiquitination-47.0221890473
299UbiquitinationLSLLEGQKIAFGGET
HHHHCCCCEECCCCC		47.0221906983
306PhosphorylationKIAFGGETDEATRYI
CEECCCCCCHHHHHC		42.27110746279
312PhosphorylationETDEATRYIAPTVLT
CCCHHHHHCCCEECC		9.3323403867
316PhosphorylationATRYIAPTVLTDVDP
HHHHCCCEECCCCCC		21.0823403867
319PhosphorylationYIAPTVLTDVDPKTK
HCCCEECCCCCCCCH		29.6423403867
3242-HydroxyisobutyrylationVLTDVDPKTKVMQEE
ECCCCCCCCHHHHHH		57.42-
324 (in isoform 1)Ubiquitination-57.4221890473
324 (in isoform 2)Ubiquitination-57.4221890473
324UbiquitinationVLTDVDPKTKVMQEE
ECCCCCCCCHHHHHH		57.4221906983
325PhosphorylationLTDVDPKTKVMQEEI
CCCCCCCCHHHHHHH		33.9729083192
326UbiquitinationTDVDPKTKVMQEEIF
CCCCCCCHHHHHHHH		41.6621906983
326 (in isoform 2)Ubiquitination-41.6621890473
326 (in isoform 1)Ubiquitination-41.6621890473
343 (in isoform 2)Ubiquitination-45.22-
343UbiquitinationILPIVPVKNVDEAIN
CCCEEECCCHHHHHH		45.2233845483
357UbiquitinationNFINEREKPLALYVF
HHHHHCCCCEEEEEE		52.1029967540
369UbiquitinationYVFSHNHKLIKRMID
EEECCCHHHHHHHHH		58.1733845483
415PhosphorylationGAYHGKHSFDTFSHQ
CCCCCCCCCCCCCCC		28.4420873877
425S-palmitoylationTFSHQRPCLLKSLKR
CCCCCCCCHHHHHHH		8.2821044946
428UbiquitinationHQRPCLLKSLKREGA
CCCCCHHHHHHHCCC		40.5729967540
428MethylationHQRPCLLKSLKREGA
CCCCCHHHHHHHCCC		40.57-
447UbiquitinationYPPNSQSKVDWGKFF
CCCCCCCCCCHHHHH		36.2522817900
452UbiquitinationQSKVDWGKFFLLKRF
CCCCCHHHHHHHHHC		28.7922817900
452 (in isoform 1)Ubiquitination-28.7921890473
452 (in isoform 2)Ubiquitination-28.7921890473
452UbiquitinationQSKVDWGKFFLLKRF
CCCCCHHHHHHHHHC		28.7921890473
457UbiquitinationWGKFFLLKRFNKEKL
HHHHHHHHHCCHHHH		58.0322817900
457AcetylationWGKFFLLKRFNKEKL
HHHHHHHHHCCHHHH		58.0325825284
457 (in isoform 2)Ubiquitination-58.0321890473
457 (in isoform 1)Ubiquitination-58.0321890473
457UbiquitinationWGKFFLLKRFNKEKL
HHHHHHHHHCCHHHH		58.0321890473
461UbiquitinationFLLKRFNKEKLGLLL
HHHHHCCHHHHHHHH		54.2222817900
470PhosphorylationKLGLLLLTFLGIVAA
HHHHHHHHHHHHHHH		19.45-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AL3A2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AL3A2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AL3A2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAND2_HUMANCAND2physical
26186194
DDX20_HUMANDDX20physical
26186194
TBC9B_HUMANTBC1D9Bphysical
26186194
TBC15_HUMANTBC1D15physical
26186194
FACD2_HUMANFANCD2physical
26186194
SAAL1_HUMANSAAL1physical
26186194
CIP2A_HUMANKIAA1524physical
26186194
HEAT1_HUMANHEATR1physical
26186194
GEMI4_HUMANGEMIN4physical
26186194
INT12_HUMANINTS12physical
26186194
XPO4_HUMANXPO4physical
26186194
TSC2_HUMANTSC2physical
26186194
ATR_HUMANATRphysical
26186194
IPO13_HUMANIPO13physical
26186194
IF4G3_HUMANEIF4G3physical
26186194
P4R3B_HUMANSMEK2physical
26186194
VPS8_HUMANVPS8physical
26186194
BIG1_HUMANARFGEF1physical
26186194
LTN1_HUMANLTN1physical
26186194
CNDH2_HUMANNCAPH2physical
26186194
INT3_HUMANINTS3physical
26186194
INT1_HUMANINTS1physical
26186194
BRAT1_HUMANBRAT1physical
26186194
THADA_HUMANTHADAphysical
26186194
HOOK2_HUMANHOOK2physical
26186194
STAG2_HUMANSTAG2physical
26186194
VATC1_HUMANATP6V1C1physical
26344197
TBC9B_HUMANTBC1D9Bphysical
28514442
HOOK2_HUMANHOOK2physical
28514442
CIP2A_HUMANKIAA1524physical
28514442
VPS8_HUMANVPS8physical
28514442
XPO4_HUMANXPO4physical
28514442
INT12_HUMANINTS12physical
28514442
P4R3B_HUMANSMEK2physical
28514442
IPO13_HUMANIPO13physical
28514442
INT1_HUMANINTS1physical
28514442
CAND2_HUMANCAND2physical
28514442
ATR_HUMANATRphysical
28514442
TBC15_HUMANTBC1D15physical
28514442
LTN1_HUMANLTN1physical
28514442
FACD2_HUMANFANCD2physical
28514442
STAG2_HUMANSTAG2physical
28514442
Drug and Disease Associations
Kegg Disease
H00162 Sjogren-Larsson syndrome
OMIM Disease
270200Sjoegren-Larsson syndrome (SLS)
Kegg Drug
D00123 Cyanamide (JP16); Cyanamide (TN)
D00131 Disulfiram (JP16/USP/INN); Antabuse (TN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AL3A2_HUMAN

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Related Literatures of Post-Translational Modification

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