TBC9B_HUMAN - dbPTM
TBC9B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TBC9B_HUMAN
UniProt AC Q66K14
Protein Name TBC1 domain family member 9B
Gene Name TBC1D9B
Organism Homo sapiens (Human).
Sequence Length 1250
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description May act as a GTPase-activating protein for Rab family protein(s)..
Protein Sequence MWLSPEEVLVANALWVTERANPFFVLQRRRGHGRGGGLTGLLVGTLDVVLDSSARVAPYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIHGIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLYLTVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGETFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRLPRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKADSSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPSTESSPAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAEDIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEASPLASDLDLFLPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSARTGRKPRDCATEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPSQLLSDDETKDDMSMSSYSVVSTGSLQCEDLADDTVLVGGEACSPTARIGGTVDTDWCISFEQILASILTESVLVNFFEKRVDIGLKIKDQKKVERQFSTASDHEQPGVSG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
34MethylationQRRRGHGRGGGLTGL
ECCCCCCCCCCHHHH		34.6054559877
39PhosphorylationHGRGGGLTGLLVGTL
CCCCCCHHHHHHHHH		29.11-
65PhosphorylationPYRILHQTQDSQVYW
CEEEEEECCCCCEEE		24.4828450419
68PhosphorylationILHQTQDSQVYWTVA
EEEECCCCCEEEEEE		16.2428450419
73PhosphorylationQDSQVYWTVACGSSR
CCCCEEEEEEECCCH		4.7928450419
78PhosphorylationYWTVACGSSRKEITK
EEEEEECCCHHHHHH		27.1828450419
79PhosphorylationWTVACGSSRKEITKH
EEEEECCCHHHHHHH		32.4328450419
114UbiquitinationITTFVKGKIHGIIAE
HHHHHHCEEEEEEEC		26.30-
124UbiquitinationGIIAEENKNLQPQGD
EEEECCCCCCCCCCC		63.41-
136UbiquitinationQGDEDPGKFKEAELK
CCCCCCCCHHHHHHH		59.66-
146AcetylationEAELKMRKQFGMPEG
HHHHHHHHHHCCCCC		46.627823187
262UbiquitinationSEGFLEDKALPRPIR
CCCCCCCCCCCCCCC		42.31-
275PhosphorylationIRPHRNISALKRDLD
CCCCCCHHHHHHHHH		30.9723401153
278UbiquitinationHRNISALKRDLDARA
CCCHHHHHHHHHHHH		43.51-
350PhosphorylationIIPLREVTIVEKADS
EEECCEEEEEEECCC		17.9830206219
357PhosphorylationTIVEKADSSSVLPSP
EEEEECCCCCCCCCC		29.4030206219
358PhosphorylationIVEKADSSSVLPSPL
EEEECCCCCCCCCCC		25.6430206219
359PhosphorylationVEKADSSSVLPSPLS
EEECCCCCCCCCCCE		31.4630206219
363PhosphorylationDSSSVLPSPLSISTK
CCCCCCCCCCEECCC		34.0230206219
366PhosphorylationSVLPSPLSISTKSKM
CCCCCCCEECCCCCE		20.2030206219
368PhosphorylationLPSPLSISTKSKMTF
CCCCCEECCCCCEEE		26.8030206219
369PhosphorylationPSPLSISTKSKMTFL
CCCCEECCCCCEEEE		37.3530206219
371PhosphorylationPLSISTKSKMTFLFA
CCEECCCCCEEEEEC		27.96-
374PhosphorylationISTKSKMTFLFANLK
ECCCCCEEEEECCCC		22.4130576142
391PhosphorylationDFLVQRISDFLQKTP
HHHHHHHHHHHHHCC		25.2123927012
396AcetylationRISDFLQKTPSKQPG
HHHHHHHHCCCCCCC		65.6319815011
397PhosphorylationISDFLQKTPSKQPGS
HHHHHHHCCCCCCCC		21.6023927012
399PhosphorylationDFLQKTPSKQPGSIG
HHHHHCCCCCCCCCC		49.5123403867
400AcetylationFLQKTPSKQPGSIGS
HHHHCCCCCCCCCCC		62.8119815021
400UbiquitinationFLQKTPSKQPGSIGS
HHHHCCCCCCCCCCC		62.81-
404PhosphorylationTPSKQPGSIGSRKAS
CCCCCCCCCCCCEEE		30.3823927012
407PhosphorylationKQPGSIGSRKASVVD
CCCCCCCCCEEEECC		29.0123927012
411PhosphorylationSIGSRKASVVDPSTE
CCCCCEEEECCCCCC		26.2129255136
416PhosphorylationKASVVDPSTESSPAP
EEEECCCCCCCCCCC		40.1029255136
417PhosphorylationASVVDPSTESSPAPQ
EEECCCCCCCCCCCC		45.3229255136
419PhosphorylationVVDPSTESSPAPQEG
ECCCCCCCCCCCCCC		41.5330266825
420PhosphorylationVDPSTESSPAPQEGS
CCCCCCCCCCCCCCC		20.8830266825
427PhosphorylationSPAPQEGSEQPASPA
CCCCCCCCCCCCCCC		32.1030266825
432PhosphorylationEGSEQPASPASPLSS
CCCCCCCCCCCCCCC		27.9029255136
435PhosphorylationEQPASPASPLSSRQS
CCCCCCCCCCCCCCC		29.7429255136
438PhosphorylationASPASPLSSRQSFCA
CCCCCCCCCCCCHHC		27.1930266825
439PhosphorylationSPASPLSSRQSFCAQ
CCCCCCCCCCCHHCC		41.8629255136
442PhosphorylationSPLSSRQSFCAQEAP
CCCCCCCCHHCCCCC		22.6025159151
450PhosphorylationFCAQEAPTASQGLLK
HHCCCCCCHHHHHHH		46.0930377224
452PhosphorylationAQEAPTASQGLLKLF
CCCCCCHHHHHHHHH		27.5330377224
463PhosphorylationLKLFQKNSPMEDLGA
HHHHHCCCCHHHHCC		32.4329255136
512PhosphorylationVLKGIPESLRGELWL
HHCCCCHHHHHHHHH		20.2920068231
545UbiquitinationLVEKSTGKYSLATEE
HHHHCCCCCEECHHH		31.58-
546PhosphorylationVEKSTGKYSLATEEI
HHHCCCCCEECHHHH		15.4023312004
547PhosphorylationEKSTGKYSLATEEIE
HHCCCCCEECHHHHH		18.2728857561
550PhosphorylationTGKYSLATEEIERDL
CCCCEECHHHHHHHH		39.1723312004
560PhosphorylationIERDLHRSMPEHPAF
HHHHHHHHCCCCHHH		28.1327251275
718PhosphorylationMEQLLGCSDEGEAMT
HHHHHCCCCHHHHHH		36.5824043423
725PhosphorylationSDEGEAMTMLGRYLD
CCHHHHHHHHHHHHH		19.1124043423
730PhosphorylationAMTMLGRYLDNVVNK
HHHHHHHHHHHCCCC		19.3324043423
739PhosphorylationDNVVNKQSVSPPIPH
HHCCCCCCCCCCCHH		26.6020068231
741PhosphorylationVVNKQSVSPPIPHLR
CCCCCCCCCCCHHHH		30.1525159151
752PhosphorylationPHLRALLSSSDDPPA
HHHHHHHHCCCCCCH		28.7530278072
753PhosphorylationHLRALLSSSDDPPAE
HHHHHHHCCCCCCHH		37.4425849741
754PhosphorylationLRALLSSSDDPPAEV
HHHHHHCCCCCCHHC		42.5328450419
775PhosphorylationKVSYEKFSSLRAEDI
HHHHHHHHCCCHHHH		39.2622210691
776PhosphorylationVSYEKFSSLRAEDIE
HHHHHHHCCCHHHHH		25.6324719451
796PhosphorylationQRLKVIQSLEDTAKR
HHHHHHHCHHHHHHH		23.7029514088
800PhosphorylationVIQSLEDTAKRSVVR
HHHCHHHHHHHHHHE		25.3829514088
802UbiquitinationQSLEDTAKRSVVRAI
HCHHHHHHHHHHEEE		47.50-
824PhosphorylationIEELEDLYMVFKAKH
HHHHHHHHHHHHHHH		11.98-
834PhosphorylationFKAKHLASQYWGCSR
HHHHHHHHHHCCCCC		30.1128857561
836PhosphorylationAKHLASQYWGCSRTM
HHHHHHHHCCCCCHH		10.9823917254
850PhosphorylationMAGRRDPSLPYLEQY
HCCCCCCCCHHHHHH		46.3928857561
853PhosphorylationRRDPSLPYLEQYRID
CCCCCCHHHHHHCCC		28.32-
857PhosphorylationSLPYLEQYRIDASQF
CCHHHHHHCCCHHHH		10.52-
897PhosphorylationLLDENKDSLINFKEF
HHCCCCCCCCCHHHH		32.5321214269
912PhosphorylationVTGMSGMYHGDLTEK
HHCCCCCCCCCHHHH		13.2321214269
917PhosphorylationGMYHGDLTEKLKVLY
CCCCCCHHHHHHHHH		35.4921214269
946PhosphorylationSALEAAHYFTEDSSS
HHHHHHHHHCCCCCC		13.89-
965 (in isoform 2)Phosphorylation-8.4328348404
967 (in isoform 2)Phosphorylation-21.3727251275
982PhosphorylationPQEEQEGSGSEERGE
CHHHHCCCCCCCCCC		38.0924275569
993PhosphorylationERGEEKGTSSPDYRH
CCCCCCCCCCHHHHH		36.7823403867
994PhosphorylationRGEEKGTSSPDYRHY
CCCCCCCCCHHHHHH		48.8425159151
995PhosphorylationGEEKGTSSPDYRHYL
CCCCCCCCHHHHHHH		22.9416964243
998PhosphorylationKGTSSPDYRHYLRMW
CCCCCHHHHHHHHHH		11.5923403867
1001PhosphorylationSSPDYRHYLRMWAKE
CCHHHHHHHHHHHHH		6.2321406692
1033PhosphorylationQFIELCKTLYNMFSE
HHHHHHHHHHHHCCC		33.2226434552
1053PhosphorylationDLYHAIATVASLLLR
HHHHHHHHHHHHHHH		15.5326434552
1056PhosphorylationHAIATVASLLLRIGE
HHHHHHHHHHHHHHH		18.4026434552
1081PhosphorylationRKPRDCATEEDEPPA
CCCCCCCCCCCCCCC		46.3630624053
1132PhosphorylationQVVVEGGSGEGQGSP
CEEEECCCCCCCCCH		44.5229514088
1138PhosphorylationGSGEGQGSPSQLLSD
CCCCCCCCHHHCCCC		17.3125159151
1140PhosphorylationGEGQGSPSQLLSDDE
CCCCCCHHHCCCCCC		34.8525850435
1144PhosphorylationGSPSQLLSDDETKDD
CCHHHCCCCCCCCCC		52.1618691976
1148PhosphorylationQLLSDDETKDDMSMS
HCCCCCCCCCCCCCC		46.9327732954
1164PhosphorylationYSVVSTGSLQCEDLA
EEEEECCCEEEECCC		18.5026657352
1191PhosphorylationPTARIGGTVDTDWCI
CCCCCCCCCCCCHHC		15.2522673903
1194PhosphorylationRIGGTVDTDWCISFE
CCCCCCCCCHHCCHH		27.3622673903
1199PhosphorylationVDTDWCISFEQILAS
CCCCHHCCHHHHHHH		21.4222673903
1206PhosphorylationSFEQILASILTESVL
CHHHHHHHHCCHHHH		18.0622673903
1209PhosphorylationQILASILTESVLVNF
HHHHHHCCHHHHHHH		25.2522673903
1211PhosphorylationLASILTESVLVNFFE
HHHHCCHHHHHHHHH		18.6022673903
1238PhosphorylationKKVERQFSTASDHEQ
HHHHHHHCCCCCCCC		18.0927273156
1239PhosphorylationKVERQFSTASDHEQP
HHHHHHCCCCCCCCC		31.3127273156
1241PhosphorylationERQFSTASDHEQPGV
HHHHCCCCCCCCCCC		39.3227273156
1249PhosphorylationDHEQPGVSG------
CCCCCCCCC------		44.7125159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TBC9B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TBC9B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TBC9B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
LMBL2_HUMANL3MBTL2physical
25416956
CLK2_HUMANCLK2physical
26496610
SEC62_HUMANSEC62physical
26496610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TBC9B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411; SER-432 ANDSER-435, AND MASS SPECTROMETRY.
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432 AND SER-435, ANDMASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411; SER-420; SER-432;SER-435 AND SER-463, AND MASS SPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420; SER-432; SER-435AND SER-463, AND MASS SPECTROMETRY.
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411 AND SER-435, ANDMASS SPECTROMETRY.

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