dbPTM

HEAT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HEAT1_HUMAN
UniProt AC	Q9H583
Protein Name	HEAT repeat-containing protein 1
Gene Name	HEATR1
Organism	Homo sapiens (Human).
Sequence Length	2144
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I..
Protein Sequence	MTSLAQQLQRLALPQSDASLLSRDEVASLLFDPKEAATIDRDTAFAIGCTGLEELLGIDPSFEQFEAPLFSQLAKTLERSVQTKAVNKQLDENISLFLIHLSPYFLLKPAQKCLEWLIHRFHIHLYNQDSLIACVLPYHETRIFVRVIQLLKINNSKHRWFWLLPVKQSGVPLAKGTLITHCYKDLGFMDFICSLVTKSVKVFAEYPGSSAQLRVLLAFYASTIVSALVAAEDVSDNIIAKLFPYIQKGLKSSLPDYRAATYMIICQISVKVTMENTFVNSLASQIIKTLTKIPSLIKDGLSCLIVLLQRQKPESLGKKPFPHLCNVPDLITILHGISETYDVSPLLHYMLPHLVVSIIHHVTGEETEGMDGQIYKRHLEAILTKISLKNNLDHLLASLLFEEYISYSSQEEMDSNKVSLLNEQFLPLIRLLESKYPRTLDVVLEEHLKEIADLKKQELFHQFVSLSTSGGKYQFLADSDTSLMLSLNHPLAPVRILAMNHLKKIMKTSKEGVDESFIKEAVLARLGDDNIDVVLSAISAFEIFKEHFSSEVTISNLLNLFQRAELSKNGEWYEVLKIAADILIKEEILSENDQLSNQVVVCLLPFMVINNDDTESAEMKIAIYLSKSGICSLHPLLRGWEEALENVIKSTKPGKLIGVANQKMIELLADNINLGDPSSMLKMVEDLISVGEEESFNLKQKVTFHVILSVLVSCCSSLKETHFPFAIRVFSLLQKKIKKLESVITAVEIPSEWHIELMLDRGIPVELWAHYVEELNSTQRVAVEDSVFLVFSLKKFIYALKAPKSFPKGDIWWNPEQLKEDSRDYLHLLIGLFEMMLNGADAVHFRVLMKLFIKVHLEDVFQLFKFCSVLWTYGSSLSNPLNCSVKTVLQTQALYVGCAMLSSQKTQCKHQLASISSPVVTSLLINLGSPVKEVRRAAIQCLQALSGVASPFYLIIDHLISKAEEITSDAAYVIQDLATLFEELQREKKLKSHQKLSETLKNLLSCVYSCPSYIAKDLMKVLQGVNGEMVLSQLLPMAEQLLEKIQKEPTAVLKDEAMVLHLTLGKYNEFSVSLLNEDPKSLDIFIKAVHTTKELYAGMPTIQITALEKITKPFFAAISDEKVQQKLLRMLFDLLVNCKNSHCAQTVSSVFKGISVNAEQVRIELEPPDKAKPLGTVQQKRRQKMQQKKSQDLESVQEVGGSYWQRVTLILELLQHKKKLRSPQILVPTLFNLLSRCLEPLPQEQGNMEYTKQLILSCLLNICQKLSPDGGKIPKDILDEEKFNVELIVQCIRLSEMPQTHHHALLLLGTVAGIFPDKVLHNIMSIFTFMGANVMRLDDTYSFQVINKTVKMVIPALIQSDSGDSIEVSRNVEEIVVKIISVFVDALPHVPEHRRLPILVQLVDTLGAEKFLWILLILLFEQYVTKTVLAAAYGEKDAILEADTEFWFSVCCEFSVQHQIQSLMNILQYLLKLPEEKEETIPKAVSFNKSESQEEMLQVFNVETHTSKQLRHFKFLSVSFMSQLLSSNNFLKKVVESGGPEILKGLEERLLETVLGYISAVAQSMERNADKLTVKFWRALLSKAYDLLDKVNALLPTETFIPVIRGLVGNPLPSVRRKALDLLNNKLQQNISWKKTIVTRFLKLVPDLLAIVQRKKKEGEEEQAINRQTALYTLKLLCKNFGAENPDPFVPVLNTAVKLIAPERKEEKNVLGSALLCIAEVTSTLEALAIPQLPSLMPSLLTTMKNTSELVSSEVYLLSALAALQKVVETLPHFISPYLEGILSQVIHLEKITSEMGSASQANIRLTSLKKTLATTLAPRVLLPAIKKTYKQIEKNWKNHMGPFMSILQEHIGVMKKEELTSHQSQLTAFFLEALDFRAQHSENDLEEVGKTENCIIDCLVAMVVKLSEVTFRPLFFKLFDWAKTEDAPKDRLLTFYNLADCIAEKLKGLFTLFAGHLVKPFADTLNQVNISKTDEAFFDSENDPEKCCLLLQFILNCLYKIFLFDTQHFISKERAEALMMPLVDQLENRLGGEEKFQERVTKHLIPCIAQFSVAMADDSLWKPLNYQILLKTRDSSPKVRFAALITVLALAEKLKENYIVLLPESIPFLAELMEDECEEVEHQCQKTIQQLETVLGEPLQSYF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTSLAQQL -------CCHHHHHH	27.64	22814378
2	Acetylation	------MTSLAQQLQ ------CCHHHHHHH	43.69	22223895
2	Phosphorylation	------MTSLAQQLQ ------CCHHHHHHH	43.69	27174698
3	Phosphorylation	-----MTSLAQQLQR -----CCHHHHHHHH	33.30	25159151
10	Methylation	SLAQQLQRLALPQSD HHHHHHHHHCCCCCC	30.44	-
16	Phosphorylation	QRLALPQSDASLLSR HHHCCCCCCHHHCCH	32.95	19691289
19	Phosphorylation	ALPQSDASLLSRDEV CCCCCCHHHCCHHHH	34.53	19691289
22	Phosphorylation	QSDASLLSRDEVASL CCCHHHCCHHHHHHH	42.87	19691289
28	Phosphorylation	LSRDEVASLLFDPKE CCHHHHHHHHCCHHH	30.68	24732914
34	2-Hydroxyisobutyrylation	ASLLFDPKEAATIDR HHHHCCHHHHCCCCH	62.93	-
34	Ubiquitination	ASLLFDPKEAATIDR HHHHCCHHHHCCCCH	62.93	21890473
84	2-Hydroxyisobutyrylation	LERSVQTKAVNKQLD HHHHHHHHHHHHHHH	32.99	-
84	Ubiquitination	LERSVQTKAVNKQLD HHHHHHHHHHHHHHH	32.99	-
175	Ubiquitination	QSGVPLAKGTLITHC CCCCCCCCCCCHHHC	61.17	-
201	Acetylation	SLVTKSVKVFAEYPG HHHHCCCHHHCCCCC	38.43	26051181
201	Ubiquitination	SLVTKSVKVFAEYPG HHHHCCCHHHCCCCC	38.43	-
248	Acetylation	KLFPYIQKGLKSSLP HHHHHHHHHHHHCCC	57.56	26051181
248	Ubiquitination	KLFPYIQKGLKSSLP HHHHHHHHHHHHCCC	57.56	21890473
251	Ubiquitination	PYIQKGLKSSLPDYR HHHHHHHHHCCCCHH	46.82	-
273	Phosphorylation	CQISVKVTMENTFVN EEEEEEEECCCHHHH	17.04	21406692
277	Phosphorylation	VKVTMENTFVNSLAS EEEECCCHHHHHHHH	18.69	22210691
281	Phosphorylation	MENTFVNSLASQIIK CCCHHHHHHHHHHHH	21.73	22210691
284	Phosphorylation	TFVNSLASQIIKTLT HHHHHHHHHHHHHHH	27.49	22210691
289	Phosphorylation	LASQIIKTLTKIPSL HHHHHHHHHHCCHHH	29.29	22210691
291	Phosphorylation	SQIIKTLTKIPSLIK HHHHHHHHCCHHHHH	31.96	22210691
292	Ubiquitination	QIIKTLTKIPSLIKD HHHHHHHCCHHHHHH	56.59	-
295	Phosphorylation	KTLTKIPSLIKDGLS HHHHCCHHHHHHHHH	46.31	24719451
302	Phosphorylation	SLIKDGLSCLIVLLQ HHHHHHHHHHHHHHH	16.65	22210691
363	Phosphorylation	VSIIHHVTGEETEGM HHHHHHHHCCCCCCC	34.22	-
367	Phosphorylation	HHVTGEETEGMDGQI HHHHCCCCCCCCCHH	33.27	-
375	Phosphorylation	EGMDGQIYKRHLEAI CCCCCHHHHHHHHHH	8.29	-
385	Acetylation	HLEAILTKISLKNNL HHHHHHHHHHHHCCH	27.18	26051181
385	Ubiquitination	HLEAILTKISLKNNL HHHHHHHHHHHHCCH	27.18	-
435	2-Hydroxyisobutyrylation	LIRLLESKYPRTLDV HHHHHHCCCCCHHHH	50.31	-
435	Acetylation	LIRLLESKYPRTLDV HHHHHHCCCCCHHHH	50.31	26051181
435	Ubiquitination	LIRLLESKYPRTLDV HHHHHHCCCCCHHHH	50.31	-
456	Acetylation	KEIADLKKQELFHQF HHHHHHHHHHHHHHH	57.19	26051181
456	Ubiquitination	KEIADLKKQELFHQF HHHHHHHHHHHHHHH	57.19	-
503	2-Hydroxyisobutyrylation	ILAMNHLKKIMKTSK HHHHHHHHHHHHHCC	32.47	-
503	Ubiquitination	ILAMNHLKKIMKTSK HHHHHHHHHHHHHCC	32.47	-
504	Ubiquitination	LAMNHLKKIMKTSKE HHHHHHHHHHHHCCC	55.16	-
508	Phosphorylation	HLKKIMKTSKEGVDE HHHHHHHHCCCCCCH	27.87	23312004
509	Phosphorylation	LKKIMKTSKEGVDES HHHHHHHCCCCCCHH	24.16	23312004
510	Acetylation	KKIMKTSKEGVDESF HHHHHHCCCCCCHHH	64.81	26051181
510	Ubiquitination	KKIMKTSKEGVDESF HHHHHHCCCCCCHHH	64.81	21906983
516	Phosphorylation	SKEGVDESFIKEAVL CCCCCCHHHHHHHHH	28.01	30266825
519	2-Hydroxyisobutyrylation	GVDESFIKEAVLARL CCCHHHHHHHHHHHH	37.30	-
519	Acetylation	GVDESFIKEAVLARL CCCHHHHHHHHHHHH	37.30	26051181
519	Ubiquitination	GVDESFIKEAVLARL CCCHHHHHHHHHHHH	37.30	21906983
539	Phosphorylation	DVVLSAISAFEIFKE HHHHHHHHHHHHHHH	26.99	19413330
568	Ubiquitination	FQRAELSKNGEWYEV HHHHHHHCCCCHHHH	79.98	21906983
573	Phosphorylation	LSKNGEWYEVLKIAA HHCCCCHHHHHHHHH	7.58	28152594
627	Ubiquitination	KIAIYLSKSGICSLH HHHHEECCCCCCCHH	50.54	-
655	Ubiquitination	IKSTKPGKLIGVANQ HHHCCCCCEEEECCH	45.52	-
663	Ubiquitination	LIGVANQKMIELLAD EEEECCHHHHHHHHH	41.47	-
699	Ubiquitination	EEESFNLKQKVTFHV CHHHCCCCHHHHHHH	49.53	-
709	Phosphorylation	VTFHVILSVLVSCCS HHHHHHHHHHHHHHH	11.41	-
731	Phosphorylation	PFAIRVFSLLQKKIK HHHHHHHHHHHHHHH	25.88	23403867
735	2-Hydroxyisobutyrylation	RVFSLLQKKIKKLES HHHHHHHHHHHHHHH	57.33	-
735	Ubiquitination	RVFSLLQKKIKKLES HHHHHHHHHHHHHHH	57.33	-
786	Phosphorylation	QRVAVEDSVFLVFSL CCEECCCCEEHHHHH	10.98	23403867
801	Ubiquitination	KKFIYALKAPKSFPK HHHHHHHHCCCCCCC	55.24	-
808	Ubiquitination	KAPKSFPKGDIWWNP HCCCCCCCCCCCCCH	68.17	-
909	Ubiquitination	SSQKTQCKHQLASIS HCCCHHHHHHHHHCC	25.27	-
917	Phosphorylation	HQLASISSPVVTSLL HHHHHCCCHHHHHHH	21.75	-
929	Phosphorylation	SLLINLGSPVKEVRR HHHHHCCCCHHHHHH	29.68	25159151
932	Ubiquitination	INLGSPVKEVRRAAI HHCCCCHHHHHHHHH	54.60	-
995	Acetylation	KKLKSHQKLSETLKN HHHHHHHHHHHHHHH	48.86	25953088
995	Ubiquitination	KKLKSHQKLSETLKN HHHHHHHHHHHHHHH	48.86	-
1016	Acetylation	SCPSYIAKDLMKVLQ HCHHHHHHHHHHHHC	41.66	26051181
1047	Ubiquitination	QLLEKIQKEPTAVLK HHHHHHHHCCCHHHC	69.96	-
1054	Ubiquitination	KEPTAVLKDEAMVLH HCCCHHHCCCHHHHH	47.10	-
1067	Phosphorylation	LHLTLGKYNEFSVSL HHHHCCCCCCCCHHH	20.37	21406692
1093	Ubiquitination	IKAVHTTKELYAGMP HHHHHHCHHHHCCCC	47.04	-
1105	Phosphorylation	GMPTIQITALEKITK CCCEEEEEEHHHHCC	14.60	-
1112	2-Hydroxyisobutyrylation	TALEKITKPFFAAIS EEHHHHCCCHHHCCC	43.21	-
1112	Acetylation	TALEKITKPFFAAIS EEHHHHCCCHHHCCC	43.21	26051181
1112	Ubiquitination	TALEKITKPFFAAIS EEHHHHCCCHHHCCC	43.21	-
1119	Phosphorylation	KPFFAAISDEKVQQK CCHHHCCCCHHHHHH	34.68	20058876
1122	Acetylation	FAAISDEKVQQKLLR HHCCCCHHHHHHHHH	50.78	26051181
1122	Ubiquitination	FAAISDEKVQQKLLR HHCCCCHHHHHHHHH	50.78	-
1126	2-Hydroxyisobutyrylation	SDEKVQQKLLRMLFD CCHHHHHHHHHHHHH	32.19	-
1126	Acetylation	SDEKVQQKLLRMLFD CCHHHHHHHHHHHHH	32.19	25953088
1148	Phosphorylation	SHCAQTVSSVFKGIS CCHHHHHHHHHCCCC	24.95	20068231
1149	Phosphorylation	HCAQTVSSVFKGISV CHHHHHHHHHCCCCC	27.51	20068231
1152	Acetylation	QTVSSVFKGISVNAE HHHHHHHCCCCCCHH	53.86	26051181
1152	Ubiquitination	QTVSSVFKGISVNAE HHHHHHHCCCCCCHH	53.86	-
1170	Ubiquitination	IELEPPDKAKPLGTV EEECCCCCCCCCCHH	65.17	-
1172	Ubiquitination	LEPPDKAKPLGTVQQ ECCCCCCCCCCHHHH	46.66	-
1176	Phosphorylation	DKAKPLGTVQQKRRQ CCCCCCCHHHHHHHH	23.87	28555341
1180	Ubiquitination	PLGTVQQKRRQKMQQ CCCHHHHHHHHHHHH	32.24	-
1189	Ubiquitination	RQKMQQKKSQDLESV HHHHHHHHHHCHHHH	49.35	-
1190	Phosphorylation	QKMQQKKSQDLESVQ HHHHHHHHHCHHHHH	35.64	25159151
1195	Phosphorylation	KKSQDLESVQEVGGS HHHHCHHHHHHHCCH	36.08	21712546
1202	Phosphorylation	SVQEVGGSYWQRVTL HHHHHCCHHHHHHHH	19.78	24732914
1203	Phosphorylation	VQEVGGSYWQRVTLI HHHHCCHHHHHHHHH	14.61	24732914
1272	Ubiquitination	KLSPDGGKIPKDILD HHCCCCCCCCHHHCC	62.46	-
1275	Ubiquitination	PDGGKIPKDILDEEK CCCCCCCHHHCCHHH	61.96	-
1340	Phosphorylation	NVMRLDDTYSFQVIN CEECCCCCCCHHHCC	22.26	-
1341	Phosphorylation	VMRLDDTYSFQVINK EECCCCCCCHHHCCC	17.93	-
1348	Acetylation	YSFQVINKTVKMVIP CCHHHCCCHHHHHHH	43.50	26051181
1348	Ubiquitination	YSFQVINKTVKMVIP CCHHHCCCHHHHHHH	43.50	-
1351	Ubiquitination	QVINKTVKMVIPALI HHCCCHHHHHHHHHH	32.45	-
1360	Phosphorylation	VIPALIQSDSGDSIE HHHHHHHCCCCCCEE	27.10	20068231
1362	Phosphorylation	PALIQSDSGDSIEVS HHHHHCCCCCCEEEC	50.15	20068231
1365	Phosphorylation	IQSDSGDSIEVSRNV HHCCCCCCEEECCCH	24.95	20068231
1369	Phosphorylation	SGDSIEVSRNVEEIV CCCCEEECCCHHHHH	12.83	20068231
1433	Phosphorylation	KTVLAAAYGEKDAIL HHHHHHHHCCCCCEE	22.53	29978859
1477	2-Hydroxyisobutyrylation	LLKLPEEKEETIPKA HHCCCHHHHCCCCCC	60.22	-
1477	Acetylation	LLKLPEEKEETIPKA HHCCCHHHHCCCCCC	60.22	26051181
1477	Ubiquitination	LLKLPEEKEETIPKA HHCCCHHHHCCCCCC	60.22	-
1483	Ubiquitination	EKEETIPKAVSFNKS HHHCCCCCCCCCCCC	58.53	21906983
1486	Phosphorylation	ETIPKAVSFNKSESQ CCCCCCCCCCCCCCH	28.14	24732914
1489	Acetylation	PKAVSFNKSESQEEM CCCCCCCCCCCHHHH	54.30	26051181
1489	Ubiquitination	PKAVSFNKSESQEEM CCCCCCCCCCCHHHH	54.30	-
1490	Phosphorylation	KAVSFNKSESQEEML CCCCCCCCCCHHHHH	43.51	25159151
1492	Phosphorylation	VSFNKSESQEEMLQV CCCCCCCCHHHHHHH	50.40	17525332
1504	Phosphorylation	LQVFNVETHTSKQLR HHHHCCCCCCCHHCC	26.60	23312004
1506	Phosphorylation	VFNVETHTSKQLRHF HHCCCCCCCHHCCCC	45.07	27251275
1507	Phosphorylation	FNVETHTSKQLRHFK HCCCCCCCHHCCCCH	15.70	27251275
1508	Acetylation	NVETHTSKQLRHFKF CCCCCCCHHCCCCHH	55.28	25953088
1508	Ubiquitination	NVETHTSKQLRHFKF CCCCCCCHHCCCCHH	55.28	-
1517	Phosphorylation	LRHFKFLSVSFMSQL CCCCHHHCHHHHHHH	20.88	25072903
1519	Phosphorylation	HFKFLSVSFMSQLLS CCHHHCHHHHHHHHC	16.32	25219547
1522	Phosphorylation	FLSVSFMSQLLSSNN HHCHHHHHHHHCCCC	18.70	25072903
1526	Phosphorylation	SFMSQLLSSNNFLKK HHHHHHHCCCCHHHH	39.34	25219547
1527	Phosphorylation	FMSQLLSSNNFLKKV HHHHHHCCCCHHHHH	35.44	25219547
1533	Ubiquitination	SSNNFLKKVVESGGP CCCCHHHHHHHCCCH	54.37	-
1537	Phosphorylation	FLKKVVESGGPEILK HHHHHHHCCCHHHHH	37.12	20068231
1544	Acetylation	SGGPEILKGLEERLL CCCHHHHHHHHHHHH	68.09	26051181
1544	Ubiquitination	SGGPEILKGLEERLL CCCHHHHHHHHHHHH	68.09	-
1575	Acetylation	NADKLTVKFWRALLS CCHHHHHHHHHHHHH	33.69	25953088
1575	Ubiquitination	NADKLTVKFWRALLS CCHHHHHHHHHHHHH	33.69	21906983
1583	Acetylation	FWRALLSKAYDLLDK HHHHHHHHHHHHHHH	51.43	26051181
1583	Ubiquitination	FWRALLSKAYDLLDK HHHHHHHHHHHHHHH	51.43	-
1597	Phosphorylation	KVNALLPTETFIPVI HHHHHCCCCCHHHHH	47.85	-
1599	Phosphorylation	NALLPTETFIPVIRG HHHCCCCCHHHHHHH	29.37	-
1614	Phosphorylation	LVGNPLPSVRRKALD HCCCCCHHHHHHHHH	35.62	23879269
1618	Ubiquitination	PLPSVRRKALDLLNN CCHHHHHHHHHHHCH	42.61	-
1626	Acetylation	ALDLLNNKLQQNISW HHHHHCHHHHHCCCC	46.75	26051181
1626	Ubiquitination	ALDLLNNKLQQNISW HHHHHCHHHHHCCCC	46.75	-
1634	2-Hydroxyisobutyrylation	LQQNISWKKTIVTRF HHHCCCCHHHHHHHH	32.99	-
1634	Acetylation	LQQNISWKKTIVTRF HHHCCCCHHHHHHHH	32.99	26051181
1634	Ubiquitination	LQQNISWKKTIVTRF HHHCCCCHHHHHHHH	32.99	-
1635	Ubiquitination	QQNISWKKTIVTRFL HHCCCCHHHHHHHHH	36.91	-
1643	Ubiquitination	TIVTRFLKLVPDLLA HHHHHHHHHHHHHHH	44.73	-
1655	Acetylation	LLAIVQRKKKEGEEE HHHHHHHHCCCCHHH	51.62	7971423
1675	Acetylation	QTALYTLKLLCKNFG HHHHHHHHHHHHHCC	31.45	26051181
1675	Ubiquitination	QTALYTLKLLCKNFG HHHHHHHHHHHHHCC	31.45	-
1679	Acetylation	YTLKLLCKNFGAENP HHHHHHHHHCCCCCC	56.11	91003
1679	Ubiquitination	YTLKLLCKNFGAENP HHHHHHHHHCCCCCC	56.11	-
1747	Phosphorylation	LLTTMKNTSELVSSE HHHHCCCHHHHHHHH	20.33	20860994
1752	Phosphorylation	KNTSELVSSEVYLLS CCHHHHHHHHHHHHH	33.15	20860994
1793	Phosphorylation	VIHLEKITSEMGSAS HHHHHHHHHHCCCHH	29.69	20068231
1794	Phosphorylation	IHLEKITSEMGSASQ HHHHHHHHHCCCHHH	29.11	20068231
1796	Sulfoxidation	LEKITSEMGSASQAN HHHHHHHCCCHHHHH	5.28	21406390
1798	Phosphorylation	KITSEMGSASQANIR HHHHHCCCHHHHHHH	24.36	20068231
1800	Phosphorylation	TSEMGSASQANIRLT HHHCCCHHHHHHHHH	31.36	20068231
1807	Phosphorylation	SQANIRLTSLKKTLA HHHHHHHHHHHHHHH	23.36	29083192
1808	Phosphorylation	QANIRLTSLKKTLAT HHHHHHHHHHHHHHH	42.66	29083192
1811	Ubiquitination	IRLTSLKKTLATTLA HHHHHHHHHHHHHHH	54.81	-
1815	Phosphorylation	SLKKTLATTLAPRVL HHHHHHHHHHHHHHH	26.00	-
1816	Phosphorylation	LKKTLATTLAPRVLL HHHHHHHHHHHHHHH	18.47	-
1820	Methylation	LATTLAPRVLLPAIK HHHHHHHHHHHHHHH	26.55	-
1827	Acetylation	RVLLPAIKKTYKQIE HHHHHHHHHHHHHHH	40.96	25953088
1828	Ubiquitination	VLLPAIKKTYKQIEK HHHHHHHHHHHHHHH	51.48	-
1831	Acetylation	PAIKKTYKQIEKNWK HHHHHHHHHHHHHHH	50.46	25825284
1831	Ubiquitination	PAIKKTYKQIEKNWK HHHHHHHHHHHHHHH	50.46	-
1835	Ubiquitination	KTYKQIEKNWKNHMG HHHHHHHHHHHHCCH	70.50	-
1882	Phosphorylation	LDFRAQHSENDLEEV HHHHHHCCCCCHHHH	26.47	-
1924	Acetylation	FKLFDWAKTEDAPKD HHHHHHHCCCCCCHH	48.47	26051181
1924	Ubiquitination	FKLFDWAKTEDAPKD HHHHHHHCCCCCCHH	48.47	-
1981	Phosphorylation	TDEAFFDSENDPEKC CCHHHCCCCCCHHHH	32.89	-
2007	Phosphorylation	YKIFLFDTQHFISKE HHHHHHCCHHHCCHH	19.33	-
2012	Phosphorylation	FDTQHFISKERAEAL HCCHHHCCHHHHHHH	27.76	-
2013	Acetylation	DTQHFISKERAEALM CCHHHCCHHHHHHHC	46.53	26051181
2036	Acetylation	NRLGGEEKFQERVTK HHCCCHHHHHHHHHH	48.31	25953088
2036	Ubiquitination	NRLGGEEKFQERVTK HHCCCHHHHHHHHHH	48.31	-
2076	Phosphorylation	ILLKTRDSSPKVRFA EEECCCCCCHHHHHH	45.29	22817900
2087	Phosphorylation	VRFAALITVLALAEK HHHHHHHHHHHHHHH	15.43	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HEAT1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HEAT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HEAT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AAGAB_HUMAN	AAGAB	physical	25416956
UTP15_HUMAN	UTP15	physical	26344197
TSYL6_HUMAN	TSPYL6	physical	28514442
GFAP_HUMAN	GFAP	physical	28514442
SBP1_HUMAN	SELENBP1	physical	28514442
LRC15_HUMAN	LRRC15	physical	28514442
S27A2_HUMAN	SLC27A2	physical	28514442
DUS14_HUMAN	DUSP14	physical	28514442
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HEAT1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1190, AND MASSSPECTROMETRY.	18691976 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1492, AND MASSSPECTROMETRY.	17525332 [Abstract]