TSYL6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSYL6_HUMAN
• UniProt AC: Q8N831
• Protein Name: Testis-specific Y-encoded-like protein 6
• Gene Name: TSPYL6
• Organism: Homo sapiens (Human).
• Sequence Length: 410
• Protein Sequence: MSLPESPHSPATLDYALEDPHQGQRSREKSKATEVMADMFDGRLEPIVFPPPRLPEEGVAPQDPADGGHTFHILVDAGRSHGAIKAGQEVTPPPAEGLEAASASLTTDGSLKNGFPGEETHGLGGEKALETCGAGRSESEVIAEGKAEDVKPEECAMFSAPVDEKPGGEEMDVAEENRAIDEVNREAGPGPGPGPLNVGLHLNPLESIQLELDSVNAEADRALLQVERRFGQIHEYYLEQRNDIIRNIPGFWVTAFRHHPQLSAMIRGQDAEMLSYLTNLEVKELRHPRTGCKFKFFFQRNPYFRNKLIVKVYEVRSFGQVVSFSTLIMWRRGHGPQSFIHRNRHVICSFFTWFSDHSLPESDRIAQIIKEDLWSNPLQYYLLGEDAHRARRRLVREPVEIPRPFGFQCG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLPESPHS ------CCCCCCCCC	53.27	23186163
6	Phosphorylation	--MSLPESPHSPATL --CCCCCCCCCCCCH	26.44	23186163
9	Phosphorylation	SLPESPHSPATLDYA CCCCCCCCCCCHHHH	21.44	23186163
12	Phosphorylation	ESPHSPATLDYALED CCCCCCCCHHHHHCC	24.44	23186163
91	Phosphorylation	IKAGQEVTPPPAEGL CCCCCCCCCCCCCCH	29.35	23532336
283	Ubiquitination	YLTNLEVKELRHPRT HHHHCCHHHHCCCCC	41.47	-
307	Ubiquitination	RNPYFRNKLIVKVYE CCHHHCCCEEEEEEE	35.02	-
313	Phosphorylation	NKLIVKVYEVRSFGQ CCEEEEEEEECCCCC	11.73	22210691
323	Phosphorylation	RSFGQVVSFSTLIMW CCCCCEEEEEEEEHH	18.02	22210691
326	Phosphorylation	GQVVSFSTLIMWRRG CCEEEEEEEEHHCCC	20.49	22210691
355	Phosphorylation	CSFFTWFSDHSLPES EEHHHHHCCCCCCCH	26.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSYL6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSYL6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSYL6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TSYL2_HUMAN	TSPYL2	physical	28514442
TBB1_HUMAN	TUBB1	physical	28514442
UBP46_HUMAN	USP46	physical	28514442
UBP12_HUMAN	USP12	physical	28514442
WDR20_HUMAN	WDR20	physical	28514442
DMXL2_HUMAN	DMXL2	physical	28514442
KDM5B_HUMAN	KDM5B	physical	28514442
DDX24_HUMAN	DDX24	physical	28514442
AMER1_HUMAN	AMER1	physical	28514442
TTC28_HUMAN	TTC28	physical	28514442
KBTB7_HUMAN	KBTBD7	physical	28514442
TRAF7_HUMAN	TRAF7	physical	28514442
WDR48_HUMAN	WDR48	physical	28514442
NSE4A_HUMAN	NSMCE4A	physical	28514442
PDPR_HUMAN	PDPR	physical	28514442
MCM8_HUMAN	MCM8	physical	28514442
ZMYM2_HUMAN	ZMYM2	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
VIR_HUMAN	KIAA1429	physical	28514442
COQ6_HUMAN	COQ6	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
PKN3_HUMAN	PKN3	physical	28514442
PSME3_HUMAN	PSME3	physical	28514442
UBP34_HUMAN	USP34	physical	28514442
GUF1_HUMAN	GUF1	physical	28514442
CENPB_HUMAN	CENPB	physical	28514442
DPOG1_HUMAN	POLG	physical	28514442
TBA1A_HUMAN	TUBA1A	physical	28514442
RN126_HUMAN	RNF126	physical	28514442
MD2L2_HUMAN	MAD2L2	physical	28514442
K0232_HUMAN	KIAA0232	physical	28514442
WDR59_HUMAN	WDR59	physical	28514442
NDKM_HUMAN	NME4	physical	28514442
SMC6_HUMAN	SMC6	physical	28514442
MDM2_HUMAN	MDM2	physical	28514442
OTUD4_HUMAN	OTUD4	physical	28514442
MADD_HUMAN	MADD	physical	28514442
AHR_HUMAN	AHR	physical	28514442
TBB4A_HUMAN	TUBB4A	physical	28514442
MKS1_HUMAN	MKS1	physical	28514442
PAPD1_HUMAN	MTPAP	physical	28514442
RRBP1_HUMAN	RRBP1	physical	28514442
ZMYM3_HUMAN	ZMYM3	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
STAR3_HUMAN	STARD3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.