TTC28_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTC28_HUMAN
• UniProt AC: Q96AY4
• Protein Name: Tetratricopeptide repeat protein 28
• Gene Name: TTC28
• Organism: Homo sapiens (Human).
• Sequence Length: 2481
• Subcellular Localization: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. At interphase, localizes to centrosomes. At prometaphase and metaphase, ass
• Protein Description: During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody..
• Protein Sequence: MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKFHEHYLGENTVENSSDFQASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETESEAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSSLPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGSSSNEYLYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWLWGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTPSMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKLVVLGSSQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQALTEILQHPERARDALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGMLHQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGKQANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQLDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPLRLPSGNGYKFLSPGRFFPSSKC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEQSPPPA -------CCCCCCCC	45.05	22814378
4	Phosphorylation	----MEQSPPPAPEP ----CCCCCCCCCCC	42.54	25159151
12	Phosphorylation	PPPAPEPTQGPTPAR CCCCCCCCCCCCCCC	44.49	30619164
16	Phosphorylation	PEPTQGPTPARSRRR CCCCCCCCCCCCCCC	36.08	25159151
20	Phosphorylation	QGPTPARSRRRREPE CCCCCCCCCCCCCCC	32.04	-
28	Phosphorylation	RRRREPESPPASAPI CCCCCCCCCCCCCCC	47.07	29255136
32	Phosphorylation	EPESPPASAPIPLFG CCCCCCCCCCCCCCC	40.11	30266825
42	Phosphorylation	IPLFGADTIGQRSPD CCCCCCCCCCCCCCC	26.86	29632367
47	Phosphorylation	ADTIGQRSPDGPVLS CCCCCCCCCCCCCCC	21.32	30266825
54	Phosphorylation	SPDGPVLSKAEFVEK CCCCCCCCHHHHHHH	30.01	27251275
55	Ubiquitination	PDGPVLSKAEFVEKV CCCCCCCHHHHHHHH	48.01	29967540
99	Phosphorylation	CILYSNRSAAYMKIQ EEEEECCCHHHHHHH	22.85	-
102	Phosphorylation	YSNRSAAYMKIQQYD EECCCHHHHHHHHHH	9.92	18083107
108	Phosphorylation	AYMKIQQYDKALDDA HHHHHHHHHHHHHHH	11.75	-
110	Ubiquitination	MKIQQYDKALDDAIK HHHHHHHHHHHHHHH	46.01	29967540
117	Ubiquitination	KALDDAIKARLLNPK HHHHHHHHHHHHCCC	29.22	29967540
129	Phosphorylation	NPKWPKAYFRQGVAL CCCCCHHHHHHCHHH	12.86	23312004
159	Phosphorylation	GLAQDPKSLQLLVGM CCCCCHHHHHHHHHH	27.08	24425749
173	Phosphorylation	MVEAAMKSPMRDSLE HHHHHHCCCCCCCCC	15.73	24425749
182	Phosphorylation	MRDSLEPTYQQLQKM CCCCCCHHHHHHHHC	25.29	22617229
183	Phosphorylation	RDSLEPTYQQLQKMK CCCCCHHHHHHHHCC	12.65	24144214
188	Ubiquitination	PTYQQLQKMKLDKSP HHHHHHHHCCCCCCC	46.74	29967540
194	Phosphorylation	QKMKLDKSPFVVVSV HHCCCCCCCEEEEEE	24.20	22210691
200	Phosphorylation	KSPFVVVSVVGQELL CCCEEEEEEECHHHH	10.24	22210691
215	Phosphorylation	TAGHHGASVVVLEAA HCCCCCCCHHHHHHH	21.75	22210691
265	Ubiquitination	QQDLDVAKTLGDQTG CHHHHHHHHHCCCCC	44.10	29967540
315	Phosphorylation	KDREAASSALSSLGH CCHHHHHHHHHHHCH	28.62	23532336
318	Phosphorylation	EAASSALSSLGHVYT HHHHHHHHHHCHHHH	24.19	23532336
364	Phosphorylation	LGNMGAVYIAMGDFE HHCCCCEEEEECCHH	5.17	-
397	Phosphorylation	KREEARAYSNLGSAY HHHHHHHHHCCHHHH	7.79	-
398	Phosphorylation	REEARAYSNLGSAYH HHHHHHHHCCHHHHH	25.29	-
402	Phosphorylation	RAYSNLGSAYHYRRN HHHHCCHHHHHHHHC	28.90	28857561
454	Ubiquitination	MQDLERAKQYHEQQL HHHHHHHHHHHHHHH	58.57	29967540
468	Ubiquitination	LGIAEDLKDRAAEGR HCCCHHHHHHHHHCC	58.45	29967540
487	Ubiquitination	LGIIHQMKGDYDTAL CCHHHHCCCCHHHHH	41.90	29967540
495	Ubiquitination	GDYDTALKLHKTHLC CCHHHHHHHHHHHHH	46.19	29967540
530	Phosphorylation	AYNALGMYDQAVKYH HHHHHCHHHHHHHHH	11.78	-
536	Phosphorylation	MYDQAVKYHRQELQI HHHHHHHHHHHHHEE	8.81	-
544	Phosphorylation	HRQELQISMEVNDRA HHHHHEEEEEECCCH	8.91	25278378
552	Phosphorylation	MEVNDRASQASTHGN EEECCCHHHHHHHCH	27.46	25278378
555	Phosphorylation	NDRASQASTHGNLAV CCCHHHHHHHCHHHH	17.19	25278378
556	Phosphorylation	DRASQASTHGNLAVA CCHHHHHHHCHHHHH	36.50	25278378
564	Phosphorylation	HGNLAVAYQALGAHD HCHHHHHHHHHCHHH	6.42	21552520
595	Ubiquitination	RDIQSEARALSNLGN HHHHHHHHHHHHCCC	31.82	21890473
610	Phosphorylation	FHCSRGEYVQAAPYY CCCCCCCEECCHHHH	10.73	-
617	Phosphorylation	YVQAAPYYEQYLRLA EECCHHHHHHHHHHC	8.76	-
620	Phosphorylation	AAPYYEQYLRLAPDL CHHHHHHHHHHCCCH	5.05	-
665	Ubiquitination	EQDLALAKDLHDKLS HHHHHHHHHHHHHHH	62.77	29967540
670	Ubiquitination	LAKDLHDKLSQAKAY HHHHHHHHHHHHHHH	39.01	29967540
683	Ubiquitination	AYCNLGLAFKALLNF HHHHHHHHHHHHHCC	11.33	21890473
687	Ubiquitination	LGLAFKALLNFSKAE HHHHHHHHHCCCCHH	4.07	21890473
699	Phosphorylation	KAEECQKYLLSLAQS CHHHHHHHHHHHHHH	6.23	25954137
706	Phosphorylation	YLLSLAQSLNNSQAK HHHHHHHHCCCHHHH	27.70	25954137
710	Phosphorylation	LAQSLNNSQAKFRAL HHHHCCCHHHHHHHH	30.37	25954137
713	Ubiquitination	SLNNSQAKFRALGNL HCCCHHHHHHHHCCC	27.96	21890473
755	Phosphorylation	KDRRLEASAYAALGT HCHHHHHHHHHHHHH	16.67	20068231
757	Phosphorylation	RRLEASAYAALGTAY HHHHHHHHHHHHHHH	7.01	20068231
762	Phosphorylation	SAYAALGTAYRMIQK HHHHHHHHHHHHHHH	22.74	20068231
764	Phosphorylation	YAALGTAYRMIQKYD HHHHHHHHHHHHHHH	10.68	20068231
770	Phosphorylation	AYRMIQKYDKALGYH HHHHHHHHHHHHCCC	13.29	20068231
826	Ubiquitination	EQLDLGQKLKDPSLE HHCCCCHHCCCCCHH	56.56	29967540
1047	Phosphorylation	YGNLGLTYESLGTFE ECCCCCCHHHCCHHH	14.46	-
1059	Phosphorylation	TFERAVVYQEQHLSI HHHEEHHHHHHHHHH	10.34	-
1171	Phosphorylation	LFDLQTSSYQALQRV HHHCCCCHHHHHHHH	25.34	19664994
1288	Phosphorylation	SVTLPTATGSALEQH CEECCCCCCHHHHHH	33.86	-
1298	Phosphorylation	ALEQHIASVREALGV HHHHHHHHHHHHHCC	22.54	-
1309	Phosphorylation	ALGVESHYSRACASS HHCCCCHHCCHHCCC	14.77	25627689
1315	Phosphorylation	HYSRACASSETESEA HHCCHHCCCCCHHHH	28.70	20873877
1316	Phosphorylation	YSRACASSETESEAG HCCHHCCCCCHHHHH	29.97	20873877
1318	Phosphorylation	RACASSETESEAGDI CHHCCCCCHHHHHHH	46.92	20873877
1320	Phosphorylation	CASSETESEAGDIMD HCCCCCHHHHHHHHH	39.92	20873877
1339	Phosphorylation	EMNNKLNSVTDPTGF HHHHHHHCCCCCHHH	36.51	28555341
1341	Phosphorylation	NNKLNSVTDPTGFLR HHHHHCCCCCHHHHH	35.76	29038488
1359	Phosphorylation	RNNLFNRSCQSMTSL HCCCCCHHHHHHHHH	20.01	27732954
1362	Phosphorylation	LFNRSCQSMTSLFSN CCCHHHHHHHHHHCC	28.49	27732954
1364	Phosphorylation	NRSCQSMTSLFSNTV CHHHHHHHHHHCCCC	27.76	22210691
1365	Phosphorylation	RSCQSMTSLFSNTVS HHHHHHHHHHCCCCC	20.83	27732954
1368	Phosphorylation	QSMTSLFSNTVSPTQ HHHHHHHCCCCCCCC	36.56	27732954
1370	Phosphorylation	MTSLFSNTVSPTQDG HHHHHCCCCCCCCCC	22.59	27732954
1372	Phosphorylation	SLFSNTVSPTQDGTS HHHCCCCCCCCCCCC	21.86	30576142
1374	Phosphorylation	FSNTVSPTQDGTSSL HCCCCCCCCCCCCCC	31.61	30576142
1378	Phosphorylation	VSPTQDGTSSLPRRQ CCCCCCCCCCCCCCC	24.35	27732954
1379	Phosphorylation	SPTQDGTSSLPRRQS CCCCCCCCCCCCCCC	35.09	25850435
1380	Phosphorylation	PTQDGTSSLPRRQSS CCCCCCCCCCCCCCC	42.08	25850435
1386	Phosphorylation	SSLPRRQSSFAKPPL CCCCCCCCCCCCCCH	26.13	23403867
1387	Phosphorylation	SLPRRQSSFAKPPLR CCCCCCCCCCCCCHH	22.38	27134283
1442	Phosphorylation	ALLKGSSSNEYLYER HHHCCCCCCHHHHHH	35.06	-
1445	Phosphorylation	KGSSSNEYLYERFGL CCCCCCHHHHHHHCC	20.87	-
1571	Phosphorylation	GNPASSKSSFGHPYT CCCCCCCCCCCCCCC	32.61	28555341
1572	Phosphorylation	NPASSKSSFGHPYTI CCCCCCCCCCCCCCC	38.70	28555341
1577	Phosphorylation	KSSFGHPYTIPESLR CCCCCCCCCCCHHHC	16.18	27642862
1582	Phosphorylation	HPYTIPESLRVQDDA CCCCCCHHHCCCCCC	19.00	20068231
1590	Phosphorylation	LRVQDDASDGESISD HCCCCCCCCCCCHHH	53.82	20873877
1594	Phosphorylation	DDASDGESISDCPPL CCCCCCCCHHHCCHH	32.68	20873877
1596	Phosphorylation	ASDGESISDCPPLQE CCCCCCHHHCCHHHH	42.30	20873877
1607	Phosphorylation	PLQELLLTAADVLDL HHHHHHHHHHHHHCC	21.55	20873877
1700	Phosphorylation	VQSSKAFSHPSNWAG HHHCCCCCCCCCCCC	39.07	23879269
1703	Phosphorylation	SKAFSHPSNWAGFML CCCCCCCCCCCCEEE	39.31	23879269
1713	Phosphorylation	AGFMLIGSDVKLNSP CCEEEECCCCCCCCH	32.03	-
1770	Phosphorylation	AMYTSQQSVENKVGG CCCCCHHHHHHCCCC	24.62	28857561
1926	Phosphorylation	GKQANRRTVHFALQS CCCCCHHHHHHHHHH	18.33	22210691
1940	Phosphorylation	SLLSLFDSTELPKRL HHHHHCCCCCCCCCC	19.22	21815630
1941	Phosphorylation	LLSLFDSTELPKRLS HHHHCCCCCCCCCCC	43.30	21815630
1948	Phosphorylation	TELPKRLSLDSSSSL CCCCCCCCCCCCCCH	33.88	24275569
2034	Phosphorylation	KNAYLQRSTLPRSQL CCCHHHCCCCCHHHC	22.72	23312004
2035	Phosphorylation	NAYLQRSTLPRSQLP CCHHHCCCCCHHHCC	42.86	23312004
2056	Phosphorylation	GNKDEEEYEGFSIIS CCCCHHHHCCEEEEC	25.32	25884760
2060	Phosphorylation	EEEYEGFSIISNEPL HHHHCCEEEECCCCC	29.84	27642862
2070	Phosphorylation	SNEPLATYQENRNTC CCCCCCCCHHCCCCC	14.28	27642862
2076	Phosphorylation	TYQENRNTCFSPDHK CCHHCCCCCCCCCCC	16.22	22210691
2079	Phosphorylation	ENRNTCFSPDHKQPQ HCCCCCCCCCCCCCC	31.40	20363803
2089	Phosphorylation	HKQPQPGTAGGMRVS CCCCCCCCCCCCEEE	28.89	22210691
2096	Phosphorylation	TAGGMRVSVSSKGSI CCCCCEEEEECCCCC	13.10	22210691
2098	Phosphorylation	GGMRVSVSSKGSIST CCCEEEEECCCCCCC	20.87	22210691
2102	Phosphorylation	VSVSSKGSISTPNSP EEEECCCCCCCCCCC	19.66	23403867
2104	Phosphorylation	VSSKGSISTPNSPVK EECCCCCCCCCCCCE	39.24	30266825
2105	Phosphorylation	SSKGSISTPNSPVKM ECCCCCCCCCCCCEE	25.48	30266825
2108	Phosphorylation	GSISTPNSPVKMTLI CCCCCCCCCCEEEEE	32.07	30266825
2113	Phosphorylation	PNSPVKMTLIPSPNS CCCCCEEEEECCCCC	18.80	23403867
2117	Phosphorylation	VKMTLIPSPNSPFQK CEEEEECCCCCCHHH	29.71	25159151
2120	Phosphorylation	TLIPSPNSPFQKVGK EEECCCCCCHHHHCC	30.40	25159151
2136	Phosphorylation	ASSDTGESDQSSTET CCCCCCCCCCCCCCC	42.15	21712546
2139	Phosphorylation	DTGESDQSSTETDST CCCCCCCCCCCCCHH	44.19	21712546
2153	Phosphorylation	TVKSQEESNPKLDPQ HCCCHHHHCCCCCHH	58.65	28555341
2170	Phosphorylation	AQKILEETQSHLIAV HHHHHHHHHHHHHHH	26.46	28555341
2183	Phosphorylation	AVERLQRSGGQVSKS HHHHHHHCCCCCCCC	34.02	21949786
2202	O-linked_Glycosylation	DGVQAPSSTAVFRAS CCCCCCCCCEEEEEC	21.23	30059200
2209	Phosphorylation	STAVFRASETSAFSR CCEEEEECCCCCCCC	36.83	28555341
2211	Phosphorylation	AVFRASETSAFSRPV EEEEECCCCCCCCCC	23.90	28555341
2212	Phosphorylation	VFRASETSAFSRPVL EEEECCCCCCCCCCC	24.22	28555341
2220	Phosphorylation	AFSRPVLSHQKSQPS CCCCCCCCCCCCCCC	24.89	28555341
2224	Phosphorylation	PVLSHQKSQPSPVTV CCCCCCCCCCCCCCC	40.53	25159151
2227	Phosphorylation	SHQKSQPSPVTVKPK CCCCCCCCCCCCCCC	25.10	25159151
2230	Phosphorylation	KSQPSPVTVKPKPPA CCCCCCCCCCCCCCC	26.62	23403867
2239	Phosphorylation	KPKPPARSSSLPKVS CCCCCCCCCCCCCCC	26.78	26699800
2240	Phosphorylation	PKPPARSSSLPKVSS CCCCCCCCCCCCCCC	30.27	26699800
2241	Phosphorylation	KPPARSSSLPKVSSG CCCCCCCCCCCCCCC	50.35	26699800
2246	O-linked_Glycosylation	SSSLPKVSSGYSSPT CCCCCCCCCCCCCCC	24.95	30059200
2246	Phosphorylation	SSSLPKVSSGYSSPT CCCCCCCCCCCCCCC	24.95	23403867
2247	Phosphorylation	SSLPKVSSGYSSPTT CCCCCCCCCCCCCCC	44.75	23403867
2249	Phosphorylation	LPKVSSGYSSPTTSE CCCCCCCCCCCCCCC	14.13	23403867
2250	Phosphorylation	PKVSSGYSSPTTSEM CCCCCCCCCCCCCCC	33.11	23403867
2251	Phosphorylation	KVSSGYSSPTTSEMS CCCCCCCCCCCCCCC	20.13	25159151
2253	Phosphorylation	SSGYSSPTTSEMSIK CCCCCCCCCCCCCCC	44.92	23403867
2254	Phosphorylation	SGYSSPTTSEMSIKD CCCCCCCCCCCCCCC	26.52	23403867
2255	Phosphorylation	GYSSPTTSEMSIKDS CCCCCCCCCCCCCCC	33.51	23403867
2258	Phosphorylation	SPTTSEMSIKDSPSQ CCCCCCCCCCCCCCC	23.57	23403867
2262	Phosphorylation	SEMSIKDSPSQHSGR CCCCCCCCCCCCCCC	22.81	23663014
2264	Phosphorylation	MSIKDSPSQHSGRPS CCCCCCCCCCCCCCC	44.47	23663014
2267	Phosphorylation	KDSPSQHSGRPSPGC CCCCCCCCCCCCCCC	28.94	23663014
2271	Phosphorylation	SQHSGRPSPGCDSQT CCCCCCCCCCCCCCC	32.34	23663014
2276	Phosphorylation	RPSPGCDSQTSQLDQ CCCCCCCCCCCCCCC	39.16	20873877
2278	Phosphorylation	SPGCDSQTSQLDQPL CCCCCCCCCCCCCCC	23.53	29978859
2279	Phosphorylation	PGCDSQTSQLDQPLF CCCCCCCCCCCCCCC	22.55	29978859
2290	Phosphorylation	QPLFKLKYPSSPYSA CCCCCCCCCCCCCCE	20.84	27732954
2292	Phosphorylation	LFKLKYPSSPYSAHI CCCCCCCCCCCCEEC	40.64	23403867
2293	Phosphorylation	FKLKYPSSPYSAHIS CCCCCCCCCCCEECC	24.29	25159151
2295	Phosphorylation	LKYPSSPYSAHISKS CCCCCCCCCEECCCC	22.04	25884760
2296	Phosphorylation	KYPSSPYSAHISKSP CCCCCCCCEECCCCC	19.43	23403867
2300	Phosphorylation	SPYSAHISKSPRNMS CCCCEECCCCCCCCC	19.74	23403867
2302	Phosphorylation	YSAHISKSPRNMSPS CCEECCCCCCCCCCC	23.46	23403867
2304	Methylation	AHISKSPRNMSPSSG EECCCCCCCCCCCCC	59.58	115919081
2307	Phosphorylation	SKSPRNMSPSSGHQS CCCCCCCCCCCCCCC	25.77	22496350
2309	Phosphorylation	SPRNMSPSSGHQSPA CCCCCCCCCCCCCCC	41.46	22496350
2310	Phosphorylation	PRNMSPSSGHQSPAG CCCCCCCCCCCCCCC	43.61	28857561
2314	Phosphorylation	SPSSGHQSPAGSAPS CCCCCCCCCCCCCCC	15.84	28857561
2318	Phosphorylation	GHQSPAGSAPSPALS CCCCCCCCCCCCCCC	38.83	28857561
2321	Phosphorylation	SPAGSAPSPALSYSS CCCCCCCCCCCCCCC	23.63	20068231
2325	Phosphorylation	SAPSPALSYSSAGSA CCCCCCCCCCCCCCC	25.69	25954137
2326	Phosphorylation	APSPALSYSSAGSAR CCCCCCCCCCCCCCC	13.90	27732954
2327	Phosphorylation	PSPALSYSSAGSARS CCCCCCCCCCCCCCC	15.44	25954137
2328	Phosphorylation	SPALSYSSAGSARSS CCCCCCCCCCCCCCC	28.54	25954137
2331	Phosphorylation	LSYSSAGSARSSPAD CCCCCCCCCCCCCCC	21.89	20068231
2334	Phosphorylation	SSAGSARSSPADAPD CCCCCCCCCCCCCCC	40.15	28450419
2335	Phosphorylation	SAGSARSSPADAPDI CCCCCCCCCCCCCCH	20.67	26657352
2366	Phosphorylation	NLKMFWQSTPQHSTG HHHHHHHCCCCCCCC	32.43	25627689
2367	Phosphorylation	LKMFWQSTPQHSTGP HHHHHHCCCCCCCCC	16.33	25159151
2371	Phosphorylation	WQSTPQHSTGPMKIF HHCCCCCCCCCCEEC	29.79	-
2379	Methylation	TGPMKIFRGAPGTMT CCCCEECCCCCCCCC	43.78	115919085
2393	Phosphorylation	TSKRDVLSLLNLSPR CCHHHHHHHHCCCCC	30.56	23403867
2398	Phosphorylation	VLSLLNLSPRHNKKE HHHHHCCCCCCCCCC	20.86	19664994
2440	Phosphorylation	HWRTETTSLGSLPLP CCCCCCCCCCCCCCC	37.85	28555341
2453	Phosphorylation	LPAGPPATAPARPLR CCCCCCCCCCCCCCC	38.66	28555341
2463	Phosphorylation	ARPLRLPSGNGYKFL CCCCCCCCCCCCCCC	49.86	-
2471	Phosphorylation	GNGYKFLSPGRFFPS CCCCCCCCCCCCCCC	28.57	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTC28_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTC28_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTC28_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TTC28_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2398, AND MASSSPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28 AND SER-32, AND MASSSPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2108; THR-2113; THR-2253AND SER-2398, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2104; SER-2108; SER-2398AND SER-2471, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-47 AND SER-2398,AND MASS SPECTROMETRY.
PubMed: 18691976