dbPTM

K0232_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	K0232_HUMAN
UniProt AC	Q92628
Protein Name	Uncharacterized protein KIAA0232
Gene Name	KIAA0232
Organism	Homo sapiens (Human).
Sequence Length	1395
Subcellular Localization
Protein Description
Protein Sequence	MYPICTVVVDGLPSESSSSSYPGPVSVSEMSLLHALGPVQTWLGQELEKCGIDAMIYTRYVLSLLLHDSYDYDLQEQENDIFLGWEKGAYKKWGKSKKKCSDLTLEEMKKQAAVQCLRSASDESSGIETLVEELCSRLKDLQSKQEEKIHKKLEGSPSPEAELSPPAKDQVEMYYEAFPPLSEKPVCLQEIMTVWNKSKVCSYSSSSSSSTAPPASTDTSSPKDCNSESEVTKERSSEVPTTVHEKTQSKSKNEKENKFSNGTIEEKPALYKKQIRHKPEGKIRPRSWSSGSSEAGSSSSGNQGELKASMKYVKVRHKAREIRNKKGRNGQSRLSLKHGEKAERNIHTGSSSSSSSGSVKQLCKRGKRPLKEIGRKDPGSTEGKDLYMENRKDTEYKEEPLWYTEPIAEYFVPLSRKSKLETTYRNRQDTSDLTSEAVEELSESVHGLCISNNNLHKTYLAAGTFIDGHFVEMPAVINEDIDLTGTSLCSLPEDNKYLDDIHLSELTHFYEVDIDQSMLDPGASETMQGESRILNMIRQKSKENTDFEAECCIVLDGMELQGERAIWTDSTSSVGAEGLFLQDLGNLAQFWECCSSSSGDADGESFGGDSPVRLSPILDSTVLNSHLLAGNQELFSDINEGSGINSCFSVFEVQCSNSVLPFSFETLNLGNENTDSSANMLGKTQSRLLIWTKNSAFEENEHCSNLSTRTCSPWSHSEETRSDNETLNIQFEESTQFNAEDINYVVPRVSSNYVDEELLDFLQDETCQQNSRTLGEIPTLVFKKTSKLESVCGIQLEQKTENKNFETTQVCNESPHGDGYSSGVIKDIWTKMADTNSVATVEIERTDAELFSADVNNYCCCLDAEAELETLQEPDKAVRRSEYHLWEGQKESLEKRAFASSELSNVDGGDYTTPSKPWDVAQDKENTFILGGVYGELKTFNSDGEWAVVPPSHTKGSLLQCAASDVVTIAGTDVFMTPGNSFAPGHRQLWKPFVSFEQNDQPKSGENGLNKGFSFIFHEDLLGACGNFQVEDPGLEYSFSSFDLSNPFSQVLHVECSFEPEGIASFSPSFKPKSILCSDSDSEVFHPRICGVDRTQYRAIRISPRTHFRPISASELSPGGGSESEFESEKDEANIPIPSQVDIFEDPQADLKPLEEDAEKEGHYYGKSELESGKFLPRLKKSGMEKSAQTSLDSQEESTGILSVGKQNQCLECSMNESLEIDLESSEANCKIMAQCEEEINNFCGCKAGCQFPAYEDNPVSSGQLEEFPVLNTDIQGMNRSQEKQTWWEKALYSPLFPASECEECYTNAKGESGLEEYPDAKETPSNEERLLDFNRVSSVYEARCTGERDSGAKSDGFRGKMCSSASSTSEETGSEGGGEWVGPSEEELFSRTHL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
101	Phosphorylation	GKSKKKCSDLTLEEM CCCCCCCCCCCHHHH	44.53	-
104	Phosphorylation	KKKCSDLTLEEMKKQ CCCCCCCCHHHHHHH	36.79	-
110	Ubiquitination	LTLEEMKKQAAVQCL CCHHHHHHHHHHHHH	43.81	-
125	Phosphorylation	RSASDESSGIETLVE HHCCCCCCCHHHHHH	41.56	22210691
129	Phosphorylation	DESSGIETLVEELCS CCCCCHHHHHHHHHH	33.90	22210691
136	Phosphorylation	TLVEELCSRLKDLQS HHHHHHHHHHHHHHH	53.96	22210691
139	Ubiquitination	EELCSRLKDLQSKQE HHHHHHHHHHHHHHH	56.11	-
156	Phosphorylation	IHKKLEGSPSPEAEL HHHHHCCCCCCCCCC	16.90	25159151
158	Phosphorylation	KKLEGSPSPEAELSP HHHCCCCCCCCCCCC	36.75	25159151
164	Phosphorylation	PSPEAELSPPAKDQV CCCCCCCCCCHHHHH	21.97	25159151
206	Phosphorylation	KVCSYSSSSSSSTAP CCCCCCCCCCCCCCC	28.44	-
208	Phosphorylation	CSYSSSSSSSTAPPA CCCCCCCCCCCCCCC	30.20	-
209	Phosphorylation	SYSSSSSSSTAPPAS CCCCCCCCCCCCCCC	33.39	22468782
211	Phosphorylation	SSSSSSSTAPPASTD CCCCCCCCCCCCCCC	45.17	22468782
216	Phosphorylation	SSTAPPASTDTSSPK CCCCCCCCCCCCCCC	32.37	28450419
217	Phosphorylation	STAPPASTDTSSPKD CCCCCCCCCCCCCCC	45.46	28450419
219	Phosphorylation	APPASTDTSSPKDCN CCCCCCCCCCCCCCC	31.06	28450419
220	Phosphorylation	PPASTDTSSPKDCNS CCCCCCCCCCCCCCC	47.67	28450419
221	Phosphorylation	PASTDTSSPKDCNSE CCCCCCCCCCCCCCC	37.75	28450419
227	Phosphorylation	SSPKDCNSESEVTKE CCCCCCCCCCCHHHH	49.16	28450419
229	Phosphorylation	PKDCNSESEVTKERS CCCCCCCCCHHHHHH	36.87	28450419
232	Phosphorylation	CNSESEVTKERSSEV CCCCCCHHHHHHCCC	24.12	28450419
242	Phosphorylation	RSSEVPTTVHEKTQS HHCCCCCCHHHHHCC	17.50	-
251	Phosphorylation	HEKTQSKSKNEKENK HHHHCCCCCCCCCCC	46.06	-
260	Phosphorylation	NEKENKFSNGTIEEK CCCCCCCCCCCCCCC	35.64	28509920
263	Phosphorylation	ENKFSNGTIEEKPAL CCCCCCCCCCCCHHH	29.48	28509920
271	Phosphorylation	IEEKPALYKKQIRHK CCCCHHHHHHHHCCC	20.46	28509920
335	Phosphorylation	RNGQSRLSLKHGEKA CCCCCCCHHCCCHHC	33.97	-
348	Phosphorylation	KAERNIHTGSSSSSS HCCCCCCCCCCCCCC	34.66	30576142
350	Phosphorylation	ERNIHTGSSSSSSSG CCCCCCCCCCCCCCH	28.36	26434776
351	Phosphorylation	RNIHTGSSSSSSSGS CCCCCCCCCCCCCHH	35.27	26434776
352	Phosphorylation	NIHTGSSSSSSSGSV CCCCCCCCCCCCHHH	35.62	26434776
353	Phosphorylation	IHTGSSSSSSSGSVK CCCCCCCCCCCHHHH	35.87	26434776
354	Phosphorylation	HTGSSSSSSSGSVKQ CCCCCCCCCCHHHHH	30.39	26434776
355	Phosphorylation	TGSSSSSSSGSVKQL CCCCCCCCCHHHHHH	40.44	26434776
356	Phosphorylation	GSSSSSSSGSVKQLC CCCCCCCCHHHHHHH	36.71	30576142
358	Phosphorylation	SSSSSSGSVKQLCKR CCCCCCHHHHHHHHC	28.26	26434776
380	Phosphorylation	IGRKDPGSTEGKDLY CCCCCCCCCCCHHCC	28.77	23186163
392	Ubiquitination	DLYMENRKDTEYKEE HCCCCCCCCCCCCCC	79.27	-
397	Ubiquitination	NRKDTEYKEEPLWYT CCCCCCCCCCCCCCC	49.74	-
410	Phosphorylation	YTEPIAEYFVPLSRK CCCCHHHHHCCCCCC	10.80	-
418	Phosphorylation	FVPLSRKSKLETTYR HCCCCCCHHCHHHHC	41.17	20068231
419	Ubiquitination	VPLSRKSKLETTYRN CCCCCCHHCHHHHCC	54.07	-
422	Phosphorylation	SRKSKLETTYRNRQD CCCHHCHHHHCCCCC	39.29	20068231
423	Phosphorylation	RKSKLETTYRNRQDT CCHHCHHHHCCCCCC	15.88	20068231
424	Phosphorylation	KSKLETTYRNRQDTS CHHCHHHHCCCCCCC	17.20	20068231
430	Phosphorylation	TYRNRQDTSDLTSEA HHCCCCCCCCCCHHH	18.79	-
431	Phosphorylation	YRNRQDTSDLTSEAV HCCCCCCCCCCHHHH	38.62	-
695	Phosphorylation	LLIWTKNSAFEENEH EEEEECCCCCCCCCC	35.57	29255136
704	Phosphorylation	FEENEHCSNLSTRTC CCCCCCCCCCCCCCC	42.59	29255136
707	Phosphorylation	NEHCSNLSTRTCSPW CCCCCCCCCCCCCCC	21.79	29255136
708	Phosphorylation	EHCSNLSTRTCSPWS CCCCCCCCCCCCCCC	32.91	29255136
710	Phosphorylation	CSNLSTRTCSPWSHS CCCCCCCCCCCCCCC	19.88	25849741
712	Phosphorylation	NLSTRTCSPWSHSEE CCCCCCCCCCCCCCC	28.88	28450419
715	Phosphorylation	TRTCSPWSHSEETRS CCCCCCCCCCCCCCC	22.11	28450419
717	Phosphorylation	TCSPWSHSEETRSDN CCCCCCCCCCCCCCC	31.45	28450419
779	Phosphorylation	RTLGEIPTLVFKKTS CCHHCCCEEEEECCC	41.01	28064214
787	Acetylation	LVFKKTSKLESVCGI EEEECCCCCHHHHCC	62.60	25953088
799	Ubiquitination	CGIQLEQKTENKNFE HCCEEEEECCCCCCC	48.72	-
803	Ubiquitination	LEQKTENKNFETTQV EEEECCCCCCCCEEE	57.70	-
807	Phosphorylation	TENKNFETTQVCNES CCCCCCCCEEECCCC	20.56	29255136
808	Phosphorylation	ENKNFETTQVCNESP CCCCCCCEEECCCCC	16.29	29255136
814	Phosphorylation	TTQVCNESPHGDGYS CEEECCCCCCCCCCC	14.27	29255136
820	Phosphorylation	ESPHGDGYSSGVIKD CCCCCCCCCCCCHHH	12.38	29255136
821	Phosphorylation	SPHGDGYSSGVIKDI CCCCCCCCCCCHHHH	26.58	23663014
822	Phosphorylation	PHGDGYSSGVIKDIW CCCCCCCCCCHHHHH	28.70	29255136
826	Ubiquitination	GYSSGVIKDIWTKMA CCCCCCHHHHHHHHC	40.53	-
883	Phosphorylation	KAVRRSEYHLWEGQK HHHHHHHHCCCCCCH	11.94	-
890	Ubiquitination	YHLWEGQKESLEKRA HCCCCCCHHHHHHHH	61.19	-
912	Phosphorylation	NVDGGDYTTPSKPWD CCCCCCCCCCCCCCC	36.65	22210691
913	Phosphorylation	VDGGDYTTPSKPWDV CCCCCCCCCCCCCCH	21.24	22210691
916	Ubiquitination	GDYTTPSKPWDVAQD CCCCCCCCCCCHHCC	51.86	-
927	Phosphorylation	VAQDKENTFILGGVY HHCCCCCCEEEEEEE	17.10	25690035
934	Phosphorylation	TFILGGVYGELKTFN CEEEEEEEEEEEEEC	14.25	25690035
995	Phosphorylation	QLWKPFVSFEQNDQP CCCCCCCCCCCCCCC	24.36	29507054
1004	Phosphorylation	EQNDQPKSGENGLNK CCCCCCCCCCCCCCC	59.01	30622161
1065	Phosphorylation	FEPEGIASFSPSFKP CCCCCCCCCCCCCCC	25.08	26074081
1067	Phosphorylation	PEGIASFSPSFKPKS CCCCCCCCCCCCCCE	19.69	26074081
1069	Phosphorylation	GIASFSPSFKPKSIL CCCCCCCCCCCCEEE	44.71	26074081
1074	Phosphorylation	SPSFKPKSILCSDSD CCCCCCCEEEECCCC	29.35	23663014
1078	Phosphorylation	KPKSILCSDSDSEVF CCCEEEECCCCCCCC	36.38	30266825
1080	Phosphorylation	KSILCSDSDSEVFHP CEEEECCCCCCCCCC	27.09	30266825
1082	Phosphorylation	ILCSDSDSEVFHPRI EEECCCCCCCCCCCC	39.34	23663014
1103	Phosphorylation	QYRAIRISPRTHFRP CEEEEEECCCCCCCC	9.85	30266825
1114	Phosphorylation	HFRPISASELSPGGG CCCCCCHHHCCCCCC	32.07	29523821
1117	Phosphorylation	PISASELSPGGGSES CCCHHHCCCCCCCHH	19.90	29523821
1122	Phosphorylation	ELSPGGGSESEFESE HCCCCCCCHHHHCCC	41.02	29523821
1124	Phosphorylation	SPGGGSESEFESEKD CCCCCCHHHHCCCCC	49.65	29523821
1128	Phosphorylation	GSESEFESEKDEANI CCHHHHCCCCCCCCC	56.09	29523821
1174	Acetylation	KSELESGKFLPRLKK HHHHHCCCCHHHHHH	53.67	25953088
1190	Phosphorylation	GMEKSAQTSLDSQEE CCCHHCCCCCCCCHH	30.85	27251275
1191	Phosphorylation	MEKSAQTSLDSQEES CCHHCCCCCCCCHHH	20.35	27251275
1194	Phosphorylation	SAQTSLDSQEESTGI HCCCCCCCCHHHHCC	44.80	29759185
1198	Phosphorylation	SLDSQEESTGILSVG CCCCCHHHHCCCCEE	31.05	27251275
1199	Phosphorylation	LDSQEESTGILSVGK CCCCHHHHCCCCEEC	31.36	27251275
1281	Phosphorylation	DIQGMNRSQEKQTWW CCCCCCHHHHHCCHH	37.37	30622161
1284	Ubiquitination	GMNRSQEKQTWWEKA CCCHHHHHCCHHHHH	45.45	-
1286	Phosphorylation	NRSQEKQTWWEKALY CHHHHHCCHHHHHHC	43.54	30622161
1293	Phosphorylation	TWWEKALYSPLFPAS CHHHHHHCCCCCCHH	17.07	26074081
1294	Phosphorylation	WWEKALYSPLFPASE HHHHHHCCCCCCHHH	18.90	25159151
1300	Phosphorylation	YSPLFPASECEECYT CCCCCCHHHCHHHHC	42.91	26074081
1306	Phosphorylation	ASECEECYTNAKGES HHHCHHHHCCCCCCC	13.30	27080861
1307	Phosphorylation	SECEECYTNAKGESG HHCHHHHCCCCCCCC	40.12	27080861
1322	Ubiquitination	LEEYPDAKETPSNEE CCCCCCCCCCCCCHH	70.29	-
1338	Phosphorylation	LLDFNRVSSVYEARC HCCHHHCCCEEEEEC	15.73	23312004
1339	Phosphorylation	LDFNRVSSVYEARCT CCHHHCCCEEEEECC	26.34	23312004
1341	Phosphorylation	FNRVSSVYEARCTGE HHHCCCEEEEECCCC	13.06	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of K0232_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of K0232_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of K0232_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
S35F6_HUMAN	SLC35F6	physical	16169070

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of K0232_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158, AND MASSSPECTROMETRY.	17081983 [Abstract]