UniProt ID | DMXL2_HUMAN | |
---|---|---|
UniProt AC | Q8TDJ6 | |
Protein Name | DmX-like protein 2 | |
Gene Name | DMXL2 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 3036 | |
Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Peripheral membrane protein . The external layer of the inferior boundary for the hypothalamus part of the human brain (the so called median eminence (ME)) displayed a punctate patte |
|
Protein Description | May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. [PubMed: 11809763 Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity] | |
Protein Sequence | MHLHQVLTGAVNPGDNCYSVGSVGDVPFTAYGSGCDIVILANDFECVQIIPGAKHGNIQVSCVECSNQQGRIAASYGNAVCIFEPLGINSHKRNCQLKCQWLKTGQFFLSSVTYNLAWDPQDNRLLTATDSIQLWAPPGDDILEEEEEIDNTVPPVLNDWKCVWQCKTSVSVHLMEWSPDGEYFATAGKDDCLLKVWYPMTGWKSSIIPQDHHEVKRRQSSTQFSFVYLAHPRAVTGFSWRKTSKYMPRGSVCNVLLTSCHDGVCRLWAETLLPEDCLLGEQICETTTSSIASSLSHAGRHKDRIQHALETIHHLKNLRKGQRRSSVLVTHAELMPDQTAMHEVQRHISHHANALCHFHIAASINPATDIPNVLVGTAFNVDDGNGGFVVHWLNNKEFHFTSSTEVFMHQLRKLSDKQVDHENDDADREDEEHSQEDRERGLHMKLDHDLSLDRESEAGTGSSEHEDGEREGSPRTYSRLSVPMPLPTVLLDRKIETLLTEWNKNPDMLFTIHPVDGTFLVWHVKYLDEYNPGIFRQVQVSFSSRIPVAFPSGDASSLSKNIMMYACINATKDSHHTLLHQEGMSVGSPHGSQPHSRSHSTHMNILAPTVMMISKHIDGSLNQWAVTFADKSAFTTVLTVSHKFRYCGHRFHLNDLACHSVLPLLLTSSHHNALLTPELDCQWDSDNKLSRLMDPVKHIKGSSKQPLRNAATRTFHDPNAIYSELILWRVDPIGPLSYTGGVSELARINSLHTSAFSNVAWLPTLIPSYCLGTYCNSASACFVASDGKNLRLYQAVVDARKLLDELSDPESSKLIGEVFNIVSQQSTARPGCIIELDAITNQCGSNTQLLHVFQEDFIIGYKPHKEDMEKKETEIFFQPSQGYRPPPFSEKFFLVVIEKDSNNNSILHMWHLHLKSVQACLAKASEGASSESLLSVPGQKNVDSSPETSPSVSPMPHSSSIANLQTASKLILSSRLVYSQPLDLPESVEVIRATPSAGHLSSSSIYPVCLAPYLVVTTCSDNKVRFWKCCMEANPECNKSDEKEIYHWKRWPLMNDEGEDNSSTVSIVGRPVAVSCSYTGRLAVAYKQPIHHNGFVSKEFSMHVCIFECESTGGSEWVLEQTIHLDDLVKVGSVLDSRVSVDSNLFVYSKSDALLSKDRYLIPNIKHLVHLDWVSKEDGSHILTVGVGANIFMYGRLSGIVTEQTNSKDGVAVITLPLGGSIKQGVKSRWVLLRSIDLVSSVDGTPSLPVSLSWVRDGILVVGMDCEMHVYAQWKHAVKFGDTEADSSNAEEAAMQDHSTFKSNMLARKSVVEGTAISDDVFCSPTVIQDGGLFEAAHVLSPTLPQYHPTQLLELMDLGKVRRAKAILSHLVKCIAGEVAIVRDPDAGEGTKRHLSRTISVSGSTAKETVTVGKDGTRDYTEIDSIPPLPLYALLAADQDTSYRISEESTKIPQSYEDQTVSQPEDQYSELFQIQDIPTDDIDLEPEKRENKSKVINLSQYGPAYFGQEHARVLSSHLMHSSLPGLTRLEQMFLVALADTVATTSTELDESRDKSCSGRDTLDECGLRYLLAMRLHTCLLTSLPPLYRVQLLHQGVSTCHFAWAFHSEAEEELINMIPAIQRGDPQWSELRAMGIGWWVRNINTLRRCIEKVAKASFQRNNDALDAALFYLSMKKKAVVWGLFRSQHDEKMTTFFSHNFNEDRWRKAALKNAFSLLGKQRFEQSAAFFLLAGSLKDAIEVCLEKMEDIQLAMVIARLYESEFETSSTYISILNQKILGCQKDGSGFSCKRLHPDPFLRSLAYWVMKDYTRALDTLLEQTPKEDDEHQVIIKSCNPVAFSFYNYLRTHPLLIRRNLASPEGTLATLGLKTEKNFVDKINLIERKLFFTTANAHFKVGCPVLALEVLSKIPKVTKTSALSAKKDQPDFISHRMDDVPSHSKALSDGNGSSGIEWSNVTSSQYDWSQPIVKVDEEPLNLDWGEDHDSALDEEEDDAVGLVMKSTDAREKDKQSDQKASDPNMLLTPQEEDDPEGDTEVDVIAEQLKFRACLKILMTELRTLATGYEVDGGKLRFQLYNWLEKEIAALHEICNHESVIKEYSSKTYSKVESDLLDQEEMVDKPDIGSYERHQIERRRLQAKREHAERRKSWLQKNQDLLRVFLSYCSLHGAQGGGLASVRMELKFLLQESQQETTVKQLQSPLPLPTTLPLLSASIASTKTVIANPVLYLNNHIHDILYTIVQMKTPPHPSIEDVKVHTLHSLAASLSASIYQALCDSHSYSQTEGNQFTGMAYQGLLLSDRRRLRTESIEEHATPNSSPAQWPGVSSLINLLSSAQDEDQPKLNILLCEAVVAVYLSLLIHALATNSSSELFRLAAHPLNNRMWAAVFGGGVKLVVKPRRQSENISAPPVLSEDIDKHRRRFNMRMLVPGRPVKDATPPPVPAERPSYKEKFIPPELSMWDYFVAKPFLPLSDSGVIYDSDESIHSDEEDDAFFSDTQIQEHQDPNSYSWALLHLTMVKLALHNVKNFFPIAGLEFSELPVTSPLGIAVIKNLENWEQILQEKMDQFEGPPPNYINTYPTDLSVGAGPAILRNKAMLEPENTPFKSRDSSAFPVKRLWHFLVKQEVLQETFIRYIFTKKRKQSEVEADLGYPGGKAKVIHKESDMIMAFSVNKANCNEIVLASTHDVQELDVTSLLACQSYIWIGEEYDRESKSSDDVDYRGSTTTLYQPSATSYSASQVHPPSSLPWLGTGQTSTGASVLMKRNLHNVKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFRQAGNARVTRLYFNSQGNKCGVADGEGFLSIWQVNQTASNPKPYMSWQCHSKATSDFAFITSSSLVATSGHSNDNRNVCLWDTLISPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKSEHAKQSIFRNIGAGVMQIDIIQGNRLFSCGADGTLKTRVLPNAFNIPNRILDIL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
92 | Acetylation | PLGINSHKRNCQLKC CCCCCCCCCCCEEEE | 45.16 | 25953088 | |
198 | Phosphorylation | DCLLKVWYPMTGWKS CEEEEEEEECCCCCC | 6.01 | - | |
221 | Phosphorylation | EVKRRQSSTQFSFVY HHHHCCCCCCEEEEE | 20.21 | 25307156 | |
246 | Phosphorylation | SWRKTSKYMPRGSVC CCEECCCCCCCCCHH | 16.48 | - | |
325 | Phosphorylation | LRKGQRRSSVLVTHA HCCCCCCCCEEEEEH | 27.30 | 28450419 | |
326 | Phosphorylation | RKGQRRSSVLVTHAE CCCCCCCCEEEEEHH | 20.05 | 28450419 | |
330 | Phosphorylation | RRSSVLVTHAELMPD CCCCEEEEEHHHCCC | 15.94 | 28450419 | |
339 | Phosphorylation | AELMPDQTAMHEVQR HHHCCCCCHHHHHHH | 33.07 | 27080861 | |
434 | Phosphorylation | DREDEEHSQEDRERG CHHCHHHCHHHHHHC | 38.25 | 24719451 | |
451 | Phosphorylation | MKLDHDLSLDRESEA CCCCCCCCCCCCCCC | 33.99 | 29255136 | |
456 | Phosphorylation | DLSLDRESEAGTGSS CCCCCCCCCCCCCCC | 33.37 | 29255136 | |
460 | Phosphorylation | DRESEAGTGSSEHED CCCCCCCCCCCCCCC | 40.72 | 29255136 | |
462 | Phosphorylation | ESEAGTGSSEHEDGE CCCCCCCCCCCCCCC | 32.18 | 29255136 | |
463 | Phosphorylation | SEAGTGSSEHEDGER CCCCCCCCCCCCCCC | 44.30 | 29255136 | |
473 | Phosphorylation | EDGEREGSPRTYSRL CCCCCCCCCCCCCCC | 13.37 | 23401153 | |
481 | Phosphorylation | PRTYSRLSVPMPLPT CCCCCCCCCCCCCCC | 24.06 | 27251275 | |
488 | Phosphorylation | SVPMPLPTVLLDRKI CCCCCCCCHHHHHHH | 31.31 | 28842319 | |
494 | Ubiquitination | PTVLLDRKIETLLTE CCHHHHHHHHHHHHH | 44.56 | - | |
500 | Phosphorylation | RKIETLLTEWNKNPD HHHHHHHHHHHCCCC | 41.91 | 24719451 | |
552 | Phosphorylation | RIPVAFPSGDASSLS CCCEECCCCCHHHCC | 42.74 | 22210691 | |
559 | Phosphorylation | SGDASSLSKNIMMYA CCCHHHCCHHHHHHH | 26.13 | 22210691 | |
565 | Phosphorylation | LSKNIMMYACINATK CCHHHHHHHHHHCCC | 4.87 | 22210691 | |
574 | Phosphorylation | CINATKDSHHTLLHQ HHHCCCCCCCCCCCC | 20.80 | 20068231 | |
577 | Phosphorylation | ATKDSHHTLLHQEGM CCCCCCCCCCCCCCC | 26.12 | 20068231 | |
585 | Phosphorylation | LLHQEGMSVGSPHGS CCCCCCCCCCCCCCC | 33.90 | 20068231 | |
588 | Phosphorylation | QEGMSVGSPHGSQPH CCCCCCCCCCCCCCC | 16.15 | 20068231 | |
592 | Phosphorylation | SVGSPHGSQPHSRSH CCCCCCCCCCCCCCC | 37.19 | 20068231 | |
596 | Phosphorylation | PHGSQPHSRSHSTHM CCCCCCCCCCCCCCH | 42.01 | 20068231 | |
598 | Phosphorylation | GSQPHSRSHSTHMNI CCCCCCCCCCCCHHH | 25.46 | 28857561 | |
600 | Phosphorylation | QPHSRSHSTHMNILA CCCCCCCCCCHHHHH | 22.66 | 28857561 | |
601 | Phosphorylation | PHSRSHSTHMNILAP CCCCCCCCCHHHHHH | 21.52 | 28857561 | |
614 | Phosphorylation | APTVMMISKHIDGSL HHHHHHHHHCCCCCC | 10.57 | 20068231 | |
676 | Phosphorylation | SHHNALLTPELDCQW CCCCCCCCCCCCCCC | 18.63 | 25332170 | |
685 | Phosphorylation | ELDCQWDSDNKLSRL CCCCCCCCCCHHHHH | 39.87 | - | |
702 | Phosphorylation | PVKHIKGSSKQPLRN HHHHCCCCCCCCCCC | 29.38 | 25999147 | |
703 | Phosphorylation | VKHIKGSSKQPLRNA HHHCCCCCCCCCCCC | 43.93 | 25999147 | |
743 | Phosphorylation | LSYTGGVSELARINS CCCCCCHHHHHHHHC | 30.12 | 20068231 | |
757 | Phosphorylation | SLHTSAFSNVAWLPT CCCCCCCCCCCCCCC | 30.06 | 28387310 | |
774 | Phosphorylation | PSYCLGTYCNSASAC CHHHHCCCCCCCCEE | 6.45 | 28387310 | |
801 | Ubiquitination | QAVVDARKLLDELSD HHHHHHHHHHHHCCC | 55.94 | - | |
925 | Phosphorylation | QACLAKASEGASSES HHHHHHHHCCCCCCH | 35.54 | 25159151 | |
929 | Phosphorylation | AKASEGASSESLLSV HHHHCCCCCCHHCCC | 45.56 | 25159151 | |
930 | Phosphorylation | KASEGASSESLLSVP HHHCCCCCCHHCCCC | 30.58 | 23911959 | |
932 | Phosphorylation | SEGASSESLLSVPGQ HCCCCCCHHCCCCCC | 36.24 | 30576142 | |
935 | Phosphorylation | ASSESLLSVPGQKNV CCCCHHCCCCCCCCC | 31.40 | 26074081 | |
944 | Phosphorylation | PGQKNVDSSPETSPS CCCCCCCCCCCCCCC | 43.43 | 23927012 | |
945 | Phosphorylation | GQKNVDSSPETSPSV CCCCCCCCCCCCCCC | 23.45 | 25159151 | |
948 | Phosphorylation | NVDSSPETSPSVSPM CCCCCCCCCCCCCCC | 49.69 | 23927012 | |
949 | Phosphorylation | VDSSPETSPSVSPMP CCCCCCCCCCCCCCC | 17.32 | 25159151 | |
951 | Phosphorylation | SSPETSPSVSPMPHS CCCCCCCCCCCCCCC | 34.69 | 23927012 | |
953 | Phosphorylation | PETSPSVSPMPHSSS CCCCCCCCCCCCCHH | 21.59 | 23927012 | |
958 | Phosphorylation | SVSPMPHSSSIANLQ CCCCCCCCHHHCCHH | 21.65 | 25850435 | |
959 | Phosphorylation | VSPMPHSSSIANLQT CCCCCCCHHHCCHHH | 23.80 | 30576142 | |
960 | Phosphorylation | SPMPHSSSIANLQTA CCCCCCHHHCCHHHH | 28.83 | 23927012 | |
966 | Phosphorylation | SSIANLQTASKLILS HHHCCHHHHHHHHHH | 35.74 | 23927012 | |
968 | Phosphorylation | IANLQTASKLILSSR HCCHHHHHHHHHHCC | 31.23 | 23927012 | |
973 | Phosphorylation | TASKLILSSRLVYSQ HHHHHHHHCCCHHCC | 13.35 | 24719451 | |
974 | Phosphorylation | ASKLILSSRLVYSQP HHHHHHHCCCHHCCC | 26.62 | 24719451 | |
1049 | Acetylation | EKEIYHWKRWPLMND CHHHHEEEECCCCCC | 31.13 | 19608861 | |
1077 | Phosphorylation | RPVAVSCSYTGRLAV CEEEEEEECCCCEEE | 20.44 | 20068231 | |
1137 | Phosphorylation | KVGSVLDSRVSVDSN ECCCCCCCCEECCCC | 30.35 | 28634120 | |
1140 | Phosphorylation | SVLDSRVSVDSNLFV CCCCCCEECCCCEEE | 21.06 | 30266825 | |
1143 | Phosphorylation | DSRVSVDSNLFVYSK CCCEECCCCEEEEEC | 33.02 | 30266825 | |
1148 | Phosphorylation | VDSNLFVYSKSDALL CCCCEEEEECHHHHH | 11.75 | 29691806 | |
1149 | Phosphorylation | DSNLFVYSKSDALLS CCCEEEEECHHHHHC | 22.00 | 29691806 | |
1151 | Phosphorylation | NLFVYSKSDALLSKD CEEEEECHHHHHCCC | 23.36 | 28348404 | |
1156 | Phosphorylation | SKSDALLSKDRYLIP ECHHHHHCCCCCCCC | 33.10 | 29691806 | |
1157 | Ubiquitination | KSDALLSKDRYLIPN CHHHHHCCCCCCCCC | 46.31 | - | |
1221 | Phosphorylation | ITLPLGGSIKQGVKS EEEECCCCHHHCCCH | 25.47 | 28857561 | |
1251 | Phosphorylation | GTPSLPVSLSWVRDG CCCCCCEEEEEEECC | 18.10 | - | |
1287 | Phosphorylation | FGDTEADSSNAEEAA CCCCCCCCCCHHHHH | 32.32 | 25627689 | |
1288 | Phosphorylation | GDTEADSSNAEEAAM CCCCCCCCCHHHHHH | 40.38 | 25627689 | |
1299 | Phosphorylation | EAAMQDHSTFKSNML HHHHHCHHHHHHHHC | 43.77 | 24260401 | |
1300 | Phosphorylation | AAMQDHSTFKSNMLA HHHHCHHHHHHHHCC | 31.49 | 28555341 | |
1303 | Phosphorylation | QDHSTFKSNMLARKS HCHHHHHHHHCCCCC | 24.23 | 23879269 | |
1365 | Ubiquitination | LGKVRRAKAILSHLV HHHHHHHHHHHHHHH | 33.86 | - | |
1396 | Phosphorylation | EGTKRHLSRTISVSG CCHHHEEEEEEEECC | 22.66 | 29514088 | |
1398 | Phosphorylation | TKRHLSRTISVSGST HHHEEEEEEEECCCC | 17.77 | 22617229 | |
1400 | Phosphorylation | RHLSRTISVSGSTAK HEEEEEEEECCCCCE | 15.04 | 25159151 | |
1402 | Phosphorylation | LSRTISVSGSTAKET EEEEEEECCCCCEEE | 21.89 | 30183078 | |
1404 | Phosphorylation | RTISVSGSTAKETVT EEEEECCCCCEEEEE | 20.06 | 25159151 | |
1405 | Phosphorylation | TISVSGSTAKETVTV EEEECCCCCEEEEEE | 45.32 | 21712546 | |
1409 | Phosphorylation | SGSTAKETVTVGKDG CCCCCEEEEEECCCC | 22.29 | 29978859 | |
1411 | Phosphorylation | STAKETVTVGKDGTR CCCEEEEEECCCCCC | 30.84 | 27486199 | |
1417 | Phosphorylation | VTVGKDGTRDYTEID EEECCCCCCCCCCCC | 30.42 | - | |
1456 | Phosphorylation | STKIPQSYEDQTVSQ CCCCCCCCCCCCCCC | 20.48 | 22817900 | |
1468 | Phosphorylation | VSQPEDQYSELFQIQ CCCCHHHHHHHCCCC | 19.21 | 28796482 | |
1469 | Phosphorylation | SQPEDQYSELFQIQD CCCHHHHHHHCCCCC | 23.38 | 28796482 | |
1488 | Ubiquitination | DIDLEPEKRENKSKV CCCCCHHHCCCCCCE | 75.60 | - | |
1494 | Acetylation | EKRENKSKVINLSQY HHCCCCCCEEEHHHC | 49.06 | 25953088 | |
1501 | Phosphorylation | KVINLSQYGPAYFGQ CEEEHHHCCCHHCCH | 23.00 | 27642862 | |
1515 | Phosphorylation | QEHARVLSSHLMHSS HHHHHHHHHHHHCCC | 16.92 | - | |
1516 | Phosphorylation | EHARVLSSHLMHSSL HHHHHHHHHHHCCCC | 19.24 | - | |
1521 | Phosphorylation | LSSHLMHSSLPGLTR HHHHHHCCCCCCCHH | 21.43 | - | |
1710 | Ubiquitination | RWRKAALKNAFSLLG HHHHHHHHHHHHHHC | 41.31 | - | |
1718 | Ubiquitination | NAFSLLGKQRFEQSA HHHHHHCHHHHHHHH | 37.97 | - | |
1733 | Phosphorylation | AFFLLAGSLKDAIEV HHHHHHHCHHHHHHH | 27.00 | 29449344 | |
1781 | Ubiquitination | QKILGCQKDGSGFSC HHHHCCCCCCCCCCC | 69.04 | - | |
1809 | O-linked_Glycosylation | YWVMKDYTRALDTLL HHHHHHHHHHHHHHH | 21.43 | 30379171 | |
1821 | Ubiquitination | TLLEQTPKEDDEHQV HHHHCCCCCCCCCCE | 76.73 | - | |
1832 | Phosphorylation | EHQVIIKSCNPVAFS CCCEEEECCCCCHHH | 14.55 | 24144214 | |
1839 | Phosphorylation | SCNPVAFSFYNYLRT CCCCCHHHHHHHHHH | 19.65 | 24144214 | |
1841 | Phosphorylation | NPVAFSFYNYLRTHP CCCHHHHHHHHHHCC | 11.16 | 24144214 | |
1843 | Phosphorylation | VAFSFYNYLRTHPLL CHHHHHHHHHHCCCH | 6.03 | 24144214 | |
1846 | Phosphorylation | SFYNYLRTHPLLIRR HHHHHHHHCCCHHCC | 25.83 | 22210691 | |
1857 | Phosphorylation | LIRRNLASPEGTLAT HHCCCCCCCCCCCCC | 27.01 | 29255136 | |
1861 | Phosphorylation | NLASPEGTLATLGLK CCCCCCCCCCCCCCC | 16.14 | 30266825 | |
1864 | Phosphorylation | SPEGTLATLGLKTEK CCCCCCCCCCCCCCC | 25.19 | 29396449 | |
1876 | Acetylation | TEKNFVDKINLIERK CCCCHHHHHHHHHHH | 28.35 | 133609 | |
1876 | Ubiquitination | TEKNFVDKINLIERK CCCCHHHHHHHHHHH | 28.35 | - | |
1907 | Ubiquitination | LALEVLSKIPKVTKT HHHHHHHCCCCCCCC | 59.89 | - | |
1913 | Ubiquitination | SKIPKVTKTSALSAK HCCCCCCCCCCCCCC | 43.39 | - | |
1914 | Phosphorylation | KIPKVTKTSALSAKK CCCCCCCCCCCCCCC | 15.18 | 29396449 | |
1915 | Phosphorylation | IPKVTKTSALSAKKD CCCCCCCCCCCCCCC | 28.86 | 29396449 | |
1918 | Phosphorylation | VTKTSALSAKKDQPD CCCCCCCCCCCCCCC | 37.45 | 29396449 | |
1921 | Ubiquitination | TSALSAKKDQPDFIS CCCCCCCCCCCCHHH | 62.40 | - | |
1960 | Phosphorylation | SNVTSSQYDWSQPIV ECCCCCCCCCCCCEE | 22.71 | 25884760 | |
1984 | Phosphorylation | DWGEDHDSALDEEED CCCCCCCCCCCCCCC | 27.58 | 22617229 | |
2022 | Phosphorylation | SDPNMLLTPQEEDDP CCCCCCCCCCCCCCC | 20.97 | - | |
2053 | Phosphorylation | ACLKILMTELRTLAT HHHHHHHHHHHHHHC | 28.55 | 28634298 | |
2057 | Phosphorylation | ILMTELRTLATGYEV HHHHHHHHHHCCCEE | 33.11 | 28634298 | |
2062 | Phosphorylation | LRTLATGYEVDGGKL HHHHHCCCEECCCEE | 14.39 | - | |
2074 | Phosphorylation | GKLRFQLYNWLEKEI CEEEHHHHHHHHHHH | 8.10 | 26074081 | |
2101 | Phosphorylation | IKEYSSKTYSKVESD HHHHHCCCCCCHHHH | 34.67 | - | |
2102 | Phosphorylation | KEYSSKTYSKVESDL HHHHCCCCCCHHHHC | 15.38 | - | |
2103 | Phosphorylation | EYSSKTYSKVESDLL HHHCCCCCCHHHHCC | 35.14 | - | |
2123 | Phosphorylation | VDKPDIGSYERHQIE CCCCCCCHHHHHHHH | 24.93 | 27732954 | |
2124 | Phosphorylation | DKPDIGSYERHQIER CCCCCCHHHHHHHHH | 16.27 | 27732954 | |
2186 | Phosphorylation | LKFLLQESQQETTVK HHHHHHHHCCCCHHH | 24.97 | 22210691 | |
2191 | Phosphorylation | QESQQETTVKQLQSP HHHCCCCHHHHHCCC | 25.59 | 22210691 | |
2197 | Phosphorylation | TTVKQLQSPLPLPTT CHHHHHCCCCCCCCH | 36.68 | 26657352 | |
2203 | Phosphorylation | QSPLPLPTTLPLLSA CCCCCCCCHHHHHHH | 48.96 | 28348404 | |
2204 | Phosphorylation | SPLPLPTTLPLLSAS CCCCCCCHHHHHHHH | 25.16 | 22210691 | |
2209 | Phosphorylation | PTTLPLLSASIASTK CCHHHHHHHHCCCCC | 27.87 | 24043423 | |
2211 | Phosphorylation | TLPLLSASIASTKTV HHHHHHHHCCCCCCE | 18.47 | 24043423 | |
2214 | Phosphorylation | LLSASIASTKTVIAN HHHHHCCCCCCEECC | 28.85 | 24043423 | |
2215 | Phosphorylation | LSASIASTKTVIANP HHHHCCCCCCEECCC | 23.01 | 24043423 | |
2235 | Phosphorylation | NHIHDILYTIVQMKT CCHHHHHHHHHHCCC | 8.51 | 26074081 | |
2236 | Phosphorylation | HIHDILYTIVQMKTP CHHHHHHHHHHCCCC | 15.95 | 26074081 | |
2242 | Phosphorylation | YTIVQMKTPPHPSIE HHHHHCCCCCCCCHH | 36.39 | 26074081 | |
2247 | Phosphorylation | MKTPPHPSIEDVKVH CCCCCCCCHHHCCHH | 35.26 | 26074081 | |
2330 | Phosphorylation | SSLINLLSSAQDEDQ HHHHHHHHCCCCCCC | 27.13 | - | |
2331 | Phosphorylation | SLINLLSSAQDEDQP HHHHHHHCCCCCCCC | 29.89 | - | |
2399 | Phosphorylation | VVKPRRQSENISAPP EECCCCCCCCCCCCC | 30.69 | 29255136 | |
2400 | Phosphorylation | VKPRRQSENISAPPV ECCCCCCCCCCCCCC | 50.69 | 24719451 | |
2403 | Phosphorylation | RRQSENISAPPVLSE CCCCCCCCCCCCCCH | 46.43 | 23927012 | |
2409 | Phosphorylation | ISAPPVLSEDIDKHR CCCCCCCCHHHHHHH | 33.19 | 29396449 | |
2434 | Phosphorylation | GRPVKDATPPPVPAE CCCCCCCCCCCCCCC | 46.60 | 25159151 | |
2435 | Phosphorylation | RPVKDATPPPVPAER CCCCCCCCCCCCCCC | 32.68 | 27251275 | |
2560 | Ubiquitination | WEQILQEKMDQFEGP HHHHHHHHHHHCCCC | 34.51 | - | |
2591 | Ubiquitination | GPAILRNKAMLEPEN CHHHHCCCCCCCCCC | 28.83 | - | |
2602 | Methylation | EPENTPFKSRDSSAF CCCCCCCCCCCCCCC | 45.87 | 115976479 | |
2603 | Phosphorylation | PENTPFKSRDSSAFP CCCCCCCCCCCCCCC | 41.52 | 23312004 | |
2606 | Phosphorylation | TPFKSRDSSAFPVKR CCCCCCCCCCCCHHH | 23.58 | 23312004 | |
2607 | Phosphorylation | PFKSRDSSAFPVKRL CCCCCCCCCCCHHHH | 37.91 | 23312004 | |
2640 | Phosphorylation | FTKKRKQSEVEADLG HCCCCCCCCCCCCCC | 46.79 | 27732954 | |
2712 | Phosphorylation | YDRESKSSDDVDYRG CCCCCCCCCCCCCCC | 41.38 | 25307156 | |
2717 | Phosphorylation | KSSDDVDYRGSTTTL CCCCCCCCCCCEEEE | 19.40 | - | |
2753 | Phosphorylation | LGTGQTSTGASVLMK CCCCCCCCCHHHHHH | 39.91 | 23663014 | |
2770 | Phosphorylation | LHNVKRMTSHPVHQY CCCCCCCCCCCCHHH | 28.10 | 24505115 | |
2771 | Phosphorylation | HNVKRMTSHPVHQYY CCCCCCCCCCCHHHE | 19.22 | 24505115 | |
2777 | Phosphorylation | TSHPVHQYYLTGAQD CCCCCHHHEECCCCC | 5.88 | 24505115 | |
2778 | Phosphorylation | SHPVHQYYLTGAQDG CCCCHHHEECCCCCC | 7.39 | 24505115 | |
2780 | Phosphorylation | PVHQYYLTGAQDGSV CCHHHEECCCCCCCE | 17.85 | 24505115 | |
2852 | Phosphorylation | YMSWQCHSKATSDFA CCEEECCCCCCCCEE | 31.45 | 25690035 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DMXL2_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DMXL2_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DMXL2_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
WDR7_HUMAN | WDR7 | physical | 12786944 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
616113 | Polyendocrine-polyneuropathy syndrome (PEPNS) | |||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Acetylation | |
Reference | PubMed |
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1049, AND MASS SPECTROMETRY. | |
Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-944; SER-945; SER-1140;SER-1143; SER-1857 AND SER-1984, AND MASS SPECTROMETRY. | |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-944; SER-945; SER-949;SER-1400; SER-1857 AND SER-1984, AND MASS SPECTROMETRY. | |
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1857, AND MASSSPECTROMETRY. | |
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1400 AND SER-1404, ANDMASS SPECTROMETRY. |