DMXL2_HUMAN - dbPTM
DMXL2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DMXL2_HUMAN
UniProt AC Q8TDJ6
Protein Name DmX-like protein 2
Gene Name DMXL2
Organism Homo sapiens (Human).
Sequence Length 3036
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Peripheral membrane protein . The external layer of the inferior boundary for the hypothalamus part of the human brain (the so called median eminence (ME)) displayed a punctate patte
Protein Description May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. [PubMed: 11809763 Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity]
Protein Sequence MHLHQVLTGAVNPGDNCYSVGSVGDVPFTAYGSGCDIVILANDFECVQIIPGAKHGNIQVSCVECSNQQGRIAASYGNAVCIFEPLGINSHKRNCQLKCQWLKTGQFFLSSVTYNLAWDPQDNRLLTATDSIQLWAPPGDDILEEEEEIDNTVPPVLNDWKCVWQCKTSVSVHLMEWSPDGEYFATAGKDDCLLKVWYPMTGWKSSIIPQDHHEVKRRQSSTQFSFVYLAHPRAVTGFSWRKTSKYMPRGSVCNVLLTSCHDGVCRLWAETLLPEDCLLGEQICETTTSSIASSLSHAGRHKDRIQHALETIHHLKNLRKGQRRSSVLVTHAELMPDQTAMHEVQRHISHHANALCHFHIAASINPATDIPNVLVGTAFNVDDGNGGFVVHWLNNKEFHFTSSTEVFMHQLRKLSDKQVDHENDDADREDEEHSQEDRERGLHMKLDHDLSLDRESEAGTGSSEHEDGEREGSPRTYSRLSVPMPLPTVLLDRKIETLLTEWNKNPDMLFTIHPVDGTFLVWHVKYLDEYNPGIFRQVQVSFSSRIPVAFPSGDASSLSKNIMMYACINATKDSHHTLLHQEGMSVGSPHGSQPHSRSHSTHMNILAPTVMMISKHIDGSLNQWAVTFADKSAFTTVLTVSHKFRYCGHRFHLNDLACHSVLPLLLTSSHHNALLTPELDCQWDSDNKLSRLMDPVKHIKGSSKQPLRNAATRTFHDPNAIYSELILWRVDPIGPLSYTGGVSELARINSLHTSAFSNVAWLPTLIPSYCLGTYCNSASACFVASDGKNLRLYQAVVDARKLLDELSDPESSKLIGEVFNIVSQQSTARPGCIIELDAITNQCGSNTQLLHVFQEDFIIGYKPHKEDMEKKETEIFFQPSQGYRPPPFSEKFFLVVIEKDSNNNSILHMWHLHLKSVQACLAKASEGASSESLLSVPGQKNVDSSPETSPSVSPMPHSSSIANLQTASKLILSSRLVYSQPLDLPESVEVIRATPSAGHLSSSSIYPVCLAPYLVVTTCSDNKVRFWKCCMEANPECNKSDEKEIYHWKRWPLMNDEGEDNSSTVSIVGRPVAVSCSYTGRLAVAYKQPIHHNGFVSKEFSMHVCIFECESTGGSEWVLEQTIHLDDLVKVGSVLDSRVSVDSNLFVYSKSDALLSKDRYLIPNIKHLVHLDWVSKEDGSHILTVGVGANIFMYGRLSGIVTEQTNSKDGVAVITLPLGGSIKQGVKSRWVLLRSIDLVSSVDGTPSLPVSLSWVRDGILVVGMDCEMHVYAQWKHAVKFGDTEADSSNAEEAAMQDHSTFKSNMLARKSVVEGTAISDDVFCSPTVIQDGGLFEAAHVLSPTLPQYHPTQLLELMDLGKVRRAKAILSHLVKCIAGEVAIVRDPDAGEGTKRHLSRTISVSGSTAKETVTVGKDGTRDYTEIDSIPPLPLYALLAADQDTSYRISEESTKIPQSYEDQTVSQPEDQYSELFQIQDIPTDDIDLEPEKRENKSKVINLSQYGPAYFGQEHARVLSSHLMHSSLPGLTRLEQMFLVALADTVATTSTELDESRDKSCSGRDTLDECGLRYLLAMRLHTCLLTSLPPLYRVQLLHQGVSTCHFAWAFHSEAEEELINMIPAIQRGDPQWSELRAMGIGWWVRNINTLRRCIEKVAKASFQRNNDALDAALFYLSMKKKAVVWGLFRSQHDEKMTTFFSHNFNEDRWRKAALKNAFSLLGKQRFEQSAAFFLLAGSLKDAIEVCLEKMEDIQLAMVIARLYESEFETSSTYISILNQKILGCQKDGSGFSCKRLHPDPFLRSLAYWVMKDYTRALDTLLEQTPKEDDEHQVIIKSCNPVAFSFYNYLRTHPLLIRRNLASPEGTLATLGLKTEKNFVDKINLIERKLFFTTANAHFKVGCPVLALEVLSKIPKVTKTSALSAKKDQPDFISHRMDDVPSHSKALSDGNGSSGIEWSNVTSSQYDWSQPIVKVDEEPLNLDWGEDHDSALDEEEDDAVGLVMKSTDAREKDKQSDQKASDPNMLLTPQEEDDPEGDTEVDVIAEQLKFRACLKILMTELRTLATGYEVDGGKLRFQLYNWLEKEIAALHEICNHESVIKEYSSKTYSKVESDLLDQEEMVDKPDIGSYERHQIERRRLQAKREHAERRKSWLQKNQDLLRVFLSYCSLHGAQGGGLASVRMELKFLLQESQQETTVKQLQSPLPLPTTLPLLSASIASTKTVIANPVLYLNNHIHDILYTIVQMKTPPHPSIEDVKVHTLHSLAASLSASIYQALCDSHSYSQTEGNQFTGMAYQGLLLSDRRRLRTESIEEHATPNSSPAQWPGVSSLINLLSSAQDEDQPKLNILLCEAVVAVYLSLLIHALATNSSSELFRLAAHPLNNRMWAAVFGGGVKLVVKPRRQSENISAPPVLSEDIDKHRRRFNMRMLVPGRPVKDATPPPVPAERPSYKEKFIPPELSMWDYFVAKPFLPLSDSGVIYDSDESIHSDEEDDAFFSDTQIQEHQDPNSYSWALLHLTMVKLALHNVKNFFPIAGLEFSELPVTSPLGIAVIKNLENWEQILQEKMDQFEGPPPNYINTYPTDLSVGAGPAILRNKAMLEPENTPFKSRDSSAFPVKRLWHFLVKQEVLQETFIRYIFTKKRKQSEVEADLGYPGGKAKVIHKESDMIMAFSVNKANCNEIVLASTHDVQELDVTSLLACQSYIWIGEEYDRESKSSDDVDYRGSTTTLYQPSATSYSASQVHPPSSLPWLGTGQTSTGASVLMKRNLHNVKRMTSHPVHQYYLTGAQDGSVRMFEWTRPQQLVCFRQAGNARVTRLYFNSQGNKCGVADGEGFLSIWQVNQTASNPKPYMSWQCHSKATSDFAFITSSSLVATSGHSNDNRNVCLWDTLISPGNSLIHGFTCHDHGATVLQYAPKQQLLISGGRKGHVCIFDIRQRQLIHTFQAHDSAIKALALDPYEEYFTTGSAEGNIKVWRLTGHGLIHSFKSEHAKQSIFRNIGAGVMQIDIIQGNRLFSCGADGTLKTRVLPNAFNIPNRILDIL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
92AcetylationPLGINSHKRNCQLKC
CCCCCCCCCCCEEEE
45.1625953088
198PhosphorylationDCLLKVWYPMTGWKS
CEEEEEEEECCCCCC
6.01-
221PhosphorylationEVKRRQSSTQFSFVY
HHHHCCCCCCEEEEE
20.2125307156
246PhosphorylationSWRKTSKYMPRGSVC
CCEECCCCCCCCCHH
16.48-
325PhosphorylationLRKGQRRSSVLVTHA
HCCCCCCCCEEEEEH
27.3028450419
326PhosphorylationRKGQRRSSVLVTHAE
CCCCCCCCEEEEEHH
20.0528450419
330PhosphorylationRRSSVLVTHAELMPD
CCCCEEEEEHHHCCC
15.9428450419
339PhosphorylationAELMPDQTAMHEVQR
HHHCCCCCHHHHHHH
33.0727080861
434PhosphorylationDREDEEHSQEDRERG
CHHCHHHCHHHHHHC
38.2524719451
451PhosphorylationMKLDHDLSLDRESEA
CCCCCCCCCCCCCCC
33.9929255136
456PhosphorylationDLSLDRESEAGTGSS
CCCCCCCCCCCCCCC
33.3729255136
460PhosphorylationDRESEAGTGSSEHED
CCCCCCCCCCCCCCC
40.7229255136
462PhosphorylationESEAGTGSSEHEDGE
CCCCCCCCCCCCCCC
32.1829255136
463PhosphorylationSEAGTGSSEHEDGER
CCCCCCCCCCCCCCC
44.3029255136
473PhosphorylationEDGEREGSPRTYSRL
CCCCCCCCCCCCCCC
13.3723401153
481PhosphorylationPRTYSRLSVPMPLPT
CCCCCCCCCCCCCCC
24.0627251275
488PhosphorylationSVPMPLPTVLLDRKI
CCCCCCCCHHHHHHH
31.3128842319
494UbiquitinationPTVLLDRKIETLLTE
CCHHHHHHHHHHHHH
44.56-
500PhosphorylationRKIETLLTEWNKNPD
HHHHHHHHHHHCCCC
41.9124719451
552PhosphorylationRIPVAFPSGDASSLS
CCCEECCCCCHHHCC
42.7422210691
559PhosphorylationSGDASSLSKNIMMYA
CCCHHHCCHHHHHHH
26.1322210691
565PhosphorylationLSKNIMMYACINATK
CCHHHHHHHHHHCCC
4.8722210691
574PhosphorylationCINATKDSHHTLLHQ
HHHCCCCCCCCCCCC
20.8020068231
577PhosphorylationATKDSHHTLLHQEGM
CCCCCCCCCCCCCCC
26.1220068231
585PhosphorylationLLHQEGMSVGSPHGS
CCCCCCCCCCCCCCC
33.9020068231
588PhosphorylationQEGMSVGSPHGSQPH
CCCCCCCCCCCCCCC
16.1520068231
592PhosphorylationSVGSPHGSQPHSRSH
CCCCCCCCCCCCCCC
37.1920068231
596PhosphorylationPHGSQPHSRSHSTHM
CCCCCCCCCCCCCCH
42.0120068231
598PhosphorylationGSQPHSRSHSTHMNI
CCCCCCCCCCCCHHH
25.4628857561
600PhosphorylationQPHSRSHSTHMNILA
CCCCCCCCCCHHHHH
22.6628857561
601PhosphorylationPHSRSHSTHMNILAP
CCCCCCCCCHHHHHH
21.5228857561
614PhosphorylationAPTVMMISKHIDGSL
HHHHHHHHHCCCCCC
10.5720068231
676PhosphorylationSHHNALLTPELDCQW
CCCCCCCCCCCCCCC
18.6325332170
685PhosphorylationELDCQWDSDNKLSRL
CCCCCCCCCCHHHHH
39.87-
702PhosphorylationPVKHIKGSSKQPLRN
HHHHCCCCCCCCCCC
29.3825999147
703PhosphorylationVKHIKGSSKQPLRNA
HHHCCCCCCCCCCCC
43.9325999147
743PhosphorylationLSYTGGVSELARINS
CCCCCCHHHHHHHHC
30.1220068231
757PhosphorylationSLHTSAFSNVAWLPT
CCCCCCCCCCCCCCC
30.0628387310
774PhosphorylationPSYCLGTYCNSASAC
CHHHHCCCCCCCCEE
6.4528387310
801UbiquitinationQAVVDARKLLDELSD
HHHHHHHHHHHHCCC
55.94-
925PhosphorylationQACLAKASEGASSES
HHHHHHHHCCCCCCH
35.5425159151
929PhosphorylationAKASEGASSESLLSV
HHHHCCCCCCHHCCC
45.5625159151
930PhosphorylationKASEGASSESLLSVP
HHHCCCCCCHHCCCC
30.5823911959
932PhosphorylationSEGASSESLLSVPGQ
HCCCCCCHHCCCCCC
36.2430576142
935PhosphorylationASSESLLSVPGQKNV
CCCCHHCCCCCCCCC
31.4026074081
944PhosphorylationPGQKNVDSSPETSPS
CCCCCCCCCCCCCCC
43.4323927012
945PhosphorylationGQKNVDSSPETSPSV
CCCCCCCCCCCCCCC
23.4525159151
948PhosphorylationNVDSSPETSPSVSPM
CCCCCCCCCCCCCCC
49.6923927012
949PhosphorylationVDSSPETSPSVSPMP
CCCCCCCCCCCCCCC
17.3225159151
951PhosphorylationSSPETSPSVSPMPHS
CCCCCCCCCCCCCCC
34.6923927012
953PhosphorylationPETSPSVSPMPHSSS
CCCCCCCCCCCCCHH
21.5923927012
958PhosphorylationSVSPMPHSSSIANLQ
CCCCCCCCHHHCCHH
21.6525850435
959PhosphorylationVSPMPHSSSIANLQT
CCCCCCCHHHCCHHH
23.8030576142
960PhosphorylationSPMPHSSSIANLQTA
CCCCCCHHHCCHHHH
28.8323927012
966PhosphorylationSSIANLQTASKLILS
HHHCCHHHHHHHHHH
35.7423927012
968PhosphorylationIANLQTASKLILSSR
HCCHHHHHHHHHHCC
31.2323927012
973PhosphorylationTASKLILSSRLVYSQ
HHHHHHHHCCCHHCC
13.3524719451
974PhosphorylationASKLILSSRLVYSQP
HHHHHHHCCCHHCCC
26.6224719451
1049AcetylationEKEIYHWKRWPLMND
CHHHHEEEECCCCCC
31.1319608861
1077PhosphorylationRPVAVSCSYTGRLAV
CEEEEEEECCCCEEE
20.4420068231
1137PhosphorylationKVGSVLDSRVSVDSN
ECCCCCCCCEECCCC
30.3528634120
1140PhosphorylationSVLDSRVSVDSNLFV
CCCCCCEECCCCEEE
21.0630266825
1143PhosphorylationDSRVSVDSNLFVYSK
CCCEECCCCEEEEEC
33.0230266825
1148PhosphorylationVDSNLFVYSKSDALL
CCCCEEEEECHHHHH
11.7529691806
1149PhosphorylationDSNLFVYSKSDALLS
CCCEEEEECHHHHHC
22.0029691806
1151PhosphorylationNLFVYSKSDALLSKD
CEEEEECHHHHHCCC
23.3628348404
1156PhosphorylationSKSDALLSKDRYLIP
ECHHHHHCCCCCCCC
33.1029691806
1157UbiquitinationKSDALLSKDRYLIPN
CHHHHHCCCCCCCCC
46.31-
1221PhosphorylationITLPLGGSIKQGVKS
EEEECCCCHHHCCCH
25.4728857561
1251PhosphorylationGTPSLPVSLSWVRDG
CCCCCCEEEEEEECC
18.10-
1287PhosphorylationFGDTEADSSNAEEAA
CCCCCCCCCCHHHHH
32.3225627689
1288PhosphorylationGDTEADSSNAEEAAM
CCCCCCCCCHHHHHH
40.3825627689
1299PhosphorylationEAAMQDHSTFKSNML
HHHHHCHHHHHHHHC
43.7724260401
1300PhosphorylationAAMQDHSTFKSNMLA
HHHHCHHHHHHHHCC
31.4928555341
1303PhosphorylationQDHSTFKSNMLARKS
HCHHHHHHHHCCCCC
24.2323879269
1365UbiquitinationLGKVRRAKAILSHLV
HHHHHHHHHHHHHHH
33.86-
1396PhosphorylationEGTKRHLSRTISVSG
CCHHHEEEEEEEECC
22.6629514088
1398PhosphorylationTKRHLSRTISVSGST
HHHEEEEEEEECCCC
17.7722617229
1400PhosphorylationRHLSRTISVSGSTAK
HEEEEEEEECCCCCE
15.0425159151
1402PhosphorylationLSRTISVSGSTAKET
EEEEEEECCCCCEEE
21.8930183078
1404PhosphorylationRTISVSGSTAKETVT
EEEEECCCCCEEEEE
20.0625159151
1405PhosphorylationTISVSGSTAKETVTV
EEEECCCCCEEEEEE
45.3221712546
1409PhosphorylationSGSTAKETVTVGKDG
CCCCCEEEEEECCCC
22.2929978859
1411PhosphorylationSTAKETVTVGKDGTR
CCCEEEEEECCCCCC
30.8427486199
1417PhosphorylationVTVGKDGTRDYTEID
EEECCCCCCCCCCCC
30.42-
1456PhosphorylationSTKIPQSYEDQTVSQ
CCCCCCCCCCCCCCC
20.4822817900
1468PhosphorylationVSQPEDQYSELFQIQ
CCCCHHHHHHHCCCC
19.2128796482
1469PhosphorylationSQPEDQYSELFQIQD
CCCHHHHHHHCCCCC
23.3828796482
1488UbiquitinationDIDLEPEKRENKSKV
CCCCCHHHCCCCCCE
75.60-
1494AcetylationEKRENKSKVINLSQY
HHCCCCCCEEEHHHC
49.0625953088
1501PhosphorylationKVINLSQYGPAYFGQ
CEEEHHHCCCHHCCH
23.0027642862
1515PhosphorylationQEHARVLSSHLMHSS
HHHHHHHHHHHHCCC
16.92-
1516PhosphorylationEHARVLSSHLMHSSL
HHHHHHHHHHHCCCC
19.24-
1521PhosphorylationLSSHLMHSSLPGLTR
HHHHHHCCCCCCCHH
21.43-
1710UbiquitinationRWRKAALKNAFSLLG
HHHHHHHHHHHHHHC
41.31-
1718UbiquitinationNAFSLLGKQRFEQSA
HHHHHHCHHHHHHHH
37.97-
1733PhosphorylationAFFLLAGSLKDAIEV
HHHHHHHCHHHHHHH
27.0029449344
1781UbiquitinationQKILGCQKDGSGFSC
HHHHCCCCCCCCCCC
69.04-
1809O-linked_GlycosylationYWVMKDYTRALDTLL
HHHHHHHHHHHHHHH
21.4330379171
1821UbiquitinationTLLEQTPKEDDEHQV
HHHHCCCCCCCCCCE
76.73-
1832PhosphorylationEHQVIIKSCNPVAFS
CCCEEEECCCCCHHH
14.5524144214
1839PhosphorylationSCNPVAFSFYNYLRT
CCCCCHHHHHHHHHH
19.6524144214
1841PhosphorylationNPVAFSFYNYLRTHP
CCCHHHHHHHHHHCC
11.1624144214
1843PhosphorylationVAFSFYNYLRTHPLL
CHHHHHHHHHHCCCH
6.0324144214
1846PhosphorylationSFYNYLRTHPLLIRR
HHHHHHHHCCCHHCC
25.8322210691
1857PhosphorylationLIRRNLASPEGTLAT
HHCCCCCCCCCCCCC
27.0129255136
1861PhosphorylationNLASPEGTLATLGLK
CCCCCCCCCCCCCCC
16.1430266825
1864PhosphorylationSPEGTLATLGLKTEK
CCCCCCCCCCCCCCC
25.1929396449
1876AcetylationTEKNFVDKINLIERK
CCCCHHHHHHHHHHH
28.35133609
1876UbiquitinationTEKNFVDKINLIERK
CCCCHHHHHHHHHHH
28.35-
1907UbiquitinationLALEVLSKIPKVTKT
HHHHHHHCCCCCCCC
59.89-
1913UbiquitinationSKIPKVTKTSALSAK
HCCCCCCCCCCCCCC
43.39-
1914PhosphorylationKIPKVTKTSALSAKK
CCCCCCCCCCCCCCC
15.1829396449
1915PhosphorylationIPKVTKTSALSAKKD
CCCCCCCCCCCCCCC
28.8629396449
1918PhosphorylationVTKTSALSAKKDQPD
CCCCCCCCCCCCCCC
37.4529396449
1921UbiquitinationTSALSAKKDQPDFIS
CCCCCCCCCCCCHHH
62.40-
1960PhosphorylationSNVTSSQYDWSQPIV
ECCCCCCCCCCCCEE
22.7125884760
1984PhosphorylationDWGEDHDSALDEEED
CCCCCCCCCCCCCCC
27.5822617229
2022PhosphorylationSDPNMLLTPQEEDDP
CCCCCCCCCCCCCCC
20.97-
2053PhosphorylationACLKILMTELRTLAT
HHHHHHHHHHHHHHC
28.5528634298
2057PhosphorylationILMTELRTLATGYEV
HHHHHHHHHHCCCEE
33.1128634298
2062PhosphorylationLRTLATGYEVDGGKL
HHHHHCCCEECCCEE
14.39-
2074PhosphorylationGKLRFQLYNWLEKEI
CEEEHHHHHHHHHHH
8.1026074081
2101PhosphorylationIKEYSSKTYSKVESD
HHHHHCCCCCCHHHH
34.67-
2102PhosphorylationKEYSSKTYSKVESDL
HHHHCCCCCCHHHHC
15.38-
2103PhosphorylationEYSSKTYSKVESDLL
HHHCCCCCCHHHHCC
35.14-
2123PhosphorylationVDKPDIGSYERHQIE
CCCCCCCHHHHHHHH
24.9327732954
2124PhosphorylationDKPDIGSYERHQIER
CCCCCCHHHHHHHHH
16.2727732954
2186PhosphorylationLKFLLQESQQETTVK
HHHHHHHHCCCCHHH
24.9722210691
2191PhosphorylationQESQQETTVKQLQSP
HHHCCCCHHHHHCCC
25.5922210691
2197PhosphorylationTTVKQLQSPLPLPTT
CHHHHHCCCCCCCCH
36.6826657352
2203PhosphorylationQSPLPLPTTLPLLSA
CCCCCCCCHHHHHHH
48.9628348404
2204PhosphorylationSPLPLPTTLPLLSAS
CCCCCCCHHHHHHHH
25.1622210691
2209PhosphorylationPTTLPLLSASIASTK
CCHHHHHHHHCCCCC
27.8724043423
2211PhosphorylationTLPLLSASIASTKTV
HHHHHHHHCCCCCCE
18.4724043423
2214PhosphorylationLLSASIASTKTVIAN
HHHHHCCCCCCEECC
28.8524043423
2215PhosphorylationLSASIASTKTVIANP
HHHHCCCCCCEECCC
23.0124043423
2235PhosphorylationNHIHDILYTIVQMKT
CCHHHHHHHHHHCCC
8.5126074081
2236PhosphorylationHIHDILYTIVQMKTP
CHHHHHHHHHHCCCC
15.9526074081
2242PhosphorylationYTIVQMKTPPHPSIE
HHHHHCCCCCCCCHH
36.3926074081
2247PhosphorylationMKTPPHPSIEDVKVH
CCCCCCCCHHHCCHH
35.2626074081
2330PhosphorylationSSLINLLSSAQDEDQ
HHHHHHHHCCCCCCC
27.13-
2331PhosphorylationSLINLLSSAQDEDQP
HHHHHHHCCCCCCCC
29.89-
2399PhosphorylationVVKPRRQSENISAPP
EECCCCCCCCCCCCC
30.6929255136
2400PhosphorylationVKPRRQSENISAPPV
ECCCCCCCCCCCCCC
50.6924719451
2403PhosphorylationRRQSENISAPPVLSE
CCCCCCCCCCCCCCH
46.4323927012
2409PhosphorylationISAPPVLSEDIDKHR
CCCCCCCCHHHHHHH
33.1929396449
2434PhosphorylationGRPVKDATPPPVPAE
CCCCCCCCCCCCCCC
46.6025159151
2435PhosphorylationRPVKDATPPPVPAER
CCCCCCCCCCCCCCC
32.6827251275
2560UbiquitinationWEQILQEKMDQFEGP
HHHHHHHHHHHCCCC
34.51-
2591UbiquitinationGPAILRNKAMLEPEN
CHHHHCCCCCCCCCC
28.83-
2602MethylationEPENTPFKSRDSSAF
CCCCCCCCCCCCCCC
45.87115976479
2603PhosphorylationPENTPFKSRDSSAFP
CCCCCCCCCCCCCCC
41.5223312004
2606PhosphorylationTPFKSRDSSAFPVKR
CCCCCCCCCCCCHHH
23.5823312004
2607PhosphorylationPFKSRDSSAFPVKRL
CCCCCCCCCCCHHHH
37.9123312004
2640PhosphorylationFTKKRKQSEVEADLG
HCCCCCCCCCCCCCC
46.7927732954
2712PhosphorylationYDRESKSSDDVDYRG
CCCCCCCCCCCCCCC
41.3825307156
2717PhosphorylationKSSDDVDYRGSTTTL
CCCCCCCCCCCEEEE
19.40-
2753PhosphorylationLGTGQTSTGASVLMK
CCCCCCCCCHHHHHH
39.9123663014
2770PhosphorylationLHNVKRMTSHPVHQY
CCCCCCCCCCCCHHH
28.1024505115
2771PhosphorylationHNVKRMTSHPVHQYY
CCCCCCCCCCCHHHE
19.2224505115
2777PhosphorylationTSHPVHQYYLTGAQD
CCCCCHHHEECCCCC
5.8824505115
2778PhosphorylationSHPVHQYYLTGAQDG
CCCCHHHEECCCCCC
7.3924505115
2780PhosphorylationPVHQYYLTGAQDGSV
CCHHHEECCCCCCCE
17.8524505115
2852PhosphorylationYMSWQCHSKATSDFA
CCEEECCCCCCCCEE
31.4525690035

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DMXL2_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DMXL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DMXL2_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WDR7_HUMANWDR7physical
12786944

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616113Polyendocrine-polyneuropathy syndrome (PEPNS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DMXL2_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1049, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-944; SER-945; SER-1140;SER-1143; SER-1857 AND SER-1984, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-944; SER-945; SER-949;SER-1400; SER-1857 AND SER-1984, AND MASS SPECTROMETRY.
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1857, AND MASSSPECTROMETRY.
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry.";
Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.;
Anal. Chem. 76:2763-2772(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1400 AND SER-1404, ANDMASS SPECTROMETRY.

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