WDR7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR7_HUMAN
• UniProt AC: Q9Y4E6
• Protein Name: WD repeat-containing protein 7
• Gene Name: WDR7
• Organism: Homo sapiens (Human).
• Sequence Length: 1490
• Protein Sequence: MAGNSLVLPIVLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFSVGNQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSEISDMQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLLCSGPSENGQTWTGGDFVSSDKVIIWTENGQSYIYKLPASCLPASDSFRSDVGKAVENLIPPVQHILLDRKDKELLICPPVTRFFYGCREYFHKLLIQGDSSGRLNIWNISDTADKQGSEEGLAMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAVPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTALISPENLQKASGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEEEDEEIMRQRREESDPEYRSSKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSRGGHMSLMLPGYNQPACKLSHGKTEVGRKLPASEGVGKGTYGVSRAVTTQHLLSIISLANTLMSMTNATFIGDHMKKGPTRPPRPSTPDLSKARGSPPTSSNIVQGQIKQVAAPVVSARSDADHSGSDPPSAPALHTCFLVNEGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRCLEVREAAQALLLAELRRIEQAGRKEAIDAWAPYLPQYIDHVISPGVTSEAAQTITTAPDASGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAEIEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRTAIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALSLIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTDVVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALYDIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNTSLLGSIGMLNSAPQLRCIKTYQVPPVQPASPGSHNALKLARLIWTSNRNVILMAHDGKEHRFMV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	CLSKACASSDKQYIV HHHHHHCCCCCEEEE	38.67	27251789
88	Phosphorylation	YIVSASESGEMCLWD EEEEECCCCCEEEEE	37.24	-
97	Phosphorylation	EMCLWDVSDGRCIEF CEEEEECCCCCEEEE	31.69	-
162	O-linked_Glycosylation	KISPDWISSMSIIRS HCCHHHHHHHHHHHC	18.74	30379171
162	Phosphorylation	KISPDWISSMSIIRS HCCHHHHHHHHHHHC	18.74	27732954
163	Phosphorylation	ISPDWISSMSIIRSH CCHHHHHHHHHHHCC	13.86	27732954
165	Phosphorylation	PDWISSMSIIRSHRT HHHHHHHHHHHCCCC	19.46	27732954
209	Phosphorylation	EPIFEEESKPIYCQN CCCCCCCCCCEECCC	47.19	21815630
229	Phosphorylation	FCAFTQRSLLVVCSK EEEECCCCHHHHHHC	19.08	27794612
235	Phosphorylation	RSLLVVCSKYWRVFD CCHHHHHHCCEEEEE	19.71	27794612
295	Phosphorylation	SCLPASDSFRSDVGK HHCCCCCHHHHHHHH	21.77	28857561
302	Ubiquitination	SFRSDVGKAVENLIP HHHHHHHHHHHHHCC	49.46	-
376	Phosphorylation	EGLAMTTSISLQEAF HHHCCEEEEHHHHHH	10.87	25332170
378	Phosphorylation	LAMTTSISLQEAFDK HCCEEEEHHHHHHHH	24.62	25332170
412	Phosphorylation	EPLKVTASVYIPAHG CCCEEEEEEEECCCC	13.19	30622161
414	Phosphorylation	LKVTASVYIPAHGRL CEEEEEEEECCCCEE	9.93	30622161
468	Phosphorylation	RGHRNKVTCLLYPHQ CCCCCCEEEEEECCC	10.07	-
636	Phosphorylation	KQAMTRRSLAALKNM HHHHHHHHHHHHHHH	21.04	28857561
641	Ubiquitination	RRSLAALKNMAHHKL HHHHHHHHHHHHHHH	39.69	29967540
647	Ubiquitination	LKNMAHHKLQTLATN HHHHHHHHHHHHHHH	32.21	29967540
650	Phosphorylation	MAHHKLQTLATNLLA HHHHHHHHHHHHHHH	28.88	-
653	Phosphorylation	HKLQTLATNLLASEA HHHHHHHHHHHHHHH	29.52	-
658	Phosphorylation	LATNLLASEASDKGN HHHHHHHHHHCCCCC	33.39	-
661	Phosphorylation	NLLASEASDKGNLPK HHHHHHHCCCCCCCC	35.48	-
663	Ubiquitination	LASEASDKGNLPKYS HHHHHCCCCCCCCCC	47.40	30230243
669	Phosphorylation	DKGNLPKYSHNSLMV CCCCCCCCCCCHHHH	17.14	28060719
670	Phosphorylation	KGNLPKYSHNSLMVQ CCCCCCCCCCHHHHH	23.48	28060719
673	Phosphorylation	LPKYSHNSLMVQAIK CCCCCCCHHHHHHHH	16.65	28060719
726	Phosphorylation	NLQKASGSSDKGGSF HHHHHCCCCCCCCCC	32.63	22210691
727	Phosphorylation	LQKASGSSDKGGSFL HHHHCCCCCCCCCCC	47.03	22210691
729	Ubiquitination	KASGSSDKGGSFLTG HHCCCCCCCCCCCCH	68.09	29967540
732	Phosphorylation	GSSDKGGSFLTGKRA CCCCCCCCCCCHHHH	26.25	27251275
735	Phosphorylation	DKGGSFLTGKRAAVL CCCCCCCCHHHHHHH	38.35	-
737	Acetylation	GGSFLTGKRAAVLFQ CCCCCCHHHHHHHHH	33.36	25953088
755	Ubiquitination	ETIKENIKEHLLDDE HHHHHHHHHHCCCCH	51.14	29967540
776	Phosphorylation	MRQRREESDPEYRSS HHHHHHHCCCCHHCC	54.43	24719451
780	Phosphorylation	REESDPEYRSSKSKP HHHCCCCHHCCCCCC	22.60	-
785	Phosphorylation	PEYRSSKSKPLTLLE CCHHCCCCCCCEEEE	41.26	24719451
793	Phosphorylation	KPLTLLEYNLTMDTA CCCEEEEEECCHHHH	18.55	-
796	Phosphorylation	TLLEYNLTMDTAKLF EEEEEECCHHHHHHH	14.90	-
832	Phosphorylation	GMLKPHCTVSFGLLS CCCCCCEEEEEEEEC	19.02	20068231
834	Phosphorylation	LKPHCTVSFGLLSRG CCCCEEEEEEEECCC	8.74	20068231
839	Phosphorylation	TVSFGLLSRGGHMSL EEEEEEECCCCEEEE	33.64	20068231
845	Phosphorylation	LSRGGHMSLMLPGYN ECCCCEEEEECCCCC	12.64	20068231
851	Phosphorylation	MSLMLPGYNQPACKL EEEECCCCCCCCCCC	14.53	20068231
859	Phosphorylation	NQPACKLSHGKTEVG CCCCCCCCCCCCCCC	18.71	20068231
868	Ubiquitination	GKTEVGRKLPASEGV CCCCCCCCCCCCCCC	53.55	29967540
872	Phosphorylation	VGRKLPASEGVGKGT CCCCCCCCCCCCCCC	32.70	23532336
877	Ubiquitination	PASEGVGKGTYGVSR CCCCCCCCCCCCCCH	45.75	-
887	Phosphorylation	YGVSRAVTTQHLLSI CCCCHHHHHHHHHHH	21.54	23663014
888	Phosphorylation	GVSRAVTTQHLLSII CCCHHHHHHHHHHHH	13.85	23663014
893	Phosphorylation	VTTQHLLSIISLANT HHHHHHHHHHHHHHH	25.00	23663014
896	Phosphorylation	QHLLSIISLANTLMS HHHHHHHHHHHHHHH	21.54	23663014
900	Phosphorylation	SIISLANTLMSMTNA HHHHHHHHHHHHCCC	20.45	23663014
903	Phosphorylation	SLANTLMSMTNATFI HHHHHHHHHCCCCCC	26.10	23663014
905	Phosphorylation	ANTLMSMTNATFIGD HHHHHHHCCCCCCHH	17.88	23663014
908	Phosphorylation	LMSMTNATFIGDHMK HHHHCCCCCCHHHHC	20.18	23663014
919	Phosphorylation	DHMKKGPTRPPRPST HHHCCCCCCCCCCCC	65.56	26657352
925	Phosphorylation	PTRPPRPSTPDLSKA CCCCCCCCCCCHHHH	54.58	23403867
926	Phosphorylation	TRPPRPSTPDLSKAR CCCCCCCCCCHHHHC	24.41	25159151
930	Phosphorylation	RPSTPDLSKARGSPP CCCCCCHHHHCCCCC	31.48	23403867
933	Methylation	TPDLSKARGSPPTSS CCCHHHHCCCCCCCC	50.27	115920025
935 (in isoform 2)	Phosphorylation	-	23.35	25849741
935	Phosphorylation	DLSKARGSPPTSSNI CHHHHCCCCCCCCCC	23.35	25159151
938 (in isoform 2)	Phosphorylation	-	48.44	29116813
938	Phosphorylation	KARGSPPTSSNIVQG HHCCCCCCCCCCCCC	48.44	30266825
939	Phosphorylation	ARGSPPTSSNIVQGQ HCCCCCCCCCCCCCC	27.45	30266825
939 (in isoform 2)	Phosphorylation	-	27.45	29116813
940 (in isoform 2)	Phosphorylation	-	32.81	29116813
940	Phosphorylation	RGSPPTSSNIVQGQI CCCCCCCCCCCCCCC	32.81	30266825
1057	Phosphorylation	WAPYLPQYIDHVISP HHHCHHHHHCEECCC	13.33	25627689
1063	Phosphorylation	QYIDHVISPGVTSEA HHHCEECCCCCCHHH	17.95	25159151
1067	Phosphorylation	HVISPGVTSEAAQTI EECCCCCCHHHHHHH	27.11	25627689
1068	Phosphorylation	VISPGVTSEAAQTIT ECCCCCCHHHHHHHC	23.88	25627689
1112	Ubiquitination	SSVPQMKKISTSYEE HCCHHHHHCCCCHHH	36.22	-
1152	Phosphorylation	KLLTRPRSSSQIPEG CCCCCCCCCCCCCCC	36.70	23401153
1153	Phosphorylation	LLTRPRSSSQIPEGF CCCCCCCCCCCCCCC	27.78	30278072
1154	Phosphorylation	LTRPRSSSQIPEGFG CCCCCCCCCCCCCCC	33.12	30278072
1163	Phosphorylation	IPEGFGLTSGGSNYS CCCCCCCCCCCCCHH	26.21	26699800
1164	Phosphorylation	PEGFGLTSGGSNYSL CCCCCCCCCCCCHHH	46.31	26074081
1167	Phosphorylation	FGLTSGGSNYSLARH CCCCCCCCCHHHHHH	35.80	26074081
1169	Phosphorylation	LTSGGSNYSLARHTC CCCCCCCHHHHHHHH	13.52	26074081
1170	Phosphorylation	TSGGSNYSLARHTCK CCCCCCHHHHHHHHH	21.58	30576142
1175	Phosphorylation	NYSLARHTCKALTFL CHHHHHHHHHHHHHH	15.33	30576142
1240	Phosphorylation	EKQLANITMGLPLSP HHHHHHCCCCCCCCH	12.66	-
1246	Phosphorylation	ITMGLPLSPAADSAR CCCCCCCCHHHHHHH	15.56	-
1290	Phosphorylation	ALAANTQSQQNMHTT HHHCCCCCHHHCCHH	31.53	28857561
1357	Phosphorylation	FPAICRFYMVSYYER HHHHHHHHHHHHHHH	4.18	-
1362	Phosphorylation	RFYMVSYYERNHRIA HHHHHHHHHHCCEEE	10.83	-
1376	Phosphorylation	AVGARHGSVALYDIR EEEECCCEEEEEECC	9.70	28857561
1380	Phosphorylation	RHGSVALYDIRTGKC CCCEEEEEECCCCCC	10.29	-
1398	Phosphorylation	HGHKGPITAVAFAPD CCCCCCEEEEEECCC	20.43	-
1412	Ubiquitination	DGRYLATYSNTDSHI CCCEEEEEECCCCCC	8.36	30230243
1423	Phosphorylation	DSHISFWQMNTSLLG CCCCEEEEECHHHHH	17.15	32142685
1426	Phosphorylation	ISFWQMNTSLLGSIG CEEEEECHHHHHHHH	18.53	32142685
1445	Ubiquitination	APQLRCIKTYQVPPV CCCCEEEEEEECCCC	44.82	30230243
1456	Phosphorylation	VPPVQPASPGSHNAL CCCCCCCCCCCCHHH	36.16	25159151
1459	Phosphorylation	VQPASPGSHNALKLA CCCCCCCCCHHHHHH	19.56	21130716
1484	Ubiquitination	ILMAHDGKEHRFMV- EEEEECCCCEECCC-	57.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DMXL2_HUMAN	DMXL2	physical	12786944
FRMD6_HUMAN	FRMD6	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.