| UniProt ID | UBP46_HUMAN | |
|---|---|---|
| UniProt AC | P62068 | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 46 | |
| Gene Name | USP46 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 366 | |
| Subcellular Localization | ||
| Protein Description | Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. [PubMed: 19075014] | |
| Protein Sequence | MTVRNIASICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTVRNIASI ------CCHHHHHHH | 28.33 | 23186163 | |
| 8 | Phosphorylation | MTVRNIASICNMGTN CCHHHHHHHHCCCCC | 24.71 | 23186163 | |
| 14 | Phosphorylation | ASICNMGTNASALEK HHHHCCCCCHHHHHC | 19.49 | 23186163 | |
| 17 | Phosphorylation | CNMGTNASALEKDIG HCCCCCHHHHHCCCC | 35.14 | 23186163 | |
| 66 | Phosphorylation | FRENVLAYKAQQKKK HHHHHHHHHHHHHHH | 11.60 | 29396449 | |
| 79 | Ubiquitination | KKENLLTCLADLFHS HHHCHHHHHHHHHHH | 2.73 | 33845483 | |
| 84 | Ubiquitination | LTCLADLFHSIATQK HHHHHHHHHHHHHCC | 4.34 | 33845483 | |
| 91 | Ubiquitination | FHSIATQKKKVGVIP HHHHHHCCCCCCCCC | 50.65 | 33845483 | |
| 153 | Ubiquitination | NGKLKNGNMNEPAEN CCCCCCCCCCCCHHC | 39.23 | 32142685 | |
| 257 | Ubiquitination | ILALHLKRFKYMEQL HHHHHHHHHHHHHHH | 39.38 | 32142685 | |
| 262 | Ubiquitination | LKRFKYMEQLHRYTK HHHHHHHHHHHHHHC | 47.07 | 32142685 | |
| 269 | Ubiquitination | EQLHRYTKLSYRVVF HHHHHHHCCCEEEEE | 26.88 | 32142685 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UBP46_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBP46_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBP46_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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