ERP44_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERP44_HUMAN
• UniProt AC: Q9BS26
• Protein Name: Endoplasmic reticulum resident protein 44
• Gene Name: ERP44
• Organism: Homo sapiens (Human).
• Sequence Length: 406
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum..
• Protein Sequence: MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFKDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQAQDVASSPPESSFQKLAPSEYRYTLLRDRDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	Phosphorylation	RVDCDQHSDIAQRYR EEECCCCCHHHHHHH	25.69	28634120
106	Acetylation	AQRYRISKYPTLKLF HHHHHHHCCCHHHHH	53.53	26210075
130	Ubiquitination	YRGQRSVKALADYIR HCCHHHHHHHHHHHH	38.64	-
135	Phosphorylation	SVKALADYIRQQKSD HHHHHHHHHHHCCCC	7.75	28152594
137	Methylation	KALADYIRQQKSDPI HHHHHHHHHCCCCHH	27.01	-
140	2-Hydroxyisobutyrylation	ADYIRQQKSDPIQEI HHHHHHCCCCHHHHH	48.79	-
140	Ubiquitination	ADYIRQQKSDPIQEI HHHHHHCCCCHHHHH	48.79	-
166	Phosphorylation	SKRNIIGYFEQKDSD HHCCEEEEEEECCCC	8.11	-
170	2-Hydroxyisobutyrylation	IIGYFEQKDSDNYRV EEEEEEECCCCCHHH	52.59	-
189	Glutathionylation	ANILHDDCAFLSAFG HHHHCCCHHHHHHHC	3.43	22555962
200	Ubiquitination	SAFGDVSKPERYSGD HHHCCCCCCCCCCCC	51.23	-
204	Phosphorylation	DVSKPERYSGDNIIY CCCCCCCCCCCCCEE	18.49	28331001
205	Phosphorylation	VSKPERYSGDNIIYK CCCCCCCCCCCCEEC	45.98	28331001
269	Sulfoxidation	PFLILFHMKEDTESL CEEEEEECCCCCCHH	3.89	28465586
289	Phosphorylation	EVARQLISEKGTINF HHHHHHHCCCCCEEE	41.68	24719451
291	2-Hydroxyisobutyrylation	ARQLISEKGTINFLH HHHHHCCCCCEEEEE	55.34	-
291	Ubiquitination	ARQLISEKGTINFLH HHHHHCCCCCEEEEE	55.34	-
301	Glutathionylation	INFLHADCDKFRHPL EEEEECCHHHCCCCC	6.77	22555962
303	2-Hydroxyisobutyrylation	FLHADCDKFRHPLLH EEECCHHHCCCCCHH	51.10	-
303	Acetylation	FLHADCDKFRHPLLH EEECCHHHCCCCCHH	51.10	26822725
318	Glutathionylation	IQKTPADCPVIAIDS CCCCCCCCCEEEEEC	2.93	22555962
343	Acetylation	KDVLIPGKLKQFVFD HHCCCCCCEEEEEEE	47.35	26822725
345	2-Hydroxyisobutyrylation	VLIPGKLKQFVFDLH CCCCCCEEEEEEECC	45.21	-
367	O-linked_Glycosylation	FHHGPDPTDTAPGEQ CCCCCCCCCCCCCHH	54.05	55834395
369	O-linked_Glycosylation	HGPDPTDTAPGEQAQ CCCCCCCCCCCHHHH	36.91	22661428
380	Phosphorylation	EQAQDVASSPPESSF HHHHHHHHCCCCHHH	43.13	28985074
380	O-linked_Glycosylation	EQAQDVASSPPESSF HHHHHHHHCCCCHHH	43.13	22661428
381	O-linked_Glycosylation	QAQDVASSPPESSFQ HHHHHHHCCCCHHHH	34.43	55834413
385	O-linked_Glycosylation	VASSPPESSFQKLAP HHHCCCCHHHHHHCC	42.07	55834419
386	O-linked_Glycosylation	ASSPPESSFQKLAPS HHCCCCHHHHHHCCH	29.99	55834425
393	O-linked_Glycosylation	SFQKLAPSEYRYTLL HHHHHCCHHHHHEEC	41.47	55832941
393	Phosphorylation	SFQKLAPSEYRYTLL HHHHHCCHHHHHEEC	41.47	-
395	Phosphorylation	QKLAPSEYRYTLLRD HHHCCHHHHHEECCC	17.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERP44_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERP44_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERP44_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ERO1A_HUMAN	ERO1L	physical	11847130
KCRB_HUMAN	CKB	physical	22863883
CNN2_HUMAN	CNN2	physical	22863883
FHL2_HUMAN	FHL2	physical	22863883
ISOC1_HUMAN	ISOC1	physical	22863883
SYLC_HUMAN	LARS	physical	22863883
NUDC1_HUMAN	NUDCD1	physical	22863883
OSGEP_HUMAN	OSGEP	physical	22863883
PAK2_HUMAN	PAK2	physical	22863883
PDC10_HUMAN	PDCD10	physical	22863883
PUR4_HUMAN	PFAS	physical	22863883
PLD3_HUMAN	PLD3	physical	22863883
TBCB_HUMAN	TBCB	physical	22863883
UBFD1_HUMAN	UBFD1	physical	22863883
VINC_HUMAN	VCL	physical	22863883
1433Z_HUMAN	YWHAZ	physical	22863883
PNPO_HUMAN	PNPO	physical	26344197
SNX2_HUMAN	SNX2	physical	26344197
AL7A1_HUMAN	ALDH7A1	physical	26496610
NRDC_HUMAN	NRD1	physical	26496610
PIAS1_HUMAN	PIAS1	physical	26496610
FA13A_HUMAN	FAM13A	physical	26496610
PACN2_HUMAN	PACSIN2	physical	26496610
E41LB_HUMAN	EPB41L4B	physical	26496610
KMT2C_HUMAN	KMT2C	physical	26496610
CSN7B_HUMAN	COPS7B	physical	26496610
TM189_HUMAN	TMEM189	physical	26496610
FOG1_HUMAN	ZFPM1	physical	28514442
MEX3A_HUMAN	MEX3A	physical	28514442
STXB4_HUMAN	STXBP4	physical	28514442
PXDN_HUMAN	PXDN	physical	28514442
MIGA1_HUMAN	FAM73A	physical	28514442
DCP1B_HUMAN	DCP1B	physical	28514442
ZN212_HUMAN	ZNF212	physical	28514442
DAPK1_HUMAN	DAPK1	physical	28514442
BCOR_HUMAN	BCOR	physical	28514442
ZN777_HUMAN	ZNF777	physical	28514442
ZMYM1_HUMAN	ZMYM1	physical	28514442
TNIP1_HUMAN	TNIP1	physical	28514442
IP3KC_HUMAN	ITPKC	physical	28514442
GNL3L_HUMAN	GNL3L	physical	28514442
RPIA_HUMAN	RPIA	physical	28514442
CTIP_HUMAN	RBBP8	physical	28514442
ERO1B_HUMAN	ERO1LB	physical	28514442
UB2Q1_HUMAN	UBE2Q1	physical	28514442
HXA5_HUMAN	HOXA5	physical	28514442
DPOD2_HUMAN	POLD2	physical	28514442
SUMF1_HUMAN	SUMF1	physical	28514442
FIGN_HUMAN	FIGN	physical	28514442
FINC_HUMAN	FN1	physical	28514442
BTD_HUMAN	BTD	physical	28514442
PRI2_HUMAN	PRIM2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.