HXA5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXA5_HUMAN
• UniProt AC: P20719
• Protein Name: Homeobox protein Hox-A5
• Gene Name: HOXA5
• Organism: Homo sapiens (Human).
• Sequence Length: 270
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'..
• Protein Sequence: MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGRYGYGYNGMDLSVGRSGSGHFGSGERARSYAASASAAPAEPRYSQPATSTHSPQPDPLPCSAVAPSPGSDSHHGGKNSLSNSSGASADAGSTHISSREGVGTASGAEEDAPASSEQASAQSEPSPAPPAQPQIYPWMRKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSMAAAGGAFRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MSSYFVNSFCG ----CCCCCCCCCCC	12.30	29759185
45	Phosphorylation	ASMHSGRYGYGYNGM HHHCCCCCCCCCCCC	20.44	-
49	Phosphorylation	SGRYGYGYNGMDLSV CCCCCCCCCCCEEEE	10.48	-
55	Phosphorylation	GYNGMDLSVGRSGSG CCCCCEEEECCCCCC	20.47	-
59	Phosphorylation	MDLSVGRSGSGHFGS CEEEECCCCCCCCCC	31.23	25002506
61	Phosphorylation	LSVGRSGSGHFGSGE EEECCCCCCCCCCCH	30.27	28857561
72	O-linked_Glycosylation	GSGERARSYAASASA CCCHHHHHHHHHCCC	20.38	30620550
76	O-linked_Glycosylation	RARSYAASASAAPAE HHHHHHHHCCCCCCC	18.00	30620550
86	Phosphorylation	AAPAEPRYSQPATST CCCCCCCCCCCCCCC	23.52	23403867
87	Phosphorylation	APAEPRYSQPATSTH CCCCCCCCCCCCCCC	30.85	23927012
91	Phosphorylation	PRYSQPATSTHSPQP CCCCCCCCCCCCCCC	40.62	30576142
92	Phosphorylation	RYSQPATSTHSPQPD CCCCCCCCCCCCCCC	26.65	23927012
93	Phosphorylation	YSQPATSTHSPQPDP CCCCCCCCCCCCCCC	23.24	23927012
95	Phosphorylation	QPATSTHSPQPDPLP CCCCCCCCCCCCCCC	25.89	23403867
104	Phosphorylation	QPDPLPCSAVAPSPG CCCCCCCCEECCCCC	24.68	23607784
109	Phosphorylation	PCSAVAPSPGSDSHH CCCEECCCCCCCCCC	31.96	30576142
112	Phosphorylation	AVAPSPGSDSHHGGK EECCCCCCCCCCCCC	39.05	23607784
114	Phosphorylation	APSPGSDSHHGGKNS CCCCCCCCCCCCCCC	21.05	25002506
121	Phosphorylation	SHHGGKNSLSNSSGA CCCCCCCCCCCCCCC	36.34	25159151
145	Phosphorylation	SSREGVGTASGAEED CCCCCCCCCCCCCCC	18.42	30576142
147	Phosphorylation	REGVGTASGAEEDAP CCCCCCCCCCCCCCC	38.07	30576142
156	Phosphorylation	AEEDAPASSEQASAQ CCCCCCCCHHHHHHC	33.09	18669648
157	Phosphorylation	EEDAPASSEQASAQS CCCCCCCHHHHHHCC	35.52	26471730
161	Phosphorylation	PASSEQASAQSEPSP CCCHHHHHHCCCCCC	26.91	26471730
164	Phosphorylation	SEQASAQSEPSPAPP HHHHHHCCCCCCCCC	51.71	26471730
167	Phosphorylation	ASAQSEPSPAPPAQP HHHCCCCCCCCCCCC	29.64	26471730
200	Phosphorylation	PEGKRARTAYTRYQT CCCHHHCHHHHHHHH	24.03	-
202	Phosphorylation	GKRARTAYTRYQTLE CHHHCHHHHHHHHHH	7.37	-
203	Phosphorylation	KRARTAYTRYQTLEL HHHCHHHHHHHHHHH	22.04	-
212	Ubiquitination	YQTLELEKEFHFNRY HHHHHHHHHHHHHHH	77.60	21890473
212	Ubiquitination	YQTLELEKEFHFNRY HHHHHHHHHHHHHHH	77.60	21890473
218	Methylation	EKEFHFNRYLTRRRR HHHHHHHHHHHHHHH	27.22	-
219	Phosphorylation	KEFHFNRYLTRRRRI HHHHHHHHHHHHHHH	17.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXA5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXA5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXA5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FOXA2_HUMAN	FOXA2	physical	12642491
FOXO1_HUMAN	FOXO1	physical	12163409
FOXA2_HUMAN	FOXA2	physical	12163409
SMAD1_HUMAN	SMAD1	physical	20211142
TF2AY_HUMAN	GTF2A1L	physical	20211142
ZN408_HUMAN	ZNF408	physical	20211142
TWST1_HUMAN	TWIST1	physical	15545268
ANM6_HUMAN	PRMT6	physical	23455924

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.