TF2AY_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF2AY_HUMAN
• UniProt AC: Q9UNN4
• Protein Name: TFIIA-alpha and beta-like factor
• Gene Name: GTF2A1L
• Organism: Homo sapiens (Human).
• Sequence Length: 478
• Subcellular Localization: Nucleus . Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa.
• Protein Description: May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription..
• Protein Sequence: MACLNPVPKLYRSVIEDVIEGVRNLFAEEGIEEQVLKDLKQLWETKVLQSKATEDFFRNSIQSPLFTLQLPHSLHQTLQSSTASLVIPAGRTLPSFTTAELGTSNSSANFTFPGYPIHVPAGVTLQTVSGHLYKVNVPIMVTETSGRAGILQHPIQQVFQQLGQPSVIQTSVPQLNPWSLQATTEKSQRIETVLQQPAILPSGPVDRKHLENATSDILVSPGNEHKIVPEALLCHQESSHYISLPGVVFSPQVSQTNSNVESVLSGSASMAQNLHDESLSTSPHGALHQHVTDIQLHILKNRMYGCDSVKQPRNIEEPSNIPVSEKDSNSQVDLSIRVTDDDIGEIIQVDGSGDTSSNEEIGSTRDADENEFLGNIDGGDLKVPEEEADSISNEDSATNSSDNEDPQVNIVEEDPLNSGDDVSEQDVPDLFDTDNVIVCQYDKIHRSKNKWKFYLKDGVMCFGGRDYVFAKAIGDAEW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
304	Phosphorylation	HILKNRMYGCDSVKQ HHHCCCCCCCCCCCC	16.03	29083192
308	Phosphorylation	NRMYGCDSVKQPRNI CCCCCCCCCCCCCCC	34.98	29083192
319	Phosphorylation	PRNIEEPSNIPVSEK CCCCCCCCCCCCCCC	51.15	27732954
324	Phosphorylation	EPSNIPVSEKDSNSQ CCCCCCCCCCCCCCC	33.31	27732954
335	Phosphorylation	SNSQVDLSIRVTDDD CCCCEEEEEEEECCC	12.13	24719451
356	Phosphorylation	VDGSGDTSSNEEIGS ECCCCCCCCCCCCCC	35.59	12107178
357	Phosphorylation	DGSGDTSSNEEIGST CCCCCCCCCCCCCCC	50.80	12107178
364	Phosphorylation	SNEEIGSTRDADENE CCCCCCCCCCCCCCC	27.62	-
418	Phosphorylation	VEEDPLNSGDDVSEQ EECCCCCCCCCCCCC	51.81	12107178
423	Phosphorylation	LNSGDDVSEQDVPDL CCCCCCCCCCCCCCC	36.21	12107178

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
356	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
356	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
357	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
357	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
418	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
418	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
423	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
423	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF2AY_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF2AY_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFOX2_HUMAN	RBFOX2	physical	20211142
MAFF_HUMAN	MAFF	physical	20211142
TLX3_HUMAN	TLX3	physical	20211142
ZBTB3_HUMAN	ZBTB3	physical	20211142
NKX23_HUMAN	NKX2-3	physical	20211142

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.