| UniProt ID | RFOX2_HUMAN | |
|---|---|---|
| UniProt AC | O43251 | |
| Protein Name | RNA binding protein fox-1 homolog 2 | |
| Gene Name | RBFOX2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 390 | |
| Subcellular Localization | Nucleus. Cytoplasm. | |
| Protein Description | RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.. | |
| Protein Sequence | MQNEPLTPGYHGFPARDSQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTGEHNLTLYGSTQAHGEQSSNSPSTQNGSLTTEGGAQTDGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATATAATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MQNEPLTPGYHGFP -CCCCCCCCCCCCCC | 25.94 | 28985074 | |
| 10 | Phosphorylation | NEPLTPGYHGFPARD CCCCCCCCCCCCCCC | 10.44 | 24275569 | |
| 15 (in isoform 10) | Phosphorylation | - | 26.17 | - | |
| 15 (in isoform 2) | Phosphorylation | - | 26.17 | - | |
| 15 (in isoform 3) | Phosphorylation | - | 26.17 | - | |
| 15 (in isoform 4) | Phosphorylation | - | 26.17 | - | |
| 15 (in isoform 5) | Phosphorylation | - | 26.17 | - | |
| 15 (in isoform 9) | Phosphorylation | - | 26.17 | - | |
| 26 (in isoform 6) | Phosphorylation | - | 47.23 | 26657352 | |
| 26 | Phosphorylation | QGNQEPTTTPDAMVQ CCCCCCCCCCCCCCC | 47.23 | 27251275 | |
| 26 (in isoform 8) | Phosphorylation | - | 47.23 | 26657352 | |
| 37 | Phosphorylation | AMVQPFTTIPFPPPP CCCCCCEECCCCCCC | 27.34 | - | |
| 50 (in isoform 8) | Phosphorylation | - | 39.66 | 21406692 | |
| 50 (in isoform 6) | Phosphorylation | - | 39.66 | 21406692 | |
| 67 (in isoform 8) | Phosphorylation | - | 35.62 | 30266825 | |
| 67 | Phosphorylation | YAGQTGEHNLTLYGS CCCCCCCCEEEEEEC | 35.62 | 27251275 | |
| 67 (in isoform 6) | Phosphorylation | - | 35.62 | 30266825 | |
| 70 (in isoform 6) | Phosphorylation | - | 24.21 | 21955146 | |
| 70 (in isoform 8) | Phosphorylation | - | 24.21 | 21955146 | |
| 106 | Phosphorylation | AQTDGQQSQTQSSEN CCCCCCCCCCCCCCC | 27.57 | - | |
| 119 | Phosphorylation | ENSESKSTPKRLHVS CCCCCCCCCCEEEEC | 36.24 | - | |
| 130 | Ubiquitination | LHVSNIPFRFRDPDL EEECCCCCCCCCHHH | 11.61 | 21890473 | |
| 138 | Methylation | RFRDPDLRQMFGQFG CCCCHHHHHHHHHHC | 33.04 | - | |
| 138 (in isoform 3) | Phosphorylation | - | 33.04 | 29083192 | |
| 142 (in isoform 3) | Phosphorylation | - | 19.30 | 29083192 | |
| 147 | Ubiquitination | MFGQFGKILDVEIIF HHHHHCCEEEEEEEE | 3.98 | 21890473 | |
| 150 (in isoform 10) | Ubiquitination | - | 5.22 | 21890473 | |
| 150 (in isoform 4) | Ubiquitination | - | 5.22 | 21890473 | |
| 150 (in isoform 5) | Ubiquitination | - | 5.22 | 21890473 | |
| 150 | Ubiquitination | QFGKILDVEIIFNER HHCCEEEEEEEEECC | 5.22 | 21890473 | |
| 151 (in isoform 2) | Ubiquitination | - | 29.99 | 21890473 | |
| 151 (in isoform 9) | Ubiquitination | - | 29.99 | 21890473 | |
| 151 | Ubiquitination | FGKILDVEIIFNERG HCCEEEEEEEEECCC | 29.99 | 21890473 | |
| 156 | Ubiquitination | DVEIIFNERGSKGFG EEEEEEECCCCCCEE | 47.90 | 21890473 | |
| 157 | Ubiquitination | VEIIFNERGSKGFGF EEEEEECCCCCCEEE | 56.65 | 21890473 | |
| 160 | Ubiquitination | IFNERGSKGFGFVTF EEECCCCCCEEEEEE | 62.17 | - | |
| 160 (in isoform 7) | Ubiquitination | - | 62.17 | 21890473 | |
| 160 (in isoform 1) | Ubiquitination | - | 62.17 | 21890473 | |
| 163 | Ubiquitination | ERGSKGFGFVTFENS CCCCCCEEEEEECCC | 25.45 | 21890473 | |
| 169 | Ubiquitination | FGFVTFENSADADRA EEEEEECCCCCHHHH | 38.00 | 32142685 | |
| 170 | Ubiquitination | GFVTFENSADADRAR EEEEECCCCCHHHHH | 21.96 | 32142685 | |
| 172 | Ubiquitination | VTFENSADADRAREK EEECCCCCHHHHHHH | 49.15 | 21890473 | |
| 173 | Ubiquitination | TFENSADADRAREKL EECCCCCHHHHHHHH | 14.12 | 21890473 | |
| 179 | Ubiquitination | DADRAREKLHGTVVE CHHHHHHHHCCEEEE | 39.98 | 32142685 | |
| 179 | Acetylation | DADRAREKLHGTVVE CHHHHHHHHCCEEEE | 39.98 | 19817231 | |
| 180 | Ubiquitination | ADRAREKLHGTVVEG HHHHHHHHCCEEEEC | 3.74 | 32142685 | |
| 183 | Phosphorylation | AREKLHGTVVEGRKI HHHHHCCEEEECCEE | 15.61 | 23532336 | |
| 194 | Ubiquitination | GRKIEVNNATARVMT CCEEEECCCEEEEEC | 43.79 | 32142685 | |
| 195 | Ubiquitination | RKIEVNNATARVMTN CEEEECCCEEEEECC | 9.46 | 21890473 | |
| 199 | Methylation | VNNATARVMTNKKMV ECCCEEEEECCCCCE | 5.28 | - | |
| 207 | Phosphorylation | MTNKKMVTPYANGWK ECCCCCEECCCCCEE | 13.69 | 21815630 | |
| 220 | Ubiquitination | WKLSPVVGAVYGPEL EECCCCCCEECCHHH | 15.01 | 21890473 | |
| 220 (in isoform 6) | Ubiquitination | - | 15.01 | 21890473 | |
| 221 | Ubiquitination | KLSPVVGAVYGPELY ECCCCCCEECCHHHH | 4.63 | 21890473 | |
| 221 (in isoform 8) | Ubiquitination | - | 4.63 | 21890473 | |
| 239 | Ubiquitination | SFQADVSLGNDAAVP CEECCCCCCCCCCEE | 8.15 | 32142685 | |
| 240 | Ubiquitination | FQADVSLGNDAAVPL EECCCCCCCCCCEEC | 23.59 | 32142685 | |
| 249 (in isoform 3) | Methylation | - | 39.68 | 24129315 | |
| 249 | Ubiquitination | DAAVPLSGRGGINTY CCCEECCCCCCCCCC | 39.68 | 32142685 | |
| 250 | Ubiquitination | AAVPLSGRGGINTYI CCEECCCCCCCCCCE | 36.47 | 32142685 | |
| 264 | Ubiquitination | IPLISLPLVPGFPYP EECEECCCCCCCCCC | 9.84 | 32142685 | |
| 265 | Ubiquitination | PLISLPLVPGFPYPT ECEECCCCCCCCCCC | 4.04 | 32142685 | |
| 267 (in isoform 5) | Methylation | - | 28.78 | 24129315 | |
| 268 (in isoform 9) | Methylation | - | 4.25 | 24129315 | |
| 275 | Sumoylation | FPYPTAATTAAAFRG CCCCCHHHHHHHHCC | 17.95 | - | |
| 277 (in isoform 7) | Methylation | - | 7.76 | 24129315 | |
| 281 | Methylation | ATTAAAFRGAHLRGR HHHHHHHCCHHHCCC | 36.34 | 54558687 | |
| 286 | Methylation | AFRGAHLRGRGRTVY HHCCHHHCCCCCEEE | 23.93 | 54558693 | |
| 293 | Phosphorylation | RGRGRTVYGAVRAVP CCCCCEEEEEEECCC | 9.96 | 28152594 | |
| 297 | Asymmetric dimethylarginine | RTVYGAVRAVPPTAI CEEEEEEECCCCCCC | 29.36 | - | |
| 297 | Methylation | RTVYGAVRAVPPTAI CEEEEEEECCCCCCC | 29.36 | - | |
| 329 | Methylation | YGGYAAYRYAQPATA CCCEEEEECCCCHHH | 18.65 | 24129315 | |
| 329 | Asymmetric dimethylarginine | YGGYAAYRYAQPATA CCCEEEEECCCCHHH | 18.65 | - | |
| 342 | Methylation | TATAATAAAAAAAAY HHHHHHHHHHHHHHH | 8.02 | - | |
| 347 | Methylation | TAAAAAAAAYSDGYG HHHHHHHHHHHCCCC | 11.38 | - | |
| 380 | Phosphorylation | VGAVASLYRGGYSRF HHHHHHHHCCCCCCC | 12.52 | - | |
| 381 | Asymmetric dimethylarginine | GAVASLYRGGYSRFA HHHHHHHCCCCCCCC | 37.04 | - | |
| 381 | Methylation | GAVASLYRGGYSRFA HHHHHHHCCCCCCCC | 37.04 | 12018239 | |
| 386 | Asymmetric dimethylarginine | LYRGGYSRFAPY--- HHCCCCCCCCCC--- | 24.22 | - | |
| 386 | Methylation | LYRGGYSRFAPY--- HHCCCCCCCCCC--- | 24.22 | 16188267 | |
| 390 | Methylation | GYSRFAPY------- CCCCCCCC------- | 27.97 | - | |
| 442 | Methylation | ----------------------------------------------------------- ----------------------------------------------------------- | - | ||
| 447 | Methylation | ---------------------------------------------------------------- ---------------------------------------------------------------- | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RFOX2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RFOX2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RFOX2_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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