| UniProt ID | DEDD2_HUMAN | |
|---|---|---|
| UniProt AC | Q8WXF8 | |
| Protein Name | DNA-binding death effector domain-containing protein 2 | |
| Gene Name | DEDD2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 326 | |
| Subcellular Localization | Nucleus, nucleolus . Nuclear, accumulated in subnuclear structures resembling nucleoli. | |
| Protein Description | May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.. | |
| Protein Sequence | MALSGSTPAPCWEEDECLDYYGMLSLHRMFEVVGGQLTECELELLAFLLDEAPGAAGGLARARSGLELLLELERRGQCDESNLRLLGQLLRVLARHDLLPHLARKRRRPVSPERYSYGTSSSSKRTEGSCRRRRQSSSSANSQQGQWETGSPPTKRQRRSRGRPSGGARRRRRGAPAAPQQQSEPARPSSEGKVTCDIRLRVRAEYCEHGPALEQGVASRRPQALARQLDVFGQATAVLRSRDLGSVVCDIKFSELSYLDAFWGDYLSGALLQALRGVFLTEALREAVGREAVRLLVSVDEADYEAGRRRLLLMEEEGGRRPTEAS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 115 | Phosphorylation | RPVSPERYSYGTSSS CCCCHHHHCCCCCCC | 12.46 | - | |
| 117 | Phosphorylation | VSPERYSYGTSSSSK CCHHHHCCCCCCCCC | 18.58 | - | |
| 119 | Phosphorylation | PERYSYGTSSSSKRT HHHHCCCCCCCCCCC | 19.73 | - | |
| 124 | Ubiquitination | YGTSSSSKRTEGSCR CCCCCCCCCCCCCCC | 66.35 | 27667366 | |
| 136 (in isoform 2) | Phosphorylation | - | 30.31 | 26434776 | |
| 137 (in isoform 2) | Phosphorylation | - | 21.70 | 26434776 | |
| 138 (in isoform 2) | Phosphorylation | - | 38.42 | 26434776 | |
| 139 (in isoform 2) | Phosphorylation | - | 33.16 | 26434776 | |
| 142 (in isoform 2) | Phosphorylation | - | 24.48 | 26434776 | |
| 146 (in isoform 2) | Phosphorylation | - | 30.41 | 26434776 | |
| 149 (in isoform 2) | Phosphorylation | - | 39.75 | 26434776 | |
| 154 | Phosphorylation | WETGSPPTKRQRRSR CCCCCCCCHHHHHHC | 42.09 | - | |
| 155 | Ubiquitination | ETGSPPTKRQRRSRG CCCCCCCHHHHHHCC | 52.92 | - | |
| 189 | Phosphorylation | QSEPARPSSEGKVTC CCCCCCCCCCCCEEE | 35.15 | - | |
| 190 | Phosphorylation | SEPARPSSEGKVTCD CCCCCCCCCCCEEEE | 53.72 | - | |
| 193 | Ubiquitination | ARPSSEGKVTCDIRL CCCCCCCCEEEEEEE | 30.25 | - | |
| 246 | Phosphorylation | LRSRDLGSVVCDIKF HHHCCCCCEEEEEEH | 20.76 | 23684312 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DEDD2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DEDD2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DEDD2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CFLAR_HUMAN | CFLAR | physical | 11741985 | |
| CFLAR_HUMAN | CFLAR | physical | 11965497 | |
| DEDD_HUMAN | DEDD | physical | 11965497 | |
| CASP8_HUMAN | CASP8 | physical | 11965497 | |
| DEDD_HUMAN | DEDD | physical | 12527898 | |
| DEDD2_HUMAN | DEDD2 | physical | 12527898 | |
| DEDD2_HUMAN | DEDD2 | physical | 11965497 | |
| TF3C3_HUMAN | GTF3C3 | physical | 11965497 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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